公开(公告)号：US6167293A

公开(公告)日：2000-12-26

申请号：US635078

申请日：1996-04-19

申请人： Thomas Leonard Chenevert ,  Thomas Kwok-Fah Foo ,  Martin R. Prince

发明人： Thomas Leonard Chenevert ,  Thomas Kwok-Fah Foo ,  Martin R. Prince

IPC分类号： A61B5/055 ,  G01R33/28 ,  G01R33/48 ,  G01R33/561 ,  G01R33/563

CPC分类号： G01R33/563 ,  G01R33/281 ,  G01R33/56308

摘要： A 3DFT MRA dynamic study is performed using a contrast agent to enhance image contrast. A monitor pulse sequence is performed at a high temporal rate to monitor the magnitude of the NMR signal produced in a monitor region after the contrast agent is injected into the patient. When the monitor signal reaches a threshold value, the patient is signaled and the 3DFT image data set is acquired.

摘要翻译： 使用造影剂进行3DFT MRA动态研究以增强图像对比度。 以高时间速率执行监视脉冲序列，以监测将造影剂注射到患者体内后的监测区域中产生的NMR信号的大小。 当监视信号达到阈值时，通知患者并获取3DFT图像数据集。

公开(公告)号：US5924987A

公开(公告)日：1999-07-20

申请号：US944426

申请日：1997-10-06

申请人： James F. M. Meaney ,  Martin R. Prince

发明人： James F. M. Meaney ,  Martin R. Prince

IPC分类号： A61B5/055

CPC分类号： A61B5/055

摘要： The present invention is a technique of, and system for, imaging vascular anatomy over distance considerably greater than the maximum practical field of view of a magnetic resonance imaging system while using substantially one contrast agent injection. The technique and system of the present invention acquires image data of a plurality of image volumes which are representative of different portions of the patient's body. The image data of each image volume includes image data which is representative of the center of k-space. The acquisition of image data which is representative of the center of k-space is correlated with a concentration of contrast agent in the artery(ies) residing in the image volume being substantially greater than the concentration of contrast agent in veins and background tissue adjacent to the artery(ies). This provides preferential enhancement of arteries relative to adjacent veins and background tissue for each acquisition, wherein each acquisition is representative of a different portion of the arterial system (e.g., abdominal aorta, femoral, popliteal, and tibial arteries).

公开(公告)号：US5762065A

公开(公告)日：1998-06-09

申请号：US705818

申请日：1996-08-30

申请人： Martin R. Prince

发明人： Martin R. Prince

IPC分类号： A61K49/18 ,  G01R33/28 ,  G01R33/561 ,  G01R33/563 ,  A61B5/055

CPC分类号： A61B5/416 ,  A61B5/411 ,  A61K49/18 ,  G01R33/5601 ,  G01R33/563 ,  A61B5/201 ,  A61B5/7285 ,  G01R33/281 ,  G01R33/5619 ,  G01R33/56308

摘要： The present invention is a method and apparatus for providing preferential enhancement of an artery of interest relative to adjacent veins and background tissue. The method and apparatus adapts the timing of a maximum or substantially elevated rate of infusion to correlate with the collection of image data corresponding to the center of k-space. The technique and apparatus temporally correlates the timing of a maximum or substantially elevated rate of infusion and the mapping of k-space according to the location of the artery of interest, the size of the artery of interest, the physical condition of the patient, the time delay due to the configuration of the contrast agent delivery system, and/or the type of pulse sequence employed by the imaging apparatus. Adapting the timing of a maximum or substantially elevated rate of infusion to correlate with the collection of image data corresponding to the center of k-space provides a period of a maximum or substantially elevated contrast concentration in the artery of interest relative to adjacent veins during collection of at least a portion of the image data corresponding to the center of k-space.

摘要翻译： 本发明是一种用于相对于相邻静脉和背景组织提供感兴趣的动脉的优先增强的方法和装置。 所述方法和装置使最大或基本上提高的输注速率的时间适应与对应于k空间中心的图像数据的收集相关。 技术和设备根据感兴趣的动脉的位置，感兴趣的动脉的大小，患者的身体状况，时间上相关联的最大或基本上升高的输注速率的时间和k空间的映射 由于造影剂传送系统的配置引起的时间延迟和/或成像装置采用的脉冲序列的类型。 适应最大或基本上提高的输注速率的时间与对应于k空间中心的图像数据的收集相关联，提供在收集期间相对于相邻静脉的感兴趣动脉中的最大或基本上升高的对比浓度的周期 的图像数据的至少一部分对应于k空间的中心。

公开(公告)号：US5133709A

公开(公告)日：1992-07-28

申请号：US484181

申请日：1990-02-23

申请人： Martin R. Prince

发明人： Martin R. Prince

IPC分类号： A61B18/22 ,  A61B18/24 ,  G02B6/255 ,  G02B6/26

CPC分类号： G02B6/2552 ,  A61B18/245 ,  G02B6/262 ,  A61B2018/2266

摘要： An apparatus for delivery of high intensity laser radiation of large spot size into arteries and a method for making same are disclosed. An optical radiating apparatus is formed on one end of a light-conducting optical fiber such that high intensity laser radiation leaves the optical radiation apparatus with a spot size that is expanded to a diameter significantly larger than the optical fiber diameter. The apparatus comprises a small diameter, flexible fiber which tapers to a large diameter, smooth, rounded ball tip. The taper allows the beam to expand to several millimeters in diameter and thereby ablate a large channel through an occluded artery. The smooth ball tip minimizes the chance of mechanical dissection or perforation. The fiber material is continuous such that there are no optical interfaces. The light radiation apparatus is manufactured to ensure uniformity of light intensity and the ability to transmit intense light without developing regions of mechanical, thermal or optical damage to the apparatus.

摘要翻译： 公开了一种用于将大斑点的高强度激光辐射输送到动脉中的装置及其制造方法。 在导光光纤的一端形成光辐射装置，使得高强度激光辐射离开光辐射装置，其光点尺寸扩大到明显大于光纤直径的直径。 该装置包括一个小直径的柔性纤维，其逐渐变细到大直径，平滑的圆形球头。 锥形允许束扩张至直径几毫米，从而通过闭塞动脉消融大通道。 平滑的球头使机械夹层或穿孔的机会最小化。 纤维材料是连续的，使得没有光学界面。 制造光辐射装置以确保光强度的均匀性和传递强光的能力，而不会对该装置发生机械，热或光学损伤的区域。

公开(公告)号：US08200311B2

公开(公告)日：2012-06-12

申请号：US11737812

申请日：2007-04-20

申请人： Pascal Spincemaille ,  Yi Wang ,  Martin R. Prince

发明人： Pascal Spincemaille ,  Yi Wang ,  Martin R. Prince

IPC分类号： A61B5/055

CPC分类号： A61B5/055 ,  A61B5/0263 ,  A61B5/0402 ,  A61B5/7285 ,  G01R33/4818 ,  G01R33/5601 ,  G01R33/5635 ,  G01R33/56509 ,  G01R33/5673

摘要： Described is a robust electrocardiogram (ECG) ordering technique of k-space for breath hold contrast enhanced magnetic resonance angiography (CE-MRA) that acquires the central part of k-space in a motion-free portion of diastole and fills in from the periphery of k-space at all other times. To make maximal use of the contrast enhancement, data is acquired continuously even when the ECG signal is lost. The ECG signal is monitored in real time. The ECG ordering technique allows a flexible acquisition matrix and is robust against ECG signal imperfections. The ECG ordering technique allows thoracic and pulmonary magnetic resonance angiography with a higher resolution when compared to the conventional gated sequence.

摘要翻译： 描述了一种用于持续对比增强磁共振血管造影（CE-MRA）的k空间的鲁棒心电图（ECG）排序技术，其获得舒张期的无运动部分中的k空间的中心部分并从周边填充 的k空间在其他时间。 为了最大限度地利用对比度增强，即使当ECG信号丢失时也可以连续获取数据。 ECG信号被实时监控。 ECG排序技术允许灵活的采集矩阵，并且针对ECG信号缺陷是鲁棒的。 与常规门控序列相比，ECG排序技术允许具有更高分辨率的胸廓和肺部磁共振血管造影。

公开(公告)号：US20120035435A1

公开(公告)日：2012-02-09

申请号：US13147072

申请日：2010-01-28

申请人： Minkyung Grace Choi ,  Martin R. Prince

发明人： Minkyung Grace Choi ,  Martin R. Prince

IPC分类号： A61B5/0408 ,  A61B5/08

CPC分类号： A61B5/1135 ,  A61B5/04085 ,  A61B5/6831 ,  A61B5/7285 ,  A61B2562/164

摘要： A device is provided for sensing an electrocardiogram signal of a patient. The device includes a substrate and a plurality of electrodes mounted to the substrate. The plurality of electrodes are configured to sense an electrocardiogram signal of a patient when the plurality of electrodes are placed in contact with the patient. The device may include a strap configured to wrap around a portion of the patient wherein the substrate mounts to the strap. The device further may include a respiration sensor mounted to the strap.

摘要翻译： 提供了用于感测患者的心电图信号的装置。 该器件包括衬底和安装到衬底的多个电极。 多个电极被配置为当多个电极与患者接触时感测患者的心电图信号。 该装置可以包括被配置成包裹患者的一部分的带，其中衬底安装到带上。 该装置还可以包括安装到带子上的呼吸传感器。

公开(公告)号：US08005530B2

公开(公告)日：2011-08-23

申请号：US12725140

申请日：2010-03-16

申请人： Martin R. Prince

发明人： Martin R. Prince

IPC分类号： A61B5/055 ,  G01V3/00

CPC分类号： A61B5/055 ,  A61B5/02007

摘要： Technique and apparatus for acquiring anatomic information used in diagnosing and characterizing abdominal aortic aneurismal disease and the like. This technique provides anatomic information, in the form of images, using a combination of a plurality of magnetic resonance angiography sequences, including a spin-echo and four contrast enhanced (e.g., gadolinium) magnetic resonance angiography sequences. The anatomic images may be used in, for example, pre-operative, operative and post-operative evaluation of aortic pathology, including aneurysms, atherosclerosis, and occlusive disease of branch vessels such as the renal arteries. The gadolinium-enhanced magnetic resonance angiography provides sufficient anatomic detail to detect aneurysms and all relevant major branch vessel abnormalities seen at angiography operation. This technique and apparatus allows for imaging the aorta at a fraction of the cost of conventional aortography and without the risks of arterial catheterization or iodinated contrast.

摘要翻译： 用于获取用于诊断和表征腹主动脉瘤性疾病等的解剖信息的技术和装置。 该技术以图像的形式使用包括自旋回波和四个对比度增强（例如，钆）磁共振血管造影序列的多个磁共振血管造影术序列的组合来提供解剖信息。 解剖图像可以用于例如主动脉病理学的术前，手术和术后评价，包括动脉瘤，动脉粥样硬化和分支血管如肾动脉的闭塞性疾病。 钆增强磁共振血管造影提供足够的解剖学细节来检测血管造影术中所见的动脉瘤和所有相关主要分支血管异常。 该技术和装置允许以常规造影术的成本的一小部分成像主动脉，并且不存在动脉导管插入或碘化对比的风险。

公开(公告)号：US07689267B2

公开(公告)日：2010-03-30

申请号：US10809835

申请日：2004-03-25

申请人： Martin R. Prince

发明人： Martin R. Prince

IPC分类号： A61B5/055

CPC分类号： A61K49/18 ,  A61B5/201 ,  A61B5/411 ,  A61B5/416 ,  A61M5/007 ,  A61M5/1456 ,  A61M5/16827 ,  G01R33/281 ,  G01R33/5601 ,  G01R33/5619 ,  G01R33/563 ,  G01R33/56308 ,  G01R33/5635

摘要： The present invention is a technique and apparatus for providing preferential enhancement of an artery of interest relative to adjacent veins and background tissue by correlating the collection of a predetermined portion of data (for example, image data which is representative of the central portion of k-space) of a magnetic resonance contrast image during the arterial phase of the magnetic resonance contrast enhancement.

摘要翻译： 本发明是一种技术和装置，用于通过将数据的预定部分的收集相关联（例如，代表k-中心部分的图像数据）来提供相对于相邻静脉和背景组织的感兴趣的动脉的优先增强， 空间）磁共振对比度增强的动脉期期间的磁共振对比度图像。

公开(公告)号：US07680527B2

公开(公告)日：2010-03-16

申请号：US11493055

申请日：2006-07-26

申请人： Martin R. Prince

发明人： Martin R. Prince

IPC分类号： A61B5/05 ,  G01V3/00

CPC分类号： A61K49/18 ,  A61B5/02007 ,  A61B5/055 ,  A61B5/201 ,  A61B5/416 ,  A61B5/7285 ,  G01R33/281 ,  G01R33/5619 ,  G01R33/563 ,  G01R33/56308

摘要： The present invention is a technique and apparatus for acquiring anatomic information used in diagnosing and characterizing abdominal aortic aneurismal disease and the like. This technique provides anatomic information, in the form of images, using a combination of a plurality of magnetic resonance angiography sequences, including a spin-echo and four contrast enhanced (e.g., gadolinium) magnetic resonance angiography sequences. The anatomic images may be used in, for example, pre-operative, operative and post-operative evaluation of aortic pathology, including aneurysms, atherosclerosis, and occlusive disease of branch vessels such as the renal arteries. The gadolinium-enhanced magnetic resonance angiography provides sufficient anatomic detail to detect aneurysms and all relevant major branch vessel abnormalities seen at angiography operation. This technique and apparatus allows for imaging the aorta at a fraction of the cost of conventional aortography and without the risks of arterial catheterization or iodinated contrast.

摘要翻译： 本发明是用于获取用于诊断和表征腹主动脉瘤性疾病等的解剖信息的技术和装置。 该技术以图像的形式使用包括自旋回波和四个对比度增强（例如，钆）磁共振血管造影序列的多个磁共振血管造影术序列的组合来提供解剖信息。 解剖图像可以用于例如主动脉病理学的术前，手术和术后评价，包括动脉瘤，动脉粥样硬化和分支血管如肾动脉的闭塞性疾病。 钆增强磁共振血管造影提供足够的解剖学细节来检测血管造影术中所见的动脉瘤和所有相关主要分支血管异常。 该技术和装置允许以常规造影术的成本的一小部分成像主动脉，并且不存在动脉导管插入或碘化对比的风险。

公开(公告)号：US20080300480A1

公开(公告)日：2008-12-04

申请号：US11964037

申请日：2007-12-25

申请人： James F. M. Meaney ,  Martin R. Prince

发明人： James F. M. Meaney ,  Martin R. Prince

IPC分类号： A61B5/055

CPC分类号： A61B5/055 ,  G01R33/5601 ,  G01R33/5635 ,  G01R33/56383 ,  G06F19/00

摘要： The present invention is a technique of, and system for, imaging vascular anatomy over distance considerably greater than the maximum practical field of view of a magnetic resonance imaging system while using substantially one contrast agent injection. The technique and system of the present invention acquires image data of a plurality of image volumes which are representative of different portions of the patient's body. The image data of each image volume includes image data which is representative of the center of k-space. The acquisition of image data which is representative of the center of k-space is correlated with a concentration of contrast agent in the artery(ies) residing in the image volume being substantially greater than the concentration of contrast agent in veins and background tissue adjacent to the artery(ies). This provides preferential enhancement of arteries relative to adjacent veins and background tissue for each acquisition, wherein each acquisition is representative of a different portion of the arterial system (e.g., abdominal aorta, femoral, popliteal, and tibial arteries).

摘要翻译： 本发明是一种技术，并且用于在使用基本上一个造影剂注射的情况下远远超过磁共振成像系统的最大实际视野来对血管解剖结构进行成像的技术和系统。 本发明的技术和系统获取代表患者身体的不同部分的多个图像体积的图像数据。 每个图像体积的图像数据包括表示k空间中心的图像数据。 代表k空间中心的图像数据的获取与静止在图像体积中的动脉中的造影剂的浓度基本上大于静脉和邻近的静脉和背景组织中造影剂的浓度相关 动脉。 这提供了相对于每个采集的相邻静脉和背景组织的动脉的优先增强，其中每个采集代表动脉系统的不同部分（例如，腹主动脉，股骨，po骨和胫骨动脉）。