公开(公告)号：US07771589B2

公开(公告)日：2010-08-10

申请号：US12144178

申请日：2008-06-23

申请人： Scott Kelly ,  Kenneth Oyler ,  James Burke

发明人： Scott Kelly ,  Kenneth Oyler ,  James Burke

IPC分类号： B01D33/46 ,  B01D33/50 ,  E02B5/08

CPC分类号： B01D33/04 ,  B01D33/333 ,  B01D33/807 ,  C02F2209/001 ,  C02F2209/003 ,  C02F2209/005 ,  C02F2209/42 ,  C02F2303/24

摘要： An apparatus and method are provided that enable the control of a screening operation based on a calculated screen blockage percentage and the velocity throughput of the screen. The apparatus includes an upstream level detector, a downstream level detector and a flow determining device which determines the volumetric flow through the screen. The apparatus may further include a blockage determination unit which determines the percent screen blockage based on the flow level upstream of the screen, the flow level downstream of the screen and the volumetric flow.

摘要翻译： 提供了一种装置和方法，其能够基于计算的屏幕阻塞百分比和屏幕的速度吞吐量来控制筛选操作。 该装置包括上游水平检测器，下游水平检测器和确定通过筛网的体积流量的流量确定装置。 该装置还可以包括阻塞确定单元，其基于屏幕上游的流量水平，屏幕下游的流量水平和体积流量来确定屏幕的堵塞百分比。

公开(公告)号：US07657002B2

公开(公告)日：2010-02-02

申请号：US11343599

申请日：2006-01-31

申请人： James Burke ,  Charles Lynn Chidester ,  Bruce A Cain ,  Rob Treseder ,  James Boye ,  Ray Daly ,  Ricky Smith ,  Paul Gene Christean

发明人： James Burke ,  Charles Lynn Chidester ,  Bruce A Cain ,  Rob Treseder ,  James Boye ,  Ray Daly ,  Ricky Smith ,  Paul Gene Christean

IPC分类号： H01J35/06

CPC分类号： H01J35/06 ,  H01J2235/06 ,  H01J2235/1026 ,  H01J2235/1216

摘要： A cathode assembly including certain features designed to protect the integrity of a filament contained therein is disclosed. In particular, the cathode assembly is configured to prevent damage to the filament should it inadvertently contact another portion of the cathode assembly. In an example embodiment, an x-ray tube incorporating features of the present invention is disclosed. The x-ray tube includes an evacuated enclosure containing a cathode assembly and an anode. The cathode assembly includes a head portion having a head surface. A slot is defined on the head surface and an electron-emitting filament is included in the slot. A protective surface is defined on the head surface proximate to a central portion of the filament. The protective surface in one embodiment is composed of tungsten and is configure to prevent fusing of the filament to the protective surface should the filament inadvertently contact the protective surface.

摘要翻译： 公开了一种阴极组件，其包括设计成保护其中所包含的细丝的完整性的某些特征。 特别地，阴极组件被构造成如果它不经意地接触阴极组件的另一部分，则防止对细丝的损坏。 在示例性实施例中，公开了包含本发明的特征的X射线管。 x射线管包括一个包含阴极组件和一个阳极的真空外壳。 阴极组件包括具有头表面的头部部分。 在头表面上限定狭缝，并且在槽中包括电子发射丝。 保护表面限定在靠近灯丝中心部分的头表面上。 一个实施例中的保护表面由钨组成，并且被配置为当灯丝不经意地接触保护表面时防止灯丝熔合到保护表面。

公开(公告)号：US20080317819A1

公开(公告)日：2008-12-25

申请号：US11821085

申请日：2007-06-21

申请人： Werhner C. Orilla ,  Michael Robinson ,  James Burke

发明人： Werhner C. Orilla ,  Michael Robinson ,  James Burke

IPC分类号： G02C7/04 ,  A61K31/502 ,  A61P27/06

CPC分类号： A61F9/0017 ,  G02C7/04

摘要： A contact lens for delivery of a multiplicity of drugs includes a lens body with a first drug incorporated in a first zonal area of the lens body and a second drug incorporated in a second zonal area of the lens body. The first and second drugs are dissimilar and the first and second zonal areas are spaced apart from one another.

摘要翻译： 用于递送多种药物的隐形眼镜包括具有并入镜片本体的第一区域中的第一药物的透镜体和并入透镜体的第二区域区域中的第二药物。 第一种和第二种药物是不相似的，并且第一和第二区带彼此间隔开。

公开(公告)号：US20060281817A1

公开(公告)日：2006-12-14

申请号：US11448260

申请日：2006-06-07

申请人： Carol Colton ,  Michael Vitek ,  Warren Strittmatter ,  Qing Xu ,  James Burke

发明人： Carol Colton ,  Michael Vitek ,  Warren Strittmatter ,  Qing Xu ,  James Burke

IPC分类号： A61K31/198 ,  A61K31/13

CPC分类号： A61K45/06 ,  A61K31/13 ,  A61K31/198 ,  A61K2300/00

摘要： A method of treating a neurodegenerative disease in a subject in need thereof comprises: (a) administering the subject an ornithine decarboxylase inhibitor such as alpha-difluoromethylornithine or a pharmaceutically acceptable salt or prodrug thereof in an amount effective to treat the disease; and concurrently (b) administering the subject a polyamine or a pharmaceutically acceptable salt or prodrug thereof in an amount effective to reduce damage to the gastroinestinal tract of the subject by the ornithine decarboxylase inhibitor.

摘要翻译： 在有需要的受试者中治疗神经变性疾病的方法包括：（a）给予受试者具有有效治疗疾病的量的鸟氨酸脱羧酶抑制剂，例如α-二氟甲基鸟氨酸或其药学上可接受的盐或前药; 并且同时（b）以有效减少鸟氨酸脱羧酶抑制剂对受试者的胃肠道损伤的量给予受试者多胺或其药学上可接受的盐或前药。

公开(公告)号：US20060201023A1

公开(公告)日：2006-09-14

申请号：US11370436

申请日：2006-03-07

申请人： James Burke

发明人： James Burke

IPC分类号： F26B13/10

CPC分类号： B60T17/004 ,  Y10S55/17 ,  Y10T137/8359

摘要： Methods and apparatuses for determining the condition of a pneumatic system air dryer are provided. An output of the pneumatic valve or of a conduit interconnected to the outlet of the pneumatic valve is positioned such that a discharge passed through the pneumatic valve while the valve is open is in view of an operator and/or is directed to a moisture sensor. Moreover, the discharge and/or an output device interconnected to the moisture sensor is in view of the operator while the operator is in a position to operate the pneumatic valve. An observation volume with a sight glass or window and/or a moisture sensor can be provided to facilitate the observation or detection of moisture or oil in the discharge.

公开(公告)号：US20060155229A1

公开(公告)日：2006-07-13

申请号：US11039056

申请日：2005-01-12

申请人： Dylann Ceriani ,  James Burke ,  Paul Oddou

发明人： Dylann Ceriani ,  James Burke ,  Paul Oddou

IPC分类号： A61F5/00

CPC分类号： A61F5/0125 ,  A61F2005/0139 ,  A61F2005/0158 ,  A61F2005/0167

摘要： An adjustable support assembly for an orthopedic brace has a support arm, a housing and a locking mechanism. The housing includes a travel track which slidably receives the support arm. The locking mechanism includes a lock lever which selectively applies a sufficient force to the support arm to prevent slidable displacement of the support arm in the travel track.

摘要翻译： 用于矫形支架的可调支撑组件具有支撑臂，壳体和锁定机构。 壳体包括可滑动地接收支撑臂的行进轨道。 锁定机构包括锁定杆，该锁定杆选择性地向支撑臂施加足够的力以防止支撑臂在行驶轨道中的滑动移位。

公开(公告)号：US20050181017A1

公开(公告)日：2005-08-18

申请号：US11039192

申请日：2005-01-19

申请人： Patrick Hughes ,  Orest Olejnik ,  Scott Whitcup ,  James Burke

发明人： Patrick Hughes ,  Orest Olejnik ,  Scott Whitcup ,  James Burke

IPC分类号： A61K9/00 ,  A61K9/10 ,  A61K9/14 ,  A61K31/00 ,  A61K47/36

CPC分类号： A61K38/13 ,  A61K9/0048 ,  A61K9/0051 ,  A61K9/10 ,  A61K9/14 ,  A61K31/00 ,  A61K47/36 ,  Y10S514/912

摘要： Compositions, and methods of using such compositions, useful for injection into the posterior segments of human or animal eyes are provided. Such compositions include small particles of a poorly soluble therapeutic agent that facilitates formation of concentrated regions of the therapeutic agent in the retinal pigmented epithelium of an eye. The particles are formed by combining a therapeutic agent with an ophthalmically acceptable polymer component. The particles have sizes less than about 3000 nanometers, and in some cases, less than about 200 nanometers. One example of a composition includes particles of triamcinolone acetonide and hyaluronic acid have a size less than about 3000 nanometers.

摘要翻译： 提供了组合物和使用这种组合物的方法，其可用于注射到人或动物眼睛的后段中。 这样的组合物包括促进在眼睛的视网膜色素上皮中形成治疗剂的浓缩区域的难溶性治疗剂的小颗粒。 通过将治疗剂与眼科可接受的聚合物组分组合来形成颗粒。 颗粒具有小于约3000纳米的尺寸，并且在一些情况下小于约200纳米。 组合物的一个实例包括曲安奈德的颗粒和透明质酸的尺寸小于约3000纳米。

公开(公告)号：US20050095616A1

公开(公告)日：2005-05-05

申请号：US10890675

申请日：2004-07-14

申请人： James Burke ,  Shulin Wang

发明人： James Burke ,  Shulin Wang

IPC分类号： C12Q1/48 ,  C12Q1/68

CPC分类号： C12Q1/485 ,  G01N2500/04 ,  G01N2500/10

摘要： The present invention relates to a functional assay for IκB kinase (IKK), the proteasome and ubiquitin ligase. Cells expressing an IκB-beta-lactamase fusion protein are used to screen for inhibitors of IKK, the proteasome and ubiquitin ligase. Inhibitors identified through the inventive assay are useful in the treatment of NF-κB disorders, such as immune and inflammatory disorders. The present invention also includes cell lines useful in assays of the invention, compounds identified by assays of the invention, compositions including such compounds and methods for the treatment of disease states.

摘要翻译： 本发明涉及IkappaB激酶（IKK），蛋白酶体和泛素连接酶的功能测定。 表达IkappaB-β-内酰胺酶融合蛋白的细胞用于筛选IKK，蛋白酶体和泛素连接酶的抑制剂。 通过本发明的测定法鉴定的抑制剂可用于治疗NF-κB病症，例如免疫和炎性疾病。 本发明还包括可用于本发明测定的细胞系，通过本发明测定鉴定的化合物，包含这些化合物的组合物和治疗疾病状态的方法。

公开(公告)号：US5972188A

公开(公告)日：1999-10-26

申请号：US675467

申请日：1996-07-03

申请人： Sallie Rice ,  Charles Browning ,  James Burke ,  Loi Nguyen

发明人： Sallie Rice ,  Charles Browning ,  James Burke ,  Loi Nguyen

IPC分类号： G01N27/447 ,  G01N27/26

CPC分类号： G01N27/44743

摘要： An apparatus and method for loading samples into a gel of an electrophoretic gel system (EGS). The preferred sample loader includes a membrane having a net negative charge, net neutral charge or no charge (preferably nitrocellulose or nylon) which releasably retains the samples such that the samples are actively released when the membrane is inserted into the gel of an EGS. In one preferred embodiment, the sample loader includes a substrate having a plurality of sample loading areas extending therefrom. In an alternative embodiment, the membrane is substantially thick and serves as its own substrate. In another embodiment, sample inhibiting agents such as hydrophobic ink are formed through the membrane to inhibit the diffusion of samples between sample loading areas. Each sample loading area includes an affixed membrane. In use, one or more samples to be subjected to electrophoretic action are applied to the membrane before the membrane is inserted into a previously polymerized gel. The membrane advantageously prevents contamination of electrode buffer solution and cross-talk or mixing between samples by inhibiting the diffusion of sample material into the gel or buffer solution before the gel is activated by a release mechanism. Once the gel is activated by the release mechanism, the membrane releases substantially all of the samples into the gel where the samples are subjected to the electrophoretic separation and identification process.

摘要翻译： 将样品加载到电泳凝胶系统（EGS）的凝胶中的装置和方法。 优选的样品装载器包括具有净负电荷，净中性电荷或无电荷（优选硝酸纤维素或尼龙）的膜，其可释放地保留样品，使得当膜插入EGS的凝胶中时样品被主动释放。 在一个优选实施例中，样品装载器包括具有从其延伸的多个样品加载区域的基底。 在替代实施例中，膜基本上是厚的并且用作其自身的基底。 在另一个实施方案中，通过膜形成样品抑制剂如疏水性油墨，以抑制样品在样品加载区域之间的扩散。 每个样品装载区域都包括固定膜。 在使用中，将一个或多个要进行电泳作用的样品施加到膜上，然后将膜插入到先前聚合的凝胶中。 该膜有利地防止电极缓冲溶液的污染和样品之间的串扰或混合，通过在凝胶被释放机制激活之前通过抑制样品材料扩散到凝胶或缓冲溶液中。 一旦凝胶被释放机制激活，膜将基本上将所有样品释放到凝胶中，其中样品进行电泳分离和鉴定过程。

公开(公告)号：US5560166A

公开(公告)日：1996-10-01

申请号：US118389

申请日：1993-09-07

申请人： James Burke ,  F. Edward Linck

发明人： James Burke ,  F. Edward Linck

IPC分类号： F16J15/06 ,  F16L51/02 ,  F16L59/21 ,  F23J13/04 ,  E04H12/28

CPC分类号： F16J15/065 ,  F16L51/024 ,  F16L59/21 ,  F23J13/04 ,  F23J2213/202

摘要： An expansion joint for protectively shielding a seal member disposed in a joint between two flue sections, includes a first shield member having a foot for attachment to an end of a first flue section, the shield member having a curved panel portion for extending over and protectively shielding a seal member, and a second shield member having a foot for attachment to an end of a second flue section, the second shield member having a curved panel portion for extending over a portion of the first shield and along the direction of gas flow.

摘要翻译： 一种用于保护性地屏蔽设置在两个烟道部分之间的接头中的密封构件的膨胀接头，包括具有用于附接到第一烟道区段的端部的脚的第一屏蔽构件，所述屏蔽构件具有用于延伸和保护的弯曲面板部分 屏蔽密封构件，以及具有用于附接到第二烟道区段的端部的脚的第二屏蔽构件，所述第二屏蔽构件具有弯曲面板部分，用于在第一屏蔽的一部分上并且沿着气体流动的方向延伸。