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    Treating renal disease, burns, wounds and spinal cord injury with selective androgen receptor modulators
    24.
    发明申请
    Treating renal disease, burns, wounds and spinal cord injury with selective androgen receptor modulators 审中-公开
    用选择性雄激素受体调节剂治疗肾脏疾病，烧伤，伤口和脊髓损伤

    公开(公告)号：US20070066568A1

    公开(公告)日：2007-03-22

    申请号：US11510844

    申请日：2006-08-28

    申请人： James Dalton ,  Duane Miller

    发明人： James Dalton ,  Duane Miller

    IPC分类号： A61K31/675 ,  A61K31/555 ,  A61K31/4709 ,  A61K31/405 ,  A61K31/4704 ,  A61K31/32 ,  A61K31/277 ,  A61K31/165

    CPC分类号： A61K31/165 ,  A61K31/277 ,  A61K31/32 ,  A61K31/405 ,  A61K31/4704 ,  A61K31/4709 ,  A61K31/555 ,  A61K31/675

    摘要： This invention provides: 1) a method of treating a subject suffering from, or predisposed to a kidney disease or disorder; 2) a method of treating a subject suffering from a wound, or reducing the incidence of, or mitigating the severity of a wound in a subject; 3) a method of treating a subject suffering from a burn, or reducing the incidence of, or mitigating the severity of a burn in a subject, comprising the step of administering to said subject a selective androgen receptor modulator (SARM) compound; 4) a method of treating a subject suffering from a spinal cord injury, by administering to the subject a selective androgen receptor modulator (SARM) and/or an analog, derivative, isomer, metabolite, pharmaceutically acceptable salt, pharmaceutical product, hydrate, N-oxide, prodrug, polymorph, impurity or crystal of said SARM compound, or any combination thereof.

    摘要翻译： 本发明提供：1）治疗患有或易患肾病或病症的受试者的方法; 2）治疗患有伤口的受试者或降低受试者的伤口的发生或减轻其严重程度的方法; 3）治疗患有烧伤的受试者或降低受试者的烧伤的发生或减轻其严重程度的方法，其包括向所述受试者施用选择性雄激素受体调节剂（SARM）化合物的步骤; 4）通过向受试者施用选择性雄激素受体调节剂（SARM）和/或其类似物，衍生物，异构体，代谢物，药学上可接受的盐，药物产品，水合物N，治疗患有脊髓损伤的受试者的方法 氧化物，前药，多晶型物，杂质或结晶，或其任何组合。

    SELECTIVE ANDROGEN RECEPTOR MODULATORS
    25.
    发明申请
    SELECTIVE ANDROGEN RECEPTOR MODULATORS 失效
    选择性雄激素受体调节剂

    公开(公告)号：US20060287547A1

    公开(公告)日：2006-12-21

    申请号：US11125159

    申请日：2005-05-10

    申请人： James Dalton ,  Duane Miller ,  Yali He ,  Donghua Yin

    发明人： James Dalton ,  Duane Miller ,  Yali He ,  Donghua Yin

    IPC分类号： C07C237/32 ,  C07C255/56

    CPC分类号： C07C235/24

    摘要： The present invention relates to androgen receptor targeting agents (ARTA) which demonstrate androgenic and anabolic activity, which are nonsteroidal ligands for the androgen receptor. The selective androgen receptor modulators (SARM) are useful for a) male contraception; b) treatment of a variety of hormone-related conditions, for example conditions associated with Androgen Decline in Aging Male (ADAM), such as fatigue, depression, decreased libido, sexual dysfunction, erectile dysfunction, hypogonadism, osteoporosis, hair loss, anemia, obesity, sarcopenia, osteopenia, osteoporosis, benign prostate hyperplasia, alterations in mood and cognition and prostate cancer; c) treatment of conditions associated with Androgen Decline in Female (ADIF), such as sexual dysfunction, decreased sexual libido, hypogonadism, sarcopenia, osteopenia, osteoporosis, alterations in cognition and mood, depression, anemia, hair loss, obesity, endometriosis, breast cancer, uterine cancer and ovarian cancer; d) treatment and/or prevention of chronic muscular wasting; e) decreasing the incidence of, halting or causing a regression of prostate cancer; f) oral androgen relacement and/or other clinical therpauetic and/or diagnostic areas.

    摘要翻译： 本发明涉及雄激素和合成代谢活性的雄激素受体靶向剂（ARTA），其是雄激素受体的非甾体配体。 选择性雄激素受体调节剂（SARM）可用于a）男性避孕; b）治疗各种激素相关病症，例如与老年雄性雄激素降低有关的病症（ADAM），如疲劳，抑郁，性欲降低，性功能障碍，勃起功能障碍，性腺机能减退，骨质疏松症，脱发，贫血， 肥胖，肌营养不良，骨质减少，骨质疏松症，良性前列腺增生，情绪和认知和前列腺癌的改变; c）治疗与男性雄激素降低相关的病症（ADIF），如性功能障碍，性欲降低，性腺机能减退，肌营养不良，骨质减少，骨质疏松症，认知和情绪改变，抑郁症，贫血，脱发，肥胖，子宫内膜异位症，乳腺癌 癌症，子宫癌和卵巢癌; d）治疗和/或预防慢性肌肉消瘦; e）降低前列腺癌的发生率，停止或导致消退; f）口服雄激素替代和/或其他临床治疗和/或诊断领域。

    Substituted acylanilides and methods of use thereof
    28.
    发明申请
    Substituted acylanilides and methods of use thereof 有权
    取代的酰基酰苯胺及其使用方法

    公开(公告)号：US20080076829A1

    公开(公告)日：2008-03-27

    申请号：US11892595

    申请日：2007-08-24

    申请人： James Dalton ,  Duane Miller

    发明人： James Dalton ,  Duane Miller

    IPC分类号： C07C255/51 ,  A61K31/167 ,  A61P15/16

    CPC分类号： C07C255/60 ,  C07B2200/07

    摘要： This invention provides SARM compounds and uses thereof in treating a variety of diseases or conditions in a subject, including, inter alia, a muscle wasting disease and/or disorder or a bone-related disease and/or disorder.

    摘要翻译： 本发明提供了SARM化合物及其用于治疗受试者中的多种疾病或病症的用途，所述疾病或病症尤其包括肌肉消瘦疾病和/或病症或骨相关疾病和/或病症。

    Treating Androgen Decline in Aging Male (ADAM)- associated conditions with SARMS
    30.
    发明申请
    Treating Androgen Decline in Aging Male (ADAM)- associated conditions with SARMS 审中-公开
    老年男性（ADAM）治疗雄激素下降 - 与SARMS相关的病症

    公开(公告)号：US20060276539A1

    公开(公告)日：2006-12-07

    申请号：US11324753

    申请日：2006-01-04

    申请人： James Dalton ,  Duane Miller ,  Mitchell Steiner ,  Karen Veverka

    发明人： James Dalton ,  Duane Miller ,  Mitchell Steiner ,  Karen Veverka

    IPC分类号： A61K31/277

    CPC分类号： A61K31/277 ,  C07K14/721

    摘要： This invention provides methods for treatment and inhibition of a male subject having an Androgen Decline in Aging Male (ADAM)-associated condition, for example sexual dysfunction, decreased sexual libido, erectile dysfunction, hypogonadism, sarcopenia, osteopenia, osteoporosis, an alteration in cognition and mood, depression, anemia, hair loss, obesity, muscle loss, dry eye, memory loss, benign prostate hyperplasia and/or prostate cancer, by administering to the subject a selective androgen receptor modulator (SARM) compound and/or its analog, derivative, isomer, metabolite, pharmaceutically acceptable salt, pharmaceutical product, hydrate, N-oxide, pro-drug, polymorph, crystal, or any combination thereof.

    摘要翻译： 本发明提供了用于治疗和抑制雄性雄性雄激素降低（ADAM）相关病症的男性受试者的方法，例如性功能障碍，性欲性降低，勃起功能障碍，性腺机能减退，肌肉减少症，骨质减少症，骨质疏松症，认知改变 通过向受试者施用选择性雄激素受体调节剂（SARM）化合物和/或其类似物，通过向受试者施用选择性雄激素受体调节剂（SARM）化合物和/或其类似物， 衍生物，异构体，代谢物，药学上可接受的盐，药物产品，水合物，N-氧化物，前药，多晶型物，晶体或其任何组合。