公开(公告)号：US20130018487A1

公开(公告)日：2013-01-17

申请号：US13554054

申请日：2012-07-20

申请人： Zhiqiang Gao

发明人： Zhiqiang Gao

IPC分类号： G05B13/04

CPC分类号： G05B13/024 ,  G05B5/01 ,  G05B11/42 ,  G05B13/042 ,  G05B15/02 ,  G05B19/416 ,  G05B2219/33347

摘要： Controller scaling and parameterization are described. Techniques that can be improved by employing the scaling and parameterization include, but are not limited to, controller design, tuning and optimization. The scaling and parameterization methods described here apply to transfer function based controllers, including PID controllers. The parameterization methods also applies to state feedback and state observer based controllers, as well as linear active disturbance rejection controllers. It is emphasized that this abstract is provided to comply with the rules requiring an abstract that will allow a searcher or other reader to quickly ascertain the subject matter of the application. It is submitted with the understanding that it will not be used to interpret or limit the scope or meaning of the claims.

公开(公告)号：US20120122715A1

公开(公告)日：2012-05-17

申请号：US13255901

申请日：2010-03-11

申请人： Zhiqiang Gao ,  Somenath Roy ,  Xiaojun Chen

发明人： Zhiqiang Gao ,  Somenath Roy ,  Xiaojun Chen

IPC分类号： C40B30/04 ,  G01N27/00 ,  B05D5/12 ,  C40B40/06

CPC分类号： G01N33/5438 ,  C12Q1/6825 ,  G01N27/3278

摘要： The present invention is direct to a sensor for detecting a nucleic acid molecule comprising an electrode arrangement with two electrodes and nucleic acid probes immobilized at the surface of the electrodes. The present invention also refers to a kit and a method of using the sensor or a sensor array. The present invention is further directed to a process of manufacturing a sensor and sensor array.

摘要翻译： 本发明直接用于检测核酸分子的传感器，该核酸分子包括具有固定在电极表面的两个电极和核酸探针的电极装置。 本发明还涉及使用传感器或传感器阵列的套件和方法。 本发明还涉及制造传感器和传感器阵列的方法。

公开(公告)号：US20120035747A1

公开(公告)日：2012-02-09

申请号：US13212274

申请日：2011-08-18

申请人： Zhiqiang Gao

发明人： Zhiqiang Gao

IPC分类号： G05B13/04 ,  G05B13/02

CPC分类号： G05B13/024 ,  G05B5/01 ,  G05B11/42 ,  G05B13/042 ,  G05B15/02 ,  G05B19/416 ,  G05B2219/33347

摘要： Controller scaling and parameterization are described. Techniques that can be improved by employing the scaling and parameterization include, but are not limited to, controller design, tuning and optimization. The scaling and parameterization methods described here apply to transfer function based controllers, including PID controllers. The parameterization methods also applies to state feedback and state observer based controllers, as well as linear active disturbance rejection controllers. It is emphasized that this abstract is provided to comply with the rules requiring an abstract that will allow a searcher or other reader to quickly ascertain the subject matter of the application. It is submitted with the understanding that it will not be used to interpret or limit the scope or meaning of the claims. 37 CFR 1.72(b).

摘要翻译： 描述控制器缩放和参数化。 可以通过使用缩放和参数化来改进的技术包括但不限于控制器设计，调整和优化。 这里描述的缩放和参数化方法适用于基于传递函数的控制器，包括PID控制器。 参数化方法也适用于状态反馈和基于状态观察器的控制器，以及线性有源扰动抑制控制器。 要强调的是，该摘要被提供以符合要求抽象的规则，允许搜索者或其他读者快速确定申请的主题。 提交它的理解是，它不会用于解释或限制权利要求的范围或含义。 37 CFR 1.72（b）。

公开(公告)号：US20110189705A1

公开(公告)日：2011-08-04

申请号：US12996609

申请日：2008-06-06

申请人： Zhiqiang Gao ,  Jie Zhang

发明人： Zhiqiang Gao ,  Jie Zhang

IPC分类号： G01N33/53 ,  C12M1/34

CPC分类号： G01N33/5438 ,  G01N33/54306

摘要： The invention provides a highly sensitive immunoassay for detection of a biological species. The immunoassay comprises exposing an electrode to an analyte liquid putatively containing the biological species so as to couple the biological species, if present in the analyte liquid, to a binding antibody on the electrode. The electrode comprises a binding antibody and an anchor group, each being coupled to an electrically conductive substrate, said binding antibody being capable of binding to the biological species and said anchor group being capable of binding to a redox polymer. The electrode is then exposed to an antibody-enzyme liquid comprising an antibody-enzyme species, said antibody-enzyme species comprising a detection antibody capable of binding to the biological species, said detection antibody being coupled to a redox enzyme, whereby, if the analyte liquid comprises the biological species, the redox enzyme couples to the electrode by means of the coupling of both the detection antibody and the binding antibody to the biological species. The electrode is then exposed to a polymer solution comprising the redox polymer and to an enzyme substrate, whereby if the redox enzyme is coupled to the anchor group on the electrode the redox polymer is reduced and couples to the anchor group on the electrode. A voltage is then applied between the electrode and a reference electrode and the electrode is exposed to an oxidisable species, whereby a magnitude of an electric current between said electrode and a reference electrode is indicative of the presence or absence of the biological species.

摘要翻译： 本发明提供用于检测生物物种的高度灵敏的免疫测定。 免疫测定包括将电极暴露于假设含有生物物质的分析物液体，以将生物物质（如果存在于分析物液体中）与电极上的结合抗体相连接。 电极包含结合抗体和锚定基团，每个锚定基团与导电底物偶联，所述结合抗体能够结合生物物种，所述锚定基团能够结合至氧化还原聚合物。 然后将电极暴露于包含抗体 - 酶物质的抗体 - 酶液体，所述抗体 - 酶物质包含能够结合生物物种的检测抗体，所述检测抗体与氧化还原酶偶联，由此，如果分析物 液体包括生物物种，氧化还原酶通过检测抗体和结合抗体与生物物种的偶联而与电极偶联。 然后将电极暴露于包含氧化还原聚合物和酶底物的聚合物溶液，由此如果氧化还原酶与电极上的锚定基团偶联，则氧化还原聚合物被还原并连接到电极上的锚定基团上。 然后将电压施加在电极和参考电极之间，并且电极暴露于可氧化物质，由此所述电极和参比电极之间的电流的大小表示生物物种的存在或不存在。

公开(公告)号：US20090143871A1

公开(公告)日：2009-06-04

申请号：US12067141

申请日：2006-09-18

申请人： Zhiqiang Gao ,  Robert Miklosovic ,  Aaron Radke ,  Wankun Zhou ,  Qing Zheng

发明人： Zhiqiang Gao ,  Robert Miklosovic ,  Aaron Radke ,  Wankun Zhou ,  Qing Zheng

IPC分类号： G05B13/04 ,  G06F17/10 ,  G06F17/11 ,  G06N5/02

CPC分类号： G05B13/04 ,  F05B2260/80 ,  G05B2219/25298

摘要： Controller scaling and parameterization are described. Techniques that can be improved by employing the scaling and parameterization include, but are not limited to, controller design, tuning and optimization. The scaling and parameterization methods described here apply to transfer function based controllers, including PID controllers. The parameterization methods also apply to state feedback and state observer based controllers, as well as linear active disturbance rejection (ADRC) controllers. Parameterization simplifies the use of ADRC. A discrete extended state observer (DESO) and a generalized extended state observer (GESO) are described. They improve the performance of the ESO and therefore ADRC. A tracking control algorithm is also described that improves the performance of the ADRC controller. A general algorithm is described for applying ADRC to multi-input multi-output systems. Several specific applications of the control systems and processes are disclosed.

摘要翻译： 描述控制器缩放和参数化。 可以通过使用缩放和参数化来改进的技术包括但不限于控制器设计，调整和优化。 这里描述的缩放和参数化方法适用于基于传递函数的控制器，包括PID控制器。 参数化方法也适用于状态反馈和基于状态观察器的控制器，以及线性有源扰动抑制（ADRC）控制器。 参数化简化了ADRC的使用。 描述了离散扩展状态观察器（DESO）和广义扩展状态观察器（GESO）。 它们提高了ESO的性能，从而提高了ADRC的性能。 还描述了一种改进ADRC控制器性能的跟踪控制算法。 描述了将ADRC应用于多输入多输出系统的一般算法。 公开了控制系统和过程的几个具体应用。

公开(公告)号：US20070209068A1

公开(公告)日：2007-09-06

申请号：US11682119

申请日：2007-03-05

申请人： Nirwan Ansari ,  Zhiqiang Gao

发明人： Nirwan Ansari ,  Zhiqiang Gao

IPC分类号： G06F15/16

CPC分类号： H04L45/00 ,  H04L63/1408 ,  H04L63/1458 ,  H04L2463/141

摘要： Embodiments are directed toward a method for Behavior-based Traffic Differentiation (BTD) that initially receives incoming packets and performs traffic classification to determine the protocol of the incoming packets. In addition, BTD performs bandwidth division/allocation to further support traffic classification amongst non-TCP traffic such as UDP and ICMP. For TCP traffic, the method for BTD determines whether a TCP connection has been established and performs at least one of rate limiting, waiting time reduction for half-open connections, and incrementing backlog queue size when the TCP connection has not been established. If the TCP connection has been established successfully, the method for BTD further includes proactive tests for traffic differentiation which identify normal traffic, which is admitted, and attack traffic, which is dropped.

摘要翻译： 实施例针对基于行为的流量分化（BTD）的方法，该方法最初接收传入分组并进行流分类以确定输入分组的协议。 此外，BTD执行带宽划分/分配，以进一步支持诸如UDP和ICMP之类的非TCP流量之间的流量分类。 对于TCP流量，BTD的方法确定TCP连接是否已经建立，并且在TCP连接尚未建立时执行速率限制，半开连接的等待时间减少以及递增积压队列大小中的至少一个。 如果TCP连接建立成功，BTD的方法还包括进行流量分类的主动测试，识别被允许的正常流量和丢弃的攻击流量。

公开(公告)号：US20120283850A1

公开(公告)日：2012-11-08

申请号：US13464558

申请日：2012-05-04

申请人： Zhiqiang Gao ,  Gang Tian

发明人： Zhiqiang Gao ,  Gang Tian

IPC分类号： G05B13/02

CPC分类号： G05B13/048 ,  G05B5/01 ,  G05B11/42 ,  G05B13/02 ,  G06F17/10

摘要： Multiple designs, systems, methods and processes for controlling a system or plant using an extended active disturbance rejection control (ADRC) based controller are presented. The extended ADRC controller accepts sensor information from the plant. The sensor information is used in conjunction with an extended state observer in combination with a predictor that estimates and predicts the current state of the plant and a co-joined estimate of the system disturbances and system dynamics. The extended state observer estimates and predictions are used in conjunction with a control law that generates an input to the system based in part on the extended state observer estimates and predictions as well as a desired trajectory for the plant to follow.

摘要翻译： 提出了使用基于扩展主动干扰抑制控制（ADRC）的控制器来控制系统或设备的多种设计，系统，方法和过程。 扩展的ADRC控制器接收来自工厂的传感器信息。 传感器信息与扩展状态观察器结合使用，预测器与估计和预测设备的当前状态以及系统干扰和系统动态的共同估计结合使用。 扩展状态观察者估计和预测结合使用一部分基于扩展状态观察者估计和预测以及工厂遵循的期望轨迹而产生系统输入的控制规则。

公开(公告)号：US08060340B2

公开(公告)日：2011-11-15

申请号：US12067141

申请日：2006-09-18

申请人： Zhiqiang Gao ,  Robert Miklosovic ,  Aaron Radke ,  Wankun Zhou ,  Qing Zheng

发明人： Zhiqiang Gao ,  Robert Miklosovic ,  Aaron Radke ,  Wankun Zhou ,  Qing Zheng

IPC分类号： G06F11/30

CPC分类号： G05B13/04 ,  F05B2260/80 ,  G05B2219/25298

摘要： Controller scaling and parameterization are described. Techniques that can be improved by employing the scaling and parameterization include, but are not limited to, controller design, tuning and optimization. The scaling and parameterization methods described here apply to transfer function based controllers, including PID controllers. The parameterization methods also apply to state feedback and state observer based controllers, as well as linear active disturbance rejection (ADRC) controllers. Parameterization simplifies the use of ADRC. A discrete extended state observer (DESO) and a generalized extended state observer (GESO) are described. They improve the performance of the ESO and therefore ADRC. A tracking control algorithm is also described that improves the performance of the ADRC controller. A general algorithm is described for applying ADRC to multi-input multi-output systems. Several specific applications of the control systems and processes are disclosed.

摘要翻译： 描述控制器缩放和参数化。 可以通过使用缩放和参数化来改进的技术包括但不限于控制器设计，调整和优化。 这里描述的缩放和参数化方法适用于基于传递函数的控制器，包括PID控制器。 参数化方法也适用于状态反馈和基于状态观察器的控制器，以及线性有源扰动抑制（ADRC）控制器。 参数化简化了ADRC的使用。 描述了离散扩展状态观察器（DESO）和广义扩展状态观察器（GESO）。 它们提高了ESO的性能，从而提高了ADRC的性能。 还描述了一种改进ADRC控制器性能的跟踪控制算法。 描述了将ADRC应用于多输入多输出系统的一般算法。 公开了控制系统和过程的几个具体应用。

公开(公告)号：US08028199B1

公开(公告)日：2011-09-27

申请号：US11525499

申请日：2006-09-22

申请人： Vankata Guruprasad ,  Zhiqiang Gao

发明人： Vankata Guruprasad ,  Zhiqiang Gao

IPC分类号： G06F11/00

CPC分类号： H04L41/0631 ,  H04L41/5035

摘要： A method, device and computer product suitable for determining the source of failing to achieve a desired level of service quality in communication between at least two components in a distributed system is disclosed. The method comprises the steps of developing a model of the distributed system, the model including at least configuration non-specific representations of types of managed components, and representations of relationships among the managed components, determining associated managed components within each route of data communication between the at least two components, augmenting the representation of the associated managed components with information associated with each of the routes of data communication, monitoring at least one performance criterion of the communication between the at least two components and determining a source of degradation when the performance criteria is indicated to be outside acceptable limits. The device discloses a processor which is capable of executing the method steps recited. The computer program product represents instructions, which when loaded into a computer system provide instruction for the computer system to execute the method steps recited.

摘要翻译： 公开了一种适用于确定在分布式系统中的至少两个组件之间的通信中未达到期望的服务质量水平的来源的方法，设备和计算机产品。 该方法包括以下步骤：开发分布式系统的模型，所述模型至少包括被管理组件的类型的非特定表示，以及被管理组件之间的关系的表示，确定每个数据通信路由之间的相关联的被管理组件 所述至少两个组件通过与每个所述数据通信路径相关联的信息来增加所述相关联的被管理组件的表示，监视所述至少两个组件之间的通信的至少一个性能标准，并且当所述性能 标准被认为在可接受的限度之外。 该设备公开了一种能够执行所述方法步骤的处理器。 计算机程序产品表示指令，当加载到计算机系统中时，提供计算机系统执行所述方法步骤的指令。

公开(公告)号：US20080318232A1

公开(公告)日：2008-12-25

申请号：US11994808

申请日：2005-07-05

申请人： Zhiqiang Gao

发明人： Zhiqiang Gao

IPC分类号： C12Q1/68

CPC分类号： G01N33/5438 ,  C12Q1/6825 ,  C12Q2565/607 ,  C12Q2563/173 ,  C12Q2523/313

摘要： The present invention relates to electrode systems, methods, apparatus and chips for ultrasensitive detection and quantification of nucleic acids using photoelectrochemical amplification. Upon hybridization of a target nucleic acid to a nucleic acid capture probe, a photoreporter comprising a threading bis-intercalator selectively binds to double-stranded nucleic acid. The stability and reversibility of the photoreporter binding activity provides for ultrasensitive detection of nucleic acid hybridization events.

摘要翻译： 本发明涉及使用光电化学扩增的用于超灵敏检测和定量核酸的电极系统，方法，装置和芯片。 当靶核酸与核酸捕获探针杂交时，包含螺旋双嵌入剂的光载体选择性结合双链核酸。 光电子结合活性的稳定性和可逆性提供了核酸杂交事件的超敏感检测。