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    GENE EXPRESSION PANEL FOR PROGNOSIS OF PROSTATE CANCER RECURRENCE
    23.
    发明申请
    GENE EXPRESSION PANEL FOR PROGNOSIS OF PROSTATE CANCER RECURRENCE 审中-公开

    公开(公告)号：US20200071770A1

    公开(公告)日：2020-03-05

    申请号：US16524617

    申请日：2019-07-29

    Applicant: Illumina, Inc. ,  University of Southern California

    Inventor： Mariana Carla Stern ,  Jacek Pinski ,  Jian-Bing Fan

    IPC: C12Q1/6886

    Abstract: Disclosed is a gene expression panel that can be used to predict prostate cancer (PCa) progression. Some embodiments provide methods for predicting clinical recurrence of PCa. Some embodiments provide a method for predicting progression of prostate cancer in an individual, the method comprising: (a) receiving expression levels of a collection of signature genes from a biological sample taken from said individual, wherein said collection of signature genes comprises at least two genes selected from the group consisting of: NKX2-1, UPK1A, ADRA2C, ABCC11, MMP11, CPVL, ZYG11A, CLEC4F, OAS2, PGC, UPK3B, PCBP3, ABLIM1, EDARADD, GPR81, MYBPC1, F10, KCNA3, GLDC, KCNQ2, RAPGEF1, TUBB2B, MB, DUOXA1, C2orf43, DUOX1, PCA3 and NPR3; (b) applying the expression levels to a predictive model relating expression levels of said collection of signature genes with prostate cancer progression; and (c) evaluating an output of said predictive model to predict progression of prostate cancer in said individual. Systems are also provided for predicting progression and/or recurrence of PCa.

    Gene expression panel for prognosis of prostate cancer recurrence
    24.
    发明授权
    Gene expression panel for prognosis of prostate cancer recurrence 有权

    公开(公告)号：US10364469B2

    公开(公告)日：2019-07-30

    申请号：US15111946

    申请日：2015-01-16

    Applicant: Illumina, Inc. ,  University of Southern California

    Inventor： Mariana Carla Stern ,  Jacek Pinski ,  Jian-Bing Fan

    IPC: C12Q1/6886

    Abstract: Disclosed is a gene expression panel that can be used to predict prostate cancer (PCa) progression. Some embodiments provide methods for predicting clinical recurrence of PCa. Some embodiments provide a method for predicting progression of prostate cancer in an individual, the method comprising: (a) receiving expression levels of a collection of signature genes from a biological sample taken from said individual, wherein said collection of signature genes comprises at least two genes selected from the group consisting of: NKX2-1, UPK1A, ADRA2C, ABCC11, MMP11, CPVL, ZYG11A, CLEC4F, OAS2, PGC, UPK3B, PCBP3, ABLIM1, EDARADD, GPR81, MYBPC1, F10, KCNA3, GLDC, KCNQ2, RAPGEF1, TUBB2B, MB, DUOXA1, C2orf43, DUOX1, PCA3 and NPR3; (b) applying the expression levels to a predictive model relating expression levels of said collection of signature genes with prostate cancer progression; and (c) evaluating an output of said predictive model to predict progression of prostate cancer in said individual. Systems are also provided for predicting progression and/or recurrence of PCa.

    Detection of nucleic acid reactions on bead arrays
    26.
    发明授权
    Detection of nucleic acid reactions on bead arrays 有权
    检测珠阵列上的核酸反应

    公开(公告)号：US09279148B2

    公开(公告)日：2016-03-08

    申请号：US13913922

    申请日：2013-06-10

    Applicant: Illumina, Inc.

    Inventor： Kevin Gunderson ,  John R. Stuelpnagel ,  Mark S. Chee ,  Jian-Bing Fan

    IPC: C12Q1/68 ,  C12M1/36 ,  C12P19/34 ,  C07H21/04

    CPC classification number: C12Q1/6837 ,  C12Q1/6858 ,  C12Q1/6874 ,  C12Q2535/131 ,  C12Q2525/191 ,  C12Q2531/137 ,  C12Q2563/149

    Abstract: The present invention is directed to methods and compositions for the use of micro sphere arrays to detect and quantify a number of nucleic acid reactions. The invention finds use in genotyping, i.e. the determination of the sequence of nucleic acids, particularly alterations such as nucleotide substitutions (mismatches) and single nucleotide polymorphisms (SNPs). Similarly, the invention finds use in the detection and quantification of a nucleic acid target using a variety of amplification techniques, including both signal amplification and target amplification. The methods and compositions of the invention can be used in nucleic acid sequencing reactions as well. All applications can include the use of adapter sequences to allow for universal arrays.

    Abstract translation: 本发明涉及使用微球阵列来检测和定量许多核酸反应的方法和组合物。 本发明用于基因分型，即确定核酸序列，特别是改变，例如核苷酸取代（错配）和单核苷酸多态性（SNP）。 类似地，本发明用于使用多种扩增技术检测和定量核酸靶，包括信号放大和靶扩增两者。 本发明的方法和组合物也可用于核酸测序反应。 所有应用程序可以包括使用适配器序列来允许通用阵列。

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