公开(公告)号：US20230355378A1

公开(公告)日：2023-11-09

申请号：US18222923

申请日：2023-07-17

Applicant: EDWARDS LIFESCIENCES CORPORATION

Inventor： Hanoch Cohen-Tzemach ,  Tamir S. Levi ,  Noam Nir ,  Bella Felsen

IPC: A61F2/24

CPC classification number: A61F2/2418 ,  A61F2210/0014 ,  A61F2220/0075 ,  A61F2230/0017 ,  A61F2230/0026 ,  A61F2230/0069 ,  A61F2250/0069 ,  A61F2250/0098

Abstract: Embodiments of a prosthetic heart valve are disclosed. An implantable prosthetic valve may be radially collapsible to a collapsed configuration and radially expandable to an expanded configuration. The prosthetic valve may comprise an annular frame, a leaflet structure positioned within the frame and a plurality of outer skirts positioned around an outer surface of the frame, each outer skirt comprising an inflow edge secured to the frame and an outflow edge secured at intervals to the frame. The plurality of outer skirts may include a first outer skirt and a second outer skirt, wherein in the expanded configuration the first and second outer skirts include openings unsecured to the frame between the intervals. The inflow edge of the first annular outer skirt may be secured to the frame with sutures including radiopaque material. The first annular outer skirt may include radiopaque dye.

公开(公告)号：US20230149165A1

公开(公告)日：2023-05-18

申请号：US18097941

申请日：2023-01-17

Applicant: Edwards Lifesciences Corporation

Inventor： Noam Nir ,  Tamir S. Levi

IPC: A61F2/24

CPC classification number: A61F2/243 ,  A61F2220/0075

Abstract: The present invention is directed toward prosthetic heart valves that include an expandable frame and a leaflet assembly mounted therein, wherein the leaflet assembly is coupled to the frame via a plurality of commissure assemblies, formed from tabs of adjacent asymmetrical leaflets secured to each other, wherein at least one of the leaflet tabs includes a vertical tab portion folded over the tab of an adjacent leaflet.

公开(公告)号：US20230113498A1

公开(公告)日：2023-04-13

申请号：US18065257

申请日：2022-12-13

Applicant: Edwards Lifesciences Corporation

Inventor： Noam Nir ,  Michael Bukin

IPC: A61F2/24

Abstract: Prosthetic implant systems for diameter adaptation may be provided. The systems may provide for increased flexibility of providing implants having various diameters, and reducing expense associated with keeping a stock of implants at various sizes. Embodiments as disclosed herein may utilize a prosthetic implant having a docking frame that may be configured to expand to a range of working diameters. The docking frame may dock with a valve frame that may be configured to expand to a working diameter that is more closely tailored to the diameter of the implantation site. The valve frame may have a lesser range of expansion of working diameters than the docking frame.

公开(公告)号：US20220346949A1

公开(公告)日：2022-11-03

申请号：US17863195

申请日：2022-07-12

Applicant: Edwards Lifesciences Corporation

Inventor： Dikla Kersh ,  Michael Bukin ,  Tamir S. Levi ,  Noam Nir

IPC: A61F2/24

Abstract: A prosthetic valve assembly includes a radially expandable and compressible annular frame. The frame includes a plurality of interconnected struts, which include a plurality of inner struts and a plurality of outer struts. The inner struts overlap adjacent outer struts at a plurality of pivot joints. Radial expansion or compression of the annular frame causes the inner struts to pivot relative to the outer struts at the pivot joints. The assembly also includes a valvular structure having a plurality of leaflets, each leaflet having a cusp edge portion. The assembly further includes one or more leaflet-supporting cords, each having a plurality of anchoring portions and a plurality of suspended portions, each suspended portion extending between two adjacent anchoring portions. The anchoring portions are affixed to respective anchoring features of the frame adjacent the pivot joints. The cusp edge portions of the leaflets are connected to the suspended portions.

公开(公告)号：US20220249227A1

公开(公告)日：2022-08-11

申请号：US17730524

申请日：2022-04-27

Applicant: Edwards Lifesciences Corporation

Inventor： Noam Nir ,  Michael Bukin ,  Elena Sherman

IPC: A61F2/24

Abstract: A leaflet assembly for a prosthetic heart valve is disclosed. As one example, a method includes: forming a plurality of leaflet sub-assemblies, each including a leaflet and a skirt and formed by placing the skirt on one side of the leaflet such that the skirt extends along a curved cusp edge portion and two commissure tabs of the leaflet, folding two end portions of the skirt around corresponding commissures tabs, stitching each folded end portion to a corresponding commissure tab to form a respective half commissure portion, and stitching the skirt to the cusp edge portion and forming the leaflet assembly by pairing each half commissure portion of each leaflet sub-assembly with a half commissure portion of another leaflet sub-assembly to form a plurality of pairs of adjacent half commissure portions, and for each pair, stitching the adjacent half commissure portions to each other to form a commissure.

公开(公告)号：US20220110742A1

公开(公告)日：2022-04-14

申请号：US17556739

申请日：2021-12-20

Applicant: Edwards Lifesciences Corporation

Inventor： Tamir S. Levi ,  Michael Bukin ,  Noam Nir ,  Ziv Yohanan ,  Elazar Levi Schwarcz ,  Oren Cohen ,  Ofir Witzman ,  Eitan Atias ,  Noam Miller ,  Khen Perlmutter ,  Boaz Manash ,  Eyal Leiba ,  Eran Goldberg

IPC: A61F2/24

Abstract: Various mechanically expandable prosthetic heart valves, as well as deliver apparatus, delivery assemblies, and methods for implanting such prosthetic heart valves. In one example, a prosthetic heart valve includes a mechanically expandable frame, a valve structure, and an actuator. The frame includes a plurality of struts and is movable between a radially compressed state and a radially expanded state. The valve structure includes a plurality of leaflets. The actuator is coupled to the frame and comprises an actuation lumen, a locking member, and a locking element. The actuation lumen is circumferentially spaced and axially parallel to the locking member. The actuation lumen is configured for receiving an axially movable actuation shaft that can move the frame between the radially compressed state and the radially expanded state. The locking element is rotatably coupled to the locking member and is configured to lock the frame at a desired state.

公开(公告)号：US11026785B2

公开(公告)日：2021-06-08

申请号：US16208263

申请日：2018-12-03

Applicant: Edwards Lifesciences Corporation

Inventor： Alexander Barash ,  Yair A. Neumann ,  Tomer Saar ,  Ziv Yohanan ,  Noam Nir ,  Michael Bukin ,  Boaz Manash

IPC: A61F2/24 ,  A61F2/95

Abstract: In one embodiment, a prosthetic valve can comprise a radially expandable and compressible frame, which can include a plurality of struts which are pivotally joined together without requiring individual rivets. In some embodiments, the struts are interwoven, and can be joined using integral hinges formed in the struts, such as by performing alternate cuts on the struts, bending the struts to form stopper tabs adjacent to joints and/or drilling holes in the struts to facilitate interconnecting struts at joints, or otherwise forming integral hinges and corresponding holes at junction points between the struts. In another embodiment, the frame comprises a plurality of inner struts and outer struts which are connected by a plurality of chains of interconnected rivets, avoiding the need to provide individual rivets at each junction between struts. In still another embodiment, separate hinges or flanged rivets are provided to interconnect the struts.

公开(公告)号：US20190202140A1

公开(公告)日：2019-07-04

申请号：US16294761

申请日：2019-03-06

Applicant: Edwards Lifesciences Corporation

Inventor： Itai Pelled ,  Elena Sherman ,  Eran Goldberg ,  Kevin D. Rupp ,  Noam Nir

IPC: B29C65/00 ,  A61F2/24

CPC classification number: B29C66/53245 ,  A61F2/2412 ,  A61F2/2415 ,  A61F2/2418 ,  A61F2/2433 ,  A61F2210/0076 ,  A61F2230/0069 ,  A61F2240/001 ,  A61F2250/0069

Abstract: An implantable prosthetic valve that is radially collapsible to a collapsed configuration and radially expandable to an expanded configuration comprises an annular frame having an inflow end and an outflow end, a leaflet structure positioned within the frame and secured thereto, and a laminate sealing member comprising an encapsulating material. The laminate sealing member has a main portion that encapsulates at least a portion of the frame and an end portion extending from the inflow end of the frame, and the end portion of the laminate sealing member is folded to form a cuff adjacent the inflow end of the frame and secured to the main portion of the laminate sealing member.

公开(公告)号：US20180049873A1

公开(公告)日：2018-02-22

申请号：US15680030

申请日：2017-08-17

Applicant: Edwards Lifesciences Corporation

Inventor： Boaz Manash ,  Oren Cohen ,  Noam Nir ,  Ilan Tamir ,  Eitan Atias ,  Ofir Witzman ,  Michal Aliza Ruchelsman

IPC: A61F2/24 ,  A61M25/01 ,  A61M25/00 ,  A61M25/09

CPC classification number: A61F2/2436 ,  A61F2/2418 ,  A61F2/2433 ,  A61F2/2439 ,  A61F2002/9511 ,  A61F2002/9517 ,  A61F2220/0008 ,  A61M25/0029 ,  A61M25/0068 ,  A61M25/0138 ,  A61M25/0147 ,  A61M25/09 ,  A61M2025/0039 ,  A61M2025/015

Abstract: Devices, systems and methods are described herein to provide improved steerability for delivering a prosthesis to a body location, for example, for delivering a replacement mitral valve to a native mitral valve location. The delivery system can include a number of advantageous steering and delivery features, in particular for the transseptal delivery approach.

公开(公告)号：US12232956B2

公开(公告)日：2025-02-25

申请号：US18195288

申请日：2023-05-09

Applicant: EDWARDS LIFESCIENCES CORPORATION

Inventor： Tamir S. Levi ,  Shahram Zamani ,  Michael Bukin ,  Ziv Yohanan ,  Noam Nir ,  Tyler Dale O'Dell ,  Elena Sherman

IPC: A61F2/24

Abstract: A method of assembling a valvular structure can include folding an upper tab of a first leaflet onto a lower tab of the first leaflet, disposing a first end of a reinforcing member on the upper tab, disposing a commissure member adjacent the lower tab, and coupling the first end of the reinforcing member, the tabs of the first leaflet, and the commissure member to one another. The method can further include folding an upper tab of a second leaflet onto a lower tab of the second leaflet, disposing the second leaflet adjacent the first leaflet such that the commissure member is positioned between the lower tabs, disposing a second end of the reinforcing member on the upper tab of the second leaflet, and coupling the reinforcing member, the upper and lower tabs of the second leaflet, and the commissure member to one another to form a commissure.