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    1-hydroxycycloalkanecarboxamide derivatives
    21.
    发明授权
    1-hydroxycycloalkanecarboxamide derivatives 有权
    1-羟基环烷烃甲酰胺衍生物

    公开(公告)号：US07816380B2

    公开(公告)日：2010-10-19

    申请号：US11920306

    申请日：2006-05-30

    申请人： Scott D. Kuduk ,  Michael R. Wood

    发明人： Scott D. Kuduk ,  Michael R. Wood

    IPC分类号： A61K31/24 ,  C07D419/00 ,  C07D413/00

    CPC分类号： C07D213/61 ,  C07D401/10 ,  C07D413/10

    摘要： α-Hydroxycycloalkanecarboxamide derivatives of formula (I) or a pharmaceutically acceptable salt thereof, wherein formula (a) is a single or double bond; R1, R2 and R3 are each independently selected from H, halogen and OH; or R1 and R2 attached to the same carbon atom together represent oxo; R4 is H or methyl; R5 is Cl or I2; R6 is selected from —CO2—C1-4alkyl, —O—C1-4alkyl, —O—C1-4haloalkyl, 2-methyltetrazol-5-yl, 5-methyl-1,2,4-oxadiazol-3-yl, 3-methyl-1,2,4-oxadiazol-5-yl, 5-halomethyl-1,2,4-oxadiazol-3-yl, 3-halomethyl-1,2,4-oxadiazol-5-yl, tetrazol-5-yl, 5-halomethyl-1,2,3-triazolyl, and 5-methyl-1,2,3-triazolyl; R7 and R8 are each independently Cl or I2; and n is 0 or 1, are bradykinin B1 antagonists or inverse agonists useful in the treatment or prevention of symptoms such as pain and inflammation associated with the bradykinin B1 pathway.

    摘要翻译： 式（I）的α-羟基环烷甲酰胺衍生物或其药学上可接受的盐，其中式（a）是单键或双键; R 1，R 2和R 3各自独立地选自H，卤素和OH; 或连接在同一碳原子上的R1和R2一起代表氧代; R4是H或甲基; R5是Cl或I2; R 6选自-CO 2 -C 1-4烷基，-O-C 1-4烷基，-O-C 1-4卤代烷基，2-甲基四唑-5-基，5-甲基-1,2,4-恶二唑-3-基，3 - 甲基-1,2,4-恶二唑-5-基，5-卤代甲基-1,2,4-恶二唑-3-基，3-卤代甲基-1,2,4-恶二唑-5-基，四唑-5 - 5-氯甲基-1,2,3-三唑基和5-甲基-1,2,3-三唑基; R 7和R 8各自独立地为Cl或I 2; 和n为0或1是缓激肽B1拮抗剂或反激动剂，其可用于治疗或预防与缓激肽B1途径相关的疼痛和炎症等症状。

    Electrical lighting tester for vehicle-towed trailers
    22.
    发明申请
    Electrical lighting tester for vehicle-towed trailers 审中-公开
    汽车牵引拖车电气照明测试仪

    公开(公告)号：US20090212784A1

    公开(公告)日：2009-08-27

    申请号：US12317198

    申请日：2008-12-22

    申请人： Joseph E. Kilian ,  Michael R. Wood

    发明人： Joseph E. Kilian ,  Michael R. Wood

    IPC分类号： G01R31/00

    CPC分类号： G01R31/44 ,  G01R31/006

    摘要： A compact, portable electrical tester to test the functionality of the lights of a lighting system of vehicle-towed commercial and utility trailers. By virtue of the presently-disclosed lighting tester, the lights of a trailer can be remotely tested by a single test taker without the presence of a tow vehicle or tow vehicle operator. Housed within the chassis of the lighting tester are a 120-volt AC/12-volt DC power supply and a set of DC test circuits. The DC test circuits are connected between the power supply and different ones of the lights of the trailer to be tested. In the preferred embodiment, each DC test circuit includes a light selection toggle switch that is connected in electrical series with a DC circuit breaker toggle switch. A particular light selection toggle switch is selectively actuated to a closed switch position so that DC power will be supplied from the power supply to illuminate a particular light or group of lights under test. A particular series connected circuit breaker toggle switch is selectively actuated to a closed circuit position to close the DC test circuit in which it is connected. Each of the light selection and circuit breaker toggle switches is accessible to be manually actuated at the front of the chassis.

    摘要翻译： 一种紧凑的便携式电气测试仪，用于测试车辆牵引的商业和实用拖车照明系统的灯的功能。 凭借目前公开的照明测试仪，拖车的灯可以由单个测试者进行远程测试，而不需要拖车或牵引车辆操作员。 在照明测试仪的底盘内装有一个120伏的交流/ 12伏直流电源和一组直流测试电路。 直流测试电路连接在电源和待测试拖车的不同灯之间。 在优选实施例中，每个DC测试电路包括与DC断路器拨动开关电连接的光选择拨动开关。 特定的光选择拨动开关被选择性地致动到闭合的开关位置，使得将从电源供应DC电力以照亮被测试的特定光或一组灯。 特定的串联连接的断路器拨动开关被选择性地启动到闭合电路位置以关闭其连接的DC测试电路。 每个灯选择和断路器拨动开关可以在机箱前部手动启动。

    1-Hydroxycycloalkanecarboxamide derivatives
    23.
    发明申请
    1-Hydroxycycloalkanecarboxamide derivatives 有权
    1-羟基环烷甲酰胺衍生物

    公开(公告)号：US20090062349A1

    公开(公告)日：2009-03-05

    申请号：US11920306

    申请日：2006-05-30

    申请人： Scott D. Kuduk ,  Michael R. Wood

    发明人： Scott D. Kuduk ,  Michael R. Wood

    IPC分类号： C07D401/10 ,  C07D413/10 ,  A61K31/44 ,  A61K31/4439 ,  A61P29/00

    CPC分类号： C07D213/61 ,  C07D401/10 ,  C07D413/10

    摘要： α-Hydroxycycloalkanecarboxamide derivatives of formula (I) or a pharmaceutically acceptable salt thereof, wherein formula (a) is a single or double bond; R1, R2 and R3 are each independently selected from H, halogen and OH; or R1 and R2 attached to the same carbon atom together represent oxo; R4 is H or methyl; R5 is Cl or I2; R6 is selected from —CO2—C3-4alkyl, —O—C1-4alkyl, —O—C1-4haloalkyl, 2-methyltetrazol-5-yl, 5-methyl-1,2,4-oxadiazol-3-yl, 3-methyl-1,2,4-oxadiazol-5-yl, 5-halomethyl-1,2,4-oxadiazol-3-yl, 3-halomethyl-1,2,4-oxadiazol-5-yl, tetrazol-5-yl, 5-halomethyl-1,2,3-triazolyl, and 5-methyl-1,2,3-triazolyl; R7 and R8 are each independently Cl or I2; and n is 0 or 1, are bradykinin B1 antagonists or inverse agonists useful in the treatment or prevention of symptoms such as pain and inflammation associated with the bradykinin B1 pathway.

    摘要翻译： 式（I）的α-羟基环烷甲酰胺衍生物或其药学上可接受的盐，其中式（a）是单键或双键; R 1，R 2和R 3各自独立地选自H，卤素和OH; 或连接在同一碳原子上的R1和R2一起代表氧代; R4是H或甲基; R5是Cl或I2; R6选自-CO 2 -C 3-4烷基，-O-C 1-4烷基，-O-C 1-4卤代烷基，2-甲基四唑-5-基，5-甲基-1,2,4-恶二唑-3-基，3 - 甲基-1,2,4-恶二唑-5-基，5-卤代甲基-1,2,4-恶二唑-3-基，3-卤代甲基-1,2,4-恶二唑-5-基，四唑-5 - 5-氯甲基-1,2,3-三唑基和5-甲基-1,2,3-三唑基; R 7和R 8各自独立地为Cl或I 2; 和n为0或1是缓激肽B1拮抗剂或反激动剂，其可用于治疗或预防与缓激肽B1途径相关的疼痛和炎症等症状。

    Alpha-hydroxy amides as bradykinin antagonists or inverse agonists
    26.
    发明授权
    Alpha-hydroxy amides as bradykinin antagonists or inverse agonists 有权
    α-羟基酰胺作为缓激肽拮抗剂或反向激动剂

    公开(公告)号：US07790754B2

    公开(公告)日：2010-09-07

    申请号：US10583675

    申请日：2004-12-17

    申请人： Michael R. Wood ,  Neville J. Anthony ,  Mark G. Bock ,  Scott D. Kuduk

    发明人： Michael R. Wood ,  Neville J. Anthony ,  Mark G. Bock ,  Scott D. Kuduk

    IPC分类号： A61K31/4439 ,  C07D413/10

    CPC分类号： C07D239/26 ,  C07C235/06 ,  C07C235/08 ,  C07C235/12 ,  C07C235/26 ,  C07C235/34 ,  C07C235/40 ,  C07C2601/02 ,  C07C2601/04 ,  C07C2601/18 ,  C07D209/12 ,  C07D213/56 ,  C07D213/61 ,  C07D257/04 ,  C07D271/06 ,  C07D275/06 ,  C07D401/10 ,  C07D413/10

    摘要： α-Hydroxy amide derivatives of the general formula (I) are bradykinin B1 antagonists or inverse agonists useful in the treatment or prevention of symptoms such as pain and inflammation associated with the bradykinin B1 pathway. R2a is selected from (1) a group selected from Ra. (2) (CH2)nNRbC(O)Ra. (3) (CH2)nNRbSO2Rd. (4) (CH2)nNRbCO2Ra. (5) (CH2)k-heterocycle optionally substituted with 1 to 3 groups independently selected from halogen.nitro, cyano.ORa.SRa.C1-4 alkyl and C1-3 haloakyl wherein said heterocycle is (a) a 5-membered heteroaromatic ring having a ring heteroatom selected from N.O and S. and optionally having up to 3 additional ring nitrogen atoms wherein said ring is optionally benzo-fused; or (b) a 6-membered heteromatic ring containing from 1 to 3 ring nitrogen atoms and N-oxydes thereof. Wherein said ring is optionally benzo-fused. (6) (CH2)kCO2Ra. and (7) (CH2)C(O)NRbRc. R2b is OH or a group selected from R2a; or R2a and R2b together with the carbon atom to which they are attached form a 3- to 7-membered carbocyclic ring optionally substituted with 1 to 4 groups independently selected from halogen. ORa. C1-4 alkyl and C1-4 haloalkyl.

    摘要翻译： 通式（I）的α-羟基酰胺衍生物是可用于治疗或预防与缓激肽B1途径相关的疼痛和炎症等症状的缓激肽B1拮抗剂或反向激动剂。 R2a选自（1）选自Ra的基团。 （2）（CH2）nNRbC（O）Ra。 （3）（CH2）nNRbSO2Rd。 （4）（CH2）nNRbCO2Ra。 （5）（CH2）k-杂环，其任选被1至3个独立地选自卤素，硝基，氰基，硫代C 1-4烷基和C 1-3卤代烷基的基团取代，其中所述杂环是（a）5元杂芳族 环，其具有选自NO和S的环杂原子，并且任选地具有至多3个另外的环氮原子，其中所述环任选地被苯并稠合; 或（b）含有1至3个环氮原子的6-元杂环和其N-氧化物。 其中所述环任选地被苯并稠合。 （6）（CH2）kCO2Ra。 和（7）（CH 2）C（O）NR b R c。 R2b是OH或选自R2a的基团; 或R 2a和R 2b与它们所连接的碳原子一起形成任选被1至4个独立地选自卤素的基团取代的3至7元碳环。 ORa。 C 1-4烷基和C 1-4卤代烷基。

    Apparatus and method for automatically orienting hosiery articles for closing toe ends thereof
    27.
    发明授权
    Apparatus and method for automatically orienting hosiery articles for closing toe ends thereof 有权
    用于自动定向袜子制品的装置和方法，用于封闭其末端

    公开(公告)号：US6158367A

    公开(公告)日：2000-12-12

    申请号：US527664

    申请日：2000-03-17

    申请人： Bobby Jordan ,  Michael R. Wood

    发明人： Bobby Jordan ,  Michael R. Wood

    IPC分类号： D05B23/00 ,  D05B33/00

    CPC分类号： D05B23/009 ,  D05B23/007

    摘要： An apparatus for orienting open-toe sock blanks includes a tube for receiving a sock blank sleeved thereover such that the open toe end of the blank extends beyond the end of the tube, a clamping mechanism for engaging the blank against the tube and for rotating the blank about the tube, a sensor system for detecting one or more predetermined features on the toe end of the blank so that the blank can be rotated to a proper orientation for sewing the toe end closed, and a spreader device that moves into the open toe end of the blank and spreads the toe end into a flattened orientation so that overlying edge portions of the open toe end are generally aligned with each other, and then moves away from the tube to remove the blank from the tube and transport the flattened toe end into an automatic sewing machine for sewing the overlying edge portions of the toe end together.

    摘要翻译： 用于定向开口袜子坯料的装置包括用于接收在其上套管的坯料坯料的管，使得坯料的开口端部延伸超出管的端部，用于将坯料接合管并将其旋转的夹紧机构 用于检测坯料的脚趾端上的一个或多个预定特征的传感器系统，使得坯料可以旋转到用于缝合脚趾端部的封闭的适当取向，以及移动到开口脚趾中的吊具装置 将端部的端部扩展成平坦的方向，使得开口脚趾端的上部边缘部分大体上彼此对准，然后远离管子移开，从管中移出坯料，并将扁平的脚趾端部 成为将脚趾端的上覆边缘部分缝合在一起的自动缝纫机。

    Apparatus for automatically orienting hosiery articles for closing toe ends thereof
    30.
    发明授权
    Apparatus for automatically orienting hosiery articles for closing toe ends thereof 有权
    用于自动定向袜子制品以用于封闭其末端的装置

    公开(公告)号：US07025011B2

    公开(公告)日：2006-04-11

    申请号：US10351747

    申请日：2003-01-24

    申请人： Bob Jordan ,  Michael R. Wood

    发明人： Bob Jordan ,  Michael R. Wood

    IPC分类号： D05B21/00

    CPC分类号： D05B23/009 ,  D05B23/007 ,  D06H1/00

    摘要： An apparatus for orienting sock blanks or the like so that the open toes of the blanks can be sewn closed includes a device for turning the sock inside out, a sock rotation device for grasping the sock and rotating it until sensors detect that the sock is in the proper orientation, a sock transfer device for taking the sock from the sock rotation device toward a sewing machine, and sock guiding and positioning mechanisms for feeding the sock into the in-feed nip of the sewing machine.

    摘要翻译： 用于定位袜子坯料等的装置，使得可以缝合坯料的开口脚趾封闭包括用于将袜子向内转动的装置，用于抓住袜子并旋转袜子的袜子旋转装置，直到传感器检测到袜子在 适当的方向，用于将袜子从袜子旋转装置朝向缝纫机取出的袜子转移装置，以及用于将袜子进给到缝纫机的进给间隙中的引导和定位机构。