Specific antagonist for both E- and P-selectins
    22.
    发明授权
    Specific antagonist for both E- and P-selectins 有权
    E-和P-选择素的特异性拮抗剂

    公开(公告)号:US07361644B2

    公开(公告)日:2008-04-22

    申请号:US10992480

    申请日:2004-11-18

    IPC分类号: A61K31/7072 C08B37/00

    CPC分类号: C07H15/18

    摘要: Compounds and methods are provided for modulating in vitro and in vivo processes mediated by selectin binding. More specifically, selectin modulators and their use are described, wherein the selectin modulators that modulate (e.g., inhibit or enhance) a selectin-mediated function comprise a particular glycomimetic linked to a particular BASA (Benzyl Amino Sulfonic Acid).

    摘要翻译: 提供化合物和方法用于调节由选择素结合介导的体外和体内过程。 更具体地,描述了选择素调节剂及其用途,其中调节(例如抑制或增强)选择素介导的功能的选择素调节剂包含与特定BASA(苄基氨基磺酸)连接的特定的糖模拟物。

    Glycomimetric inhibitors of the PA-IL lectin, PA-IIL lectin or both the lectins from Pseudomonas
    27.
    发明授权
    Glycomimetric inhibitors of the PA-IL lectin, PA-IIL lectin or both the lectins from Pseudomonas 有权
    PA-IL凝集素,PA-IIL凝集素或来​​自假单胞菌的凝集素的两者的模拟抑制剂

    公开(公告)号:US07517980B2

    公开(公告)日:2009-04-14

    申请号:US11501464

    申请日:2006-08-08

    IPC分类号: C07H3/06 A61K31/702 C07H3/02

    摘要: Compositions and methods are provided related to Pseudomonas bacteria. The compositions and methods may be used for diagnosis and therapy of medical conditions involving infection with Pseudomonas bacteria. Such infections include Pseudomonas aeruginosa in the lungs of patients with cystic fibrosis. A compound useful in the present methods may be used in combination with a therapeutic agent or may be linked to a therapeutic agent. Pseudomonas bacteria may be inhibited by blocking colonization, inhibiting virulence factors, arresting growth or killing the bacteria.

    摘要翻译: 提供了与假单胞菌属相关的组合物和方法。 组合物和方法可用于诊断和治疗涉及感染假单胞菌的医学病症。 这种感染包括铜绿假单胞菌在囊性纤维化患者的肺部。 可用于本发明方法的化合物可与治疗剂组合使用或可与治疗剂连接。 通过阻断定植,抑制毒力因子,阻止生长或杀死细菌,可以抑制假单胞菌。

    Halogenated phenolic polyols and rigid cellular compositions made
therefrom
    28.
    发明授权
    Halogenated phenolic polyols and rigid cellular compositions made therefrom 失效
    由其制成的卤化酚多元醇和刚性细胞组合物

    公开(公告)号:US4555530A

    公开(公告)日:1985-11-26

    申请号:US581429

    申请日:1984-05-07

    摘要: Modified benzyl ether-containing resole polyols derived from a phenolic component, a non-aqueous aldehyde, and a halogen-containing aliphatic hydroxyl component are prepared using a metal derivative as a catalyst. These polyols react with organic polyisocyanates to yield closed cell, low friability, low combustibility, rigid polyurethane foams without the need for post curing at elevated temperature. They are also useful in the preparation of modified rigid polyisocyanurate foams.

    摘要翻译: 使用金属衍生物作为催化剂制备得自酚成分,非水性醛和含卤素脂族羟基成分的改性苄基醚的甲阶酚醛树脂。 这些多元醇与有机多异氰酸酯反应以产生闭孔,低脆性,低可燃性,硬质聚氨酯泡沫,而不需要在高温下后固化。 它们也可用于制备改性的刚性聚异氰脲酸酯泡沫。

    Rigid, non-cellular polyurethane modified with reaction product of an
isocyanate and an alcohol
    30.
    发明授权
    Rigid, non-cellular polyurethane modified with reaction product of an isocyanate and an alcohol 失效
    用异氰酸酯和醇的反应产物改性的刚性,非细胞聚氨酯

    公开(公告)号:US4334052A

    公开(公告)日:1982-06-08

    申请号:US243537

    申请日:1981-03-13

    摘要: Rigid, solid, non-cellular, urethane polymer compositions can be prepared which are the reaction product of at least one polyhydric alcohol with at least one organic polyisocyanate in the presence of a low molecular weight urethane modifier adduct which is the reaction product prepared, for instance, by reacting (1) at least one polyisocyanate and at least one monohydric alcohol or (2) at least one monofunctional isocyanate with at least one monohydric or polyhydric alcohol. Said adduct can also consist of mixtures of (1) and (2). Such polymers when prepared in the presence of any catalyst for urethane formation which is a liquid or solid at ambient temperature, set quickly to solid, rigid polymers having a density of at least one gram per cubic centimeter. They can be demolded after combining the materials, without the addition of heat from an external source, within a period of less than one minute to about 15 minutes. By proper selection of the urethane modifier adduct, flame-retardant polymers can be prepared.

    摘要翻译: 可以制备刚性,固体,非细胞的聚氨酯聚合物组合物,其是在制备反应产物的低分子量氨基甲酸酯改性剂加合物存在下,至少一种多元醇与至少一种有机多异氰酸酯的反应产物,其用于 例如,通过使(1)至少一种多异氰酸酯和至少一种一元醇或(2)至少一种单官能异氰酸酯与至少一种一元醇或多元醇反应。 所述加合物也可以由(1)和(2)的混合物组成。 当在任何催化剂存在下制备聚氨酯形成时,这种聚合物在环境温度下是液体或固体,快速固化成具有至少1克/立方厘米密度的固体刚性聚合物。 在不少于1分钟至15分钟的时间内,不需要外部来源加热就能将材料组合起来。 通过适当选择氨基甲酸酯改性剂加合物,可以制备阻燃聚合物。