公开(公告)号：US20230284944A1

公开(公告)日：2023-09-14

申请号：US18198085

申请日：2023-05-16

Applicant: Dexcom, Inc.

Inventor： Shanger Wang ,  Devon M. Headen ,  Sebastian Bohm ,  Jonathan Hughes ,  Ted Tang Lee ,  Peter C. Simpson ,  Jiong Zou

IPC: A61B5/1486 ,  A61B5/00 ,  C12Q1/00 ,  A61B5/145 ,  C12Q1/54

CPC classification number: A61B5/14865 ,  A61B5/0022 ,  C12Q1/006 ,  C12Q1/002 ,  A61B5/14532 ,  A61B5/14546 ,  C12Q1/54 ,  G01N27/3271

Abstract: Flexible analyte sensors are provided. Flexible analyte sensors may be flexible continuous analyte sensors that facilitate continuous monitoring of an analyte such as blood glucose. The flexible analyte sensor may have a relatively flexible conductive or non-conductive core, may be formed from a plurality of substantially planar layers, or may be configured to transform from a freestanding sensor ex vivo to a non-freestanding sensor in vivo.

公开(公告)号：US20230138407A1

公开(公告)日：2023-05-04

申请号：US18091658

申请日：2022-12-30

Applicant: DexCom, Inc.

Inventor： Jiong Zou ,  Robert J. Boock ,  Andrew Trinin Dennis ,  Ted Tang Lee ,  Jeff T. Suri ,  David Sze ,  Mark A. Tapsak ,  Huashi Zhang ,  Shanger Wang

IPC: G01N27/327 ,  C12N11/089 ,  C12N11/093 ,  C12N11/08 ,  C08L39/06 ,  C08L69/00 ,  C08L75/04 ,  C12Q1/00 ,  A61B5/00 ,  A61B5/145 ,  A61B5/1486 ,  G01N33/66 ,  A61K31/045 ,  A61K31/137 ,  A61K31/46 ,  A61K31/465 ,  A61K31/485 ,  A61K31/515 ,  A61K31/56 ,  A61K33/00 ,  A61K36/185 ,  A61K38/28 ,  A61B5/1473

Abstract: Disclosed are devices for determining an analyte concentration (e.g., glucose). The devices comprise a sensor configured to generate a signal associated with a concentration of an analyte and a sensing membrane located over the sensor. The sensing membrane comprises an enzyme layer, wherein the enzyme layer comprises an enzyme and a polymer comprising polyurethane and/or polyurea segments and one or more zwitterionic repeating units. The enzyme layer protects the enzyme and prevents it from leaching from the sensing membrane into a host or deactivating.

公开(公告)号：US20220214300A1

公开(公告)日：2022-07-07

申请号：US17560566

申请日：2021-12-23

Applicant: DEXCOM, INC.

Inventor： Shanger Wang ,  Robert J. Boock ,  Andrew Trinin Dennis ,  Ted Tang Lee ,  Jeff T. Suri ,  David Sze ,  Mark A. Tapsak ,  Huashi Zhang ,  Jiong Zou

IPC: G01N27/327 ,  C08G18/08 ,  C08G18/48 ,  C08G18/40 ,  C08G18/38 ,  C08G18/12 ,  C08G18/44 ,  C08G18/75 ,  C12N11/089 ,  C12N11/093 ,  C12N11/08 ,  C08L39/06 ,  C08L69/00 ,  C08L75/04 ,  C12Q1/00 ,  A61B5/00 ,  A61B5/145 ,  A61B5/1486 ,  G01N33/66 ,  A61K31/045 ,  A61K31/137 ,  A61K31/46 ,  A61K31/465 ,  A61K31/485 ,  A61K31/515 ,  A61K31/56 ,  A61K33/00 ,  A61K36/185 ,  A61K38/28 ,  A61B5/1473

Abstract: Disclosed are devices for determining an analyte concentration (e.g., glucose). The devices comprise a sensor configured to generate a signal associated with a concentration of an analyte and a sensing membrane located over the sensor. The sensing membrane comprises a biointerface layer which interfaces with a biological fluid containing the analyte to be measured. The biointerface layer can comprises a biointerface polymer, wherein the biointerface polymer comprises polyurethane and/or polyurea segments and one or more zwitterionic repeating units. The sensing membrane can also comprise an enzyme layer, wherein the enzyme layer comprises an enzyme and a polymer comprising polyurethane and/or polyurea segments and one or more zwitterionic repeating units. The sensing membrane can also comprise a diffusion-resistance layer, which can comprise a base polymer having a lowest Tg of greater than −50 C.

公开(公告)号：US20200205705A1

公开(公告)日：2020-07-02

申请号：US16728945

申请日：2019-12-27

Applicant: DexCom, Inc.

Inventor： Ted Tang Lee ,  Anna Leigh Davis ,  Peter C. Simpson ,  Liang Wang ,  Shanger Wang ,  Jiong Zou ,  Stephen J. Vanslyke ,  Rui Ma ,  Wenjie Lan

IPC: A61B5/145 ,  A61B5/1495 ,  A61B5/1473

Abstract: Various examples described herein are directed to systems, apparatuses, and methods for mitigating break-in in an analyte sensor. An example analyte sensor system comprises an analyte sensor applicator comprising a needle; an analyte sensor comprising at least a working electrode and a reference electrode, the analyte sensor positioned at least partially within a lumen of the needle; and a hydrating agent positioned within the lumen of the needle to at least partially hydrate the needle.

公开(公告)号：US20180199873A1

公开(公告)日：2018-07-19

申请号：US15874503

申请日：2018-01-18

Applicant: DexCom, Inc.

Inventor： Shanger Wang ,  Devon M. Headen ,  Sebastian Bohm ,  Jonathan Hughes ,  Ted Tang Lee ,  Peter C. Simpson ,  Jiong Zou

IPC: A61B5/1486 ,  G01N27/327 ,  A61B5/00 ,  C12Q1/00 ,  C12Q1/54

CPC classification number: A61B5/14865 ,  A61B5/0022 ,  A61B5/14532 ,  A61B5/14546 ,  A61B2562/125 ,  A61B2562/164 ,  C12Q1/002 ,  C12Q1/006 ,  C12Q1/54 ,  G01N27/3271

Abstract: Flexible analyte sensors are provided. Flexible analyte sensors may be flexible continuous analyte sensors that facilitate continuous monitoring of an analyte such as blood glucose. The flexible analyte sensor may have a relatively flexible conductive or non-conductive core, may be formed from a plurality of substantially planar layers, or may be configured to transform from a freestanding sensor ex vivo to a non-freestanding sensor in vivo.

公开(公告)号：US20170188916A1

公开(公告)日：2017-07-06

申请号：US15395892

申请日：2016-12-30

Applicant: DexCom, Inc.

Inventor： Shanger Wang ,  Robert J. Boock ,  Andrew Trinin Dennis ,  Ted Tang Lee ,  Jeff T. Suri ,  David Sze ,  Mark A Tapsak ,  Huashi Zhang ,  Jiong Zou

IPC: A61B5/145 ,  C12N11/08 ,  G01N33/66 ,  C12Q1/00

CPC classification number: G01N27/3273 ,  A61B5/0004 ,  A61B5/002 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1473 ,  A61B5/1486 ,  A61B5/14865 ,  A61B2562/12 ,  A61K31/045 ,  A61K31/137 ,  A61K31/46 ,  A61K31/465 ,  A61K31/485 ,  A61K31/515 ,  A61K31/56 ,  A61K33/00 ,  A61K36/185 ,  A61K38/28 ,  C08G18/0828 ,  C08G18/12 ,  C08G18/3857 ,  C08G18/4018 ,  C08G18/44 ,  C08G18/4833 ,  C08G18/755 ,  C08L39/06 ,  C08L69/00 ,  C08L75/04 ,  C12N11/08 ,  C12Q1/002 ,  C12Q1/006 ,  G01N27/3275 ,  G01N33/66 ,  C08G18/3234

Abstract: Disclosed are devices for determining an analyte concentration (e.g., glucose). The devices comprise a sensor configured to generate a signal associated with a concentration of an analyte and a sensing membrane located over the sensor. The sensing membrane comprises a biointerface layer which interfaces with a biological fluid containing the analyte to be measured. The biointerface layer can comprises a biointerface polymer, wherein the biointerface polymer comprises polyurethane and/or polyurea segments and one or more zwitterionic repeating units. The sensing membrane can also comprise an enzyme layer, wherein the enzyme layer comprises an enzyme and a polymer comprising polyurethane and/or polyurea segments and one or more zwitterionic repeating units. The sensing membrane can also comprise a diffusion-resistance layer, which can comprise a base polymer having a lowest Tg of greater than −50 C.

公开(公告)号：US20250064358A1

公开(公告)日：2025-02-27

申请号：US18945222

申请日：2024-11-12

Applicant: DexCom, Inc.

Inventor： Peter C. Simpson ,  Jennifer Blackwell ,  Sebastian Bohm ,  Michael J. Estes ,  Jeff Jackson ,  Jason Mitchell ,  Jack Pryor ,  Daiting Rong ,  Sean T. Saint ,  Disha B. Sheth ,  Shanger Wang

IPC: A61B5/1473 ,  A61B5/00 ,  A61B5/145 ,  A61B17/00 ,  A61B17/34

Abstract: Sensor devices including dissolvable tissue-piercing tips are provided. The sensor devices can be used in conjunction with dissolvable needles configured for inserting the sensor devices into a host. Hardening agents for strengthening membranes on sensor devices are also provided. Methods of using and fabricating sensor devices are also provided.

公开(公告)号：US20250025076A1

公开(公告)日：2025-01-23

申请号：US18399162

申请日：2023-12-28

Applicant: DexCom, Inc.

Inventor： Shuyu Lin ,  Daiting Rong ,  Stacy Hunt DuVall ,  Wenjie Lan ,  Jason M. Halac ,  Jiong Zou ,  Devon M. Headen ,  Shanger Wang ,  Shane Richard Parnell ,  Berta Esteban Fernandez de Avila ,  Shannon Reuben Woodruff

IPC: A61B5/1473

Abstract: An analyte monitoring sensor configured for in vivo measurement of at least one analyte is provided, the sensor comprising a substrate having a substrate surface, an aptamer protective layer encapsulating at least a portion of the substrate surface, the aptamer protective layer permeable to the at least one analyte, one or more aptamer conjugates associated with at least a portion of the substrate surface and positioned between the aptamer protective layer and the substrate for obtaining measurements related to the at least one analyte in vivo. Methods of extending in vivo performance of the analyte monitoring sensor are also described.

公开(公告)号：US11696710B2

公开(公告)日：2023-07-11

申请号：US16917578

申请日：2020-06-30

Applicant: DexCom, Inc.

Inventor： Peter C. Simpson ,  Jennifer Blackwell ,  Sebastian Bohm ,  Michael J. Estes ,  Jeff Jackson ,  Jason Mitchell ,  Jack Pryor ,  Daiting Rong ,  Sean T. Saint ,  Disha B. Sheth ,  Shanger Wang

IPC: A61B5/1473 ,  A61B5/145

CPC classification number: A61B5/1473 ,  A61B5/14532

Abstract: Sensor devices including dissolvable tissue-piercing tips are provided. The sensor devices can be used in conjunction with dissolvable needles configured for inserting the sensor devices into a host. Hardening agents for strengthening membranes on sensor devices are also provided. Methods of using and fabricating sensor devices are also provided.

公开(公告)号：US11262326B2

公开(公告)日：2022-03-01

申请号：US15395892

申请日：2016-12-30

Applicant: DexCom, Inc.

Inventor： Shanger Wang ,  Robert J. Boock ,  Andrew Trinin Dennis ,  Ted Tang Lee ,  Jeff T. Suri ,  David Sze ,  Mark A Tapsak ,  Huashi Zhang ,  Jiong Zou

IPC: A61B5/145 ,  G01N27/327 ,  C08G18/08 ,  C08G18/48 ,  C08G18/40 ,  C08G18/38 ,  C08G18/12 ,  C08G18/44 ,  C08G18/75 ,  C12N11/089 ,  C12N11/093 ,  C08L39/06 ,  C08L69/00 ,  C08L75/04 ,  C12Q1/00 ,  A61B5/00 ,  A61B5/1486 ,  G01N33/66 ,  A61K31/045 ,  A61K31/137 ,  A61K31/46 ,  A61K31/465 ,  A61K31/485 ,  A61K31/515 ,  A61K31/56 ,  A61K33/00 ,  A61K36/185 ,  A61K38/28 ,  A61B5/1473

Abstract: Disclosed are devices for determining an analyte concentration (e.g., glucose). The devices comprise a sensor configured to generate a signal associated with a concentration of an analyte and a sensing membrane located over the sensor. The sensing membrane comprises a biointerface layer which interfaces with a biological fluid containing the analyte to be measured. The biointerface layer can comprises a biointerface polymer, wherein the biointerface polymer comprises polyurethane and/or polyurea segments and one or more zwitterionic repeating units. The sensing membrane can also comprise an enzyme layer, wherein the enzyme layer comprises an enzyme and a polymer comprising polyurethane and/or polyurea segments and one or more zwitterionic repeating units. The sensing membrane can also comprise a diffusion-resistance layer, which can comprise a base polymer having a lowest Tg of greater than −50 C.