公开(公告)号：US20160083395A1

公开(公告)日：2016-03-24

申请号：US14957988

申请日：2015-12-03

Applicant: Gilead Sciences, Inc.

Inventor： John O. Link ,  Jeromy J. Cottell ,  Teresa Alejandra Trejo Martin ,  Elizabeth M. Bacon

IPC: C07D491/052 ,  A61K45/06 ,  A61K31/4188

CPC classification number: C07D491/052 ,  A61K31/352 ,  A61K31/4188 ,  A61K31/7056 ,  A61K31/7068 ,  A61K31/7072 ,  A61K38/21 ,  A61K45/06 ,  C07D491/04

Abstract: The disclosure is related to anti-viral compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.

公开(公告)号：US09233974B2

公开(公告)日：2016-01-12

申请号：US13830346

申请日：2013-03-14

Applicant: Gilead Sciences, Inc.

Inventor： John O. Link ,  Jeromy J. Cottell ,  Teresa Alejandra Trejo Martin ,  Elizabeth M. Bacon

IPC: C07D491/052 ,  A61K31/352 ,  A61K31/4188 ,  A61K31/7056 ,  A61K31/7068 ,  A61K31/7072 ,  A61K38/21 ,  C07D491/04

CPC classification number: C07D491/052 ,  A61K31/352 ,  A61K31/4188 ,  A61K31/7056 ,  A61K31/7068 ,  A61K31/7072 ,  A61K38/21 ,  A61K45/06 ,  C07D491/04

Abstract: The disclosure is related to anti-viral compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.

公开(公告)号：US08940718B2

公开(公告)日：2015-01-27

申请号：US13679874

申请日：2012-11-16

Applicant: Gilead Sciences, Inc.

Inventor： Elizabeth M. Bacon ,  Jeromy J. Cottell ,  Ashley Anne Katana ,  Darryl Kato ,  Evan S. Krygowski ,  John O. Link ,  James Taylor ,  Chinh Viet Tran ,  Teresa Alejandra Trejo Martin ,  Zheng-Yu Yang ,  Sheila Zipfel

IPC: A01N43/16 ,  A61K31/35 ,  A01N33/18 ,  A01N33/24 ,  A61K31/04 ,  C07D207/46 ,  A61K31/4188 ,  A61K45/06 ,  C07D491/052

CPC classification number: C07D491/052 ,  A61K31/4188 ,  A61K31/7056 ,  A61K31/7064 ,  A61K31/7072 ,  A61K38/06 ,  A61K38/07 ,  A61K38/21 ,  A61K45/06 ,  A61K47/60 ,  C07D405/12 ,  C07F5/025 ,  Y10S514/894 ,  A61K2300/00

Abstract: The disclosure is related to anti-viral compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.

公开(公告)号：US20140017198A1

公开(公告)日：2014-01-16

申请号：US13934090

申请日：2013-07-02

Applicant: Gilead Sciences, Inc.

Inventor： Kyla Bjornson ,  Eda Canales ,  Jeromy J. Cottell ,  Kapil Kumar Karki ,  Ashley Anne Katana ,  Darryl Kato ,  Tetsuya Kobayashi ,  John O. Link ,  Ruben Martinez ,  Barton W. Phillips ,  Hyung-Jung Pyun ,  Michael Sangi ,  Adam James Schrier ,  Dustin Siegel ,  James G. Taylor ,  Chinh Viet Tran ,  Teresa Alejandra Trejo Martin ,  Randall W. Vivian ,  Zheng-Yu Yang ,  Jeff Zablocki ,  Sheila Zipfel

IPC: C07D498/16 ,  C07D498/22 ,  A61K45/06 ,  A61K31/506 ,  A61K31/519 ,  A61K31/4985 ,  A61K31/4745

CPC classification number: A61K31/498 ,  A61K31/10 ,  A61K31/401 ,  A61K31/4745 ,  A61K31/4985 ,  A61K31/506 ,  A61K31/519 ,  A61K38/00 ,  A61K38/06 ,  A61K38/21 ,  A61K45/06 ,  C07D241/36 ,  C07D403/14 ,  C07D498/16 ,  C07D498/22 ,  C07K5/08 ,  C07K5/0808 ,  C07K5/0812 ,  C07K5/0827 ,  A61K2300/00

Abstract: Compounds of Formula I are disclosed As well as pharmaceutically acceptable salts thereof. Methods of using said compounds and pharmaceutical compositions containing said compounds are also disclosed.

Abstract translation: 公开的式I化合物及其药学上可接受的盐。 还公开了使用所述化合物和含有所述化合物的药物组合物的方法。

公开(公告)号：US20130309195A1

公开(公告)日：2013-11-21

申请号：US13828104

申请日：2013-03-14

Applicant: Gilead Sciences, Inc.

Inventor： John O. Link ,  Jeromy J. Cottell ,  Teresa Alejandra Trejo Martin

IPC: C07D403/14 ,  A61K31/7056 ,  C07D405/14 ,  A61K45/06 ,  A61K31/7072 ,  A61K31/4178 ,  A61K38/21

CPC classification number: C07D403/14 ,  A61K31/4178 ,  A61K31/7056 ,  A61K31/7064 ,  A61K31/7072 ,  A61K38/21 ,  A61K45/06 ,  C07D401/14 ,  C07D405/14 ,  A61K2300/00

Abstract: The invention is related to anti-viral compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.

公开(公告)号：US12084455B2

公开(公告)日：2024-09-10

申请号：US17224557

申请日：2021-04-07

Applicant: Gilead Sciences, Inc.

Inventor： Elizabeth M. Bacon ,  Elbert Chin ,  Jeromy J. Cottell ,  Ashley Anne Katana ,  Darryl Kato ,  John O. Link ,  Nathan Shapiro ,  Teresa Alejandra Trejo Martin ,  Zheng-Yu Yang

IPC: C07D405/14 ,  A61K31/52 ,  A61K31/55 ,  A61K31/553 ,  A61K31/685 ,  A61K31/688 ,  A61K45/06 ,  A61P31/18 ,  C07C243/28 ,  C07C275/16 ,  C07D401/12 ,  C07D403/12 ,  C07D471/08 ,  C07D487/08 ,  C07D487/10 ,  C07D491/04

CPC classification number: C07D487/08 ,  A61K31/52 ,  A61K31/55 ,  A61K31/553 ,  A61K31/685 ,  A61K31/688 ,  A61K45/06 ,  A61P31/18 ,  C07C243/28 ,  C07C275/16 ,  C07D401/12 ,  C07D403/12 ,  C07D405/14 ,  C07D471/08 ,  C07D487/10 ,  C07D491/04

Abstract: The invention provides a compound of Formula I:






or a pharmaceutically acceptable salt thereof as described herein. The invention also provides pharmaceutical compositions comprising a compound of Formula I, processes for preparing compounds of Formula I, therapeutic methods for treating the proliferation of the HIV virus, treating AIDS or delaying the onset of AIDS symptoms in a mammal using compounds of Formula I.

公开(公告)号：US11548901B2

公开(公告)日：2023-01-10

申请号：US16868119

申请日：2020-05-06

Applicant: Gilead Sciences, Inc.

Inventor： Elizabeth M. Bacon ,  Zhenhong R. Cai ,  Xiaowu Chen ,  Jeromy J. Cottell ,  Manoj C. Desai ,  Mingzhe Ji ,  Haolun Jin ,  Scott E. Lazerwith ,  Michael R. Mish ,  Philip Anthony Morganelli ,  Hyung-Jung Pyun ,  James G. Taylor ,  Teresa Alejandra Trejo Martin

IPC: A61K31/4985 ,  C07D487/14 ,  C07D498/14 ,  A61K31/537 ,  C07D471/22 ,  A61K31/529 ,  A61K31/551 ,  A61K31/498 ,  C07D471/18 ,  A61K45/06 ,  C07D498/18 ,  A61K31/553

Abstract: Compounds for use in the treatment of human immunodeficiency virus (HIV) infection are disclosed. The compounds have the following Formula (I): including stereoisomers and pharmaceutically acceptable salts thereof, wherein R1, X, W, Y1, Y2, Z1, and Z4 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.

公开(公告)号：US20220233525A1

公开(公告)日：2022-07-28

申请号：US17532148

申请日：2021-11-22

Applicant: Gilead Sciences, Inc.

Inventor： Manoj C. Desai ,  Mingzhe Ji ,  Haolun Jin ,  Hyung-Jung Pyun ,  Teresa Alejandra Trejo Martin

IPC: A61K31/4985 ,  C07D471/18 ,  C07D471/14

Abstract: Compounds for use in the treatment of human immunodeficiency virus (HIV) infection are disclosed. The compounds have the following Formula (I): including stereoisomers and pharmaceutically acceptable salts thereof, wherein L, R1, R5, W, X, Y1, Y2, and Z are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.

公开(公告)号：US11213523B2

公开(公告)日：2022-01-04

申请号：US16572159

申请日：2019-09-16

Applicant: Gilead Sciences, Inc.

Inventor： Manoj C. Desai ,  Mingzhe Ji ,  Haolun Jin ,  Hyung-Jung Pyun ,  Teresa Alejandra Trejo Martin

IPC: A61K31/4985 ,  C07D487/22 ,  C07D471/18 ,  C07D471/14

Abstract: Compounds for use in the treatment of human immunodeficiency virus (HIV) infection are disclosed. The compounds have the following Formula (I): including stereoisomers and pharmaceutically acceptable salts thereof, wherein L, R1, R5, W, X, Y1, Y2, and Z are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.

公开(公告)号：US10456395B2

公开(公告)日：2019-10-29

申请号：US15982197

申请日：2018-05-17

Applicant: Gilead Sciences, Inc.

Inventor： Hyung-Jung Pyun ,  Manoj C. Desai ,  Haolun Jin ,  Mingzhe Ji ,  Teresa Alejandra Trejo Martin

IPC: A61K31/4985 ,  C07D487/04 ,  C07D471/18 ,  C07D471/14

Abstract: Compounds for use in the treatment of human immunodeficiency virus (HIV) infection are disclosed. The compounds have the following Formula (I): including stereoisomers and pharmaceutically acceptable salts thereof, wherein L, R1, R5, W, X, Y1, Y2, and Z are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.