公开(公告)号：US10426299B2

公开(公告)日：2019-10-01

申请号：US15963908

申请日：2018-04-26

Applicant: James Snyder

Inventor： James Snyder

IPC: A45D34/04 ,  A47K7/03 ,  A47K7/04 ,  A61H7/00 ,  A61M35/00 ,  A47K7/02

Abstract: An exfoliation and body cream application mitt is configured to apply a thickened liquid to a human user. The exfoliation and body cream application mitt has a back side and a front side joined to one another forming a pocket therebetween. The front side is adapted to accomplish exfoliation and the back side is adapted to accomplish lotion application. A soft fabric arranged within the back side and configured to gently spread body creams, foams and lotions to a skin surface. A wrist section is arranged between the back side and the front side, defining an opening for receiving a hand of a user.

公开(公告)号：US20190125138A1

公开(公告)日：2019-05-02

申请号：US15963908

申请日：2018-04-26

Applicant: James Snyder

Inventor： James Snyder

IPC: A47K7/03 ,  A61H7/00 ,  A45D34/04

CPC classification number: A47K7/03 ,  A45D34/04 ,  A45D2200/1054 ,  A47K7/02 ,  A61H7/003 ,  A61H2201/165 ,  A61H2201/1692 ,  A61M35/003

Abstract: An exfoliation and body cream application mitt is configured to apply a thickened liquid to a human user. The exfoliation and body cream application mitt has a back side and a front side joined to one another forming a pocket therebetween. The front side is adapted to accomplish exfoliation and the back side is adapted to accomplish lotion application. A soft fabric arranged within the back side and configured to gently spread body creams, foams and lotions to a skin surface. A wrist section is arranged between the back side and the front side, defining an opening for receiving a hand of a user.

公开(公告)号：US20100076924A1

公开(公告)日：2010-03-25

申请号：US12630808

申请日：2009-12-03

Applicant: James Snyder ,  Harry Lai ,  Shirish Reddy ,  Jimmy Wan

Inventor： James Snyder ,  Harry Lai ,  Shirish Reddy ,  Jimmy Wan

IPC: G06F17/30

CPC classification number: G06F17/30592

Abstract: A method of managing application service provider product line variations is disclosed. The method includes receiving a client customization request, creating a configuration managed file tailored to the client customization request, binding the configuration managed file to at least one customizable resource, and deploying the customizable resource to a data store. The customizable resource is instantiated after disposition at the data store.

Abstract translation: 公开了一种管理应用服务提供商产品线变化的方法。 该方法包括接收客户端定制请求，创建针对客户端定制请求定制的配置管理文件，将配置管理文件绑定到至少一个可定制资源，以及将可定制资源部署到数据存储。 可定制的资源在数据存储处理后实例化。

公开(公告)号：US20070270464A1

公开(公告)日：2007-11-22

申请号：US11678156

申请日：2007-02-23

Applicant: Dennis Liotta ,  James Snyder ,  Mamoru Shoji ,  Yang Lu ,  Aiming Sun

Inventor： Dennis Liotta ,  James Snyder ,  Mamoru Shoji ,  Yang Lu ,  Aiming Sun

IPC: A61K38/10 ,  A61K31/4433 ,  A61K31/4436 ,  A61K31/4545 ,  A61P3/10 ,  C07D211/44 ,  C07D211/82 ,  C07D401/12 ,  C07D405/06 ,  C07D409/06 ,  A61K38/08 ,  A61K38/06 ,  A61K38/05

CPC classification number: C07D211/74

Abstract: The invention provides sulfur-linked and nitrogen-linked peptidic conjugates of curcumin analogs that can provide increased water solubility and photostability as compared to the corresponding unmodified curcumin analogs without sacrificing therapeutic efficacy. The conjugates, which are believed to act as prodrugs, can be used therapeutically in the same manner as the unmodified curcumin analogs, such as in the treatment or prevention of cancer, diabetes, or inflammatory diseases. One conjugate comprises 3,5-Bis-(2-fluorobenzylidene)-piperidin-4-one, or a salt thereof, covalently attached through a sulfur linkage to a thiol-containing peptide such as glutathione.

Abstract translation: 本发明提供与相应的未修饰的姜黄素类似物相比，可以提供增加的水溶性和光稳定性的姜黄素类似物的硫连接和氮连接的肽共轭物，而不牺牲治疗功效。 被认为用作前药的缀合物可以以与未修饰的姜黄素类似物相同的方式治疗地使用，例如在治疗或预防癌症，糖尿病或炎症性疾病中。 一个缀合物包含通过硫键共价连接到含硫醇的肽如谷胱甘肽的3,5-双 - （2-氟亚苄基） - 哌啶-4-酮或其盐。

公开(公告)号：US20070054930A1

公开(公告)日：2007-03-08

申请号：US11328900

申请日：2006-01-09

Applicant: Hyunsuk Shim ,  Dennis Liotta ,  James Snyder ,  Weiqiang Zhan ,  Zhongxing Liang

Inventor： Hyunsuk Shim ,  Dennis Liotta ,  James Snyder ,  Weiqiang Zhan ,  Zhongxing Liang

IPC: A61K31/506 ,  A61K31/444

CPC classification number: C07D239/42 ,  A61K31/4402 ,  A61K31/444 ,  A61K31/505 ,  A61K31/506 ,  C07C51/412

Abstract: The invention provides compounds, pharmaceutical compositions and methods of use of certain compounds that are antagonists of the chemokine CXCR4 receptor for the treatment of proliferative conditions mediated by CXCR4 receptors. The compounds provided interfere with the binding of SDF1 to the receptor. These compounds are particularly useful for treating or reducing the severity of hyperproliferative diseases by inhibiting metastasis.

Abstract translation: 本发明提供化合物，药物组合物和使用作为趋化因子CXCR4受体的拮抗剂的某些化合物用于治疗CXCR4受体介导的增殖性病症的化合物，药物组合物和方法。 所提供的化合物干扰SDF1与受体的结合。 这些化合物特别可用于通过抑制转移来治疗或降低过度增殖性疾病的严重性。

公开(公告)号：US20060217000A1

公开(公告)日：2006-09-28

申请号：US11435414

申请日：2006-05-16

Applicant: Jerry Zucker ,  James Schaeffer ,  Richard Ferencz ,  James Snyder ,  Tim Krause ,  Nick Carter

Inventor： Jerry Zucker ,  James Schaeffer ,  Richard Ferencz ,  James Snyder ,  Tim Krause ,  Nick Carter

IPC: H01R24/00

CPC classification number: D01D4/02 ,  B29C48/05 ,  B29C48/08 ,  B29C48/16 ,  B29C48/18 ,  B29C48/285 ,  B29C48/30 ,  B29C48/304 ,  B29C48/31 ,  B29C48/345 ,  B29K2067/00 ,  B29K2077/00 ,  B29K2105/12 ,  B29K2311/10

Abstract: The present invention is directed to a modular die unit comprising a plurality of individually shaped plates wherein the shaped plates are stacked in face to face juxtaposition, and when placed into such a juxtaposition exhibit useful polymer forming attributes heretofore unattainable by prior art practices. Single die plates are formed such that the plates exhibit a finite geometric relationship, which in turn provides resistance to flexural deformation of the individually shaped die plates and conversely, improved resistance to variability of the modular die unit and enhanced and predictable formation characteristics of the polymer material formed therewith. Each of said single die plates within the stack forming the modular die unit exhibit an x-direction, a y-direction, and a z-direction, wherein any one of said single die plates exhibit in said x-direction and y-direction to have at least a 50% planar continuity of the total planar continuity.

Abstract translation: 本发明涉及一种模块化模具单元，其包括多个单独成形的板，其中成形板以并列方式堆叠，并且当放置成这样并列时，显示出迄今为止由现有技术实践不可达到的有用的聚合物形成属性。 形成单模板，使得板呈现有限的几何关系，其又提供抵抗单独成型的模板的弯曲变形的阻力，反之，提高了模块化模具单元的变异性，并且增强了且可预测的聚合物的形成特性 形成的材料。 形成模块化单元的堆叠内的每个所述单模板呈现x方向，y方向和z方向，其中所述单模板中的任何一个在所述x方向和y方向上表现为 具有总平面连续性的至少50％的平面连续性。

公开(公告)号：US20050263139A1

公开(公告)日：2005-12-01

申请号：US11194824

申请日：2005-08-01

Applicant: Thomas Ryan ,  Robert Burrahm ,  Rudolf Stanglmaier ,  Charles Roberts ,  James Snyder ,  Lee Dodge ,  Daniel Stewart ,  Timothy Callahan ,  John Kubesh

Inventor： Thomas Ryan ,  Robert Burrahm ,  Rudolf Stanglmaier ,  Charles Roberts ,  James Snyder ,  Lee Dodge ,  Daniel Stewart ,  Timothy Callahan ,  John Kubesh

IPC: F02B1/04 ,  F02D13/02 ,  F02D21/08 ,  F02D41/00 ,  F02D41/02 ,  F02D41/14 ,  F02D41/36 ,  F02D41/40 ,  F02P9/00 ,  F02M51/00 ,  F02M25/07

CPC classification number: F02D13/0215 ,  F02B1/04 ,  F02D21/08 ,  F02D41/0047 ,  F02D41/0087 ,  F02D41/0235 ,  F02D41/1454 ,  F02D41/402 ,  F02D41/403 ,  F02D2041/001 ,  F02M26/16 ,  F02M26/23 ,  F02M26/71 ,  F02P9/002 ,  Y02T10/18

Abstract: A heavy-duty flame propagation engine has control systems and exhaust after treatment systems adapted to provide ultra-low emissions relative to Diesel engines while achieving comparable fuel consumption at reduced emission levels. The control systems include exhaust gas circulation, variable valve actuation, cylinder deactivation, pilot fuel injection, high energy ignition systems and combinations thereof to provide substantially stoichiometric combustion conditions over an entire load range of the engine. In one embodiment, the engine has direct in-cylinder fuel injection, is adapted for lean air-fuel mixture operation, and includes an oxidation catalyst and a lean NOx adsorber.

Abstract translation: 重型火焰传播发动机具有控制系统和排气后处理系统，适用于相对于柴油发动机提供超低排放，同时在降低排放水平的同时实现可比较的燃料消耗。 控制系统包括废气循环，可变气门致动，气缸停用，先导燃料喷射，高能点火系统及其组合，以在发动机的整个负载范围内提供基本上化学计量的燃烧条件。 在一个实施例中，发动机具有直接的缸内燃料喷射，适用于稀薄的空气 - 燃料混合物操作，并且包括氧化催化剂和贫NOx吸附器。

公开(公告)号：US20050069551A1

公开(公告)日：2005-03-31

申请号：US10900490

申请日：2004-07-28

Applicant: Mamoru Shoji ,  James Snyder ,  Dennis Liotta ,  Aiming Sun

Inventor： Mamoru Shoji ,  James Snyder ,  Dennis Liotta ,  Aiming Sun

IPC: A61K47/48 ,  C07D213/63 ,  C12N9/64 ,  A61K39/395 ,  C07K16/46

CPC classification number: C12N9/6437 ,  A61K47/64 ,  A61K47/642 ,  A61K47/6849 ,  C07D213/63 ,  C12Y304/21021

Abstract: Compositions and methods are provided for delivering cytotoxic compounds, such as natural curcumoids and synthetic curcumin analogs, specifically to cancer cells and to blood vessels that nourish solid tumors. The compositions include a cytotoxic drug tethered to a protein, such as factor VIIa, which can bind with high affinity to a receptor, such as tissue factor, expressed on the surface of cancer cells and vascular endothelial cells within the tumor microenvironment. Upon binding, the drug-protein-receptor complex is endocytosed and the drug is subsequently liberated inside the target cell via proteolytic cleavage. The compositions and methods may increase the efficacy of the cytotoxic agets and decrease their side effects by delivering the agents to specific target cells, such as cancer cells, vascular endothelial cells in a tumor, and metastatic foci anywhere in the body, providing the target cells express surface bound tissue factor. Additionally, methods of synthesis of cytotoxic compound-protein conjugates are provided, for example, curcuminoid-tether-linker-factor VIIa composition, as well as pharmaceutically acceptable compositions and methods for delivering a therapeutically-effective amount of a cytotoxic compound-protein conjugate together with one or more pharmaceutically acceptable carriers (additives) and/or diluents to an animal or human patient.

Abstract translation: 提供组合物和方法用于递送细胞毒性化合物，例如天然的姜黄素和合成的姜黄素类似物，特别是癌细胞和滋养实体瘤的血管。 组合物包括与诸如因子VIIa结合的蛋白质的细胞毒性药物，其可以高度亲和力结合到在肿瘤微环境中在癌细胞表面和血管内皮细胞表面上的受体，例如组织因子。 结合后，药物 - 蛋​​白 - 受体复合物被内吞，并且药物随后通过蛋白水解切割在靶细胞内释放。 组合物和方法可以通过将药物递送到特定靶细胞，例如肿瘤中的癌细胞，血管内皮细胞和体内任何地方的转移灶，来增加细胞毒性作用的功效并降低其副作用，提供靶细胞 表达结合组织因子。 此外，提供了合成细胞毒性化合物 - 蛋​​白质缀合物的方法，例如，姜黄素 - 链 - 连接体 - 因子VIIa组合物，以及用于将治疗有效量的细胞毒性化合物 - 蛋​​白质缀合物一起递送的药学上可接受的组合物和方法 与动物或人类患者的一种或多种药学上可接受的载体（添加剂）和/或稀释剂。