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    Water-based binder solutions for use in additive manufacturing processes
    1.
    发明授权
    Water-based binder solutions for use in additive manufacturing processes 有权

    公开(公告)号：US12221553B2

    公开(公告)日：2025-02-11

    申请号：US17876028

    申请日：2022-07-28

    Applicant: General Electric Company

    Inventor： Arunkumar Natarajan ,  William C. Alberts

    IPC: C09D139/06 ,  B29C64/165 ,  B33Y10/00 ,  B33Y70/00 ,  C09D7/20 ,  C09D7/45

    Abstract: A water-based binder solution comprises a thermoplastic binder, greater than or equal to 4 wt % to less than or equal to 20 wt % of a non-aqueous solvent having a boiling point greater than or equal to 100° C. and less than or equal to 175° C., and water. The thermoplastic binder comprises a first polymer strand having a weight average molecular weight (Mw) of from 5,000 g/mol to 15,000 g/mol; and at least one of a second polymer strand having a weight average molecular weight (Mw) of from 10,000 g/mol to 50,000 g/mol and a third polymer strand having a weight average molecular weight (Mw) of from 1,000 g/mol to 5,000 g/mol. A method of monitoring a print head of an additive manufacture process comprises depositing a water-based binder solution on the thermal paper.

    WATER-BASED BINDER SOLUTIONS FOR USE IN ADDITIVE MANUFACTURING PROCESSES
    6.
    发明申请
    WATER-BASED BINDER SOLUTIONS FOR USE IN ADDITIVE MANUFACTURING PROCESSES 有权

    公开(公告)号：US20210371641A1

    公开(公告)日：2021-12-02

    申请号：US17326698

    申请日：2021-05-21

    Applicant: General Electric Company

    Inventor： Arunkumar Natarajan ,  William C. Alberts ,  Vadim Bromberg

    IPC: C08L39/06 ,  B22F10/14 ,  B29C64/165 ,  B33Y70/00 ,  B33Y10/00 ,  B33Y80/00

    Abstract: In various embodiments, a water-based binder solution for use in additive manufacturing, includes a thermoplastic binder. The thermoplastic binder includes a first polymer strand having a weight average molecular weight (Mw) of from greater than or equal to 5,000 g/mol to less than or equal to 15,000 g/mol, a second polymer strand having a weight average molecular weight of from greater than or equal to 10,000 g/mol to less than or equal to 50,000 g/mol, and a third polymer strand having a weight average molecular weight of from greater than or equal to 1,000 g/mol to less than or equal to 5,000 g/mol. The binder solution further comprises from greater than or equal to 0.1 wt % to less than or equal to 5 wt % of a non-aqueous solvent having a boiling point of greater than 100° C.

    METHODS OF ANALYZING AN H&E STAINED BIOLOGICAL SAMPLE
    9.
    发明申请
    METHODS OF ANALYZING AN H&E STAINED BIOLOGICAL SAMPLE 有权
    分析H＆E污染生物样品的方法

    公开(公告)号：US20160069782A1

    公开(公告)日：2016-03-10

    申请号：US14772305

    申请日：2014-03-05

    Applicant: GENERAL ELECTRIC COMPANY

    Inventor： Anup Sood ,  Kevin Bernard Kenny ,  Arunkumar Natarajan ,  Lakshmi Sireesha Kaanumalle ,  Elizabeth Mary McDonough

    IPC: G01N1/30 ,  G01N33/58

    CPC classification number: G01N1/30 ,  G01N33/5005 ,  G01N33/582

    Abstract: Methods comprising probing multiple targets in an H&E stained biological sample are provided. The methods include the steps of providing a hematoxylin and eosin stained biological sample containing multiple targets, optionally detecting H&E staining of the sample, removing the hematoxylin and eosin signals, and detecting additional features or targets in the biological sample. The detecting step may include performing the steps of binding at least one probe to one or more targets to the sample, detecting a signal from the probe and contacting the sample with a bleaching agent. The process of binding, detecting and bleaching may be iteratively repeated.

    Abstract translation: 提供了包括在H＆E染色的生物样品中探测多个靶标的方法。 所述方法包括提供一个苏木精和曙红含有多个目标染色生物样本，任选检测所述样品的H＆E染色，除去苏木精和曙红信号，并且检测生物样品中另外的特征或对象的步骤。 检测步骤可以包括执行中的至少一个探针结合到一个或多个目标的样品中，检测来自探针的信号，并且与漂白剂接触所述样品的步骤。 结合，检测和漂白的过程可以迭代重复。

    PHOTOACTIVATED CHEMICAL BLEACHING OF DYES
    10.
    发明申请
    PHOTOACTIVATED CHEMICAL BLEACHING OF DYES 有权
    激光化学漂白剂

    公开(公告)号：US20130345089A1

    公开(公告)日：2013-12-26

    申请号：US14010889

    申请日：2013-08-27

    Applicant: General Electric Company

    Inventor： Arunkumar Natarajan ,  Anup Sood ,  Lakshmi Sireesha Kaanumalle ,  Kwok Pong Chan

    IPC: G01N33/58

    CPC classification number: G01N33/582 ,  G01N21/64 ,  G01N21/6428

    Abstract: Methods comprising the use of photoactivated chemical bleaching for detecting multiple targets in a biological sample are provided. The methods include the steps of providing a biological sample containing multiple targets, binding at least one probe to one or more target present in the sample, and observing a signal from the probe. The method further includes the steps of contacting the sample comprising the bound probe with an electron transfer reagent and irradiating the sample, thereby initiating a photoreaction that substantially inactivates the probe by photoactivated chemical bleaching. The method further includes the steps of binding at least one probe to one or more target present in the sample, and observing a signal from the probe. The process of binding, observing and bleaching may be iteratively repeated.

    Abstract translation: 提供了包括使用光活化化学漂白来检测生物样品中的多个靶的方法。 所述方法包括以下步骤：提供含有多个靶标的生物样品，将至少一个探针结合到样品中存在的一个或多个靶，并观察来自探针的信号。 该方法还包括以下步骤：将包含结合的探针的样品与电子转移试剂接触并照射样品，从而引发光激活，其通过光活化的化学漂白使探针基本上灭活。 该方法还包括将至少一个探针结合到样品中存在的一个或多个靶，并观察来自探针的信号的步骤。 结合，观察和漂白的过程可以迭代地重复。

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