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公开(公告)号：US12187753B2
公开(公告)日：2025-01-07
申请号：US18236532
申请日：2023-08-22
Applicant: Gilead Sciences, Inc.
Inventor： Julie Farand , Tezcan Guney , Darryl Kato , John O. Link , James B. C. Mack , William J. Watkins
IPC: C07F9/09
Abstract: The present disclosure relates generally to certain compounds, pharmaceutical compositions comprising said compounds, and methods of making and using said compounds and pharmaceutical compositions. The compounds and compositions provided herein may be used for the treatment or prevention of a Retroviridae infection, including an HIV infection.
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公开(公告)号：US20240376077A1
公开(公告)日：2024-11-14
申请号：US18632593
申请日：2024-04-11
Applicant: Gilead Sciences, Inc.
Inventor： Michael Graupe , Steven J. Henry , John O. Link , Charles William Rowe , Roland D. Saito , Scott D. Schroeder , Dimitrios Stefanidis , Winston C. Tse , Jennifer R. Zhang
IPC: C07D401/14 , A61K31/4439 , A61K31/537 , A61K31/675 , A61K31/7076 , A61K45/06 , C07C317/08 , C07D231/54 , C07F5/02
Abstract: The present disclosure relates to a compound of formula (Ia), (Ib), (IIa), and (IIb): which are useful in the treatment of a Retroviridae viral infection including an infection caused by the HIV virus.
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公开(公告)号：US12077537B2
公开(公告)日：2024-09-03
申请号：US18110126
申请日：2023-02-15
Applicant: Gilead Sciences, Inc.
Inventor： Chienhung Chou , Scott E. Lazerwith , John O. Link , Scott D. Schroeder , Winston C. Tse , Jennifer R. Zhang
IPC: C07D513/06 , A61K31/4365 , A61K31/437 , A61K45/06 , C07D403/12 , C07D471/04 , C07D471/06 , C07D498/04 , C07D513/04 , C07D519/00
CPC classification number: C07D471/04 , A61K45/06 , C07D403/12 , C07D498/04 , C07D513/04 , C07D519/00
Abstract: The present disclosure relates generally to certain compounds, pharmaceutical compositions comprising said compounds, and methods of making and using said compounds and pharmaceutical compositions. The compounds and compositions disclosed herein may be used for the treatment or prevention of a Retroviridae viral infection, including an infection caused by the HIV virus.
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公开(公告)号：US11905299B2
公开(公告)日：2024-02-20
申请号：US17317041
申请日：2021-05-11
Applicant: Gilead Sciences, Inc.
Inventor： Elizabeth M. Bacon , Gayatri Balan , Chien-Hung Chou , Christopher T. Clark , Jeromy J. Cottell , Musong Kim , Thorsten A. Kirschberg , John O. Link , Gary Phillips , Scott D. Schroeder , Neil H. Squires , Kirk L. Stevens , James G. Taylor , William J. Watkins , Nathan E. Wright , Sheila M. Zipfel
IPC: C07D401/12 , C07D498/04 , C07D405/14 , C07D413/14 , C07D409/14 , C07D417/14 , C07D471/04 , C07D495/04 , C07D401/14 , C07B59/00
CPC classification number: C07D498/04 , C07B59/002 , C07D401/12 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D495/04 , C07B2200/05
Abstract: The present disclosure relates generally to modulators of Cot (cancer Osaka thyroid) and methods of use and manufacture thereof.
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公开(公告)号：US11318119B2
公开(公告)日：2022-05-03
申请号：US16849747
申请日：2020-04-15
Applicant: Gilead Sciences, Inc.
Inventor： Aesop Cho , John O. Link , Jie Xu
IPC: A61K31/4196 , A61K31/52 , A61K31/537 , A61K31/675 , A61K45/06 , A61P31/18 , A61K31/7076 , C07D403/10 , C07D403/14
Abstract: The present disclosure provides compounds, or a pharmaceutically acceptable salt thereof as described herein, useful for treating the proliferation of the HIV virus, treating AIDS or delaying the onset of AIDS symptoms in a subject. The disclosure also provides pharmaceutical compositions comprising these compounds, processes for preparing them, therapeutic methods for treating the proliferation of the HIV virus, treating AIDS or delaying the onset of AIDS symptoms in a subject using these compounds. The present disclosure also provides compounds, or a pharmaceutically acceptable salt thereof as described herein, useful for treating the proliferation of a coronavirus, treating coronavirus symptoms or delaying the onset of coronavirus symptoms in a subject. The disclosure also provides pharmaceutical compositions comprising these compounds, processes for preparing them, therapeutic methods for treating the proliferation of a coronavirus, treating coronavirus symptoms or delaying the onset of coronavirus symptoms in a subject using these compounds.
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Patent Agency Ranking
公开(公告)号：US11078208B1
公开(公告)日：2021-08-03
申请号：US16805933
申请日：2020-03-02
Applicant: Gilead Sciences, Inc.
Inventor： Elizabeth M. Bacon , Elbert Chin , Jeromy J. Cottell , Ashley Anne Katana , Darryl Kato , John O. Link , Nathan Shapiro , Teresa Alejandra Trejo Martin , Zheng-Yu Yang
IPC: C07D405/14 , C07D487/08 , C07D491/04 , A61P31/18 , A61K45/06 , C07C275/16 , C07D401/12 , C07D471/08 , C07D487/10 , C07C243/28 , A61K31/52 , A61K31/55 , A61K31/553 , A61K31/685 , A61K31/688 , C07D403/12
Abstract: The invention provides a compound of Formula I: or a pharmaceutically acceptable salt thereof as described herein. The invention also provides pharmaceutical compositions comprising a compound of Formula I, processes for preparing compounds of Formula I, therapeutic methods for treating the proliferation of the HIV virus, treating AIDS or delaying the onset of AIDS symptoms in a mammal using compounds of Formula I.
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公开(公告)号：US11066414B2
公开(公告)日：2021-07-20
申请号：US16717074
申请日：2019-12-17
Applicant: Gilead Sciences, Inc.
Inventor： Elizabeth M. Bacon , Gayatri Balan , Chien-Hung Chou , Christopher T. Clark , Jeromy J. Cottell , Musong Kim , Thorsten A. Kirschberg , John O. Link , Gary Phillips , Scott D. Schroeder , Neil H. Squires , Kirk L. Stevens , James G. Taylor , William J. Watkins , Nathan E. Wright , Sheila M. Zipfel
IPC: C07D401/14 , C07D498/04 , C07D405/14 , C07D413/14 , C07D401/12 , C07D409/14 , C07D417/14 , C07D471/04 , C07D495/04 , C07B59/00
Abstract: The present disclosure relates generally to modulators of Cot (cancer Osaka thyroid) and methods of use and manufacture thereof.
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公开(公告)号：US11034668B2
公开(公告)日：2021-06-15
申请号：US16419578
申请日：2019-05-22
Applicant: Gilead Sciences, Inc.
Inventor： Steven S. Bondy , Carina E. Cannizzaro , Chien-Hung Chou , Randall L. Halcomb , Yunfeng E. Hu , John O. Link , Qi Liu , Scott D. Schroeder , Winston C. Tse , Jennifer R. Zhang
IPC: A61K31/50 , A61K45/06 , A61K31/444 , A61K31/506 , C07D213/40 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D409/14 , C07D413/14 , C07D471/04 , C07C403/14 , C07D471/06 , C07D487/04 , C07D491/04 , C07D495/04 , A61K31/4439 , A61K31/4545 , A61K31/4709 , A61K31/4985 , A61K31/5377 , C07D491/052
Abstract: The invention provides compounds of formula (I): or a salt thereof as described herein. The invention also provides pharmaceutical compositions comprising a compound of formula (I), processes for preparing compounds of formula (I), intermediates useful for preparing compounds of formula I and therapeutic methods for treating a Retroviridae viral infection including an infection caused by the HIV virus.
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公开(公告)号：US10370358B2
公开(公告)日：2019-08-06
申请号：US15902883
申请日：2018-02-22
Applicant: Gilead Sciences, Inc.
Inventor： Steven S. Bondy , Carina E. Cannizzaro , Chien-Hung Chou , Randall L. Halcomb , Yunfeng Eric Hu , John O. Link , Qi Liu , Scott D. Schroeder , Winston C. Tse , Jennifer R. Zhang
IPC: A61K31/50 , A61K45/06 , A61K31/444 , A61K31/506 , C07D213/40 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D409/14 , C07D413/14 , C07D471/04 , C07D471/06 , C07D487/04 , C07D491/04 , C07D495/04 , A61K31/4439 , A61K31/4545 , A61K31/4709 , A61K31/4985 , A61K31/5377 , C07D491/052
Abstract: The invention provides compounds of formula (I): or a salt thereof as described herein. The invention also provides pharmaceutical compositions comprising a compound of formula (I), processes for preparing compounds of formula (I), intermediates useful for preparing compounds of formula I and therapeutic methods for treating a Retroviridae viral infection including an infection caused by the HIV virus.
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公开(公告)号：US20190008858A1
公开(公告)日：2019-01-10
申请号：US16005111
申请日：2018-06-11
Applicant: Gilead Sciences, Inc.
Inventor： Kyla Bjornson , Eda Canales , Jeromy J. Cottell , Kapil K. Karki , Ashley A. Katana , Darryl Kato , Tetsuya Kobayashi , John O. Link , Ruben Martinez , Barton W. Phillips , Hyung-jung Pyun , Michael Sangi , Adam J. Schrier , Dustin Siegel , James G. Taylor , Chinh V. Tran , Teresa A. Trejo Martin , Randall W. Vivian , Zheng-Yu Yang , Jeff Zablocki , Sheila Zipfel
IPC: A61K31/498 , C07K5/08 , A61K31/10 , C07K5/083 , C07D498/22 , C07D498/16 , C07D403/14 , C07D241/36 , A61K45/06 , A61K38/21 , A61K38/06 , C07K5/087 , A61K31/519 , A61K31/506 , A61K31/4985 , A61K31/4745 , A61K31/401 , A61K38/00
CPC classification number: A61K31/498 , A61K31/10 , A61K31/401 , A61K31/4745 , A61K31/4985 , A61K31/506 , A61K31/519 , A61K38/00 , A61K38/06 , A61K38/21 , A61K45/06 , C07D241/36 , C07D403/14 , C07D498/16 , C07D498/22 , C07K5/08 , C07K5/0808 , C07K5/0812 , C07K5/0827 , A61K2300/00
Abstract: Compounds of Formula I are disclosed As well as pharmaceutically acceptable salts thereof. Methods of using said compounds and pharmaceutical compositions containing said compounds are also disclosed.
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