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公开(公告)号：US20050079577A1
公开(公告)日：2005-04-14
申请号：US10893802
申请日：2004-07-16
申请人： Avi Ashkenazi , Kevin Baker , David Botstein , Luc Desnoyers , Dan Eaton , Napoleone Ferrara , Ellen Filvaroff , Sherman Fong , Wei-Qiang Gao , Hanspeter Gerber , Mary Gerritsen , Audrey Goddard , Paul Godowski , J. Grimaldi , Austin Gurney , Kenneth Hillan , Ivar Kljavin , Sophia Kuo , Mary Napier , James Pan , Nicholas Paoni , Margaret Roy , David Shelton , Timothy Stewart , Daniel Tumas , P. Williams , William Wood
发明人： Avi Ashkenazi , Kevin Baker , David Botstein , Luc Desnoyers , Dan Eaton , Napoleone Ferrara , Ellen Filvaroff , Sherman Fong , Wei-Qiang Gao , Hanspeter Gerber , Mary Gerritsen , Audrey Goddard , Paul Godowski , J. Grimaldi , Austin Gurney , Kenneth Hillan , Ivar Kljavin , Sophia Kuo , Mary Napier , James Pan , Nicholas Paoni , Margaret Roy , David Shelton , Timothy Stewart , Daniel Tumas , P. Williams , William Wood
IPC分类号： A61K38/00 , C07K14/47 , C07K14/705 , C07H21/04 , C12N9/00
CPC分类号： C07K14/47 , A61K38/00 , C07K14/4703 , C07K14/705 , C07K2319/00 , C07K2319/30 , C12N2799/026 , C12N2799/027
摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
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公开(公告)号：US20070191270A1
公开(公告)日：2007-08-16
申请号：US11234694
申请日：2005-09-22
申请人： Kevin Baker , Dan Eaton , Ellen Filvaroff , Audrey Goddard , J. Grimaldi , Austin Gurney , Victoria Smith , Jean Stephan , Colin Watanabe , William Wood , Zemin Zhang , Sherman Fong
发明人： Kevin Baker , Dan Eaton , Ellen Filvaroff , Audrey Goddard , J. Grimaldi , Austin Gurney , Victoria Smith , Jean Stephan , Colin Watanabe , William Wood , Zemin Zhang , Sherman Fong
CPC分类号： G01N33/57484 , C07K14/47 , C07K14/705 , C12Q1/6886 , C12Q2600/136
摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
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公开(公告)号：US20070160594A1
公开(公告)日：2007-07-12
申请号：US11612263
申请日：2006-12-18
申请人： Ellen Filvaroff , J. Grimaldi , William Wood , Audrey Goddard
发明人： Ellen Filvaroff , J. Grimaldi , William Wood , Audrey Goddard
IPC分类号： A61K38/48 , G01N33/567 , C07H21/04 , C12P21/06 , C12N9/64
CPC分类号： C07K14/8114 , A61K38/00 , C07K2319/00 , C12N2501/998
摘要： The present invention is directed to novel polypeptides having sequence similarity to human inter-alpha-trypsin inhibitor and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided herein are methods of using the polypeptide to diagnose and treat damage to cartilage resulting from injury and/or cartilaginous disorders.
摘要翻译： 本发明涉及与人α间胰蛋白酶抑制剂和编码这些多肽的核酸分子具有序列相似性的新型多肽。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。 本文还提供了使用多肽来诊断和治疗由损伤和/或软骨障碍引起的软骨损伤的方法。
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公开(公告)号：US20070020735A1
公开(公告)日：2007-01-25
申请号：US11529324
申请日：2006-09-29
申请人： Jian Chen , Ellen Filvaroff , Sherman Fong , Dorothy French , Audrey Goddard , Paul Godowski , J. Grimaldi , Austin Gumey , Kenneth Hillan , Sarah Hymowitz , Hanzhong Li , James Pan , Melissa Starovasnik , Daniel Tumas , Menno Lookeren , Richard Vandlen , Colin Watanabe , P. Williams , William Wood , Daniel Yansura
发明人： Jian Chen , Ellen Filvaroff , Sherman Fong , Dorothy French , Audrey Goddard , Paul Godowski , J. Grimaldi , Austin Gumey , Kenneth Hillan , Sarah Hymowitz , Hanzhong Li , James Pan , Melissa Starovasnik , Daniel Tumas , Menno Lookeren , Richard Vandlen , Colin Watanabe , P. Williams , William Wood , Daniel Yansura
CPC分类号： C07K16/244 , A61K38/00 , C07H21/04 , C07K14/54 , C07K14/7155 , C07K2317/21 , C07K2317/24 , C07K2317/35 , C07K2317/54 , C07K2317/55 , C07K2317/62 , G01N33/505 , G01N33/564 , G01N33/574 , G01N33/57407 , G01N33/57423 , G01N33/57438 , G01N33/57492 , G01N2333/54 , G01N2333/7155
摘要： The present invention is directed to novel polypeptides having sequence identity with IL-17, IL-17 receptors and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided herein are methods for treating degenerative cartilaginous disorders and other inflammatory diseases.
摘要翻译： 本发明涉及与IL-17，IL-17受体和编码那些多肽的核酸分子具有序列同一性的新型多肽。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。 本文还提供了治疗退行性软骨疾病和其它炎性疾病的方法。
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公开(公告)号：US20060073552A1
公开(公告)日：2006-04-06
申请号：US10243236
申请日：2002-09-12
申请人： Kevin Baker , Dan Eaton , Ellen Filvaroff , Audrey Goddard , J. Grimaldi , Austin Gurney , Victoria Smith , Jean Stephan , Colin Watanabe , William Wood , Zemin Zhang , Sherman Fong
发明人： Kevin Baker , Dan Eaton , Ellen Filvaroff , Audrey Goddard , J. Grimaldi , Austin Gurney , Victoria Smith , Jean Stephan , Colin Watanabe , William Wood , Zemin Zhang , Sherman Fong
CPC分类号： C07K14/47 , C07K14/705
摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
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公开(公告)号：US20060073549A1
公开(公告)日：2006-04-06
申请号：US10242902
申请日：2002-09-13
申请人： Kevin Baker , Dan Eaton , Ellen Filvaroff , Audrey Goddard , J. Grimaldi , Austin Gurney , Victoria Smith , Jean Stephan , Colin Watanabe , William Wood , Zemin Zhang , Sherman Fong
发明人： Kevin Baker , Dan Eaton , Ellen Filvaroff , Audrey Goddard , J. Grimaldi , Austin Gurney , Victoria Smith , Jean Stephan , Colin Watanabe , William Wood , Zemin Zhang , Sherman Fong
CPC分类号： C07K14/47 , G01N33/57484
摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
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公开(公告)号：US20060073548A1
公开(公告)日：2006-04-06
申请号：US10242586
申请日：2002-09-11
申请人： Kevin Baker , Dan Eaton , Ellen Filvaroff , Audrey Goddard , J. Grimaldi , Austin Gurney , Victoria Smith , Jean Stephan , Colin Watanabe , William Wood , Zemin Zhang , Sherman Fong
发明人： Kevin Baker , Dan Eaton , Ellen Filvaroff , Audrey Goddard , J. Grimaldi , Austin Gurney , Victoria Smith , Jean Stephan , Colin Watanabe , William Wood , Zemin Zhang , Sherman Fong
CPC分类号： C07K14/47 , A61K38/00 , C07K14/705 , C12N9/00
摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
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公开(公告)号：US20050227328A1
公开(公告)日：2005-10-13
申请号：US11129762
申请日：2005-05-13
申请人： Avi Ashkenazi , Kevin Baker , David Botstein , Luc Desnoyers , Dan Eaton , Napoleone Ferrara , Ellen Filvaroff , Sherman Fong , Wei-Qiang Gao , Hanspeter Gerber , Mary Gerritsen , Audrey Goddard , Paul Godowski , J. Grimaldi , Austin Gurney , Kenneth Hillan , Ivar Kljavin , Sophia Kuo , Mary Napier , James Pan , Nicholas Paoni , Margaret Roy , David Shelton , Timothy Stewart , Daniel Tumas , P. Williams , William Wood
发明人： Avi Ashkenazi , Kevin Baker , David Botstein , Luc Desnoyers , Dan Eaton , Napoleone Ferrara , Ellen Filvaroff , Sherman Fong , Wei-Qiang Gao , Hanspeter Gerber , Mary Gerritsen , Audrey Goddard , Paul Godowski , J. Grimaldi , Austin Gurney , Kenneth Hillan , Ivar Kljavin , Sophia Kuo , Mary Napier , James Pan , Nicholas Paoni , Margaret Roy , David Shelton , Timothy Stewart , Daniel Tumas , P. Williams , William Wood
IPC分类号： A61K38/00 , A61K39/395 , C07K14/47 , C07K14/705 , C07K16/28 , C12N5/10 , C12N15/12 , C12N15/62 , C12N15/63 , C07H21/04 , C07K16/18 , C12N9/00 , C12N15/09
摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
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公开(公告)号：US20060078964A1
公开(公告)日：2006-04-13
申请号：US10216161
申请日：2002-08-09
申请人： Avi Ashkenazi , Kevin Baker , David Botstein , Luc Desnoyers , Dan Eaton , Napoleone Ferrara , Ellen Filvaroff , Sherman Fong , Wei-Qiang Gao , Hanspeter Gerber , Mary Gerritsen , Audrey Goddard , Paul Godowski , J. Grimaldi , Austin Gurney , Kenneth Hillan , Ivar Kljavin , Sophia Kuo , Mary Napier , James Pan , Nicholas Paoni , Margaret Roy , David Shelton , Timothy Stewart , Daniel Tumas , P. Williams , William Wood
发明人： Avi Ashkenazi , Kevin Baker , David Botstein , Luc Desnoyers , Dan Eaton , Napoleone Ferrara , Ellen Filvaroff , Sherman Fong , Wei-Qiang Gao , Hanspeter Gerber , Mary Gerritsen , Audrey Goddard , Paul Godowski , J. Grimaldi , Austin Gurney , Kenneth Hillan , Ivar Kljavin , Sophia Kuo , Mary Napier , James Pan , Nicholas Paoni , Margaret Roy , David Shelton , Timothy Stewart , Daniel Tumas , P. Williams , William Wood
CPC分类号： C07K14/705
摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
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公开(公告)号：US20060073556A1
公开(公告)日：2006-04-06
申请号：US10243357
申请日：2002-09-13
申请人： Kevin Baker , Dan Eaton , Ellen Filvaroff , Audrey Goddard , J. Grimaldi , Austin Gurney , Victoria Smith , Jean Stephan , Colin Watanabe , William Wood , Zemin Zhang , Sherman Fong
发明人： Kevin Baker , Dan Eaton , Ellen Filvaroff , Audrey Goddard , J. Grimaldi , Austin Gurney , Victoria Smith , Jean Stephan , Colin Watanabe , William Wood , Zemin Zhang , Sherman Fong
CPC分类号： C07H21/04 , C07K14/435 , C12N5/06 , C12N9/00 , C12P21/02
摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
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