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公开(公告)号：US08389529B2
公开(公告)日：2013-03-05
申请号：US12722467
申请日：2010-03-11
申请人： Magdalene M. Moran , Christopher Fanger , Jayhong A. Chong , Colleen McNamara , Xiaoguang Zhen , Josh Mandel-Brehm
发明人： Magdalene M. Moran , Christopher Fanger , Jayhong A. Chong , Colleen McNamara , Xiaoguang Zhen , Josh Mandel-Brehm
IPC分类号： A61K31/522 , A61P11/06 , A61P37/08
CPC分类号： C07D473/08 , A61K31/505 , A61K31/513 , A61K31/522 , A61K31/555 , C07D239/22 , C07K14/705
摘要： The present application relates to compounds and methods for treating pain, incontinence and other conditions.
摘要翻译： 本申请涉及治疗疼痛，失禁等条件的化合物和方法。
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公开(公告)号：US20110009430A1
公开(公告)日：2011-01-13
申请号：US12722467
申请日：2010-03-11
申请人： Magdalene M. Moran , Christopher Fanger , Jayhong A. Chong , Colleen McNamara , Xiaoguang Zhen , Josh Mandel-Brehm
发明人： Magdalene M. Moran , Christopher Fanger , Jayhong A. Chong , Colleen McNamara , Xiaoguang Zhen , Josh Mandel-Brehm
IPC分类号： A61K31/522 , A61P29/00 , A61P11/06 , C12N5/071
CPC分类号： C07D473/08 , A61K31/505 , A61K31/513 , A61K31/522 , A61K31/555 , C07D239/22 , C07K14/705
摘要： The present application relates to compounds and methods for treating pain, incontinence and other conditions.
摘要翻译： 本申请涉及治疗疼痛，失禁等条件的化合物和方法。
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公开(公告)号：US20060270688A1
公开(公告)日：2006-11-30
申请号：US11431942
申请日：2006-05-09
申请人： Jayhong Chong , Christopher Fanger , Glenn Larsen , William Lumma , Magdalene Moran , Amy Ripka , Dennis Underwood , Manfred Weigele , Xiaoguang Zhen
发明人： Jayhong Chong , Christopher Fanger , Glenn Larsen , William Lumma , Magdalene Moran , Amy Ripka , Dennis Underwood , Manfred Weigele , Xiaoguang Zhen
IPC分类号： A61K31/506 , A61K31/4709
CPC分类号： A61K31/4709 , A61K9/0014 , A61K9/0053 , A61K31/427 , A61K31/47 , A61K31/498 , A61K31/506 , A61K31/538 , A61K31/55 , C07D215/54 , C07D409/04 , C07D495/04
摘要： The present application relates to compounds and methods for treating pain and other conditions related to TRPV3.
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公开(公告)号：US20070179164A1
公开(公告)日：2007-08-02
申请号：US11592783
申请日：2006-11-03
申请人： Jayhong Chong , Christopher Fanger , Glenn Larsen , William Lumma , Magdalene Moran , Amy Ripka , Dennis Underwood , Manfred Weigele , Xiaoguang Zhen
发明人： Jayhong Chong , Christopher Fanger , Glenn Larsen , William Lumma , Magdalene Moran , Amy Ripka , Dennis Underwood , Manfred Weigele , Xiaoguang Zhen
IPC分类号： A61K31/517 , C07D239/91
CPC分类号： C07D487/04 , A61K31/517 , C07D239/91 , C07D401/06 , C07D471/04
摘要： The present application relates to compounds and methods for treating pain and other conditions related to TRPV3.
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公开(公告)号：US20090143377A1
公开(公告)日：2009-06-04
申请号：US12144354
申请日：2008-06-23
申请人： Howard Ng , Manfred Weigele , Magdalene Moran , Jayhong Chong , Christopher Fanger , Glenn R. Larsen , Donato Del Camino , Neil Hayward , Steven P. Adams , Amy Ripka
发明人： Howard Ng , Manfred Weigele , Magdalene Moran , Jayhong Chong , Christopher Fanger , Glenn R. Larsen , Donato Del Camino , Neil Hayward , Steven P. Adams , Amy Ripka
IPC分类号： A61K31/522 , A61K31/5377 , A61P43/00
CPC分类号： A61K31/105 , A61K31/11 , C07D487/04
摘要： Compounds and compositions for treating disorders related to TRPA1 are described herein.
摘要翻译： 本文描述了用于治疗与TRPA1相关的疾病的化合物和组合物。
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公开(公告)号：US08163761B2
公开(公告)日：2012-04-24
申请号：US12144354
申请日：2008-06-23
申请人： Howard Ng , Manfred Weigele , Magdalene Moran , Jayhong Chong , Christopher Fanger , Glenn R. Larsen , Donato Del Camino , Neil Hayward , Steven P. Adams , Amy Ripka
发明人： Howard Ng , Manfred Weigele , Magdalene Moran , Jayhong Chong , Christopher Fanger , Glenn R. Larsen , Donato Del Camino , Neil Hayward , Steven P. Adams , Amy Ripka
IPC分类号： A61K31/519 , A61K31/535 , A01N43/90
CPC分类号： A61K31/105 , A61K31/11 , C07D487/04
摘要： Compounds and compositions for treating disorders related to TRPA1 are described herein.
摘要翻译： 本文描述了用于治疗与TRPA1相关的疾病的化合物和组合物。
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公开(公告)号：US20070213321A1
公开(公告)日：2007-09-13
申请号：US11600514
申请日：2006-11-15
申请人： Jayhong Chong , Christopher Fanger , Glenn Larsen , William Lumma , Magdalene Moran , Amy Ripka , Dennis Underwood , Manfred Weigele , Xiaoguang Zhen
发明人： Jayhong Chong , Christopher Fanger , Glenn Larsen , William Lumma , Magdalene Moran , Amy Ripka , Dennis Underwood , Manfred Weigele , Xiaoguang Zhen
IPC分类号： A61K31/55 , A61K31/4709
CPC分类号： C07D513/04 , A61K8/49 , A61K8/4906 , A61K8/4926 , A61K31/428 , A61K31/47 , A61K31/4709 , A61K31/498 , A61K31/538 , A61K31/55 , A61Q7/02 , C07D215/08 , C07D223/16 , C07D277/70 , C07D401/12 , C07D409/14 , C07D413/12 , C07D417/12
摘要： The present application relates to compounds and methods for treating pain and other conditions related to TRPV3.
摘要翻译： 本申请涉及用于治疗与TRPV3相关的疼痛和其它病症的化合物和方法。
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公开(公告)号：US20130059869A1
公开(公告)日：2013-03-07
申请号：US13402720
申请日：2012-02-22
申请人： Howard Ng , Manfred Weigele , Magdalene Moran , Jayhong Chong , Christopher Fanger , Glenn R. Larsen , Donato Del Camino , Neil Hayward , Steven P. Adams , Amy Ripka
发明人： Howard Ng , Manfred Weigele , Magdalene Moran , Jayhong Chong , Christopher Fanger , Glenn R. Larsen , Donato Del Camino , Neil Hayward , Steven P. Adams , Amy Ripka
摘要： Compounds and compositions for treating disorders related to TRPA1 are described herein.
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公开(公告)号：US20140100230A1
公开(公告)日：2014-04-10
申请号：US14102020
申请日：2013-12-10
申请人： Jayhong A. Chong , Christopher Fanger , Magdalene M. Moran , Elisha Singer , Timothy Strassmaier , Howard Ng
发明人： Jayhong A. Chong , Christopher Fanger , Magdalene M. Moran , Elisha Singer , Timothy Strassmaier , Howard Ng
IPC分类号： C07D409/12 , C07D405/14 , C07D409/06 , C07D251/16 , C07D251/46 , C07D235/30 , C07D263/58 , C07D251/52
CPC分类号： A61K31/423 , A61K31/00 , A61K31/164 , A61K31/4184 , A61K31/4196 , A61K31/53 , C07D235/30 , C07D251/16 , C07D251/46 , C07D251/52 , C07D263/58 , C07D405/14 , C07D409/06 , C07D409/12
摘要： Methods of treating a TRPC5 mediated disorder in a subject by administering an effective amount of a TRPC5 antagonist, such as a compound disclosed herein, are described.
摘要翻译： 描述了通过施用有效量的TRPC5拮抗剂（例如本文公开的化合物）来治疗受试者中TRPC5介导的病症的方法。
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公开(公告)号：US09139573B2
公开(公告)日：2015-09-22
申请号：US14102020
申请日：2013-12-10
申请人： Jayhong A. Chong , Christopher Fanger , Magdalene M. Moran , Elisha Singer , Timothy Strassmaier , Howard Ng
发明人： Jayhong A. Chong , Christopher Fanger , Magdalene M. Moran , Elisha Singer , Timothy Strassmaier , Howard Ng
IPC分类号： A61K31/00 , A61K31/164 , A61K31/53 , C07D409/12 , A61K31/4184 , C07D235/30 , C07D251/16 , C07D251/46 , C07D251/52 , C07D263/58 , C07D405/14 , C07D409/06
CPC分类号： A61K31/423 , A61K31/00 , A61K31/164 , A61K31/4184 , A61K31/4196 , A61K31/53 , C07D235/30 , C07D251/16 , C07D251/46 , C07D251/52 , C07D263/58 , C07D405/14 , C07D409/06 , C07D409/12
摘要： Methods of treating a TRPC5 mediated disorder in a subject by administering an effective amount of a TRPC5 antagonist, such as a compound disclosed herein, are described.
摘要翻译： 描述了通过施用有效量的TRPC5拮抗剂（例如本文公开的化合物）来治疗受试者中TRPC5介导的病症的方法。
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