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公开(公告)号：US10292817B2
公开(公告)日：2019-05-21
申请号：US16202967
申请日：2018-11-28
Applicant: Edwards Lifesciences Corporation
Inventor： Ilia Hariton , Netanel Benichou , Yaacov Nitzan , Bella Felsen , Diana Nguyen-Thien-Nhon , Rajesh A. Khanna , Son V. Nguyen , Tamir S. Levi , Itai Pelled
Abstract: A method of crimping an implantable prosthetic valve can include placing protective material over at least a portion of the implantable prosthetic valve. The protective material can be configured to occupy space between open cells of a frame of the implantable prosthetic valve to prevent damage to a leaflet structure of the implantable prosthetic valve. The method can also include crimping the implantable prosthetic valve with the protective material on the implantable prosthetic valve, and removing the protective material from between the frame and the leaflet structure of the implantable prosthetic valve.
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公开(公告)号：US20180177592A1
公开(公告)日：2018-06-28
申请号：US15901782
申请日：2018-02-21
Applicant: Edwards Lifesciences Corporation
Inventor： Netanel Benichou , Stanton J. Rowe , Sean Chow
IPC: A61F2/24
Abstract: Disclosed replacement heart valves can be designed to be delivered to a native valve site while crimped on a delivery catheter. The crimped profile of the replacement valve can be minimized by, for example, separating a frame or stent structure from a leaflet structure, along the axial direction. Disclosed replacement valves can be transitioned from a delivery configuration, in which the crimped profile can be minimized, to an operating configuration. The replacement valve can be fully assembled in both the delivery and operating configurations. In some embodiments, the leaflets can be positioned outside of the stent in the delivery configuration, and positioned inside of the stent lumen in the operating configuration. Disclosed replacement valves can include a flexible sleeve coupling the leaflets to the stent and facilitating the transition to the operating configuration. Methods of implanting said replacement valves are also disclosed.
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公开(公告)号：US09114008B2
公开(公告)日：2015-08-25
申请号：US14154495
申请日：2014-01-14
Applicant: Edwards Lifesciences Corporation
Inventor： Netanel Benichou , Benjamin Spenser , Assaf Bash
CPC classification number: A61F2/2412 , A61F2/2415 , A61F2/2418 , A61F2002/9522 , A61F2220/0008 , A61F2220/0016 , A61F2220/0075 , A61F2230/0054 , A61F2250/0097
Abstract: An implantable prosthetic valve assembly having a frame comprising a first frame portion and a second frame portion connected end-to-end exhibits enhanced rigidity. Each frame portion includes a plurality of circumferential struts formed with multiple bends, with the bends of the first frame portion having angles that are less than the bends of the second frame portion. Some embodiments of the frame have a semi-collapsed state in which the first frame portion is frustoconical and the second frame portion is generally cylindrical. A valve member is attached to the first frame portion.
Abstract translation: 具有包括第一框架部分和端对端连接的第二框架部分的框架的可植入假体瓣膜组件具有增强的刚性。 每个框架部分包括形成有多个弯曲部的多个周向支柱，第一框架部分的弯曲部具有小于第二框架部分的弯曲部的角度。 框架的一些实施例具有半折叠状态，其中第一框架部分是截头圆锥形的，并且第二框架部分大致为圆柱形。 阀构件附接到第一框架部分。
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公开(公告)号：US20150105856A1
公开(公告)日：2015-04-16
申请号：US14571141
申请日：2014-12-15
Applicant: Edwards Lifesciences Corporation
Inventor： Stanton J. Rowe , Larry L. Wood , Henry Bourang , George Bakis , Benjamin Spenser , Netanel Benichou , Assaf Bash , Yaron Keidar
CPC classification number: A61F2/2418 , A61F2/2409 , A61F2/2412 , A61F2/2445 , A61F2/90 , A61F2220/0008 , A61F2220/0016 , A61F2220/0025 , A61F2220/0041 , A61F2220/0066 , A61F2220/0075 , A61F2220/0083 , A61F2230/0078 , A61F2250/006 , A61F2250/0098 , A61L27/3625
Abstract: A heart valve prosthesis that can be quickly and easily implanted during a surgical procedure is provided. The prosthetic valve comprises a support structure that is deployed at a treatment site. The prosthetic valve further comprises a valve member configured to be quickly connected to the support structure. The support structure may take the form of a stent that is expanded at the site of a native valve. If desired, the native leaflets may remain and the stent may be used to hold the native valve open. In this case, the stent may be balloon expandable and configured to resist the powerful recoil force of the native leaflets. The support structure is provided with a coupling means for attachment to the valve member, thereby fixing the position of the valve member in the body. The valve member may be expandable or a non-expandable type.
Abstract translation: 提供了可以在手术过程中快速且容易地植入的心脏瓣膜假体。 假体瓣膜包括部署在治疗部位的支撑结构。 假体瓣膜还包括构造成快速连接到支撑结构的阀构件。 支撑结构可以采取在天然瓣膜部位扩张的支架的形式。 如果需要，天然传单可以保留，并且支架可以用于保持天然瓣膜打开。 在这种情况下，支架可以是球囊可扩张的并且被配置为抵抗天然传单的强大后坐力。 支撑结构设置有用于附接到阀构件的联接装置，从而将阀构件的位置固定在主体中。 阀构件可以是可膨胀型或不可膨胀型。
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公开(公告)号：US20140128968A1
公开(公告)日：2014-05-08
申请号：US14154495
申请日：2014-01-14
Applicant: Edwards Lifesciences Corporation
Inventor： Netanel Benichou , Benjamin Spenser , Assaf Bash
IPC: A61F2/24
CPC classification number: A61F2/2412 , A61F2/2415 , A61F2/2418 , A61F2002/9522 , A61F2220/0008 , A61F2220/0016 , A61F2220/0075 , A61F2230/0054 , A61F2250/0097
Abstract: An implantable prosthetic valve assembly having a frame comprising a first frame portion and a second frame portion connected end-to-end exhibits enhanced rigidity. Each frame portion includes a plurality of circumferential struts formed with multiple bends, with the bends of the first frame portion having angles that are less than the bends of the second frame portion. Some embodiments of the frame have a semi-collapsed state in which the first frame portion is frustoconical and the second frame portion is generally cylindrical. A valve member is attached to the first frame portion.
Abstract translation: 具有包括第一框架部分和端对端连接的第二框架部分的框架的可植入假体瓣膜组件具有增强的刚性。 每个框架部分包括形成有多个弯曲部的多个周向支柱，第一框架部分的弯曲部具有小于第二框架部分的弯曲部的角度。 框架的一些实施例具有半折叠状态，其中第一框架部分是截头圆锥形的，并且第二框架部分大致为圆柱形。 阀构件附接到第一框架部分。
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Patent Agency Ranking
公开(公告)号：US20130317598A1
公开(公告)日：2013-11-28
申请号：US13954822
申请日：2013-07-30
Applicant: Edwards Lifesciences Corporation
Inventor： Stanton J. Rowe , Larry L. Wood , Henry Bourang , George Bakis , Benjamin Spenser , Netanel Benichou , Assaf Bash , Yaron Keidar
IPC: A61F2/24
CPC classification number: A61F2/2418 , A61F2/2409 , A61F2/2412 , A61F2/2445 , A61F2/90 , A61F2220/0008 , A61F2220/0016 , A61F2220/0025 , A61F2220/0041 , A61F2220/0066 , A61F2220/0075 , A61F2220/0083 , A61F2230/0078 , A61F2250/006 , A61F2250/0098 , A61L27/3625
Abstract: A heart valve prosthesis that can be quickly and easily implanted during a surgical procedure is provided. The prosthetic valve comprises a support structure that is deployed at a treatment site. The prosthetic valve further comprises a valve member configured to be quickly connected to the support structure. The support structure may take the form of a stent that is expanded at the site of a native valve. If desired, the native leaflets may remain and the stent may be used to hold the native valve open. In this case, the stent may be balloon expandable and configured to resist the powerful recoil force of the native leaflets. The support structure is provided with a coupling means for attachment to the valve member, thereby fixing the position of the valve member in the body. The valve member may be expandable or a non-expandable type.
Abstract translation: 提供了可以在手术过程中快速且容易地植入的心脏瓣膜假体。 假体瓣膜包括部署在治疗部位的支撑结构。 假体瓣膜还包括构造成快速连接到支撑结构的阀构件。 支撑结构可以采取在天然瓣膜部位扩张的支架的形式。 如果需要，天然传单可以保留，并且支架可以用于保持天然瓣膜打开。 在这种情况下，支架可以是球囊可扩张的并且被配置为抵抗天然传单的强大后坐力。 支撑结构设置有用于附接到阀构件的联接装置，从而将阀构件的位置固定在主体中。 阀构件可以是可膨胀型或不可膨胀型。
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公开(公告)号：US20250161045A1
公开(公告)日：2025-05-22
申请号：US19027973
申请日：2025-01-17
Applicant: EDWARDS LIFESCIENCES CORPORATION
Inventor： David Alon , Netanel Benichou , Oded Meiri
Abstract: Prosthetic valve delivery assemblies including a prosthetic heart valve and a delivery apparatus. The prosthetic heart valve includes a frame having posts extending from a terminal outflow end of the frame and a valve structure disposed within the frame. The delivery apparatus includes an inner shaft including a valve connection portion having recesses configured to receive the posts of the frame of the prosthetic heart valve, an outer shaft including a valve sheath for retaining the prosthetic valve in a radially compressed state and retaining the posts within the recesses, and a handle including a control knob for moving the valve sheath proximally and distally relative to the handle. The control knob is seated within the handle housing such that the housing partially covers a circumferentially extending outer surface of the control knob.
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公开(公告)号：US20250049572A1
公开(公告)日：2025-02-13
申请号：US18932308
申请日：2024-10-30
Applicant: EDWARDS LIFESCIENCES CORPORATION
Inventor： Emil Karapetian , Maria Charles Vija Stanislaus , Gregory Bak-Boychuk , Christopher J. Olson , Cristobal R. Hernandez , William C. Brunnett , Netanel Benichou , Lauren R. Freschauf , Alexander J. Siegel , Stanton J. Rowe , Alison S. Curtis
Abstract: This application relates to methods, systems, and apparatus for replacing native heart valves with prosthetic heart valves and treating valvular insufficiency. In some implementations, a heart valve leaflet clipping mechanism includes a delivery apparatus and clipping arms. The clipping arms are coupled to the delivery apparatus. The clipping arms are movable between an open position and a closed position. The two clipping arms are biased to the closed position. The delivery apparatus is configured to hold the clipping arms in the open position. The delivery apparatus is configured to allow the clipping arms to move to the closed position to engage native heart valve leaflet tissue.
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公开(公告)号：US11648111B2
公开(公告)日：2023-05-16
申请号：US17558322
申请日：2021-12-21
Applicant: Edwards Lifesciences Corporation
Inventor： Ilia Hariton , Netanel Benichou , Yaacov Nitzan , Bella Felsen , Diana Nguyen-Thien-Nhon , Rajesh A. Khanna , Son V. Nguyen , Tamir S. Levi , Itai Pelled
CPC classification number: A61F2/2418 , A61F2/2412 , A61F2/2433 , A61F2/2475 , A61F2/95 , B05B1/185 , E03C1/025 , E03C1/066 , A61F2/9522 , A61F2220/005 , A61F2220/0033 , A61F2220/0075 , A61F2230/0054 , Y10T29/49863
Abstract: An implantable prosthetic valve includes a radially collapsible and expandable annular frame having three commissure attachment posts and four rows of circumferential struts. The rows include a first row, a second row downstream of the first row, a third row downstream of the second row, and a fourth row downstream of the third row and defining an outflow end of the frame. Each row of circumferential struts includes angled struts arranged in a zig-zag pattern. A leaflet structure includes three leaflets forming three commissures, each commissure being connected to one of the commissure attachment posts only at locations along the commissure attachment posts between a first plane that is perpendicular to a longitudinal axis of the frame and intersects crowns of the third row of struts and a second plane that is perpendicular to the longitudinal axis and intersects crowns of the fourth row of struts.
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公开(公告)号：US20220233305A1
公开(公告)日：2022-07-28
申请号：US17658584
申请日：2022-04-08
Applicant: Edwards Lifesciences Corporation
Inventor： Ziv Yohanan , Tamir S. Levi , Netanel Benichou , Michael Bukin , Nikolay Gurovich , Elena Sherman
IPC: A61F2/24
Abstract: A method of implanting a prosthetic heart valve within a patient can comprise inserting a distal end portion of a delivery apparatus and a prosthetic heart valve into the patient and advancing the prosthetic heart valve to a deployment location within the heart of the patient and inflating one or more of a plurality of differently-sized balloons in a balloon-assembly on the distal end portion of the delivery apparatus. The prosthetic heart valve can be mounted on the balloon assembly in a crimped state and the inflating of the one or more of the plurality of differently-sized balloons can expand the prosthetic heart valve from the crimped state to a radially expanded state having a non-cylindrical shape.
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