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1.发明申请MICROORGANISMS AND METHODS FOR ENHANCING THE AVAILABILITY OF REDUCING EQUIVALENTS IN THE PRESENCE OF METHANOL, FOR PRODUCING METHACRYLIC ACID 审中-公开用于提高甲醇存在下生产甲基丙酸的减少等效物的可行性的微生物和方法公开(公告)号：US20170073691A1
公开(公告)日：2017-03-16
申请号：US15133150
申请日：2016-04-19
Applicant: Genomatica, Inc.
Inventor： Anthony P. BURGARD , Robin E. OSTERHOUT , Stephen J. VAN DIEN , Cara Ann TRACEWELL , Priti PHARKYA , Stefan ANDRAE
CPC classification number: C12N15/52 , C08F120/06 , C08G63/664 , C12N9/0006 , C12N9/0028 , C12N9/1007 , C12N15/63 , C12P7/24 , C12P7/40 , C12P7/42 , C12P7/62 , C12Y101/01244 , C12Y105/0102 , C12Y201/0109
Abstract: Provided herein is a non-naturally occurring microbial organism having a methanol metabolic pathway that can enhance the availability of reducing equivalents in the presence of methanol. Such reducing equivalents can be used to increase the product yield of organic compounds produced by the microbial organism, such as 3-hydroxyisobutyrate or MAA. Also provided herein are methods for using such an organism to produce 3-hydroxyisobutyrate or MAA.
Abstract translation: 本文提供了具有甲醇代谢途径的非天然存在的微生物生物，其可以在甲醇存在下增强还原当量的可用性。 这种还原当量可用于增加由微生物生物体如3-羟基异丁酸酯或MAA产生的有机化合物的产物产率。 本文还提供了使用这种生物体产生3-羟基异丁酸酯或MAA的方法。
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公开(公告)号：US10000758B2
公开(公告)日：2018-06-19
申请号：US15133150
申请日：2016-04-19
Applicant: Genomatica, Inc.
Inventor： Anthony P. Burgard , Robin E. Osterhout , Stephen J. Van Dien , Cara Ann Tracewell , Priti Pharkya , Stefan Andrae
IPC: C12N15/52 , C12P7/42 , C08F120/06 , C08G63/664 , C12N15/63 , C12P7/24 , C12P7/40 , C12N9/04 , C12N9/06 , C12N9/10 , C12P7/62
CPC classification number: C12N15/52 , C08F120/06 , C08G63/664 , C12N9/0006 , C12N9/0028 , C12N9/1007 , C12N15/63 , C12P7/24 , C12P7/40 , C12P7/42 , C12P7/62 , C12Y101/01244 , C12Y105/0102 , C12Y201/0109
Abstract: Provided herein is a non-naturally occurring microbial organism having a methanol metabolic pathway that can enhance the availability of reducing equivalents in the presence of methanol. Such reducing equivalents can be used to increase the product yield of organic compounds produced by the microbial organism, such as 3-hydroxyisobutyrate or MAA. Also provided herein are methods for using such an organism to produce 3-hydroxyisobutyrate or MAA.
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公开(公告)号：US20160168598A1
公开(公告)日：2016-06-16
申请号：US14963836
申请日：2015-12-09
Applicant: UNIVERSITY OF WASHINGTON
Inventor： JOHN ARTHUR LEIGH , THOMAS JOSEPH LIE
CPC classification number: C12P7/16 , C12N9/1007 , C12N9/13 , C12P7/04 , C12P7/065 , C12Y201/0109 , C12Y208/04001 , Y02E50/10 , Y02E50/17
Abstract: Provided herein is technology relating to genetically modified organisms and particularly, but not exclusively, to compositions comprising one or more genetically modified microorganisms, and related methods and systems, for producing liquid fuels from alkanes such as methane.
Abstract translation: 本文提供了与转基因生物相关的技术，特别地但不排他地涉及包含一种或多种转基因微生物的组合物，以及用于从诸如甲烷的烷烃生产液体燃料的相关方法和系统。
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4.发明授权Microorganisms and methods for enhancing the availability of reducing equivalents in the presence of methanol, and for producing 3-hydroxyisobutyrate or methacrylic acid related thereto 有权用于提高在甲醇存在下还原当量的可用性的微生物和方法，以及用于生产与其相关的3-羟基异丁酸酯或甲基丙烯酸公开(公告)号：US09346902B2
公开(公告)日：2016-05-24
申请号：US14071339
申请日：2013-11-04
Applicant: Genomatica, Inc.
Inventor： Anthony P. Burgard , Robin E. Osterhout , Stephen J. Van Dien , Cara Ann Tracewell , Priti Pharkya , Stefan Andrae
IPC: C12P7/42 , C08F120/06 , C08G63/664 , C12N15/63 , C12P7/24 , C12P7/40 , C12N15/52
CPC classification number: C12N15/52 , C08F120/06 , C08G63/664 , C12N9/0006 , C12N9/0028 , C12N9/1007 , C12N15/63 , C12P7/24 , C12P7/40 , C12P7/42 , C12P7/62 , C12Y101/01244 , C12Y105/0102 , C12Y201/0109
Abstract: Provided herein is a non-naturally occurring microbial organism having a methanol metabolic pathway that can enhance the availability of reducing equivalents in the presence of methanol. Such reducing equivalents can be used to increase the product yield of organic compounds produced by the microbial organism, such as 3-hydroxyisobutyrate or MAA. Also provided herein are methods for using such an organism to produce 3-hydroxyisobutyrate or MAA.
Abstract translation: 本文提供了具有甲醇代谢途径的非天然存在的微生物生物，其可以在甲醇存在下增强还原当量的可用性。 这种还原当量可用于增加由微生物生物体如3-羟基异丁酸酯或MAA产生的有机化合物的产物产率。 本文还提供了使用这种生物体产生3-羟基异丁酸酯或MAA的方法。
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公开(公告)号：US20240052379A1
公开(公告)日：2024-02-15
申请号：US18346715
申请日：2023-07-03
Applicant: Genomatica, Inc.
Inventor： Anthony P. Burgard , Robin E. Osterhout , Stephen J. Van Dien , Cara Ann Tracewell , Priti Pharkya , Stefan Andrae
IPC: C12P7/18 , C12N9/04 , C12N9/06 , C12N9/10 , C07D207/12 , C08G18/32 , C08G63/06 , C08G63/12 , C08G63/66 , C08G69/26 , C12N9/88 , C12P7/24 , C12P19/02
CPC classification number: C12P7/18 , C12N9/0006 , C12N9/0028 , C12N9/1007 , C12Y105/0102 , C12Y201/01 , C12Y101/01244 , C12Y101/02007 , C07D207/12 , C08G18/3206 , C08G63/06 , C08G63/12 , C08G63/66 , C08G69/26 , C12N9/88 , C12P7/24 , C12P19/02 , C12Y101/01224 , C12Y201/0109 , C12Y402/01 , Y02P20/52
Abstract: Provided herein is a non-naturally occurring microbial organism having a methanol metabolic pathway (MMP) that can enhance the availability of reducing equivalents in the presence of methanol. Such reducing equivalents can be used to increase the product yield of organic compounds produced by the microbial organism, such as 1,4-butanediol (BDO). Also provided herein are methods for using such an organism to produce BDO.
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Patent Agency Ranking
6.发明申请MICROORGANISMS AND METHODS FOR ENHANCING THE AVAILABILITY OF REDUCING EQUIVALENTS IN THE PRESENCE OF METHANOL, AND FOR PRODUCING 1.4-BUTANEDIOL RELATED THERETO 审中-公开用于提高甲醇存在下降低等效物质和生产与其相关的1,4-丁二醇的可行性的微生物和方法公开(公告)号：US20150203875A1
公开(公告)日：2015-07-23
申请号：US14424404
申请日：2013-08-27
Applicant: Genomatica, Inc.
Inventor： Anthony P. Burgard , Robin E. Osterhout , Stephen J. Van Dien , Cara Ann Tracewell , Priti Pharkya , Stefan Andrae
IPC: C12P7/18 , C12P19/02 , C12N9/04 , C12N9/88 , C12N9/10 , C07D207/12 , C08G18/32 , C08G63/12 , C08G63/66 , C08G69/26 , C08G63/06 , C12P7/24 , C12N9/06
CPC classification number: C12P7/18 , C07D207/12 , C08G18/3206 , C08G63/06 , C08G63/12 , C08G63/66 , C08G69/26 , C12N9/0006 , C12N9/0028 , C12N9/1007 , C12N9/88 , C12P7/24 , C12P19/02 , C12Y101/01224 , C12Y101/01244 , C12Y101/02007 , C12Y105/0102 , C12Y201/01 , C12Y201/0109 , C12Y402/01 , Y02P20/52
Abstract: Provided herein is a non-naturally occurring microbial organism having a methanol metabolic pathway (MMP) that can enhance the availability of reducing equivalents in the presence of methanol. Such reducing equivalents can be used to increase the product yield of organic compounds produced by the microbial organism, such as 1,4-butanediol (BDO). Also provided herein are methods for using such an organism to produce BDO.
Abstract translation: 本文提供了具有甲醇代谢途径（MMP）的非天然存在的微生物生物，其可以在甲醇存在下增强还原当量的可用性。 这种还原当量可用于增加由微生物生物例如1,4-丁二醇（BDO）产生的有机化合物的产物产率。 本文还提供了使用这种生物体产生BDO的方法。
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公开(公告)号：US20180030484A1
公开(公告)日：2018-02-01
申请号：US15488320
申请日：2017-04-14
Applicant: Genomatica, Inc.
Inventor： Anthony P. Burgard , Robin E. Osterhout , Stephen J. Van Dien , Cara Ann Tracewell , Priti Pharkya , Stefan Andrae
IPC: C12P7/18 , C08G69/26 , C08G63/66 , C08G63/12 , C08G63/06 , C12N9/10 , C12P19/02 , C12P7/24 , C08G18/32 , C12N9/88 , C12N9/04 , C12N9/06 , C07D207/12
CPC classification number: C12P7/18 , C07D207/12 , C08G18/3206 , C08G63/06 , C08G63/12 , C08G63/66 , C08G69/26 , C12N9/0006 , C12N9/0028 , C12N9/1007 , C12N9/88 , C12P7/24 , C12P19/02 , C12Y101/01224 , C12Y101/01244 , C12Y101/02007 , C12Y105/0102 , C12Y201/01 , C12Y201/0109 , C12Y402/01 , Y02P20/52
Abstract: Provided herein is a non-naturally occurring microbial organism having a methanol metabolic pathway that can enhance the availability of reducing equivalents in the presence of methanol. Such reducing equivalents can be used to increase the product yield of organic compounds produced by the microbial organism, such as 1,4-butanediol (BDO). Also provided herein are methods for using such an organism to produce BDO.
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公开(公告)号：US09657316B2
公开(公告)日：2017-05-23
申请号：US13975678
申请日：2013-08-26
Applicant: Genomatica, Inc.
Inventor： Anthony P. Burgard , Robin E. Osterhout , Stephen J. Van Dien , Cara Ann Tracewell , Priti Pharkya , Stefan Andrae
IPC: C12P7/24 , C12P7/28 , C12P7/18 , C12N1/20 , C12N1/00 , C07H21/04 , C08G18/00 , C08G63/00 , C08G63/02 , C12N9/04 , C12N9/06 , C12N9/10 , C07D207/12 , C08G18/32 , C08G63/06 , C08G63/12 , C08G63/66 , C08G69/26 , C12N9/88 , C12P19/02
CPC classification number: C12P7/18 , C07D207/12 , C08G18/3206 , C08G63/06 , C08G63/12 , C08G63/66 , C08G69/26 , C12N9/0006 , C12N9/0028 , C12N9/1007 , C12N9/88 , C12P7/24 , C12P19/02 , C12Y101/01224 , C12Y101/01244 , C12Y101/02007 , C12Y105/0102 , C12Y201/01 , C12Y201/0109 , C12Y402/01 , Y02P20/52
Abstract: Provided herein is a non-naturally occurring microbial organism having a methanol metabolic pathway that can enhance the availability of reducing equivalents in the presence of methanol. Such reducing equivalents can be used to increase the product yield of organic compounds produced by the microbial organism, such as 1,4-butanediol (BDO). Also provided herein are methods for using such an organism to produce BDO.
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9.发明申请MICROORGANISMS AND METHODS FOR ENHANCING THE AVAILABILITY OF REDUCING EQUIVALENTS IN THE PRESENCE OF METHANOL, AND FOR PRODUCING 3-HYDROXYISOBUTYRATE OR METHACRYLIC ACID RELATED THERETO 有权用于提高甲醇存在下减少等效物的可行性的微生物和方法，以及用于生产与其相关的3-羟基异丁酸酯或甲基丙烯酸公开(公告)号：US20140288254A1
公开(公告)日：2014-09-25
申请号：US14071339
申请日：2013-11-04
Applicant: Genomatica, Inc.
Inventor： Anthony P. Burgard , Robin E. Osterhout , Stephen J. Van Dien , Cara Ann Tracewell , Priti Pharkya , Stefan Andrae
IPC: C12P7/42 , C08F120/06 , C12P7/24 , C08G63/664 , C12N15/63 , C12P7/40
CPC classification number: C12N15/52 , C08F120/06 , C08G63/664 , C12N9/0006 , C12N9/0028 , C12N9/1007 , C12N15/63 , C12P7/24 , C12P7/40 , C12P7/42 , C12P7/62 , C12Y101/01244 , C12Y105/0102 , C12Y201/0109
Abstract: Provided herein is a non-naturally occurring microbial organism having a methanol metabolic pathway that can enhance the availability of reducing equivalents in the presence of methanol. Such reducing equivalents can be used to increase the product yield of organic compounds produced by the microbial organism, such as 3-hydroxyisobutyrate or MAA. Also provided herein are methods for using such an organism to produce 3-hydroxyisobutyrate or MAA.
Abstract translation: 本文提供了具有甲醇代谢途径的非天然存在的微生物生物，其可以在甲醇存在下增强还原当量的可用性。 这种还原当量可用于增加由微生物生物体如3-羟基异丁酸酯或MAA产生的有机化合物的产物产率。 本文还提供了使用这种生物体产生3-羟基异丁酸酯或MAA的方法。
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10.发明申请MICROORGANISMS AND METHODS FOR ENHANCING THE AVAILABILITY OF REDUCING EQUIVALENTS IN THE PRESENCE OF METHANOL, AND FOR PRODUCING 1,4-BUTANEDIOL RELATED THERETO 有权用于提高甲醇存在下降低等效物质和生产1,4-丁二醇相关物质的可行性的微生物和方法公开(公告)号：US20140058056A1
公开(公告)日：2014-02-27
申请号：US13975678
申请日：2013-08-26
Applicant: Genomatica, Inc.
Inventor： Anthony P. Burgard , Robin E. Osterhout , Stephen J. Van Dien , Cara Ann Tracewell , Priti Pharkya , Stefan Andrae
IPC: C12P7/18
CPC classification number: C12P7/18 , C07D207/12 , C08G18/3206 , C08G63/06 , C08G63/12 , C08G63/66 , C08G69/26 , C12N9/0006 , C12N9/0028 , C12N9/1007 , C12N9/88 , C12P7/24 , C12P19/02 , C12Y101/01224 , C12Y101/01244 , C12Y101/02007 , C12Y105/0102 , C12Y201/01 , C12Y201/0109 , C12Y402/01 , Y02P20/52
Abstract: Provided herein is a non-naturally occurring microbial organism having a methanol metabolic pathway that can enhance the availability of reducing equivalents in the presence of methanol. Such reducing equivalents can be used to increase the product yield of organic compounds produced by the microbial organism, such as 1,4-butanediol (BDO). Also provided herein are methods for using such an organism to produce BDO.
Abstract translation: 本文提供了具有甲醇代谢途径的非天然存在的微生物生物，其可以在甲醇存在下增强还原当量的可用性。 这种还原当量可用于增加由微生物生物例如1,4-丁二醇（BDO）产生的有机化合物的产物产率。 本文还提供了使用这种生物体产生BDO的方法。
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