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公开(公告)号：US09607375B2
公开(公告)日：2017-03-28
申请号：US14729982
申请日：2015-06-03
Applicant: GENERAL ELECTRIC COMPANY
Inventor： Brion Daryl Sarachan , John Frederick Graf , Anup Sood , Vidya Pundalik Kamath
CPC classification number: G06F17/30259 , G06F19/00 , G06F19/321
Abstract: Dynamic linking of pathway maps and cell maps is disclosed in certain embodiments. In such embodiments, the pathway maps are linked to spatially-localized regional nucleic acid data (e.g., sequence data), as opposed to non-spatially selected nucleic acid data. The pathway map and cell map data may be linked so that interactions results in changes or updates to the linked map, such as the selection or highlighting of cells exhibiting pathway map characteristics specified by a user of updating of node values or states to correspond to that of a cell or cells selected by the user.
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公开(公告)号：US20160237097A1
公开(公告)日：2016-08-18
申请号：US14621776
申请日：2015-02-13
Applicant: GENERAL ELECTRIC COMPANY
Inventor： Arunkumar Natarajan , Anup Sood , Lakshmi Sireesha Kaanumalle
IPC: C07F5/02
CPC classification number: C07F5/02
Abstract: A borate compound for use as photoinduced chemical bleaching reagent is disclosed having improved bleaching performance under certain conditions, compared to neutral borates. The compounds are comprised of Formula I; R1R2R3R4BXa I where each R1, R2, and R3 and R4 is, independently, an alkyl, alkylaryl, or arylalkyl, with the proviso that at least one of R1, R2, and R3 and R4 is an alkyl group and at least two of R1, R2, R3 and R4 group is positively charged; X is an anion; and a equals 1, 2, or 3.
Abstract translation: 公开了与中性硼酸盐相比，用于光诱导化学漂白剂的硼酸盐化合物在某些条件下具有改善的漂白性能。 该化合物由式I组成; R1R2R3R4BXa其中R1，R2和R3和R4独立地为烷基，烷基芳基或芳基烷基，条件是R1，R2和R3和R4中的至少一个是烷基，R1至少两个 ，R2，R3和R4基团带正电荷; X是阴离子; 和等于1,2或3。
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公开(公告)号：US09250245B2
公开(公告)日：2016-02-02
申请号：US14010889
申请日：2013-08-27
Applicant: GENERAL ELECTRIC COMPANY
Inventor： Arunkumar Natarajan , Anup Sood , Lakshmi Sireesha Kaanumalle , Kwok Pong Chan
IPC: G01N33/53 , G01N33/532 , G01N33/533 , G01N21/76 , G01N33/58 , G01N21/64
CPC classification number: G01N33/582 , G01N21/64 , G01N21/6428
Abstract: Methods comprising the use of photoactivated chemical bleaching for detecting multiple targets in a biological sample are provided. The methods include the steps of providing a biological sample containing multiple targets, binding at least one probe to one or more target present in the sample, and observing a signal from the probe. The method further includes the steps of contacting the sample comprising the bound probe with an electron transfer reagent and irradiating the sample, thereby initiating a photoreaction that substantially inactivates the probe by photoactivated chemical bleaching. The method further includes the steps of binding at least one probe to one or more target present in the sample, and observing a signal from the probe. The process of binding, observing and bleaching may be iteratively repeated.
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公开(公告)号：US11512288B2
公开(公告)日：2022-11-29
申请号：US16339077
申请日：2017-08-24
Applicant: General Electric Company
Inventor： Ernest William Kovacs , Anup Sood , Reginald Donovan Smith , Evelina Roxana Loghin , Padmaparna Chaudhuri , Vandana Keskar , Chrystal Mae Chadwick , Martin James Brown
IPC: C12N5/0783 , C07K16/28
Abstract: Provided herein are methods of activating immune cells. The method includes providing a population of immune cells and contacting the population of immune cells with a first agent and a second agent. The first agent includes an immune cell activator attached to a first binder moiety, and the second agent includes at least one capture oligomer. The at least one capture oligomer is capable of associating with the first binder moiety. Also provided are kits for activating immune cells.
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Patent Agency Ranking
公开(公告)号：US20200181572A1
公开(公告)日：2020-06-11
申请号：US16339077
申请日：2017-08-24
Applicant: General Electric Company
Inventor： Ernest William Kovacs , Anup Sood , Reginald Donovan Smith , Evelina Roxana Loghin , Padmaparna Chaudhuri , Vandana Keskar , Chrystal Mae Chadwick , Martin James Brown
IPC: C12N5/0783 , C07K16/28
Abstract: Provided herein are methods of activating immune cells. The method includes providing a population of immune cells and contacting the population of immune cells with a first agent and a second agent. The first agent includes an immune cell activator attached to a first binder moiety, and the second agent includes at least one capture oligomer. The at least one capture oligomer is capable of associating with the first binder moiety. Also provided are kits for activating immune cells.
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公开(公告)号：US10004760B2
公开(公告)日：2018-06-26
申请号：US15219419
申请日：2016-07-26
Applicant: General Electric Company
Inventor： Praveena Mohan , Anup Sood , James Edward Rothman , John Donald Burczak , Hae Won Lim , Lisa Anne Lowery
IPC: A61K31/713 , A61K41/00 , C12N15/87 , C12N15/11 , A61K9/00 , A61K47/06 , A61M37/00 , C12N15/113 , A61K47/54 , A61K47/64 , A61K47/69
CPC classification number: A61K31/713 , A61K9/0019 , A61K41/0028 , A61K47/06 , A61K47/554 , A61K47/64 , A61K47/643 , A61K47/6925 , A61M37/0092 , A61M2037/0007 , C12N15/111 , C12N15/1136 , C12N15/87 , C12N2310/14 , C12N2310/3515 , C12N2320/32
Abstract: The present invention relates to a microbubble complex comprising a microbubble having an outer shell comprising a mixture of native and denatured albumin encapsulating a perfluorocarbon gas, a therapeutic agent, a bifunctional linker having one end attached to the therapeutic agent and the other attached to a ligand and wherein the ligand is bound to the other shell of the microbubble through hydrophobic interactions. Also included are methods for delivering the aforementioned microbubble complex to a tissue target.
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27.发明申请公开(公告)号：US20170109880A1
公开(公告)日：2017-04-20
申请号：US15270061
申请日：2016-09-20
Applicant: GENERAL ELECTRIC COMPANY
Inventor： Yousef Al-Kofahi , Anup Sood , Fiona Ginty , Qing Li , Christopher James Sevinsky , Alberto Santamaria-Pang
IPC: G06T7/00
CPC classification number: G06T7/0012 , G06T7/12 , G06T7/143 , G06T7/174 , G06T7/181 , G06T7/194 , G06T11/008 , G06T11/60 , G06T2207/10004 , G06T2207/10056 , G06T2207/10064 , G06T2207/20076 , G06T2207/20081 , G06T2207/30024 , G06T2207/30101 , G06T2207/30172 , G06T2207/30204 , G06T2211/404
Abstract: Disclosed are novel computer-implemented methods for creating a blood vessel map of a biological tissue. The methods comprise the steps of, accessing image data corresponding to multi-channel multiplexed image of a fluorescently stained biological tissue manifesting expression levels of a primary marker and at least one auxiliary marker of blood vasculature, and extracting features of blood vessels using the primary marker as an input to create a single channel segmentation of the blood vessels. The method further comprises the steps of extracting features of blood vessels using the auxiliary marker to create auxiliary channels as a second input and apply multi-channel blood vessel enhancement. Blood vessel maps are created using the features and tracing the blood vasculature by iteratively extending the centerlines of the initial segmentation using statistical models and geometric rules
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公开(公告)号：US20150099650A1
公开(公告)日：2015-04-09
申请号：US14047233
申请日：2013-10-07
Applicant: General Electric Company
Inventor： Anup Sood , Arunkumar Natarajan , Michael James Rishel , Michael John Gerdes
IPC: C12Q1/68
CPC classification number: C12Q1/6825 , C12Q2523/319 , G01N33/53 , G01N33/533 , G01N33/542 , G01N33/6854
Abstract: Disclosed are high throughput methods of probing multiple targets in a biological sample where the recurrent time-consuming antibody incubation steps and individual signal modification and activation steps are replaced by simultaneous hybridization of biomarkers and sequential detection by combining signal removal and activation into a single step. Also disclosed are images obtained by such methods.
Abstract translation: 公开了探测生物样品中多个靶标的高通量方法，其中复发耗时的抗体孵育步骤和单独的信号修饰和激活步骤被生物标志物的同时杂交和通过将信号去除和活化组合到单个步骤中的顺序检测来代替。 还公开了通过这种方法获得的图像。
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公开(公告)号：US20140057282A1
公开(公告)日：2014-02-27
申请号：US14071805
申请日：2013-11-05
Applicant: General Electric Company
CPC classification number: G01N1/34 , C07K14/001 , C12N2539/10 , G01N33/5375 , G01N33/54333
Abstract: Methods and kits for binding and releasing biological targets, comprising, a binder having an environmentally reactive molecular switch that can switch between a high affinity state, to bind the target, to a low affinity state, to release the target. In one embodiment, the binder is a pre-existing chemical sequence, composition, or structural configuration but unknown or unspecified and still viable as a binder for attaching a molecular switch.
Abstract translation: 用于结合和释放生物靶的方法和试剂盒，包括具有环境反应性分子开关的粘合剂，所述粘合剂可以在高亲和力状态之间切换以将靶结合到低亲和性状态以释放靶。 在一个实施方案中，粘合剂是预先存在的化学序列，组合物或结构构型，但是未知的或未指定的，并且作为用于连接分子开关的粘合剂仍然可行。
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