Patent search ap:("Illumina Page Inc.") AND inv:"Mark S. Chee"

1.

发明授权
Combinatorial decoding of random nucleic acid arrays 有权
Title translation: 随机核酸阵列的组合解码

公开(公告)号：US09163283B2

公开(公告)日：2015-10-20

申请号：US14035611

申请日：2013-09-24

Applicant: ILLUMINA, INC.

Inventor： Mark S. Chee , David R. Walt

IPC: C12Q1/68 , C07H21/00 , C40B20/04 , C40B40/06 , C40B70/00

CPC classification number: C12Q1/6874 , B01J2219/005 , B01J2219/00572 , B01J2219/00585 , B01J2219/00596 , B01J2219/00648 , B01J2219/00659 , B01J2219/00702 , B01J2219/00722 , C07B2200/11 , C07H21/00 , C12Q1/6837 , C40B20/04 , C40B40/06 , C40B70/00 , C12Q2563/161 , C12Q2563/185 , C12Q2525/179 , C12Q2563/155 , C12Q2565/514

Abstract: Methods disclosed herein relate to identification of nucleotides in a nucleotide sequence.

Abstract translation: 本文公开的方法涉及鉴定核苷酸序列中的核苷酸。

2.

发明申请
USE OF MICROFLUIDIC SYSTEMS IN THE DETECTION OF TARGET ANALYTES USING MICROSPHERE ARRAYS 有权
Title translation: 微流感系统在使用微波阵列检测目标分析仪时的应用

公开(公告)号：US20150024965A1

公开(公告)日：2015-01-22

申请号：US14508939

申请日：2014-10-07

Applicant: Illumina, Inc.

Inventor： Mark S. Chee , Todd A. Dickinson , Kevin Gunderson , Don O'Neil

IPC: B01L3/00 , C12Q1/68

CPC classification number: B01L3/502761 , B01L2200/0668 , B01L2300/0816 , B01L2300/0867 , B01L2400/0415 , C12Q1/68 , C12Q1/6816 , C12Q1/6869 , C12Q1/6874 , C12Q2565/629 , C12Q2563/149

Abstract: The invention relates generally to methods and apparatus for conducting analyses, particularly microfluidic devices for the detection of target analytes.

Abstract translation: 本发明一般涉及用于进行分析的方法和装置，特别是用于检测目标分析物的微流体装置。

3.

发明申请
USE OF MICROFLUIDIC SYSTEMS IN THE DETECTION OF TARGET ANALYTES USING MICROSPHERE ARRAYS 有权

公开(公告)号：US20130345067A1

公开(公告)日：2013-12-26

申请号：US13912668

申请日：2013-06-07

Applicant: Illumina, Inc

Inventor： Mark S. Chee , Todd A. Dickinson , Kevin Gunderson , Don O'Neil , John R. Stuelpnagel

IPC: C12Q1/68

CPC classification number: B01L3/502761 , B01L2200/0668 , B01L2300/0816 , B01L2300/0867 , B01L2400/0415 , C12Q1/68 , C12Q1/6816 , C12Q1/6869 , C12Q1/6874 , C12Q2565/629 , C12Q2563/149

Abstract: The invention relates generally to methods and apparatus for conducting analyses, particularly microfluidic devices for the detection of target analytes.

4.

发明申请
COMPOSITIONS AND METHODS FOR PREPARING OLIGONUCLEOTIDE SOLUTIONS 审中-公开

公开(公告)号：US20200002700A1

公开(公告)日：2020-01-02

申请号：US16512986

申请日：2019-07-16

Applicant: Illumina, Inc.

Inventor： John R. Stuelpnagel , Mark S. Chee

IPC: C12N15/10 , C12Q1/6834 , C12Q1/6837 , C12Q1/6876 , G11C7/10 , H03K19/096 , C12Q1/686 , C12Q1/6806

Abstract: The present invention is directed to methods and compositions for generating a pool of oligonucleotides. The invention finds use in preparing a population or subpopulations of oligonucleotides in solution. The pool of oligonucleotides finds use in a variety of nucleic acid detection and/or amplification assays.

5.

发明申请
MULTIPLEX NUCLEIC ACID REACTIONS 审中-公开

公开(公告)号：US20180094316A1

公开(公告)日：2018-04-05

申请号：US15827141

申请日：2017-11-30

Applicant: Illumina, Inc.

Inventor： Arnold Oliphant , John R. Stuelpnagel , Mark S. Chee , Scott L. Butler , Jian-Bing Fan , Min-Jui Richard Shen

IPC: C12Q1/68

CPC classification number: C12Q1/6876 , C12Q1/6834 , C12Q1/6837 , C12Q2600/16 , Y10T436/143333 , C12Q2525/155 , C12Q2563/131 , C12Q2563/179

Abstract: A method for detecting nucleic acids by (a) providing a sample having target nucleic acids, each nucleic acid having contiguous first, second, and third domains; (b) contacting the sample with probe sets to form hybridization complexes, wherein each probe set includes (i) a first probe having a sequence that is complementary to the first domain; and (ii) a second probe having a sequence substantially complementary to the third domain; (c) extending the first probes along the second domains of the complexes while the complexes are immobilized on a solid support; (d) ligating the extended first probes to the second probes to form templates; (e) amplifying the templates with primers that are complementary to the first and second priming sequences to produce amplicons; and (f) detecting the amplicons on the surface of a nucleic acid array.

6.

发明授权
Use of microfluidic systems in the detection of target analytes using microsphere arrays 有权
Title translation: 使用微流体系统检测目标分析物使用微球阵列

公开(公告)号：US09289766B2

公开(公告)日：2016-03-22

申请号：US14508939

申请日：2014-10-07

Applicant: Illumina, Inc.

Inventor： Mark S. Chee , Todd A. Dickinson , Kevin Gunderson , Don O'Neil

IPC: C12Q1/68 , B01L3/00

CPC classification number: B01L3/502761 , B01L2200/0668 , B01L2300/0816 , B01L2300/0867 , B01L2400/0415 , C12Q1/68 , C12Q1/6816 , C12Q1/6869 , C12Q1/6874 , C12Q2565/629 , C12Q2563/149

Abstract: The invention relates generally to methods and apparatus for conducting analyzes, particularly microfluidic devices for the detection of target analytes.

Abstract translation: 本发明一般涉及用于进行分析的方法和装置，特别是用于检测目标分析物的微流体装置。

7.

发明授权
Detection of nucleic acid reactions on bead arrays 有权
Title translation: 检测珠阵列上的核酸反应

公开(公告)号：US09279148B2

公开(公告)日：2016-03-08

申请号：US13913922

申请日：2013-06-10

Applicant: Illumina, Inc.

Inventor： Kevin Gunderson , John R. Stuelpnagel , Mark S. Chee , Jian-Bing Fan

IPC: C12Q1/68 , C12M1/36 , C12P19/34 , C07H21/04

CPC classification number: C12Q1/6837 , C12Q1/6858 , C12Q1/6874 , C12Q2535/131 , C12Q2525/191 , C12Q2531/137 , C12Q2563/149

Abstract: The present invention is directed to methods and compositions for the use of micro sphere arrays to detect and quantify a number of nucleic acid reactions. The invention finds use in genotyping, i.e. the determination of the sequence of nucleic acids, particularly alterations such as nucleotide substitutions (mismatches) and single nucleotide polymorphisms (SNPs). Similarly, the invention finds use in the detection and quantification of a nucleic acid target using a variety of amplification techniques, including both signal amplification and target amplification. The methods and compositions of the invention can be used in nucleic acid sequencing reactions as well. All applications can include the use of adapter sequences to allow for universal arrays.

Abstract translation: 本发明涉及使用微球阵列来检测和定量许多核酸反应的方法和组合物。本发明用于基因分型，即确定核酸序列，特别是改变，例如核苷酸取代（错配）和单核苷酸多态性（SNP）。类似地，本发明用于使用多种扩增技术检测和定量核酸靶，包括信号放大和靶扩增两者。本发明的方法和组合物也可用于核酸测序反应。所有应用程序可以包括使用适配器序列来允许通用阵列。