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42 条记录 (耗时 0.019 秒)

    Cellulase-containing cell-free fermentate produced from microorganism ATCC 55702
    21.
    发明授权
    Cellulase-containing cell-free fermentate produced from microorganism ATCC 55702 失效
    由微生物ATCC 55702生产的含纤维素酶的无细胞的发酵液

    公开(公告)号：US5698429A

    公开(公告)日：1997-12-16

    申请号：US729819

    申请日：1996-10-08

    申请人： H. Craig Dees

    发明人： H. Craig Dees

    IPC分类号： C11D3/386 ,  C12N9/42 ,  C12N1/20 ,  C12N9/24

    CPC分类号： C12R1/38 ,  C11D3/38645 ,  C12N15/01 ,  C12N9/2437

    摘要： Bacteria which produce large amounts of cellulase-containing cell-free fermentate have been identified. The original bacterium (ATCC 55703) was genetically altered using nitrosoguanidine (MNNG) treatment to produce the enhanced cellulase producing bacterium (ATCC 55702), which was identified through replicate plating. ATCC 55702 has improved characteristics and qualities for the degradation of cellulosic waste materials for fuel production, food processing, textile processing, and other industrial applications. ATCC 55702 is an improved bacterial host for genetic manipulations using recombinant DNA techniques, and is less likely to destroy genetic manipulations using standard mutagenesis techniques.

    摘要翻译： 已经鉴定出产生大量含纤维素酶的无细胞发酵物的细菌。 使用亚硝基胍（MNNG）处理将原始细菌（ATCC 55703）进行遗传改变以产生增强的纤维素酶生产细菌（ATCC 55702），其通过重复电镀鉴定。 ATCC 55702具有用于燃料生产，食品加工，纺织加工和其它工业应用的纤维素废料降解的特性和质量。 ATCC 55702是使用重组DNA技术进行基因操作的改进的细菌宿主，并且不太可能使用标准诱变技术破坏遗传操作。

    Medicaments for Chemotherapeutic Treatment of Disease
    22.
    发明申请
    Medicaments for Chemotherapeutic Treatment of Disease 失效
    化疗药物治疗疾病

    公开(公告)号：US20080118567A1

    公开(公告)日：2008-05-22

    申请号：US11951800

    申请日：2007-12-06

    申请人： Timothy C. Scott ,  H. Craig Dees ,  Eric A. Wachter

    发明人： Timothy C. Scott ,  H. Craig Dees ,  Eric A. Wachter

    IPC分类号： A61K31/352 ,  A61P35/04 ,  A61K9/14

    CPC分类号： A61K9/0019 ,  A61K31/352

    摘要： New chemotherapeutic medicaments and certain medical uses and methods for use of such chemotherapeutic medicaments for treatment of disease in human or animal tissue are described, wherein a primary active component of such medicaments is a halogenated xanthene or halogenated xanthene derivative. Preferably, the halogenated xanthene is Rose Bengal or a functional derivative of Rose Bengal. The halogenated xanthenes constitute a family of useful chemotherapeutic agents that afford selective, persistent accumulation in certain tissues. In preferred embodiments, such medicaments are used for treatment of a variety of conditions affecting the skin and related organs, the mouth and digestive tract and related organs, the urinary and reproductive tracts and related organs, the respiratory tract and related organs, the circulatory system and related organs, the head and neck, the endocrine and lymphoreticular systems and related organs, various other tissues, such as connective tissues and various tissue surfaces exposed during surgery, as well as various tissues exhibiting microbial or parasitic infection. In another preferred embodiment, such medicaments are produced in various formulations useful for intracorporeal or topical administration, including in liquid, semisolid, solid or aerosol delivery vehicles.

    摘要翻译： 描述了新的化学治疗药物和某些医疗用途以及用于治疗人或动物组织中的这种化学治疗药物的方法，其中这种药物的主要活性成分是卤化呫吨或卤代呫吨衍生物。 优选地，卤代呫吨是玫瑰红或玫瑰红的功能衍生物。 卤代呫吨构成一系列有用的化学治疗剂，其在某些组织中提供选择性的，持续的积累。 在优选的实施方案中，这些药物用于治疗影响皮肤和相关器官，口腔和消化道及相关器官，泌尿生殖道和相关器官，呼吸道及相关器官，循环系统 内脏和淋巴系统及相关器官，各种其他组织，如结缔组织和手术期间暴露的各种组织表面，以及表现出微生物或寄生虫感染的各种组织。 在另一个优选的实施方案中，这些药物可用于体内或局部给药的各种制剂，包括在液体，半固体，固体或气溶胶输送载体中。

    Methods for positron emission imaging with radiolabeled halogenated xanthenes diagnostic agents
    23.
    发明授权
    Methods for positron emission imaging with radiolabeled halogenated xanthenes diagnostic agents 有权
    用放射性标记的卤代呫吨酶诊断剂进行正电子发射成像的方法

    公开(公告)号：US07338652B2

    公开(公告)日：2008-03-04

    申请号：US11050512

    申请日：2005-02-03

    申请人： Timothy C. Scott ,  H. Craig Dees ,  Eric A. Wachter

    发明人： Timothy C. Scott ,  H. Craig Dees ,  Eric A. Wachter

    IPC分类号： A61K49/04

    CPC分类号： A61K51/0421

    摘要： New diagnostic agents for positron emission tomography (PET) and methods for use of such agents for imaging of human or animal tissue are described, wherein a primary active component of such agents is a radiolabeled halogenated xanthene or halogenated xanthene derivative. Preferably, the radiolabeled halogenated xanthene is radiolabeled Rose Bengal or a functional derivative of Rose Bengal.

    摘要翻译： 描述了用于正电子发射断层摄影（PET）的新诊断剂和用于这种药剂用于人或动物组织成像的方法，其中这种药剂的主要活性成分是放射性标记的卤化呫吨或卤代呫吨衍生物。 优选地，放射性标记的卤代呫吨是放射性标记的玫瑰红或玫瑰红的功能衍生物。

    Method for improved selectivity in photo-activation and detection of molecular diagnostic agents
    26.
    发明授权
    Method for improved selectivity in photo-activation and detection of molecular diagnostic agents 失效
    提高光激活和分子诊断剂检测选择性的方法

    公开(公告)号：US5832931A

    公开(公告)日：1998-11-10

    申请号：US741370

    申请日：1996-10-30

    申请人： Eric A. Wachter ,  Walter G. Fisher ,  H. Craig Dees

    发明人： Eric A. Wachter ,  Walter G. Fisher ,  H. Craig Dees

    IPC分类号： G01N21/64 ,  A61B17/00 ,  A61B19/00 ,  A61K41/00 ,  A61K49/00

    CPC分类号： A61N5/062 ,  A61K41/008 ,  A61K49/0017 ,  A61K49/0039 ,  A61K49/0043 ,  A61B2017/00057 ,  B82Y15/00

    摘要： A method for the imaging of a particular volume of plant or animal tissue, wherein the plant or animal tissue contains at least one photo-active molecular agent. The method includes the steps of treating the particular volume of the plant or animal tissue with light sufficient to promote a simultaneous two-photon excitation of the photo-active molecular agent contained in the particular volume of the plant or animal tissue, photo-activating at least one of the at least one photo-active molecular agent in the particular volume of the plant or animal tissue, thereby producing at least one photo-activated molecular agent, wherein the at least one photo-activated molecular agent emits energy, detecting the energy emitted by the at least one photo-activated molecular agent, and producing a detected energy signal which is characteristic of the particular volume of plant or animal tissue. The present invention is also a method for the imaging of a particular volume of material, wherein the material contains at least one photo-active molecular agent.

    摘要翻译： 用于对特定体积的植物或动物组织进行成像的方法，其中所述植物或动物组织含有至少一种光活性分子试剂。 该方法包括以下步骤：用足以促进包含在植物或动物组织的特定体积中的光活性分子试剂的同时双光子激发的光照射植物或动物组织的特定体积，在 在植物或动物组织的特定体积中的至少一种光活性分子试剂中的至少一种，从而产生至少一种光活化分子试剂，其中至少一种光活化分子试剂发射能量，检测能量 由至少一种光活化分子试剂发射，并产生检测到的能量信号，其特征在于植物或动物组织的特定体积。 本发明也是用于对特定体积的材料进行成像的方法，其中所述材料含有至少一种光活性分子试剂。

    Medicaments for chemotherapeutic treatment of disease
    28.
    发明授权
    Medicaments for chemotherapeutic treatment of disease 失效
    化疗药物治疗疾病

    公开(公告)号：US07648695B2

    公开(公告)日：2010-01-19

    申请号：US09900355

    申请日：2001-07-06

    申请人： H. Craig Dees ,  Timothy C. Scott

    发明人： H. Craig Dees ,  Timothy C. Scott

    IPC分类号： A61K51/00 ,  A61M36/14 ,  G01N33/00

    CPC分类号： A61K41/0057 ,  A61B2017/22062 ,  A61B2017/22087 ,  A61F7/00 ,  A61K9/0014 ,  A61K9/0019 ,  A61K31/352 ,  A61K41/0071 ,  A61K47/10 ,  A61K47/12 ,  A61K47/20 ,  A61N5/0601 ,  A61N5/062 ,  C07D311/82 ,  Y02A50/473 ,  Y10T436/193333

    摘要： New chemotherapeutic medicaments and certain medical uses and methods for use of such chemotherapeutic medicaments for treatment of disease in human or animal tissue are described, wherein a primary active component of such medicaments is a halogenated xanthene or halogenated xanthene derivative. Preferably, the halogenated xanthene is Rose Bengal or a functional derivative of Rose Bengal. The halogenated xanthenes constitute a family of useful chemotherapeutic agents that afford selective, persistent accumulation in certain tissues. In preferred embodiments, such medicaments are used for treatment of a variety of conditions affecting the skin and related organs, the mouth and digestive tract and related organs, the urinary and reproductive tracts and related organs, the respiratory tract and related organs, the circulatory system and related organs, the head and neck, the endocrine and lymphoreticular systems and related organs, various other tissues, such as connective tissues and various tissue surfaces exposed during surgery, as well as various tissues exhibiting microbial or parasitic infection. In another preferred embodiment, such medicaments are produced in various formulations useful for intracorporeal or topical administration, including in liquid, semisolid, solid or aerosol delivery vehicles.

    摘要翻译： 描述了新的化学治疗药物和用于治疗人或动物组织中的这种化学治疗药物的某些医疗用途和方法，其中这种药物的主要活性成分是卤化呫吨或卤代呫吨衍生物。 优选地，卤代呫吨是玫瑰红或玫瑰红的功能衍生物。 卤代呫吨构成一系列有用的化学治疗剂，其在某些组织中提供选择性的，持续的积累。 在优选的实施方案中，这些药物用于治疗影响皮肤和相关器官，口腔和消化道及相关器官，泌尿生殖道和相关器官，呼吸道及相关器官，循环系统 内脏和淋巴系统及相关器官，各种其他组织，如结缔组织和手术期间暴露的各种组织表面，以及表现出微生物或寄生虫感染的各种组织。 在另一个优选的实施方案中，这些药物可用于体内或局部给药的各种制剂，包括在液体，半固体，固体或气溶胶输送载体中。

    Treatment of pigmented tissues using optical energy
    29.
    发明授权
    Treatment of pigmented tissues using optical energy 失效
    用光能处理色素组织

    公开(公告)号：US07036516B1

    公开(公告)日：2006-05-02

    申请号：US09130213

    申请日：1998-08-06

    申请人： H. Craig Dees ,  Eric A. Wachter

    发明人： H. Craig Dees ,  Eric A. Wachter

    IPC分类号： A61B19/00

    CPC分类号： A61B18/203 ,  A61B2017/00769 ,  A61B2018/00452 ,  A61B2018/00458 ,  A61B2018/0047 ,  A61B2018/00476 ,  A61N5/062

    摘要： A method and apparatus for selectively photobleaching or killing pigmented tissues by photochemically converting pigments in the tissues using light and specifically two-photon excitation. Phototoxic products thereby produced then kill pigmented cells. Hyperthermia or an exogenous agent can also be added to augment efficacy. The present invention is also directed to selective thermal destruction of pigmented tissues using related optical means.

    摘要翻译： 一种用于通过使用光和具体的双光子激发光化学转换组织中的颜料来选择性漂白或杀死有色组织的方法和装置。 由此产生的光毒产物然后杀死色素细胞。 也可以加入热疗或外源性药剂以增强功效。 本发明还涉及使用相关光学装置对着色组织的选择性热破坏。