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公开(公告)号：US20060002908A1
公开(公告)日：2006-01-05
申请号：US10975353
申请日：2004-10-29
CPC分类号： C12R1/01 , A23C9/1234 , A23L33/135 , A23V2002/00 , A23Y2220/77 , A61K39/09 , A61K2039/52 , A61K2039/542 , C12N1/20 , Y10S435/822 , Y10S435/853 , A23V2200/3204 , A23V2200/324
摘要： A strain of Bifidobacterium isolated from resected and washed human gastrointestinal tract is significantly immunomodulatory following oral consumption in humans. The strain is useful in the prophylaxis and/or treatment of undesirable inflammatroy activity, especially gastrointestinal inflammatory activity such as inflammatory bowel disease or irritable bowel syndrome. The inflammatory activity may also be due to cancer.
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公开(公告)号：US20050100971A1
公开(公告)日：2005-05-12
申请号：US10811140
申请日：2004-03-29
申请人： John Collins , Liam O'Mahony
发明人： John Collins , Liam O'Mahony
IPC分类号： A23C9/123 , A61K35/74 , G01N33/50 , G01N33/567 , A61K38/00
CPC分类号： G01N33/5047 , A23C9/1234 , A23Y2220/77
摘要： An in vitro for testing the immunomodulatory especially anti-inflammatory or pro-inflammatory effect of a test material comprises placing a microporous support having a monolayer of epithelial cells therein in contact with a nutrient medium in a culture well. Cells of the immune system such as peripheral blood mononuclear cells are introduced into the medium and a test material is also introduced into the nutrient medium. A change in an immunological marker, especially a cytokine, particularly TNF&agr; or IL-8 in response to the test material is determined. The test material may be a strain of Lactobacillus or Bifidobacterium or other material which may be a probiotic.
摘要翻译： 用于测试测试材料的免疫调节特别是抗炎或促炎作用的体外试验包括将具有单层上皮细胞的微孔载体置于与培养井中的营养培养基接触中。 将诸如外周血单核细胞的免疫系统的细胞引入培养基中，并将测试材料引入营养培养基中。 确定免疫学标记物，尤其是细胞因子，特别是对测试材料的响应的TNFα或IL-8的变化。 测试材料可以是乳杆菌属或双歧杆菌属的菌株或其它可能是益生菌的物质。
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公开(公告)号：US20050084482A1
公开(公告)日：2005-04-21
申请号：US10804223
申请日：2004-03-19
IPC分类号： A23L1/30 , A23C9/123 , A61K9/14 , A61K9/20 , A61K9/48 , A61K39/00 , A61K47/02 , A61K47/04 , A61K47/06 , A61K47/08 , A61K47/18 , A61K47/26 , A61K47/42 , A61K47/44 , A61K47/46 , A61P1/00 , A61P1/04 , A61P1/12 , A61P19/02 , A61P29/00 , A61P31/04 , A61P31/12 , A61P35/00 , A61P37/04 , A61P37/06 , A61P43/00 , C12N1/20 , C12R1/01 , C12R1/225 , A61K45/00
CPC分类号： C12R1/01 , A23C9/1234 , A23L33/135 , A23V2002/00 , A23Y2220/77 , A61K39/09 , A61K2039/52 , A61K2039/542 , C12N1/20 , Y10S435/822 , Y10S435/853 , A23V2200/3204 , A23V2200/324
摘要： Lactobacillus salivarius is useful in the prophylaxis or treatment of undesirable inflammatory activity, especially gastrointestinal inflammatory activity such as inflammatory bowel disease or irritable bowel syndrome. The inflammatory activity may also be due to cancer. The Lactobacillus salivarius is of human origin isolated from resected and washed human gastrointestinal tract. One such strain is UCC 118 described in WO-A-9835014.
摘要翻译： 唾液乳杆菌可用于预防或治疗不希望的炎性活动，特别是胃肠炎症活动，如炎性肠病或肠易激综合征。 炎症活动也可能是由于癌症。 唾液乳杆菌是从切除和洗涤的人类胃肠道分离的人源。 一种这样的菌株是在WO-A-9835014中描述的UCC 118。
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公开(公告)号：US20050074441A1
公开(公告)日：2005-04-07
申请号：US10783020
申请日：2004-02-23
IPC分类号： A23L1/30 , A23C9/123 , A61K9/14 , A61K9/20 , A61K9/48 , A61K39/00 , A61K47/02 , A61K47/04 , A61K47/06 , A61K47/08 , A61K47/18 , A61K47/26 , A61K47/42 , A61K47/44 , A61K47/46 , A61P1/00 , A61P1/04 , A61P1/12 , A61P19/02 , A61P29/00 , A61P31/04 , A61P31/12 , A61P35/00 , A61P37/04 , A61P37/06 , A61P43/00 , C12N1/20 , C12R1/01 , C12R1/225 , A61K45/00
CPC分类号： C12R1/01 , A23C9/1234 , A23L33/135 , A23V2002/00 , A23Y2220/77 , A61K39/09 , A61K2039/52 , A61K2039/542 , C12N1/20 , Y10S435/822 , Y10S435/853 , A23V2200/3204 , A23V2200/324
摘要： A strain of Bifidobacterium isolated from resected and washed human gastrointestinal tract is significantly immunomodulatory following oral consumption in humans. The strain is useful in the prophylaxis and/or treatment of undesirable inflammatroy activity, especially gastrointestinal inflammatory activity such as inflammatory bowel disease or irritable bowel syndrome. The inflammatory activity may also be due to cancer.
摘要翻译： 从切除和洗涤的人类胃肠道分离的双歧杆菌菌株在人类口服消费后是显着的免疫调节。 该菌株可用于预防和/或治疗不期望的炎症活性，特别是胃肠炎症活动如炎性肠病或肠易激综合征。 炎症活动也可能是由于癌症。
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公开(公告)号：US08357794B2
公开(公告)日：2013-01-22
申请号：US12451250
申请日：2008-05-02
申请人： Raymond Alan Grant , Liam O'Mahony , Barbara Sheil
发明人： Raymond Alan Grant , Liam O'Mahony , Barbara Sheil
IPC分类号： C08B37/00 , C07H5/04 , C07H5/06 , A01N43/04 , A61K31/715
CPC分类号： C07H5/06 , A23L33/135 , A61K31/715 , C08B37/006
摘要： An isolated polysaccharide has the structure [-β(1,3)-D-GalpNAc-β(1,4)-D-Glcp-]n The polysaccharide may be from a Bifidobacterium strain NCIMB41003. The polysaccharide exhibits immunomodulatory activity.
摘要翻译： 分离的多糖具有结构[ - ＆bgr;（1,3）-D-GalpNAc-＆bgr;（1,4）-D-Glcp-] n多糖可以来自双歧杆菌菌株NCIMB41003。 多糖表现出免疫调节活性。
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公开(公告)号：US20070141039A1
公开(公告)日：2007-06-21
申请号：US11478545
申请日：2006-06-29
CPC分类号： C12R1/01 , A23C9/1234 , A23L33/135 , A23V2002/00 , A23Y2220/77 , A61K39/09 , A61K2039/52 , A61K2039/542 , C12N1/20 , Y10S435/822 , Y10S435/853 , A23V2200/3204 , A23V2200/324
摘要： A strain of Bifidobacterium isolated from resected and washed human gastrointestinal tract is significantly immunomodulatory following oral consumption in humans. The strain is useful in the prophylaxis and/or treatment of undesirable inflammatory activity, especially gastrointestinal inflammatory activity such as inflammatory bowel disease or irritable bowel syndrome. The inflammatory activity may also be due to cancer.
摘要翻译： 从切除和洗涤的人类胃肠道分离的双歧杆菌菌株在人类口服消费后是显着的免疫调节。 该菌株可用于预防和/或治疗不期望的炎性活动，特别是胃肠道炎症活动，如炎性肠病或肠易激综合征。 炎症活动也可能是由于癌症。
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公开(公告)号：US07195906B2
公开(公告)日：2007-03-27
申请号：US10783020
申请日：2004-02-23
CPC分类号： C12R1/01 , A23C9/1234 , A23L33/135 , A23V2002/00 , A23Y2220/77 , A61K39/09 , A61K2039/52 , A61K2039/542 , C12N1/20 , Y10S435/822 , Y10S435/853 , A23V2200/3204 , A23V2200/324
摘要： A strain of Bifidobacterium isolated from resected and washed human gastrointestinal tract is significantly immunomodulatory following oral consumption in humans. The strain is useful in the prophylaxis and/or treatment of undesirable inflammatroy activity, especially gastrointestinal inflammatory activity such as inflammatory bowel disease or irritable bowel syndrome. The inflammatory activity may also be due to cancer.
摘要翻译： 从切除和洗涤的人类胃肠道分离的双歧杆菌菌株在人类口服消费后是显着的免疫调节。 该菌株可用于预防和/或治疗不期望的炎症活性，特别是胃肠炎症活动如炎性肠病或肠易激综合征。 炎症活动也可能是由于癌症。
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公开(公告)号：US20060292133A1
公开(公告)日：2006-12-28
申请号：US11311632
申请日：2005-12-20
CPC分类号： C12R1/01 , A23C9/1234 , A23L33/135 , A23V2002/00 , A23Y2220/77 , A61K39/09 , A61K2039/52 , A61K2039/542 , C12N1/20 , Y10S435/822 , Y10S435/853 , A23V2200/3204 , A23V2200/324
摘要： Lactobacillus salivarius is useful in the prophylaxis or treatment of undesirable inflammatory activity, especially gastrointestinal inflammatory activity such as inflammatory bowel disease or irritable bowel syndrome. The inflammatory activity may also be due to cancer. The Lactobacillus salivarius is of human origin isolated from resected and washed human gastrointestinal tract. One such strain is UCC 118 described in WO-A-9835014.
摘要翻译： 唾液乳杆菌可用于预防或治疗不希望的炎性活动，特别是胃肠炎症活动，如炎性肠病或肠易激综合征。 炎症活动也可能是由于癌症。 唾液乳杆菌是从切除和洗涤的人类胃肠道分离的人源。 一种这样的菌株是在WO-A-9835014中描述的UCC 118。
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公开(公告)号：US20100183559A1
公开(公告)日：2010-07-22
申请号：US12616752
申请日：2009-11-11
申请人： Douwe Van Sinderen , Jun Xu , Wenzhu (Steven) Zhao , Raymond A. Grant , Song Yuli , Charles Bascom , Duane Larry Charbonneau , Liam O'Mahony
发明人： Douwe Van Sinderen , Jun Xu , Wenzhu (Steven) Zhao , Raymond A. Grant , Song Yuli , Charles Bascom , Duane Larry Charbonneau , Liam O'Mahony
CPC分类号： C12R1/01 , A23C9/1234 , A23C19/0323 , A23C19/062 , A23L2/382 , A23L33/135 , A23Y2300/55 , A61K35/745 , C12P19/04
摘要： The multiple embodiments described herein comprise the genome of a probiotic Bifidobacterium longum bifidobacteria strain and genes encoded by the genome. Various novel Bifidobacterium longum are described.
摘要翻译： 本文描述的多个实施方案包括益生菌双歧杆菌长双歧杆菌菌株的基因组和由基因组编码的基因。 描述了各种新型双歧杆菌。
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公开(公告)号：US20100112003A1
公开(公告)日：2010-05-06
申请号：US12479364
申请日：2009-06-05
CPC分类号： C12R1/01 , A23C9/1234 , A23L33/135 , A23V2002/00 , A23Y2220/77 , A61K39/09 , A61K2039/52 , A61K2039/542 , C12N1/20 , Y10S435/822 , Y10S435/853 , A23V2200/3204 , A23V2200/324
摘要： A strain of Bifidobacterium isolated from resected and washed human gastrointestinal tract is significantly immunomodulatory following oral consumption in humans. The strain is useful in the prophylaxis and/or treatment of undesirable inflammatory activity, especially gastrointestinal inflammatory activity such as inflammatory bowel disease or irritable bowel syndrome. The inflammatory activity may also be due to cancer.
摘要翻译： 从切除和洗涤的人类胃肠道分离的双歧杆菌菌株在人类口服消费后是显着的免疫调节。 该菌株可用于预防和/或治疗不期望的炎性活动，特别是胃肠道炎症活动，如炎性肠病或肠易激综合征。 炎症活动也可能是由于癌症。
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