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公开(公告)号：US09687638B2
公开(公告)日：2017-06-27
申请号：US14006901
申请日：2012-03-23
申请人： Hans Zou , Jeff Shimizu
发明人： Hans Zou , Jeff Shimizu
CPC分类号： A61M31/00 , A61K9/4808 , A61M31/002
摘要： The invention relates to a swallowable medication capsule capable 200 of dispensing fluid medicine stored in a medication compartment 211 through a valveless exit hole 207. A vent hole 206 enables ventilation of an actuator cavity 212 which houses an actuator used for displacing a surface 205 which separates the medication cavity 211 and the actuator cavity 212. By locating the vent and exit holes close to each other so that contact with contracting parts of the gastrointestinal tract and the exterior surface 221 is not able to prohibit a pressure passageway between the vent and exit holes, creation of a pressure difference of pressures in the medication and actuator cavity is prohibited.
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公开(公告)号：US20110089050A1
公开(公告)日：2011-04-21
申请号：US12673845
申请日：2008-08-29
申请人： Lucian R. Albu , Hans Zou , Jeff Shimizu
发明人： Lucian R. Albu , Hans Zou , Jeff Shimizu
IPC分类号： G01N27/413 , G01N27/416
CPC分类号： A63B69/0002 , A63B69/3641 , A63B2069/0008 , A63B2209/00 , A63B2210/50 , A63B2225/09 , A63B2225/093
摘要： An apparatus and method for electrochemical fluid analysis comprises a chamber (1202) having a depth dimension for accommodating a volume of a fluid under test, first and second electrodes (A1) disposed within the chamber and extending along the depth dimension in spaced relation with each other, and a soluble solid, such as an annealed polymer, e.g. EUDRAGIT occupying a lateral gap between the first and second electrodes. The rate of dissolution as monitored by electrochemical impedance spectroscopy (EIS) of the soluble solid within the fluid depends on the chemical concentration of a corresponding analyte present in solution in the fluid. In one embodiment a silicon-based integrated circuit device defining an upper margin includes an array of electrodes disposed along said upper margin to permit direct exposure of the electrode array to the fluid under test. The device is constructed using CMOS technology.
摘要翻译： 用于电化学流体分析的装置和方法包括具有用于容纳待测流体体积的深度尺寸的腔室（1202），设置在腔室内的第一和第二电极（A1），并且沿与所述腔室间隔开的深度尺寸延伸 另一种和可溶性固体，例如退火的聚合物，例如 EUDRAGIT占据第一和第二电极之间的横向间隙。 通过流体中可溶性固体的电化学阻抗谱（EIS）监测的溶解速率取决于流体中溶液中存在的相应分析物的化学浓度。 在一个实施例中，限定上边缘的硅基集成电路器件包括沿着所述上边缘设置的电极阵列，以允许电极阵列直接暴露于待测流体。 该器件采用CMOS技术构建。
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公开(公告)号：US08585878B2
公开(公告)日：2013-11-19
申请号：US12673845
申请日：2008-08-29
申请人： Lucian R. Albu , Hans Zou , Jeff Shimizu
发明人： Lucian R. Albu , Hans Zou , Jeff Shimizu
IPC分类号： G01N27/26
CPC分类号： A63B69/0002 , A63B69/3641 , A63B2069/0008 , A63B2209/00 , A63B2210/50 , A63B2225/09 , A63B2225/093
摘要： An apparatus and method for electrochemical fluid analysis comprises a chamber (1202) having a depth dimension for accommodating a volume of a fluid under test, first and second electrodes (A1) disposed within the chamber and extending along the depth dimension in spaced relation with each other, and a soluble solid, such as an annealed polymer, e.g. EUDRAGIT occupying a lateral gap between the first and second electrodes. The rate of dissolution as monitored by electrochemical impedance spectroscopy (EIS) of the soluble solid within the fluid depends on the chemical concentration of a corresponding analyte present in solution in the fluid. In one embodiment a silicon-based integrated circuit device defining an upper margin includes an array of electrodes disposed along said upper margin to permit direct exposure of the electrode array to the fluid under test. The device is constructed using CMOS technology.
摘要翻译： 用于电化学流体分析的装置和方法包括具有用于容纳待测流体体积的深度尺寸的腔室（1202），设置在腔室内的第一和第二电极（A1），并且沿与所述腔室间隔开的深度尺寸延伸 另一种和可溶性固体，例如退火的聚合物，例如 EUDRAGIT占据第一和第二电极之间的横向间隙。 通过流体中可溶性固体的电化学阻抗谱（EIS）监测的溶解速率取决于流体中溶液中存在的相应分析物的化学浓度。 在一个实施例中，限定上边缘的硅基集成电路器件包括沿着所述上边缘设置的电极阵列，以允许电极阵列直接暴露于待测流体。 该器件采用CMOS技术构建。
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公开(公告)号：US20130172694A1
公开(公告)日：2013-07-04
申请号：US13516356
申请日：2010-12-14
申请人： Hans Zou , Jeff Shimizu
发明人： Hans Zou , Jeff Shimizu
CPC分类号： A61B5/07 , A61B5/0008 , A61B5/01 , A61B5/036 , A61B5/0538 , A61B5/14539 , A61B5/14546 , A61B5/155 , A61B5/157 , A61B5/4839 , A61B5/4848 , A61B5/7246 , A61M31/002
摘要： A swallowable capsule (10) is provided with a drug reservoir (18) and at least one sensor (13). The drug reservoir (18) is arranged to hold a pharmaceutical composite. A wall (12) of the drug reservoir (18) comprises at least one opening for allowing fluid from the surroundings of the capsule (10) to enter the drug reservoir (18) and for allowing dissolved drug or liberated particles of the pharmaceutical composite to enter the surroundings of the capsule (10). The at least one sensor (13) is provided for monitoring a condition of the surroundings of the capsule (10).
摘要翻译： 吞咽胶囊（10）设置有药物储存器（18）和至少一个传感器（13）。 药物储存器（18）被布置成容纳药物复合物。 药物储存器（18）的壁（12）包括至少一个开口，用于允许来自胶囊（10）的周围的流体进入药物储存器（18）并允许药物复合物的溶解药物或释放的颗粒 进入胶囊（10）的周围。 所述至少一个传感器（13）被提供用于监测所述胶囊（10）的周围环境的状况。
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公开(公告)号：US20120143171A1
公开(公告)日：2012-06-07
申请号：US13262861
申请日：2010-04-01
申请人： Jeff Shimizu , Hans Zou , Johan Frederik Dijksman
发明人： Jeff Shimizu , Hans Zou , Johan Frederik Dijksman
CPC分类号： A61M5/14244 , A61M5/14276 , A61M2206/12 , A61M2210/1042
摘要： A drug delivery device (10) comprising a drug reservoir (13), at least one dispensing hole (14), an actuator system (17) and an exit path (15). The drug reservoir (13) is provided for comprising a drug. The dispensing hole (14) delivers the drug to an environment of the drug delivery device (10) when the actuator system (17) pushes the drug from the drug reservoir (13) through the dispensing hole (14). The exit path (15) couples the drug reservoir (13) to the dispensing hole (14). The exit path (15) comprises at least one entry point (16) for coupling the exit path (15) to the drug reservoir (13) and is arranged in such a way that for any possible orientation of the drug delivery device (10) at least a part of the exit path (15) is situated above the gravity center of said drug reservoir or below the dispensing hole (14).
摘要翻译： 包括药物储存器（13），至少一个分配孔（14），致动器系统（17）和出口路径（15）的药物输送装置（10）。 提供药物储存器（13）以包含药物。 当致动器系统（17）通过分配孔（14）将药物从药物储存器（13）推动时，分配孔（14）将药物输送到药物输送装置（10）的环境。 出口路径（15）将药物储存器（13）连接到分配孔（14）。 出口路径（15）包括用于将出口路径（15）耦合到药物储存器（13）的至少一个入口点（16），并且被布置成使得对于药物输送装置（10）的任何可能的取向， 所述出口路径（15）的至少一部分位于所述药物储存器的重心的上方或所述分配孔（14）的下方。
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公开(公告)号：US09616206B2
公开(公告)日：2017-04-11
申请号：US13879003
申请日：2011-09-29
申请人： Michel Gerardus Pardoel , Hans Zou , Jeff Shimizu
发明人： Michel Gerardus Pardoel , Hans Zou , Jeff Shimizu
IPC分类号： A61M31/00
CPC分类号： A61M31/002 , A61M2202/064
摘要： The invention relates to an electronic pill (102) for delivery of a medication (104) inside a mammal. The electronic pill (102) comprises a reservoir (106) for releasing the medication (104) in response to a predefined level of pressure. Furthermore a primary elastic element (108) is comprised for applying said predefined level of pressure to the reservoir (106) via a piston (110) upon release from the piston (110) of its constrained position. The piston (110) in its turn, when in constrained position, induces a predefined level of stress in the primary elastic element (108) by accordingly deforming it. The electronic pill (102) comprises a mechanism (114) for changing, upon actuation, from a constraining configuration in which the piston (110) is maintained at its constrained position to a releasing configuration in which the piston (110) is released. The mechanism (112) limits the displacement of the piston (110) during changing between said configurations to a level which is substantially smaller than the deformation introduced in the primary elastic element (108).
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公开(公告)号：US20150141967A1
公开(公告)日：2015-05-21
申请号：US13879003
申请日：2011-09-29
申请人： Michel Gerardus Pardoel , Hans Zou , Jeff Shimizu
发明人： Michel Gerardus Pardoel , Hans Zou , Jeff Shimizu
IPC分类号： A61M31/00
CPC分类号： A61M31/002 , A61M2202/064
摘要： The invention relates to an electronic pill (102) for delivery of a medication (104) inside a mammal. The electronic pill (102) comprises a reservoir (106) for releasing the medication (104) in response to a predefined level of pressure. Furthermore a primary elastic element (108) is comprised for applying said predefined level of pressure to the reservoir (106) via a piston (110) upon release from the piston (110) of its constrained position. The piston (110) in its turn, when in constrained position, induces a predefined level of stress in the primary elastic element (108) by accordingly deforming it. The electronic pill (102) comprises a mechanism (114) for changing, upon actuation, from a constraining configuration in which the piston (110) is maintained at its constrained position to a releasing configuration in which the piston (110) is released. The mechanism (112) limits the displacement of the piston (110) during changing between said configurations to a level which is substantially smaller than the deformation introduced in the primary elastic element (108).
摘要翻译： 本发明涉及用于在哺乳动物内部递送药物（104）的电子药丸（102）。 电子药丸（102）包括用于响应于预定水平的压力释放药物（104）的贮存器（106）。 此外，主弹性元件（108）被包括用于在从其约束位置的活塞（110）释放时经由活塞（110）将所述预定水平的压力施加到储存器（106）。 当处于约束位置时，活塞（110）又通过相应地使其变形而在主弹性元件（108）中引起预定水平的应力。 电子药片（102）包括用于在致动时从其中将活塞（110）保持在其约束位置的约束构造改变为释放活塞（110）的释放构造的机构（114）。 所述机构（112）在所述构造之间的变化期间将活塞（110）的位移限制到基本上小于在主弹性元件（108）中引入的变形的水平。
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公开(公告)号：US08852155B2
公开(公告)日：2014-10-07
申请号：US13390110
申请日：2010-08-09
申请人： Hans Zou , Jeff Shimizu , Lucian Remus Albu
发明人： Hans Zou , Jeff Shimizu , Lucian Remus Albu
CPC分类号： A61M31/00 , A61M31/002
摘要： A medicine reservoir (10) is provided for use with a drug delivery device (50). The medicine reservoir (10) is arranged for comprising a drug (13) and comprises a dispensing hole (15) for dispensing the drug (13) into an environment of the drug delivery device (50). The medicine reservoir (10) further comprises a deformable plug (14) which plug (14) is removable by pressure caused by a dispensing action of the drug delivery device (50).
摘要翻译： 提供药物贮存器（10）以与药物输送装置（50）一起使用。 药液贮存器（10）被布置成包括药物（13），并且包括用于将药物（13）分配到药物输送装置（50）的环境中的分配孔（15）。 药物储存器（10）还包括可变形插塞（14），该插塞（14）可以由药物输送装置（50）的分配动作引起的压力移除。
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公开(公告)号：US20140135698A1
公开(公告)日：2014-05-15
申请号：US14006901
申请日：2012-03-23
申请人： Hans Zou , Jeff Shimizu
发明人： Hans Zou , Jeff Shimizu
IPC分类号： A61M31/00
CPC分类号： A61M31/00 , A61K9/4808 , A61M31/002
摘要： The invention relates to a swallowable medication capsule capable 200 of dispensing fluid medicine stored in a medication compartment 211 through a valveless exit holt 207. A vent hole 206 enables ventilation of an actuator cavity 212 which houses an actuator used for displacing a surface 205 which separates the medication cavity 211 and the actuator cavity 212. By locating the vent and exit holes close to each other so that contact with contracting parts of the gastrointestinal tract and the exterior surface 221 is not able to prohibit a pressure passageway between the vent and exit holes, creation of a pressure difference of pressures in the medication and actuator cavity is prohibited.
摘要翻译： 本发明涉及一种能够通过无阀出口套管207分配存储在药物室211中的流体药物的可吞咽药物胶囊。通气孔206使得能够通过容纳用于移动表面205的致动器的致动器腔212的通风， 药腔211和致动器空腔212.通过使通气孔和出口孔彼此靠近，使得与胃肠道的收缩部分和外表面221的接触不能禁止通气孔和出口孔之间的压力通道 ，禁止在药物和致动器腔中形成压力差。
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公开(公告)号：US20130204233A1
公开(公告)日：2013-08-08
申请号：US13390111
申请日：2010-08-10
申请人： Hans Zou , Jeff Shimizu , Johan Frederik Dijksman
发明人： Hans Zou , Jeff Shimizu , Johan Frederik Dijksman
IPC分类号： A61M5/145
CPC分类号： A61M5/1452 , A61M31/002
摘要： A drug delivery device (50) is provided comprising a drug reservoir (10) and a piston (11). The drug reservoir (10) is provided for comprising a drug and comprises a flexible wall (22) and a dispensing hole (15) for dispensing the drug into an environment of the drug de delivery device (50). The piston (11) is provide for pressing against the flexible wall (22) to compress the drug reservoir (10) for pushing an amount of the drug through the dispensing hole (15). An adhesion interface (51) between a surface of the piston (11) and the flexible wall (22) prevents sliding between the surface of the piston (11) and the flexible wall (22).
摘要翻译： 提供了药物输送装置（50），其包括药物储存器（10）和活塞（11）。 药物储存器（10）被设置成包括药物并且包括柔性壁（22）和用于将药物分配到药物递送装置（50）的环境中的分配孔（15）。 活塞（11）用于压靠柔性壁（22）以压缩药物储存器（10），用于推动一定量的药物通过分配孔（15）。 在活塞（11）的表面和柔性壁（22）之间的粘合界面（51）防止活塞（11）的表面和柔性壁（22）之间的滑动。
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