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    Storage device, system, and method
    21.
    发明授权
    Storage device, system, and method 有权

    公开(公告)号：US11282588B2

    公开(公告)日：2022-03-22

    申请号：US17254459

    申请日：2020-05-26

    Applicant: ILLUMINA, INC.

    Inventor： Craig Ciesla ,  Ali Agah ,  Stanley Hong ,  Tarun Khurana ,  Aathavan Karunakaran ,  Arvin Emadi ,  Merek Siu

    IPC: G16B50/30 ,  G06F3/06 ,  G16B30/10 ,  C12Q1/6869 ,  G11C13/02 ,  B01L3/00 ,  C12Q1/6874

    Abstract: A system writes input data to a storage device as machine-written polynucleotides; and reads machine written polynucleotides from the storage device as output data. The storage device includes a flow cell including a plurality of storage wells in which machine written polynucleotides may be stored. The storage device may include a set of electrodes corresponding to the storage wells that allow for selective interactions with wells across the surface of a flow cell. Operation of the storage device may include receiving a read request associated with a particular location in the storage device, creating a copy of a nucleotide sequence located at the particular location in the storage device, transferring the copy of the nucleotide sequence to a read location, and reading the copy of the nucleotide sequence at the read location.

    Obtaining information from a biological sample in a flow cell
    22.
    发明授权
    Obtaining information from a biological sample in a flow cell 有权

    公开(公告)号：US11137385B2

    公开(公告)日：2021-10-05

    申请号：US17254473

    申请日：2020-05-26

    Applicant: ILLUMINA, INC.

    Inventor： Tarun Khurana ,  Ali Agah ,  Aathavan Karunakaran ,  Xi-Jun Chen

    IPC: C12Q1/00 ,  G01N33/483 ,  G01N33/50 ,  G01N33/53 ,  A61K39/12

    Abstract: Methods are used for obtaining, cataloguing, and/or storing data derived from a biological source using a flow cell body, electrodes, and an imaging assembly. The data may include DNA and/or RNA obtained from a biological source, such as from the cells of an organism. The methods may be used to obtain, catalog, and/or store data such as DNA or RNA sequence from a pathogen such as a virus and/or a bacteria, human health data over time, and immune system information from an individual. The data obtained using the disclosed methods may be used for a variety of different purposes, including the manufacture of vaccine compositions, and for restoring the immune system of an individual who has undergone an immune system depleting event. The methods may be used for storage of biological cells, which may be used for the screening of compounds, such as small molecules with potential for therapeutic indications.

    DEPENDENCE OF BASE CALLING ON FLOW CELL TILT
    26.
    发明公开
    DEPENDENCE OF BASE CALLING ON FLOW CELL TILT 审中-公开

    公开(公告)号：US20230407386A1

    公开(公告)日：2023-12-21

    申请号：US18208069

    申请日：2023-06-09

    Applicant: Illumina, Inc. ,  Illumina Software, Inc.

    Inventor： Stanley Hong ,  Michael Gallaspy ,  Merek Siu ,  Jeffrey Gau ,  Anindita Dutta ,  Aathavan Karunakaran ,  Simon Prince

    IPC: C12Q1/6874 ,  G16B30/00 ,  G16B40/10

    CPC classification number: C12Q1/6874 ,  G16B30/00 ,  G16B40/10

    Abstract: Defocus is introduced during sequencing by synthesis by tilt of a flow cell and by variations in flatness of the flow cell. Effects of the defocus are reduced, and base calling quality is improved using techniques relating to dependence of base calling on flow cell tilt. For example, the flow cell surface height is measured throughout the flow cell. A focal height of an imager having a sensor for the sequencing is set, optionally adaptively, one or more times during the sequencing. Each image captured by the sensor is partitioned, e.g., based on differences between focal height and the measured flow cell surface height across areas of the sensor. Filters, e.g., related to defocus correction, are selected based at least in part on the difference between the focal height and the measured flow cell surface height at a particular area of the image being corrected for defocus.

    SYSTEM AND METHOD FOR STORAGE
    27.
    发明公开
    SYSTEM AND METHOD FOR STORAGE 审中-公开

    公开(公告)号：US20230285974A1

    公开(公告)日：2023-09-14

    申请号：US18103625

    申请日：2023-01-31

    Applicant: ILLUMINA, INC.

    Inventor： Merek Siu ,  Ali Agah ,  Stanley Hong ,  Tarun Khurana ,  Aathavan Karunakaran ,  Craig Ciesla ,  Amirali Kia

    IPC: B01L3/00 ,  G16B50/30 ,  G11C13/02

    CPC classification number: B01L3/50855 ,  G11C13/02 ,  G16B50/30 ,  B01L2300/0645 ,  B01L2300/0829 ,  C12Q1/6869

    Abstract: Devices, systems, and methods for non-volatile storage include a well activation device operable to modify one or more wells from a plurality of wells of a flow cell to provide a set of readable wells. Readable wells are configured to allow exposure of a well to substances from nucleotide sequencing fluids, and prevent exposure to other substances and fluids, such as nucleotide synthesizing fluids. The well activation device may also modify wells to provide a set of writeable wells. This set of wells is configured to allow exposure to the nucleotide synthesizing fluids and substances; and prevent exposure to the nucleotide sequencing fluids and substances. There may also be provisions made for risk mitigation for data errors such as generating commands to write specified data to a nucleotide sequence associated with a particular location in a storage device, reading the nucleotide sequence and performing a comparison.

    FLOW CELL WITH ONE OR MORE BARRIER FEATURES
    28.
    发明申请
    FLOW CELL WITH ONE OR MORE BARRIER FEATURES 有权

    公开(公告)号：US20220003728A1

    公开(公告)日：2022-01-06

    申请号：US17479342

    申请日：2021-09-20

    Applicant: Illumina, Inc.

    Inventor： Tarun Khurana ,  Ali Agah ,  Aathavan Karunakaran ,  Stanley Hong ,  Merek Siu ,  Arvin Emadi ,  Craig Ciesla

    IPC: G01N30/74 ,  C12Q1/6874

    Abstract: An apparatus includes a flow cell body, a plurality of electrodes, an imaging assembly, and one or more barrier features. The flow cell body defines one or more flow channels and a plurality of wells defined as recesses in the floor of each flow channel. Each well is fluidically coupled with the corresponding flow channel. The flow cell body further defines interstitial surfaces between adjacent wells. Each well defines a corresponding depth. Each electrode is positioned in a corresponding well of the plurality of wells. The electrodes are to effect writing of polynucleotides in the wells. The imaging assembly is to capture images of polynucleotides written in the wells. The one or more barrier features are positioned in the wells, between the wells, or above the wells. The one or more barrier features contain reactions in each well, reduce diffusion between the wells, or reduce optical cross-talk between the wells.

    OBTAINING INFORMATION FROM A BIOLOGICAL SAMPLE IN A FLOW CELL
    29.
    发明申请
    OBTAINING INFORMATION FROM A BIOLOGICAL SAMPLE IN A FLOW CELL 有权

    公开(公告)号：US20210405019A1

    公开(公告)日：2021-12-30

    申请号：US17470228

    申请日：2021-09-09

    Applicant: ILLUMINA, INC.

    Inventor： Tarun Khurana ,  Ali Agah ,  Aathavan Karunakaran ,  Xi-Jun Chen

    IPC: G01N33/483 ,  G01N33/50 ,  G01N33/53

    Abstract: Methods are used for obtaining, cataloguing, and/or storing data derived from a biological source using a flow cell body, electrodes, and an imaging assembly. The data may include DNA and/or RNA obtained from a biological source, such as from the cells of an organism. The methods may be used to obtain, catalog, and/or store data such as DNA or RNA sequence from a pathogen such as a virus and/or a bacteria, human health data over time, and immune system information from an individual. The data obtained using the disclosed methods may be used for a variety of different purposes, including the manufacture of vaccine compositions, and for restoring the immune system of an individual who has undergone an immune system depleting event. The methods may be used for storage of biological cells, which may be used for the screening of compounds, such as small molecules with potential for therapeutic indications.

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