公开(公告)号：US20130203620A1

公开(公告)日：2013-08-08

申请号：US13733197

申请日：2013-01-03

申请人： Eli N. Glezer ,  Kent Johnson ,  Bandele Jeffrey-Coker ,  Alan Kishbaugh ,  Charles M. Clinton

发明人： Eli N. Glezer ,  Kent Johnson ,  Bandele Jeffrey-Coker ,  Alan Kishbaugh ,  Charles M. Clinton

IPC分类号： G01N21/76

CPC分类号： G01N21/76 ,  B01L3/5085 ,  B01L3/50855 ,  B01L2300/021 ,  B01L2300/0645 ,  B01L2300/0829 ,  B01L2300/0851 ,  G01N21/253 ,  G01N21/66 ,  G01N33/54366 ,  G01N35/028

摘要： Luminescence test measurements are conducted using an assay module having integrated electrodes with a reader apparatus adapted to receive assay modules, induce luminescence, preferably electrode induced luminescence, in the wells or assay regions of the assay modules and measure the induced luminescence.

摘要翻译： 使用具有集成电极的测定模块进行发光测试测量，所述测量模块具有适于接收测定模块的读取器设备，在测定模块的孔或测定区域中诱导发光，优选电极诱导的发光并测量诱导的发光。

公开(公告)号：US20110143947A1

公开(公告)日：2011-06-16

申请号：US12844440

申请日：2010-07-27

申请人： Ian Chamberlin ,  Charles M. Clinton ,  Eli N. Glezer ,  Bandele Jeffrey-Coker ,  Manish Kochar ,  Sandor Kovacs ,  DT Le ,  Aaron Leimkuehler ,  Greg Pinckney ,  Kristian Roth ,  George Sigal ,  Fei Yin

发明人： Ian Chamberlin ,  Charles M. Clinton ,  Eli N. Glezer ,  Bandele Jeffrey-Coker ,  Manish Kochar ,  Sandor Kovacs ,  DT Le ,  Aaron Leimkuehler ,  Greg Pinckney ,  Kristian Roth ,  George Sigal ,  Fei Yin

IPC分类号： C40B30/00 ,  C40B60/12 ,  B08B9/00

CPC分类号： G01N33/5304 ,  B01L3/5085 ,  B01L2200/16 ,  B01L2300/021 ,  B01L2300/022 ,  B01L2300/0829 ,  B01L2300/105 ,  G01N21/6452 ,  G01N21/66 ,  G01N21/76 ,  G01N33/54326 ,  G01N33/54366 ,  G01N33/56983 ,  G01N2035/0425 ,  Y02A90/26

摘要： We describe apparatuses, method, reagents, and kits for conducting assays as well as process for their preparation. They are particularly well suited for conducting automated sampling, sample preparation, and analysis in a multi-well plate assay format. For example, they may be used for automated analysis of liquid samples in a clinical point of care setting.

摘要翻译： 我们描述用于进行测定的装置，方法，试剂和试剂盒以及其制备方法。 它们特别适合进行多孔板测定格式的自动采样，样品制备和分析。 例如，它们可用于临床护理设置中的液体样品的自动分析。

公开(公告)号：US20150190810A1

公开(公告)日：2015-07-09

申请号：US14412866

申请日：2013-07-03

申请人： Eli N. Glezer ,  Bandele Jeffrey-Coker ,  Kenneth Page ,  Sandor Kovacs ,  Sudeep Kumar ,  Kristian Roth

发明人： Eli N. Glezer ,  Bandele Jeffrey-Coker ,  Kenneth Page ,  Sandor Kovacs ,  Sudeep Kumar ,  Kristian Roth

IPC分类号： B01L3/00

CPC分类号： B01L3/567 ,  B01L3/502 ,  B01L3/502738 ,  B01L3/5085 ,  B01L2300/0681 ,  B01L2300/0816 ,  B01L2300/0867 ,  B01L2300/0874 ,  B01L2400/0487 ,  B01L2400/0622 ,  B01L2400/0644 ,  F16K11/0743 ,  Y10T436/2575

摘要： Assay cartridges are described that have a plurality of chambers and a fluidic network that includes fluidic conduits and a multi-port valve designed to selectively connect the valve inlet and one valve outlet through a fluidic connector in the valve as the remaining valve outlets are sealed.

摘要翻译： 分析盒被描述为具有多个腔室和包括流体导管的流体网络以及设计成随着剩余的阀出口被密封而选择性地将阀入口和一个阀出口通过阀中的流体连接器连接的多口阀。

公开(公告)号：US10794914B2

公开(公告)日：2020-10-06

申请号：US13290059

申请日：2011-11-05

申请人： Charles M. Clinton ,  Eli N. Glezer ,  Bandele Jeffrey-Coker ,  Sandor L. Kovacs ,  Sudeep M. Kumar ,  George Sigal ,  Carl Stevens ,  Michael Vock

发明人： Charles M. Clinton ,  Eli N. Glezer ,  Bandele Jeffrey-Coker ,  Sandor L. Kovacs ,  Sudeep M. Kumar ,  George Sigal ,  Carl Stevens ,  Michael Vock

IPC分类号： G01N35/10 ,  B67B7/00 ,  G01N33/58 ,  G01N21/64 ,  G01N21/66 ,  G01N33/53 ,  G01N35/02 ,  G01N35/04

摘要： We describe apparatuses, systems, method, reagents, and kits for conducting assays as well as process for their preparation. They are particularly well suited for conducting automated sampling, sample preparation, and analysis in a multi-well plate assay format. For example, they may be used for automated analysis of particulates in air and/or liquid samples derived therefrom in environmental monitoring.

公开(公告)号：US10302649B2

公开(公告)日：2019-05-28

申请号：US11642968

申请日：2006-12-21

申请人： Charles M. Clinton ,  Eli N. Glezer ,  Bandele Jeffrey-Coker ,  Sandor L. Kovacs ,  Sudeep M. Kumar ,  George Sigal ,  Carl Stevens ,  Michael Vock

发明人： Charles M. Clinton ,  Eli N. Glezer ,  Bandele Jeffrey-Coker ,  Sandor L. Kovacs ,  Sudeep M. Kumar ,  George Sigal ,  Carl Stevens ,  Michael Vock

IPC分类号： G01N35/10 ,  B67B7/00 ,  G01N33/58 ,  G01N21/64 ,  G01N21/66 ,  G01N33/53 ,  G01N35/02 ,  G01N35/04

摘要： We describe apparatuses, systems, method, reagents, and kits for conducting assays as well as process for their preparation. They are particularly well suited for conducting automated sampling, sample preparation, and analysis in a multi-well plate assay format. For example, they may be used for automated analysis of particulates in air and/or liquid samples derived therefrom in environmental monitoring.

公开(公告)号：US10272436B2

公开(公告)日：2019-04-30

申请号：US14412866

申请日：2013-07-03

申请人： Eli N. Glezer ,  Bandele Jeffrey-Coker ,  Kenneth Page ,  Sandor Kovacs ,  Sudeep Kumar ,  Kristian Roth

发明人： Eli N. Glezer ,  Bandele Jeffrey-Coker ,  Kenneth Page ,  Sandor Kovacs ,  Sudeep Kumar ,  Kristian Roth

IPC分类号： B01L3/00 ,  F16K11/074

摘要： Assay cartridges are described that have a plurality of chambers and a fluidic network that includes fluidic conduits and a multi-port valve designed to selectively connect the valve inlet and one valve outlet through a fluidic connector in the valve as the remaining valve outlets are sealed.

公开(公告)号：US20180074082A1

公开(公告)日：2018-03-15

申请号：US15564581

申请日：2016-04-06

申请人： Eli N. GLEZER ,  Carl EDENS ,  Bandele JEFFREY-COKER ,  Sandor KOVACS ,  Christopher FRYE ,  Meso Scale Technologies, LLC.

发明人： Eli N. Glezer ,  Carl Edens ,  Bandele Jeffery-Coker ,  Sandor Kovacs ,  Christopher Frye

IPC分类号： G01N35/00 ,  B01F11/00 ,  G01N35/10 ,  G01N33/543 ,  B06B1/16

摘要： The present invention relates to a system for performing assays on a solid phase to measure the level of analyte in a sample. Such a system may perform immunoassays using electrochemiluminescence (ECL) including a counterbalanced orbital shaking apparatus for assay consumables.

公开(公告)号：US20120195800A1

公开(公告)日：2012-08-02

申请号：US13290059

申请日：2011-11-05

申请人： Charles M. Clinton ,  Eli N. Glezer ,  Bandele Jeffrey-Coker ,  Sandor L. Kovacs ,  Sudeep M. Kumar ,  George Sigal ,  Carl Stevens ,  Michael Vock

发明人： Charles M. Clinton ,  Eli N. Glezer ,  Bandele Jeffrey-Coker ,  Sandor L. Kovacs ,  Sudeep M. Kumar ,  George Sigal ,  Carl Stevens ,  Michael Vock

IPC分类号： G01N21/75

摘要： We describe apparatuses, systems, method, reagents, and kits for conducting assays as well as process for their preparation. They are particularly well suited for conducting automated sampling, sample preparation, and analysis in a multi-well plate assay format. For example, they may be used for automated analysis of particulates in air and/or liquid samples derived therefrom in environmental monitoring.

摘要翻译： 我们描述用于进行测定的装置，系统，方法，试剂和试剂盒以及其制备方法。 它们特别适合进行多孔板测定格式的自动采样，样品制备和分析。 例如，它们可用于在环境监测中对其中衍生的空气和/或液体样品中的颗粒进行自动分析。

公开(公告)号：US09354230B2

公开(公告)日：2016-05-31

申请号：US12977271

申请日：2010-12-23

申请人： Eli N. Glezer ,  Kent Johnson ,  Michael Tsionsky ,  John H. Kenten ,  Jeff D. Debad ,  Robert M. Umek ,  Paula Denney Eason ,  Hans Biebuyck ,  Jacob N. Wohlstadter ,  James Wilbur ,  George Sigal ,  Niranjan Y. Sardesai

发明人： Eli N. Glezer ,  Kent Johnson ,  Michael Tsionsky ,  John H. Kenten ,  Jeff D. Debad ,  Robert M. Umek ,  Paula Denney Eason ,  Hans Biebuyck ,  Jacob N. Wohlstadter ,  James Wilbur ,  George Sigal ,  Niranjan Y. Sardesai

IPC分类号： G01N33/543 ,  C12Q1/48 ,  G01N33/68

CPC分类号： G01N33/5304 ,  C12Q1/485 ,  G01N33/54366 ,  G01N33/54373 ,  G01N33/5438 ,  G01N33/54386 ,  G01N33/56944 ,  G01N33/56983 ,  G01N33/56988 ,  G01N33/573 ,  G01N33/68 ,  G01N33/6803 ,  G01N33/6842 ,  G01N33/6845 ,  G01N2333/11 ,  G01N2333/135 ,  G01N2333/16 ,  G01N2333/525 ,  G01N2333/5412 ,  G01N2333/545 ,  G01N2333/57 ,  G01N2333/71 ,  G01N2333/9121 ,  Y10S436/807

摘要： Multiplexed test measurements are conducted using an assay module having a plurality of assay domains. In preferred embodiments, these measurements are conducted in assay modules having integrated electrodes with a reader apparatus adapted to receive assay modules, induce luminescence, preferably electrode induced luminescence, in the wells or assay regions of the assay modules and measure the induced luminescence.

公开(公告)号：US20100316992A1

公开(公告)日：2010-12-16

申请号：US12818093

申请日：2010-06-17

申请人： Jeff D. Debad ,  Eli N. Glezer ,  Sudeep M. Kumar

发明人： Jeff D. Debad ,  Eli N. Glezer ,  Sudeep M. Kumar

IPC分类号： C12Q1/70 ,  C40B30/04 ,  G01N33/566

CPC分类号： G01N33/6893 ,  G01N33/6863 ,  G01N2333/523 ,  G01N2333/525 ,  G01N2333/70578 ,  G01N2800/065 ,  G01N2800/52

摘要： Disclosed are methods for conducting diagnostic tests for the detection of the inflammatory bowel diseases, such as Crohn's disease and ulcerative colitis. Also described are methods for monitoring a patient by administering tests of the present invention. Also described are methods for monitoring patient's treatment by administering tests of the present invention. Also described are methods for evaluating the effectiveness of a drug or a drug candidate by administering tests of the present invention to samples from patients, animal models, and cell cultures treated with a drug or a drug candidate. Also disclosed are methods for determining the usefulness of analytes, e.g. cytokines, for acting as diagnostic and monitoring markers for inflammatory bowel disease in the various methods of the invention.

摘要翻译： 公开了用于进行诸如克罗恩病和溃疡性结肠炎的炎症性肠病的检测的诊断测试的方法。 还描述了通过管理本发明的测试来监测患者的方法。 还描述了通过管理本发明的测试来监测患者治疗的方法。 还描述了通过将本发明的试验施用于用药物或候选药物治疗的患者，动物模型和细胞培养物的样品来评价药物或药物候选物的有效性的方法。 还公开了用于确定分析物的有用性的方法，例如， 用作本发明各种方法中用于炎性肠病的诊断和监测标志物的细胞因子。