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公开(公告)号：US20230136909A1
公开(公告)日：2023-05-04
申请号：US17833695
申请日：2022-06-06
Applicant: Genomatica, Inc.
Inventor： Anthony P. Burgard , Robin E. Osterhout , Stephen J. Van Dien , Cara Ann Tracewell , Priti Pharkya , Stefan Andrae
IPC: C12N15/52 , C12P7/42 , C08F120/06 , C08G63/664 , C12N15/63 , C12P7/24 , C12P7/40 , C12N9/04 , C12N9/06 , C12N9/10 , C12P7/62
Abstract: Provided herein is a non-naturally occurring microbial organism having a methanol metabolic pathway that can enhance the availability of reducing equivalents in the presence of methanol. Such reducing equivalents can be used to increase the product yield of organic compounds produced by the microbial organism, such as 3-hydroxyisobutyrate or MAA. Also provided herein are methods for using such an organism to produce 3-hydroxyisobutyrate or MAA.
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公开(公告)号：US11535874B2
公开(公告)日：2022-12-27
申请号：US14436722
申请日：2013-10-21
Applicant: Genomatica, Inc.
Inventor： Anthony P. Burgard , Robin E. Osterhout , Stephen J. Van Dien , Cara Ann Tracewell , Priti Pharkya , Stefan Andrae
IPC: C12N9/96 , C12P7/46 , C12N9/04 , C12N9/06 , C12N9/10 , C07C55/10 , C08G63/00 , C12N15/70 , C12N15/81 , C12P7/24 , C07C59/235 , C12N15/74 , C12N15/77
Abstract: Provided herein is a non-naturally occurring microbial organism (NNOMO) having a methanol metabolic pathway (MMP) that can enhance the availability of reducing equivalents in the presence of methanol. Such reducing equivalents can be used to increase the product yield of organic compounds produced by the microbial organism, such as succinate. Also provided herein are methods for using such an organism to produce succinate.
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23.发明申请公开(公告)号：US20220348932A1
公开(公告)日：2022-11-03
申请号：US17516424
申请日：2021-11-01
Applicant: Genomatica, Inc.
Inventor： Robin E. Osterhout , Anthony P. Burgard , Priti Pharkya , Stefan Andrae
Abstract: The invention provides non-naturally occurring microbial organisms having a formaldehyde fixation pathway, a formate assimilation pathway, and/or a methanol metabolic pathway in combination with a fatty alcohol, fatty aldehyde, fatty acid or isopropanol pathway, wherein the microbial organisms selectively produce a fatty alcohol, fatty aldehyde or fatty acid of a specified length or isopropanol. The microbial organisms provided advantageously enhance the production of substrates and/or pathway intermediates for the production of chain length specific fatty alcohols, fatty aldehydes, fatty acids or isopropanol. In some aspects, the microbial organisms of the invention have select gene disruptions or enzyme attenuations that increase production of fatty alcohols, fatty aldehydes or fatty acids. The invention additionally provides methods of using the above microbial organisms to produce a fatty alcohol, a fatty aldehyde, a fatty acid or isopropanol.
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公开(公告)号：US11447804B2
公开(公告)日：2022-09-20
申请号：US16178432
申请日：2018-11-01
Applicant: Genomatica, Inc.
Inventor： Anthony P. Burgard , Robin E. Osterhout , Stephen J. Van Dien , Cara Ann Tracewell , Priti Pharkya , Stefan Andrae
IPC: C12P17/10 , C12P7/44 , C12P7/24 , C12P13/00 , C12N9/04 , C08G63/78 , C08G73/02 , C08G69/16 , C08G69/08 , A23L29/00 , C12N15/52
Abstract: Provided herein is a non-naturally occurring microbial organism having a methanol metabolic pathway that can enhance the availability of reducing equivalents in the presence of methanol. Such reducing equivalents can be used to increase the product yield of organic compounds produced by the microbial organism, such as adipate, 6-aminocaproate, hexamethylenediamine or caprolactam. Also provided herein are methods for using such an organism to produce adipate, 6-aminocaproate, hexamethylenediamine or caprolactam.
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公开(公告)号：US11384340B2
公开(公告)日：2022-07-12
申请号：US16792592
申请日：2020-02-17
Applicant: Genomatica, Inc.
Inventor： Stefan Andrae , Michael Patrick Kuchinskas , Jingyi Li , Harish Nagarajan , Priti Pharkya
Abstract: Described herein are non-natural NAD+-dependent alcohol dehydrogenases (ADHs) capable of at least two fold greater conversion of methanol or ethanol to formaldehyde or acetaldehyde, respectively, as compared to its unmodified counterpart. Nucleic acids encoding the non-natural alcohol dehydrogenases, as well as expression constructs including the nucleic acids, and engineered cells comprising the nucleic acids or expression constructs are described. Also described are engineered cells expressing a non-natural NAD+-dependent alcohol dehydrogenase, optionally include one or more additional metabolic pathway transgene(s), methanol metabolic pathway genes, target product pathway genes, cell culture compositions including the cells, methods for promoting production of the target product or intermediate thereof from the cells, compositions including the target product or intermediate, and products made from the target product or intermediate.
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Patent Agency Ranking
26.发明申请公开(公告)号：US20210238609A1
公开(公告)日：2021-08-05
申请号：US17008243
申请日：2020-08-31
Applicant: Genomatica, Inc.
Inventor： Anthony P. Burgard , Robin E. Osterhout , Priti Pharkya , Stefan Andrae , Ewa Teresa Lis , Carla Risso , John Douglas Trawick
IPC: C12N15/63 , C12P5/02 , C12P7/04 , C12P7/18 , C12N9/88 , C07K14/195 , C12N15/52 , C12N9/10 , C12N9/90 , C07C1/24 , C07C11/167 , C07C31/20 , C07C33/025 , C09D147/00 , C09J147/00
Abstract: Provided herein are non-naturally occurring microbial organisms having a FaldFP, a FAP and/or metabolic modifications which can further include a MMP, a MOP, a hydrogenase and/or a CODH. These microbial organisms can further include a butadiene, 13BDO, CrotOH, MVC or 3-buten-1-ol pathway. Additionally provided are methods of using such microbial organisms to produce butadiene, 13BDO, CrotOH, MVC or 3-buten-1-ol.
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公开(公告)号：US20190300919A1
公开(公告)日：2019-10-03
申请号：US16178432
申请日：2018-11-01
Applicant: Genomatica, Inc.
Inventor： Anthony P. Burgard , Robin E. Osterhout , Stephen J. Van Dien , Cara Ann Tracewell , Priti Pharkya , Stefan Andrae
IPC: C12P17/10 , C12P13/00 , A23L29/00 , C12N15/52 , C08G69/08 , C08G69/16 , C12P7/24 , C08G63/78 , C12P7/44 , C08G73/02 , C12N9/04
Abstract: Provided herein is a non-naturally occurring microbial organism having a methanol metabolic pathway that can enhance the availability of reducing equivalents in the presence of methanol. Such reducing equivalents can be used to increase the product yield of organic compounds produced by the microbial organism, such as adipate, 6-aminocaproate, hexamethylenediamine or caprolactam. Also provided herein are methods for using such an organism to produce adipate, 6-aminocaproate, hexamethylenediamine or caprolactam.
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28.发明申请公开(公告)号：US20190017078A1
公开(公告)日：2019-01-17
申请号：US15890716
申请日：2018-02-07
Applicant: Genomatica, Inc.
Inventor： Anthony P. Burgard , Robin E. Osterhout , Priti Pharkya , Stefan Andrae
Abstract: Provided herein are non-naturally occurring microbial organisms having a formaldehyde fixation pathway and a formate assimilation pathway, which can further include a methanol metabolic pathway, a methanol oxidation pathway, a hydrogenase and/or a carbon monoxide dehydrogenase. These microbial organisms can further include a butadiene, 1,3-butanediol, crotyl alcohol or 3-buten-2-ol pathway. Additionally provided are methods of using such microbial organisms to produce butadiene, 1,3-butanediol, crotyl alcohol or 3-buten-2-ol.
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公开(公告)号：US20180030484A1
公开(公告)日：2018-02-01
申请号：US15488320
申请日：2017-04-14
Applicant: Genomatica, Inc.
Inventor： Anthony P. Burgard , Robin E. Osterhout , Stephen J. Van Dien , Cara Ann Tracewell , Priti Pharkya , Stefan Andrae
IPC: C12P7/18 , C08G69/26 , C08G63/66 , C08G63/12 , C08G63/06 , C12N9/10 , C12P19/02 , C12P7/24 , C08G18/32 , C12N9/88 , C12N9/04 , C12N9/06 , C07D207/12
CPC classification number: C12P7/18 , C07D207/12 , C08G18/3206 , C08G63/06 , C08G63/12 , C08G63/66 , C08G69/26 , C12N9/0006 , C12N9/0028 , C12N9/1007 , C12N9/88 , C12P7/24 , C12P19/02 , C12Y101/01224 , C12Y101/01244 , C12Y101/02007 , C12Y105/0102 , C12Y201/01 , C12Y201/0109 , C12Y402/01 , Y02P20/52
Abstract: Provided herein is a non-naturally occurring microbial organism having a methanol metabolic pathway that can enhance the availability of reducing equivalents in the presence of methanol. Such reducing equivalents can be used to increase the product yield of organic compounds produced by the microbial organism, such as 1,4-butanediol (BDO). Also provided herein are methods for using such an organism to produce BDO.
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公开(公告)号：US09657316B2
公开(公告)日：2017-05-23
申请号：US13975678
申请日：2013-08-26
Applicant: Genomatica, Inc.
Inventor： Anthony P. Burgard , Robin E. Osterhout , Stephen J. Van Dien , Cara Ann Tracewell , Priti Pharkya , Stefan Andrae
IPC: C12P7/24 , C12P7/28 , C12P7/18 , C12N1/20 , C12N1/00 , C07H21/04 , C08G18/00 , C08G63/00 , C08G63/02 , C12N9/04 , C12N9/06 , C12N9/10 , C07D207/12 , C08G18/32 , C08G63/06 , C08G63/12 , C08G63/66 , C08G69/26 , C12N9/88 , C12P19/02
CPC classification number: C12P7/18 , C07D207/12 , C08G18/3206 , C08G63/06 , C08G63/12 , C08G63/66 , C08G69/26 , C12N9/0006 , C12N9/0028 , C12N9/1007 , C12N9/88 , C12P7/24 , C12P19/02 , C12Y101/01224 , C12Y101/01244 , C12Y101/02007 , C12Y105/0102 , C12Y201/01 , C12Y201/0109 , C12Y402/01 , Y02P20/52
Abstract: Provided herein is a non-naturally occurring microbial organism having a methanol metabolic pathway that can enhance the availability of reducing equivalents in the presence of methanol. Such reducing equivalents can be used to increase the product yield of organic compounds produced by the microbial organism, such as 1,4-butanediol (BDO). Also provided herein are methods for using such an organism to produce BDO.
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