公开(公告)号：US06595908B2

公开(公告)日：2003-07-22

申请号：US09788226

申请日：2001-02-16

Applicant: Edgar German Loffler ,  Johann Kindlein ,  Arie Luite Visscher ,  Jan D. Breemer

Inventor： Edgar German Loffler ,  Johann Kindlein ,  Arie Luite Visscher ,  Jan D. Breemer

IPC: A61M3600

CPC classification number: A61N5/1007 ,  A61N5/1027 ,  A61N2005/1008 ,  A61N2005/1009 ,  A61N2005/1011

Abstract: A modular device for implanting radioactive seeds in an animal body through needles implanted in the body. Trains of radioactive seeds and non-radioactive spacers are assembled in an assembly unit. The assembly unit comprises a device for determining activity of the seeds with an accuracy that allows distinguishing between different activities within tolerance ranges of specified nominal activities for the seeds. After implantation of the seeds in the body a pre-plan may be recalculated taking into consideration actual activities of seeds implanted. Not correctly composed trains may be disposed of. A post-plan may be determined based upon actually measured activities of implanted seeds.

Abstract translation: 用于通过植入体内的针将放射性种子植入动物体内的模块化装置。 放射性种子和非放射性隔离物的火车组装在组装单元中。 组装单元包括用于以准确度确定种子的活动的装置，其允许区分种子指定的标称活动的容许范围内的不同活动。 将种子植入体内后，可以考虑植入种子的实际活动来重新计算预先计划。 不正确组合的火车可能会被处置。 可以基于实际测量的植入种子的活动来确定后期计划。

公开(公告)号：US09730608B2

公开(公告)日：2017-08-15

申请号：US13347225

申请日：2012-01-10

Applicant: Wilco Van Der Lugt ,  Jeroen Schuurman ,  Johan Henning ,  Stefan Kwa ,  Johann Kindlein

Inventor： Wilco Van Der Lugt ,  Jeroen Schuurman ,  Johan Henning ,  Stefan Kwa ,  Johann Kindlein

IPC: A61B8/00 ,  A61B5/055 ,  G06T11/00 ,  A61B6/06 ,  A61B8/12 ,  A61B17/00 ,  A61B18/00 ,  A61N5/10 ,  A61B8/08 ,  A61B90/00

CPC classification number: A61B5/055 ,  A61B6/06 ,  A61B8/12 ,  A61B8/4461 ,  A61B8/483 ,  A61B90/36 ,  A61B2017/00274 ,  A61B2018/00547 ,  A61N5/1027 ,  A61N5/1049 ,  A61N2005/1011 ,  G06T11/008 ,  G06T2211/428

Abstract: The invention relates to a method for determining the position of a surgical tool relative to a target volume inside an animal body according to a pre-plan comprising the steps of i) obtaining a plurality of two-dimensional images of said target volume using imaging means, each 2D-image being represented by an image data slice I(x,y,z); ii) reconstructing from said plurality of image data slices I(x,y,z) a three-dimensional image of said target volume using transformation means, said 3D-image being represented by a volumetric image data array V(x,y,z); iii) displaying said three-dimensional image of said target volume to an user using displaying means.

公开(公告)号：US08105238B2

公开(公告)日：2012-01-31

申请号：US10921896

申请日：2004-08-20

Applicant: Wilco Van Der Lugt ,  Jeroen Schuurman ,  Johan Henning ,  Stefan Kwa ,  Johann Kindlein

Inventor： Wilco Van Der Lugt ,  Jeroen Schuurman ,  Johan Henning ,  Stefan Kwa ,  Johann Kindlein

IPC: A61B8/00

CPC classification number: A61B5/055 ,  A61B6/06 ,  A61B8/12 ,  A61B8/4461 ,  A61B8/483 ,  A61B90/36 ,  A61B2017/00274 ,  A61B2018/00547 ,  A61N5/1027 ,  A61N5/1049 ,  A61N2005/1011 ,  G06T11/008 ,  G06T2211/428

Abstract: A method for determining the position of a surgical tool relative to a target volume inside an animal body according to a pre-plan. The method includes the steps of i) obtaining a plurality of two-dimensional images of said target volume using an imaging device, each 2D-image being represented by an image data slice I(x,y,z); ii) reconstructing from said plurality of image data slices I(x,y,z) a three-dimensional image of said target volume using a transformation device, said 3D-image being represented by a volumetric image data array V(x,y,z); iii) displaying said three-dimensional image of said target volume to an user using a display.

Abstract translation: 根据预先计划确定外科手术工具相对于动物体内目标体积的位置的方法。 该方法包括以下步骤：i）使用成像装置获得所述目标体积的多个二维图像，每个2D图像由图像数据切片I（x，y，z）表示; ii）使用变换装置从所述多个图像数据切片I（x，y，z）重建所述目标体积的三维图像，所述3D图像由体积图像数据阵列V（x，y， z）; iii）使用显示器将所述目标体积的所述三维图像显示给用户。

公开(公告)号：US20100208274A1

公开(公告)日：2010-08-19

申请号：US12704979

申请日：2010-02-12

Applicant: Johann Kindlein ,  Tim Thurn

Inventor： Johann Kindlein ,  Tim Thurn

IPC: G01B11/24

CPC classification number: A61N5/1049 ,  A61B6/032 ,  A61B6/08 ,  A61B6/548 ,  A61B90/13 ,  A61B2090/366 ,  A61N2005/105 ,  A61N2005/1059

Abstract: The invention is related to an apparatus for the representation of a geometrical figure on the surface of a patient's body that is situated on a support, comprising at least one projection device, by which a given geometrical figure can be projected onto the three-dimensional surface of the patient's body, at least one control device and at least one optical sensor device, by which the geometrical figure projected onto the surface of the patient's body can be acquired and the acquired data can be supplied to the control device, wherein the control device is realised to determine the three-dimensional coordinates of the geometrical figure projected onto the patient's body from the data acquired by the sensor device, and wherein the control device is realised to compare the determined three-dimensional coordinates of the geometrical figure projected onto the patient's body with desired three-dimensional coordinates.

Abstract translation: 本发明涉及一种用于在患者身体的表面上表示位于支撑体上的几何图形的装置，该装置包括至少一个投影装置，通过该装置可以将给定的几何图形投影到三维表面上 患者身体的至少一个控制装置和至少一个光学传感器装置，通过该至少一个光学传感器装置可以获取投影到患者身体表面上的几何图形，并且可以将所获取的数据提供给控制装置，其中控制装置 被实现为根据由传感器装置获取的数据来确定投影到患者身体上的几何图形的三维坐标，并且其中实现控制装置以比较所确定的投影到病人身体上的几何图形的三维坐标 身体具有所需的三维坐标。

公开(公告)号：US07507197B2

公开(公告)日：2009-03-24

申请号：US10615844

申请日：2003-07-10

Applicant: Johann Kindlein ,  Wilco Van Der Lugt ,  Arie Luite Visscher

Inventor： Johann Kindlein ,  Wilco Van Der Lugt ,  Arie Luite Visscher

IPC: A61N5/00

CPC classification number: A61B18/1485 ,  A61B18/1477 ,  A61B2017/00274 ,  A61B2018/00547 ,  A61B2018/1425 ,  A61N5/1007 ,  A61N2005/1011

Abstract: A device for effecting radiation treatment of benign or malign prostate hyperplasia. The device includes a catheter probe having an elongated body with a circumferential surface which is inserted within the urethra towards the prostate. The elongated body has a longitudinal bore extending towards at least one outlet opening present in the circumferential surface near the proximal end. A catheter tube is inserted with a proximal sharp end through the longitudinal bore of the elongated body, with an outlet opening and through the urethral wall towards a desired location within the prostate. A pre-planned amount of radiation is delivered via the catheter tube at a location within the prostate for effecting the radiation treatment. The urethral insertion probe allows a quick and accurate positioning of the catheter probe and the catheter tube relative to the prostate without discomforting the patient. The catheter probe is movably accommodated within the urethral probe.

Abstract translation: 用于进行良性或恶性前列腺增生的放射治疗的装置。 该装置包括具有细长主体的导管探针，其具有朝向前列腺插入尿道内的圆周表面。 细长主体具有朝向近端附近的圆周表面中存在的至少一个出口开口延伸的纵向孔。 导管管插入具有通过细长体的纵向孔的近端尖端，具有出口开口并穿过尿道壁朝向前列腺内的期望位置。 预先计划的辐射量通过前列腺内的一个位置处的导管传送，以进行放射治疗。 尿道插入探针允许导管探针和导管相对于前列腺的快速和准确的定位，而不会使患者不舒服。 导管探针可移动地容纳在尿道探针内。

公开(公告)号：US20070038205A1

公开(公告)日：2007-02-15

申请号：US11487303

申请日：2006-07-17

Applicant: Johann Kindlein ,  Arie Visscher ,  Johan Henning ,  Wouter Engels

Inventor： Johann Kindlein ,  Arie Visscher ,  Johan Henning ,  Wouter Engels

IPC: A61B18/18

CPC classification number: A61N5/1007 ,  A61N5/1075 ,  A61N2005/1008 ,  A61N2005/1012 ,  A61N2005/1094

Abstract: The invention relates to an apparatus for effecting radiation treatment on a pre-selected anatomical portion of an animal body comprising: a group of n hollow treatment channels being inserted at one or more pre-planned positions in said pre-selected anatomical portion; a group of m delivery channels to be connected to a corresponding number m from said group of n hollow treatment channels with m being 2 or more and n being 1 or more; identifying means for identifying which one of said m delivery channels is being connected with which one of said n hollow treatment channels, said identifying means comprising a tracking element accommodated in a tracking channel, said tracking element being intended to be displaced from said tracking channel through each of said interconnected m delivery channels and m treatment channels; storage means for storing k energy emitting sources in a corresponding source-channel, with k≦m; delivery means for temporarily inserting said k energy emitting sources from their source-channels through a corresponding one of said interconnected m delivery channels and m treatment channels towards one of said pre-planned positions in said anatomical portion; coupling means for coupling at least one of said m delivery channels with a corresponding treatment channel.

Abstract translation: 本发明涉及一种用于对动物体的预先选择的解剖部分进行辐射治疗的装置，包括：一组n个中空治疗通道，其插入在所述预先选择的解剖部分中的一个或多个预先计划的位置; 一组m个传送通道，其与m个为2个以上且n为1以上的n个中空处理通道组相对应的m个连接; 用于识别所述m个输送通道中的哪一个正在与所述n个中空治疗通道中的一个连接的所述识别装置，所述识别装置包括容纳在跟踪通道中的跟踪元件，所述跟踪元件旨在从所述跟踪通道移位通过 每个所述相互连接的输送通道和m个治疗通道; 存储装置，用于将k个能量发射源存储在相应的源信道中，k <= m; 递送装置，用于将所述k个能量发射源从其源通道中通过所述互连的m个输送通道和m个治疗通道中的相应一个朝向所述解剖部分中的所述预先计划的位置之一插入; 用于将所述m个输送通道中的至少一个与相应的治疗通道联接的联接装置。

公开(公告)号：US07027560B2

公开(公告)日：2006-04-11

申请号：US10871055

申请日：2004-06-21

Applicant: Johann Kindlein

Inventor： Johann Kindlein

IPC: H01J35/12

CPC classification number: A61N5/1001 ,  A61N2005/005 ,  H01J35/065 ,  H01J35/12 ,  H01J35/32 ,  H01J2235/1204 ,  H01J2235/1212 ,  H01J2235/1216 ,  H01J2235/122 ,  H01J2235/127 ,  H01J2235/1275 ,  H01J2235/186

Abstract: The invention relates to a miniature X-ray source device connected to a distal end of a guiding wire for insertion towards a desired location within an animal body for effecting radiation therapy, said X-ray source device at least comprising a vacuum tube accommodated in said housing containing a cathode and an anode spaced apart at some distance from each other; electron freeing means for freeing electrons from the cathode; electric field means for applying during use a high-voltage electric field between said cathode and said anode for accelerating said free electrons; said vacuum tube being at least partly transparent to X-ray radiation emitted by said anode, as well as cooling means for cooling at least said anode.It is an object to provide a miniature X-ray source device having further limited constructional dimensions and an improved control of the working temperature of at least the anode and hence the working conditions of the miniature X-ray source device.According to the invention the miniature X-ray source device is hereto characterised in that said cooling means are cryogenic cooling means. More in particular in a specific embodiment of said miniature X-ray source device said cooling means comprise at least one supply passageway for supplying pressurized gas towards said anode and at least one exhaust passageway for exhausting said pressurized gas from said anode, said supply passageway and said exhaust passageway being interconnected by means of an expansion chamber surrounding at least partly said anode.

Abstract translation: 本发明涉及一种连接到导丝的远端的微型X射线源装置，用于向动物体内的所需位置插入以进行放射治疗，所述X射线源装置至少包括容纳在所述的X射线源装置中的真空管 壳体包含彼此间隔开一定距离的阴极和阳极; 用于从阴极释放电子的电子释放装置; 电场装置，用于在使用期间施加所述阴极和所述阳极之间的高压电场，用于加速所述自由电子; 所述真空管对于由所述阳极发射的X射线辐射至少部分透明，以及用于冷却至少所述阳极的冷却装置。 本发明的目的是提供一种具有进一步有限的结构尺寸的微型X射线源装置，以及对至少阳极的工作温度的改进控制以及微型X射线源装置的工作条件的改进。 根据本发明，微型X射线源装置的特征在于所述冷却装置是低温冷却装置。 更具体地在所述微型X射线源装置的具体实施例中，所述冷却装置包括用于向所述阳极供应加压气体的至少一个供应通道和用于从所述阳极排出所述加压气体的至少一个排气通道，所述供应通道和 所述排气通道通过至少部分地围绕所述阳极的膨胀室相互连接。

公开(公告)号：US20050090733A1

公开(公告)日：2005-04-28

申请号：US10921896

申请日：2004-08-20

Applicant: Wilco Van Der Lugt ,  Jeroen Schuurman ,  Johan Henning ,  Stefan Kwa ,  Johann Kindlein

Inventor： Wilco Van Der Lugt ,  Jeroen Schuurman ,  Johan Henning ,  Stefan Kwa ,  Johann Kindlein

IPC: G01R33/28 ,  A61B5/055 ,  A61B5/06 ,  A61B6/06 ,  A61B8/12 ,  A61B17/00 ,  A61B19/00 ,  A61N5/10 ,  A61B5/05

CPC classification number: A61B5/055 ,  A61B6/06 ,  A61B8/12 ,  A61B8/4461 ,  A61B8/483 ,  A61B90/36 ,  A61B2017/00274 ,  A61B2018/00547 ,  A61N5/1027 ,  A61N5/1049 ,  A61N2005/1011 ,  G06T11/008 ,  G06T2211/428

Abstract: The invention relates to a method for determining the position of a surgical tool relative to a target volume inside an animal body according to a pre-plan comprising the steps of i) obtaining a plurality of two-dimensional images of said target volume using imaging means, each 2D-image being represented by an image data slice I(x,y,z); ii) reconstructing from said plurality of image data slices I(x,y,z) a three-dimensional image of said target volume using transformation means, said 3D-image being represented by a volumetric image data array V(x,y,z); iii) displaying said three-dimensional image of said target volume to an user using displaying means.

Abstract translation: 本发明涉及一种用于根据预先计划确定外科手术工具相对于动物体内的目标体积的位置的方法，包括以下步骤：i）使用成像装置获得所述目标体积的多个二维图像 每个2D图像由图像数据切片I（x，y，z）表示; ii）使用变换装置从所述多个图像数据切片I（x，y，z）重建所述目标体积的三维图像，所述3D图像由体积图像数据阵列V（x，y，z）表示 ）; iii）使用显示装置将所述目标体积的所述三维图像显示给用户。

公开(公告)号：US20050074093A1

公开(公告)日：2005-04-07

申请号：US10811938

申请日：2004-03-30

Applicant: Johann Kindlein ,  Rudolf Scholte

Inventor： Johann Kindlein ,  Rudolf Scholte

IPC: G21K5/02 ,  A61N5/10 ,  G21K5/08 ,  H01J35/06 ,  H01J35/20 ,  H01J35/32 ,  H01J35/00 ,  H01J5/18 ,  H01J35/22

CPC classification number: A61N5/1001 ,  H01J35/065 ,  H01J35/32 ,  H01J2235/186 ,  H01J2235/205

Abstract: The invention relates to a solid state brachytherapy applicator for performing radiation therapy treatment in an animal body, said applicator at least comprising an X-ray emitting surface composed of: a vacuum cavity containing a cathode and an anode spaced apart at some distance from each other; emitting means for emitting free electrons from the cathode; electric field means for applying during use a high-voltage electric field between said cathode and said anode for accelerating said emitted free electrons towards said anode; wherein said vacuum cavity being at least partly transparent to X-ray radiation emitted by said anode. The invention furthermore relates to a radiation therapy treatment system for performing radiation therapy treatment in an animal body and to a method for performing radiation therapy treatment in an animal body using a solid state brachytherapy applicator according to the invention. According to the invention said vacuum cavity is bound by first and second plate-shaped elements spaced some distance from each other, said first plate-shaped element serving as cathode and said second plate-shaped element serving as anode.

Abstract translation: 本发明涉及用于在动物体内进行放射治疗治疗的固态近距离放射疗法施加器，所述施用器至少包括由X射线发射表面组成的真空腔，所述真空腔包含彼此间隔一定距离的阴极和阳极 ; 用于从阴极发射自由电子的发射装置; 电场装置，用于在所述阴极和所述阳极之间施加高电压电场，用于将所述发射的自由电子加速到所述阳极; 其中所述真空腔对于由所述阳极发射的X射线辐射至少部分透明。 本发明还涉及一种用于在动物体内进行放射治疗治疗的放射线治疗治疗系统和使用根据本发明的固态近距离放射疗法施加器在动物体内进行放射治疗治疗的方法。 根据本发明，所述真空腔由彼此隔开一定距离的第一和第二板状元件结合，所述第一板状元件用作阴极，所述第二板状元件用作阳极。

公开(公告)号：US09364685B2

公开(公告)日：2016-06-14

申请号：US13411132

申请日：2012-03-02

Applicant: Johann Kindlein

Inventor： Johann Kindlein

IPC: A61B5/05 ,  A61N5/10 ,  A61B19/00

CPC classification number: A61N5/1007 ,  A61B2034/2051 ,  A61N5/103 ,  A61N5/1048 ,  A61N2005/1008 ,  A61N2005/1012 ,  A61N2005/1018 ,  A61N2005/1058

Abstract: The invention relates to a method for identifying the location at least one treatment channel from a group of a plurality of treatment channels as wells as a system for effecting radiation treatment on a pre-selected anatomical portion of an animal body.According to the invention the identifying method being characterized by the steps of A selecting at least one of said plurality of treatment channels; B reconstructing the actual location of said selected treatment channel relative to said animal body; and C comparing said reconstructed location said pre-planned plurality of locations. Furthermore the system according to the invention is characterized in that identifying means are present for identifying the location of at least one treatment channel from said group of said plurality of inserted treatment channels and comparing said identified location with one or more of said pre-planned locations present in said treatment plan.

Abstract translation: 本发明涉及一种用于鉴定来自多个治疗通道的组的至少一个治疗通道的位置的方法，作为用于对预先选择的动物体的解剖部分进行辐射治疗的系统。 根据本发明，识别方法的特征在于以下步骤：A选择所述多个治疗通道中的至少一个; B重建所述选择的治疗通道相对于所述动物体的实际位置; 和C比较所述重建位置所述预先计划的多个位置。 此外，根据本发明的系统的特征在于，存在用于识别来自所述多个插入的治疗通道的所述组的至少一个治疗通道的位置的识别装置，并且将所述识别的位置与一个或多个所述预先计划的位置进行比较 出现在治疗计划中。