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21.发明授权Systems and methods for obtaining desired lesion characteristics while ablating body tissue 失效用于在消融身体组织时获得所需病变特征的系统和方法
公开(公告)号：US6056745A
公开(公告)日：2000-05-02
申请号：US962918
申请日：1997-10-27
CPC分类号： A61B18/00 , A61B18/12 , A61B18/1206 , A61B18/1492 , A61B2017/00017 , A61B2017/00084 , A61B2018/00011 , A61B2018/00023 , A61B2018/00029 , A61B2018/00047 , A61B2018/00083 , A61B2018/00095 , A61B2018/00208 , A61B2018/00351 , A61B2018/00577 , A61B2018/00642 , A61B2018/0066 , A61B2018/00666 , A61B2018/00684 , A61B2018/00702 , A61B2018/00744 , A61B2018/00761 , A61B2018/00791 , A61B2018/00815 , A61B2018/00886 , A61B2018/124 , A61B2018/1253 , A61B2018/126 , A61B2018/1425 , A61B2018/1435 , A61B2018/1861 , A61B2218/002 , A61M2230/50
摘要： Systems and methods for ablating body tissue use an electrode for contacting tissue to form a tissue-electrode interface. The electrode is coupled to a source of ablation energy for transmitting ablation energy at a prescribed ablation power level into tissue to form, over a prescribed ablation time period, a therapeutic result. The therapeutic result includes a lesion that extends beneath the tissue-electrode interface to a boundary depth between viable and nonviable tissue and a maximum tissue temperature developed within the lesion between the tissue-electrode interface and the boundary depth. The systems and methods include an element to cool the electrode. An input element inputs a desired therapeutic result including at least a targeted lesion boundary depth. The systems and methods employ a processing element that retains a function correlating an observed relationship among lesion boundary depth, ablation power level, ablation time, actual or predicted sub-surface tissue temperature, and electrode temperature. The processing element compares the desired therapeutic result to the function. The processing element selects an operating condition based upon the comparison to achieve the desired therapeutic result without exceeding a prescribed actual or predicted sub-surface tissue temperature, at least in part by cooling the electrode to control electrode temperature while the electrode transmits ablation energy.
摘要翻译： 用于烧蚀身体组织的系统和方法使用用于接触组织的电极以形成组织 - 电极界面。 电极耦合到消融能量源，用于以规定的消融功率电平将消融能量传输到组织中，以在规定的消融时间段内形成治疗结果。 治疗结果包括在组织 - 电极界面下方延伸到存活组织和非活动组织之间的边界深度的病变以及在组织 - 电极界面和边界深度之间的损伤之内形成的最大组织温度。 该系统和方法包括用于冷却电极的元件。 输入元件输入包括至少目标病变边界深度的所需治疗结果。 系统和方法采用处理元件，该处理元件保持与损伤边界深度，消融功率水平，消融时间，实际或预测的子表面组织温度和电极温度之间的观察到的关系相关的功能。 处理元件将期望的治疗结果与功能进行比较。 所述处理元件至少部分地通过冷却所述电极来控制电极温度，同时所述电极传输消融能量，而基于所述比较选择操作条件以实现期望的治疗结果而不超过规定的实际或预测的子表面组织温度。
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22.发明授权Systems and methods for sensing sub-surface temperatures in body tissue during ablation with actively cooled electrodes 失效用于在主动冷却的电极消融期间检测身体组织中的亚表面温度的系统和方法
公开(公告)号：US6053912A
公开(公告)日：2000-04-25
申请号：US942321
申请日：1997-10-01
CPC分类号： A61B18/1492 , A61N1/403 , A61B18/1206 , A61B2017/00084 , A61B2017/00243 , A61B2018/00023 , A61B2018/00029 , A61B2018/0069 , A61B2018/126 , A61B2018/1861
摘要： Systems and associated methods for ablating body tissue employ an electrode for contacting tissue to form a tissue-electrode interface. The electrode is adapted to be connected to a source of ablation energy to conduct ablation energy for transmission by the electrode into tissue at the tissue-electrode interface. The systems and methods also include an element to cool the electrode. The systems and methods hold a tissue temperature sensing element in a carrier in thermal conductive contact with tissue beneath the tissue-electrode interface. The systems and methods include a controller that is coupled to the tissue temperature sensing element to control either the supply of ablation energy, or the rate at which the electrode is cooled, or both based, at least in part, upon temperature sensed by the temperature sensing element.
摘要翻译： 用于烧蚀身体组织的系统和相关方法使用用于接触组织的电极以形成组织 - 电极界面。 电极适于连接到消融能量源，以传导消融能量，以将电极传输到组织 - 电极界面处的组织中。 该系统和方法还包括用于冷却电极的元件。 系统和方法将组织温度感测元件保持在与组织 - 电极界面下面的组织进行导热接触的载体中。 系统和方法包括耦合到组织温度感测元件的控制器，以控制消融能量的供应，或电极被冷却的速率，或者基于至少部分地基于由温度感测的温度 传感元件。
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公开(公告)号：US5853411A
公开(公告)日：1998-12-29
申请号：US629363
申请日：1996-04-08
申请人： James G. Whayne , Thomas F. Kordis , Sidney D. Fleischman , Dorin Panescu , David K. Swanson , Patrick M. Owens , Jerome Jackson , Russell B. Thompson , David McGee
发明人： James G. Whayne , Thomas F. Kordis , Sidney D. Fleischman , Dorin Panescu , David K. Swanson , Patrick M. Owens , Jerome Jackson , Russell B. Thompson , David McGee
CPC分类号： A61N1/056 , A61B18/1492 , A61B2017/00053 , A61B2017/00243 , A61B2017/22051 , A61B2017/22061 , A61B2018/00083 , A61B2018/00095 , A61B2018/00107 , A61B2018/00148 , A61B2018/00214 , A61B2018/0022
摘要： Enhanced electrical connections for electrodes are provided. In one implementation, an electrode body comprises a first electrically nonconductive layer and a second electrically nonconductive layer overlying at least a portion of the first layer. An intermediate region is formed between the first and second layers. An electrically conductive pathway extends within the intermediate region. An formed opening extends to the intermediate region, exposing a part of the electrically conductive pathway. An electrically conductive material is deposited on the second layer so that a part of the electrically conductive material passes through the opening to establish electrical contact between the electrically conductive material and the electrically conductive pathway.
摘要翻译： 提供了电极的增强电连接。 在一个实施方案中，电极体包括覆盖在第一层的至少一部分上的第一非导电层和第二非导电层。 在第一和第二层之间形成中间区域。 导电通路在中间区域内延伸。 形成的开口延伸到中间区域，暴露导电路径的一部分。 导电材料沉积在第二层上，使得导电材料的一部分通过开口以在导电材料和导电通路之间建立电接触。
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公开(公告)号：US5853409A
公开(公告)日：1998-12-29
申请号：US789294
申请日：1997-01-27
CPC分类号： A61B18/00 , A61B18/12 , A61B18/1206 , A61B18/1492 , A61N1/056 , A61N1/403 , A61B2017/00017 , A61B2017/00084 , A61B2017/00243 , A61B2018/00023 , A61B2018/00029 , A61B2018/00083 , A61B2018/00095 , A61B2018/00351 , A61B2018/00577 , A61B2018/00642 , A61B2018/0066 , A61B2018/00666 , A61B2018/00684 , A61B2018/0069 , A61B2018/00791 , A61B2018/00815 , A61B2018/124 , A61B2018/1253 , A61B2018/126 , A61B2018/1425 , A61B2018/1435 , A61B2018/1861 , A61M2230/50
摘要： An apparatus for ablating body tissue has an electrode for contacting tissue to transmit ablation energy. A tissue temperature sensing element is held in a thermally conducting carrier on the electrode. The carrier holds the tissue temperature sensing element in thermal conductive contact with tissue, while keeping the temperature sensing element in isolation from thermal conductive contact with the electrode. The carrier has prescribed thermal conductive characteristics that significantly improve the sensitivity of the temperature sensing element to tissue temperature and not the temperature of the electrode.
摘要翻译： 用于烧蚀身体组织的装置具有用于接触组织以传递消融能量的电极。 组织温度感测元件保持在电极上的导热载体中。 载体将组织温度感测元件保持与组织的热传导接触，同时保持温度感测元件与电极的导热接触隔离。 载体规定了导热特性，其显着地提高了温度感测元件对组织温度的灵敏度，而不是电极的温度。
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25.发明授权Systems and methods for ablating body tissue using predicted maximum tissue temperature 失效使用预测的最大组织温度消融体组织的系统和方法
公开(公告)号：US5735846A
公开(公告)日：1998-04-07
申请号：US431775
申请日：1995-05-01
CPC分类号： A61B18/1492 , A61B18/00 , A61B18/12 , A61B18/1206 , A61B18/20 , A61B2017/00092 , A61B2017/00154 , A61B2017/003 , A61B2018/00011 , A61B2018/00023 , A61B2018/00029 , A61B2018/00047 , A61B2018/00083 , A61B2018/00095 , A61B2018/00101 , A61B2018/00107 , A61B2018/0016 , A61B2018/00351 , A61B2018/00577 , A61B2018/00636 , A61B2018/0066 , A61B2018/0069 , A61B2018/00744 , A61B2018/00761 , A61B2018/00791 , A61B2018/00797 , A61B2018/00803 , A61B2018/00815 , A61B2018/00821 , A61B2018/00886 , A61B2018/124 , A61B2018/1253 , A61B2018/126 , A61B2018/128 , A61B2018/1467 , A61B2018/1472
摘要： Systems and methods ablate body tissue using an electrode for contacting tissue at a tissue-electrode interface to transmit ablation energy at a determinable power level. The systems and methods include an element to remove heat from the electrode at a determinable rate. The systems and methods employ a processing element to derive a prediction of the maximum tissue temperature condition occurring beneath the tissue-electrode interface. The processing element controls the power level of ablation energy transmitted by the electrode, or the rate at which the electrode is cooled, or both, based, at least in part, upon the maximum tissue temperature prediction.
摘要翻译： 系统和方法使用用于接触组织 - 电极界面处的组织的电极来消融身体组织，以在可确定的功率水平传递消融能量。 该系统和方法包括以可确定的速率从电极去除热量的元件。 系统和方法采用处理元件来导出在组织 - 电极界面下方发生的最大组织温度条件的预测。 处理元件至少部分地基于最大组织温度预测来控制由电极传递的消融能量的功率水平，或电极冷却速率或两者。
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公开(公告)号：US20110077672A1
公开(公告)日：2011-03-31
申请号：US12946987
申请日：2010-11-16
IPC分类号： A61B17/12
CPC分类号： A61B17/12013 , A61B17/00234 , A61B17/00491 , A61B17/0218 , A61B17/0401 , A61B17/0469 , A61B17/064 , A61B2017/00243 , A61B2017/00349 , A61B2017/0443 , A61B2017/0464 , A61B2017/0649 , A61B2017/3488 , A61F2/2487
摘要： Devices for insertion into an atrial appendage of stasis reducing components such as mesh members, chemical bonding agents or expandable anchors are disclosed.
摘要翻译： 公开了用于插入龋齿减少组件如网状构件，化学粘合剂或可扩张锚的心房附件的装置。
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27.发明授权公开(公告)号：US07335196B2
公开(公告)日：2008-02-26
申请号：US10941678
申请日：2004-09-14
IPC分类号： A61B18/18
CPC分类号： A61B18/1492 , A61B5/6858 , A61B18/1402 , A61B18/1815 , A61B2017/00084 , A61B2017/00292 , A61B2017/003 , A61B2018/00107 , A61B2018/00148 , A61B2018/0016 , A61B2018/00214 , A61B2018/00755 , A61B2018/00875 , A61B2018/124 , A61B2018/1253 , A61B2018/126 , A61B2018/1435 , A61B2018/1861 , A61L29/085 , A61L29/145 , A61L31/10 , A61L31/145 , A61N1/06 , A61N1/403 , C08L1/02
摘要： A device for creating the lesions in body tissue includes a support element having an electromagnetic energy emitting region. When caused to emit electromagnetic energy, the region creates a single continuous lesion that is long and thin, having a length that is substantially greater than its width.
摘要翻译： 用于在身体组织中产生损伤的装置包括具有电磁能发射区域的支撑元件。 当引起发射电磁能时，该区域产生长且薄的单个连续病变，其长度远大于其宽度。
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28.发明授权Composite structures and methods for ablating tissue to form complex lesion patterns in the treatment of cardiac conditions and the like 失效用于在治疗心脏病况等中烧蚀组织以形成复杂病变图案的复合结构和方法公开(公告)号：US07115122B1
公开(公告)日：2006-10-03
申请号：US09505354
申请日：2000-02-16
CPC分类号： A61B18/1492 , A61B2017/003 , A61B2018/00083 , A61B2018/00196 , A61B2018/00214 , A61B2018/00267 , A61B2018/00577 , A61B2018/00839 , A61B2018/1437 , A61B2018/1467 , A61B2018/1497
摘要： A method of ablating tissue in the heart to treat atrial fibrillation introduces into a selected atrium an energy emitting element. The method exposes the element to a region of the atrial wall and applies ablating energy to the element to thermally destroy tissue. The method forms a convoluted lesion pattern comprising elongated straight lesions and elongated curvilinear lesions. The lesion pattern directs electrical impulses within the atrial myocardium along a path that activates the atrial myocardium while interrupting reentry circuits that, if not interrupted, would cause fibrillation. The method emulates the surgical maze procedure, but lends itself to catheter-based procedures that do not require open heart surgical techniques. A composite structure for performing the method is formed using a template that displays in planar view a desired lesion pattern for the tissue. An array of spaced apart element is laid on the template. Guided by the template, energy emitting and non-energy emitting zones are formed on the elements. By overlaying the elements, the composite structure is formed, which can be introduced into the body to ablate tissue using catheter-based, vascular access techniques.
摘要翻译： 心脏中消融组织以治疗心房颤动的方法将所选择的心房引入能量发射元件。 该方法将该元件暴露于心房壁的一个区域，并向该元件施加消融能量以热破坏组织。 该方法形成包括细长的直线损伤和细长的曲线损伤的褶皱病变图案。 病变图案沿着激活心房心肌的路径引导心房心肌内的电脉冲，同时中断再入电路，如果不中断，将引起原纤维化。 该方法模拟外科迷宫手术，但适用于不需要开放心脏手术技术的基于导管的手术。 用于执行该方法的复合结构使用在平面图中显示用于组织的期望损伤图案的模板来形成。 间隔开的元件阵列放置在模板上。 在模板的指导下，在元件上形成能量发射和非能量发射区。 通过覆盖元件，形成复合结构，其可以引入体内以使用基于导管的血管通路技术来烧蚀组织。
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公开(公告)号：US06830576B2
公开(公告)日：2004-12-14
申请号：US10098695
申请日：2002-03-15
IPC分类号： A61B1704
CPC分类号： A61B17/0218 , A61B17/00234 , A61B17/0469 , A61B17/064 , A61B17/12013 , A61B2017/00243 , A61B2017/00349 , A61B2017/0443 , A61B2017/0464 , A61B2017/048 , A61B2017/0649 , A61B2017/3488
摘要： Devices for insertion into an atrial appendage of stasis reducing components such as mesh members, chemical bonding agents or expandable anchors are disclosed.
摘要翻译： 公开了用于插入龋齿减少组件如网状构件，化学粘合剂或可扩张锚的心房附件的装置。
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30.发明授权Resilient radiopaque electrophysiology electrodes and probes including the same 失效弹性不透射线电生理学电极和探针包括相同公开(公告)号：US06540743B2
公开(公告)日：2003-04-01
申请号：US09826200
申请日：2001-04-03
IPC分类号： A61B1818
CPC分类号： A61B5/6858 , A61B5/0422 , A61B18/1492 , A61B2017/00088 , A61B2017/0088 , A61B2018/00083 , A61B2018/00107 , A61B2018/00148 , A61B2018/0016 , A61B2018/00791 , A61B2018/1435 , A61L29/145 , A61L31/10 , A61L31/145 , A61N1/056 , A61N1/06 , A61N1/40 , G01K1/026 , G01K3/14
摘要： A coil electrode for use in an electrophysiology probe includes a first material having a relatively high radiopacity and a second material having a relatively high resiliency. This combination provides the necessary levels of durability, resiliency and radiopacity. An electrophysiological probe includes a support structure, at least one first electrode defining a first radiopacity supported on the support structure and at least one second electrode defining a second radiopacity supported on the support structure, the second radiopacity being greater than the first radiopacity. When viewed under a fluoroscope, the pattern of electrodes of varying radiopacities allows the physician to distinguish between individual electrodes.
摘要翻译： 用于电生理学探针的线圈电极包括具有较高放射不透性的第一材料和具有较高弹性的第二材料。 这种组合提供了必要的耐久性，弹性和不透射度。 电生理探针包括支撑结构，限定支撑在支撑结构上的第一不透射线的至少一个第一电极和限定支撑在支撑结构上的第二不透射线的至少一个第二电极，第二射线不透明度大于第一射线不透性。 当在荧光镜下观察时，具有不同放射性的电极的图案允许医师在各个电极之间进行区分。
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