公开(公告)号：US20160067255A1

公开(公告)日：2016-03-10

申请号：US14842609

申请日：2015-09-01

Applicant: Gilead Sciences, Inc.

Inventor： Darius M. Babusis ,  Adrian S. Ray ,  Jianhong Wang

IPC: A61K31/5365 ,  A61K31/506 ,  A61K31/675

CPC classification number: A61K31/5365 ,  A61K31/506 ,  A61K31/513 ,  A61K31/675 ,  A61K2300/00

Abstract: The disclosure describes methods for treating or preventing HIV in a patient using a combination of tenofovir alafenamide and dolutegravir, and to compositions containing such compounds.

Abstract translation: 本公开描述了使用替诺福韦甲酰胺和dolutegravir的组合治疗或预防HIV的方法，以及含有这些化合物的组合物。

公开(公告)号：US20130090302A1

公开(公告)日：2013-04-11

申请号：US13626687

申请日：2012-09-25

Applicant: Gilead Sciences, Inc.

Inventor： Constantine G. BOOJAMRA ,  Kuei-Ying Lin ,  Richard L. Mackman ,  David Y. Markevitch ,  Oleg V. Petrakovsky ,  Adrian S. Ray ,  Lijun Zhang

IPC: C07H19/20

CPC classification number: C07H19/16 ,  A61K31/341 ,  A61K31/513 ,  A61K31/662 ,  A61K31/675 ,  A61K31/683 ,  A61K45/06 ,  C07F9/65616 ,  C07H19/00 ,  C07H19/20 ,  A61K2300/00

Abstract: The invention is related to phosphorus substituted anti-viral inhibitory compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.

Abstract translation: 本发明涉及磷取代的抗病毒抑制化合物，含有这些化合物的组合物，以及包括施用这些化合物的治疗方法以及可用于制备这些化合物的方法和中间体。

公开(公告)号：US20130090299A1

公开(公告)日：2013-04-11

申请号：US13653982

申请日：2012-10-17

Applicant: Gilead Sciences, Inc.

Inventor： Constantine G. Boojamra ,  Kuei-Ying Lin ,  Richard L. Mackman ,  David Y. Markevitch ,  Oleg V. Petrakovsky ,  Adrian S. Ray ,  Lijun Zhang

IPC: C07F9/6561 ,  A61K45/06 ,  A61K31/675

CPC classification number: C07H19/16 ,  A61K31/341 ,  A61K31/513 ,  A61K31/662 ,  A61K31/675 ,  A61K31/683 ,  A61K45/06 ,  C07F9/65616 ,  C07H19/00 ,  C07H19/20 ,  A61K2300/00

Abstract: The invention is related to phosphorus substituted anti-viral inhibitory compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.

Abstract translation: 本发明涉及磷取代的抗病毒抑制化合物，含有这些化合物的组合物，以及包括施用这些化合物的治疗方法以及可用于制备这些化合物的方法和中间体。

公开(公告)号：US20230027727A1

公开(公告)日：2023-01-26

申请号：US17748400

申请日：2022-05-19

Applicant: Gilead Sciences, Inc.

Inventor： Michael O`Neil Hanrahan Clarke ,  Joy Yang Feng ,  Robert Jordan ,  Richard L. Mackman ,  Adrian S. Ray ,  Dustin Siegel

IPC: A61K31/706 ,  A61K31/7056

Abstract: Provided are methods for treating Arenaviridae and Coronaviridae virus infections by administering nucleosides and prodrugs thereof, of Formula I. wherein the 1′ position of the nucleoside sugar is substituted. The compounds, compositions, and methods provided are particularly useful for the treatment of Lassa virus and Junin virus infections.

公开(公告)号：US11382926B2

公开(公告)日：2022-07-12

申请号：US17222066

申请日：2021-04-05

Applicant: Gilead Sciences, Inc.

Inventor： Michael O'Neil Hanrahan Clarke ,  Joy Yang Feng ,  Robert Jordan ,  Richard L. Mackman ,  Adrian S. Ray ,  Dustin Siegel

IPC: A61K31/706 ,  A61K31/7056

Abstract: Provided are methods for treating Arenaviridae and Coronaviridae virus infections by administering nucleosides and prodrugs thereof, of Formula I: wherein the 1′ position of the nucleoside sugar is substituted. The compounds, compositions, and methods provided are particularly useful for the treatment of Lassa virus and Junin virus infections.

公开(公告)号：US20210393659A1

公开(公告)日：2021-12-23

申请号：US17222066

申请日：2021-04-05

Applicant: Gilead Sciences, Inc.

Inventor： Michael O`Neil Hanrahan Clarke ,  Joy Yang Feng ,  Robert Jordan ,  Richard L. Mackman ,  Adrian S. Ray ,  Dustin Siegel

IPC: A61K31/706 ,  A61K31/7056

Abstract: Provided are methods for treating Arenaviridae and Coronaviridae virus infections by administering nucleosides and prodrugs thereof, of Formula I: wherein the 1′ position of the nucleoside sugar is substituted. The compounds, compositions, and methods provided are particularly useful for the treatment of Lassa virus and Junin virus infections.

公开(公告)号：US11007208B2

公开(公告)日：2021-05-18

申请号：US16863566

申请日：2020-04-30

Applicant: GILEAD SCIENCES, INC.

Inventor： Michael O' Neil Hanrahan Clarke ,  Joy Yang Feng ,  Robert Jordan ,  Richard L. Mackman ,  Adrian S. Ray ,  Dustin Siegel

IPC: A61K31/7056 ,  A61K31/706

Abstract: Provided are methods for treating Arenaviridae and Coronaviridae virus infections by administering nucleosides and prodrugs thereof, of Formula I: wherein the 1′ position of the nucleoside sugar is substituted. The compounds, compositions, and methods provided are particularly useful for the treatment of Lassa virus and Junin virus infections.

公开(公告)号：US10980810B2

公开(公告)日：2021-04-20

申请号：US16153497

申请日：2018-10-05

Applicant: Gilead Sciences, Inc.

Inventor： Jamie Geier Bates ,  Adrian S. Ray

IPC: A61K31/519 ,  A61K31/216 ,  A61P1/16

Abstract: The present disclosure provides methods and compositions for treating, stabilizing or lessening the severity or progression of a non-alcoholic fatty liver disease.

公开(公告)号：US20180311263A1

公开(公告)日：2018-11-01

申请号：US15902690

申请日：2018-02-22

Applicant: Gilead Sciences, Inc.

Inventor： Byoung Kwon Chun ,  Michael O' Neil Hanrahan Clarke ,  Edward Doerffler ,  Hon Chung Hui ,  Robert Jordan ,  Richard L. Mackman ,  Jay P. Parrish ,  Adrian S. Ray ,  Dustin Siegel

IPC: A61K31/685 ,  A61K31/53 ,  A61K31/00 ,  A61K31/6615 ,  A61K31/665 ,  A61K31/683 ,  C07D487/04 ,  C07H15/18 ,  C07H11/00 ,  C07H1/02 ,  C07H1/00 ,  A61K45/06 ,  A61K31/675 ,  C07F9/6561 ,  C07F9/24 ,  C07D519/00

CPC classification number: A61K31/685 ,  A61K31/00 ,  A61K31/53 ,  A61K31/6615 ,  A61K31/665 ,  A61K31/675 ,  A61K31/683 ,  A61K31/7056 ,  A61K31/706 ,  A61K45/06 ,  C07D487/04 ,  C07D519/00 ,  C07F9/2429 ,  C07F9/65616 ,  C07H1/00 ,  C07H1/02 ,  C07H11/00 ,  C07H15/18 ,  A61K2300/00

Abstract: Provided are compounds, methods, and pharmaceutical compositions for treating Filoviridae virus infections by administering ribosides, riboside phosphates and prodrugs thereof, of Formula IV: The compounds, compositions, and methods provided are particularly useful for the treatment of Marburg virus, Ebola virus and Cueva virus infections.

公开(公告)号：US20180086784A1

公开(公告)日：2018-03-29

申请号：US15643168

申请日：2017-07-06

Applicant: Gilead Sciences, Inc.

Inventor： Constantine G. Boojamra ,  Kuei-Ying Lin ,  Richard L. Mackman ,  David Y. Markevitch ,  Oleg V. Petrakovsky ,  Adrian S. Ray ,  Lijun Zhang

IPC: C07H19/16

Abstract: The invention is related to phosphorus substituted anti-viral inhibitory compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.