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公开(公告)号:US08003354B2
公开(公告)日:2011-08-23
申请号:US12032581
申请日:2008-02-15
申请人: Min-Jui Richard Shen , Arnold Oliphant , Scott L. Butler , John R. Stuelpnagel , Mark S. Chee , Kenneth M. Kuhn , Jian-Bing Fan
发明人: Min-Jui Richard Shen , Arnold Oliphant , Scott L. Butler , John R. Stuelpnagel , Mark S. Chee , Kenneth M. Kuhn , Jian-Bing Fan
CPC分类号: C12Q1/6827 , C12Q1/6858 , C12Q2535/125 , C12Q2537/143 , C12Q2561/125 , C12Q2565/515
摘要: The invention is directed to a variety of multiplexing methods used to amplify and/or genotype a variety of samples simultaneously.
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公开(公告)号:US07226734B2
公开(公告)日:2007-06-05
申请号:US10187321
申请日:2002-06-28
CPC分类号: C12Q1/6837 , B01J19/0046 , B01J2219/00317 , B01J2219/00459 , B01J2219/00466 , B01J2219/005 , B01J2219/00572 , B01J2219/00576 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00617 , B01J2219/00619 , B01J2219/00621 , B01J2219/00626 , B01J2219/0063 , B01J2219/00637 , B01J2219/00641 , B01J2219/00644 , B01J2219/00648 , B01J2219/00659 , B01J2219/00677 , B01J2219/00702 , B01J2219/00722 , B01L3/5085 , B82Y30/00 , C12Q1/6816 , C12Q1/6825 , C12Q1/6834 , C40B40/06 , C40B60/14 , C40B70/00 , G01N33/54313 , G06K9/6202 , Y10S977/924 , C12Q2563/155 , C12Q2563/179 , C12Q2563/107 , C12Q2527/137 , C12Q2521/313 , C12Q2537/143
摘要: The invention relates to compositions and methods for multiplex decoding of microsphere array sensors.
摘要翻译: 本发明涉及微球阵列传感器的复用解码的组合物和方法。
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公开(公告)号:US20100311064A1
公开(公告)日:2010-12-09
申请号:US12790757
申请日:2010-05-28
申请人: Arnold Oliphant , John R. Stuelpnagel , Mark S. Chee , Scott L. Butler , Jian-Bing Fan , Min-Jui Richard Shen
发明人: Arnold Oliphant , John R. Stuelpnagel , Mark S. Chee , Scott L. Butler , Jian-Bing Fan , Min-Jui Richard Shen
CPC分类号: C12Q1/6876 , C12Q1/6834 , C12Q1/6837 , C12Q2600/16 , Y10T436/143333 , C12Q2525/155 , C12Q2563/131 , C12Q2563/179
摘要: The invention is directed to a variety of multiplexing methods used to amplify and/or genotype a variety of samples simultaneously.
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公开(公告)号:US07582420B2
公开(公告)日:2009-09-01
申请号:US10194958
申请日:2002-07-12
申请人: Arnold Oliphant , John R. Stuelpnagel , Mark S. Chee , Scott L. Butler , Jian-Bing Fan , Min-Jui Richard Shen
发明人: Arnold Oliphant , John R. Stuelpnagel , Mark S. Chee , Scott L. Butler , Jian-Bing Fan , Min-Jui Richard Shen
CPC分类号: C12Q1/6876 , C12Q1/6834 , C12Q1/6837 , C12Q2600/16 , Y10T436/143333 , C12Q2525/155 , C12Q2563/131 , C12Q2563/179
摘要: The invention is directed to a variety of multiplexing methods used to amplify and/or genotype a variety of samples simultaneously.
摘要翻译: 本发明涉及用于同时扩增和/或基因型多种样品的多种多样化方法。
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公开(公告)号:US20090186349A1
公开(公告)日:2009-07-23
申请号:US12212585
申请日:2008-09-17
IPC分类号: C12Q1/68
CPC分类号: C12Q1/6837 , C12Q1/6858 , C12Q1/6874 , C12Q2535/131 , C12Q2525/191 , C12Q2531/137 , C12Q2563/149
摘要: The present invention is directed to methods and compositions for the use of microsphere arrays to detect and quantify a number of nucleic acid reactions. The invention finds use in genotyping, i.e. the determination of the sequence of nucleic acids, particularly alterations such as nucleotide substitutions (mismatches) and single nucleotide polymorphisms (SNPs). Similarly, the invention finds use in the detection and quantification of a nucleic acid target using a variety of amplification techniques, including both signal amplification and target amplification. The methods and compositions of the invention can be used in nucleic acid sequencing reactions as well. All applications can include the use of adapter sequences to allow for universal arrays.
摘要翻译: 本发明涉及使用微球阵列来检测和定量许多核酸反应的方法和组合物。 本发明用于基因分型,即确定核酸序列,特别是改变,例如核苷酸取代(错配)和单核苷酸多态性(SNP)。 类似地,本发明用于使用多种扩增技术检测和定量核酸靶,包括信号放大和靶扩增两者。 本发明的方法和组合物也可用于核酸测序反应。 所有应用程序可以包括使用适配器序列来允许通用阵列。
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公开(公告)号:US06913884B2
公开(公告)日:2005-07-05
申请号:US09931285
申请日:2001-08-16
申请人: John R. Stuelpnagel , Mark S. Chee
发明人: John R. Stuelpnagel , Mark S. Chee
CPC分类号: C12Q1/6837 , C12Q2565/518 , C12Q2561/125 , C12Q2533/101
摘要: The present invention relates to detection or genotyping (or other sample analysis) of target nucleic acids following immobilization of the target nucleic acids onto a surface. The target nucleic acids can be re-used multiple times, thus conserving sample materials and simplifying sample preparation.
摘要翻译: 本发明涉及将靶核酸固定在表面上之后的靶核酸的检测或基因分型(或其他样品分析)。 目标核酸可以重复使用多次,从而节省样品物质,简化样品制备。
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公开(公告)号:US08460865B2
公开(公告)日:2013-06-11
申请号:US11739668
申请日:2007-04-24
CPC分类号: C12Q1/6837 , B01J19/0046 , B01J2219/00317 , B01J2219/00459 , B01J2219/00466 , B01J2219/005 , B01J2219/00572 , B01J2219/00576 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00617 , B01J2219/00619 , B01J2219/00621 , B01J2219/00626 , B01J2219/0063 , B01J2219/00637 , B01J2219/00641 , B01J2219/00644 , B01J2219/00648 , B01J2219/00659 , B01J2219/00677 , B01J2219/00702 , B01J2219/00722 , B01L3/5085 , B82Y30/00 , C12Q1/6816 , C12Q1/6825 , C12Q1/6834 , C40B40/06 , C40B60/14 , C40B70/00 , G01N33/54313 , G06K9/6202 , Y10S977/924 , C12Q2563/155 , C12Q2563/179 , C12Q2563/107 , C12Q2527/137 , C12Q2521/313 , C12Q2537/143
摘要: The invention relates to compositions and methods for multiplex decoding of microsphere array sensors.
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公开(公告)号:US20100015626A1
公开(公告)日:2010-01-21
申请号:US12507022
申请日:2009-07-21
申请人: Arnold Oliphant , John R. Stuelpnagel , Mark S. Chee , Scott L. Butler , Jian-Bing Fan , Min-Jui Richard Shen
发明人: Arnold Oliphant , John R. Stuelpnagel , Mark S. Chee , Scott L. Butler , Jian-Bing Fan , Min-Jui Richard Shen
IPC分类号: C12Q1/68
CPC分类号: C12Q1/6876 , C12Q1/6834 , C12Q1/6837 , C12Q2600/16 , Y10T436/143333 , C12Q2525/155 , C12Q2563/131 , C12Q2563/179
摘要: The invention is directed to a variety of multiplexing methods used to amplify and/or genotype a variety of samples simultaneously.
摘要翻译: 本发明涉及用于同时扩增和/或基因型多种样品的多种多样化方法。
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公开(公告)号:US20080242555A1
公开(公告)日:2008-10-02
申请号:US12032581
申请日:2008-02-15
申请人: Min-Jui Richard Shen , Arnold Oliphant , Scott L. Butler , John R. Stuelpnagel , Mark S. Chee , Kenneth M. Kuhn , Jian-Bing Fan
发明人: Min-Jui Richard Shen , Arnold Oliphant , Scott L. Butler , John R. Stuelpnagel , Mark S. Chee , Kenneth M. Kuhn , Jian-Bing Fan
IPC分类号: C40B30/04
CPC分类号: C12Q1/6827 , C12Q1/6858 , C12Q2535/125 , C12Q2537/143 , C12Q2561/125 , C12Q2565/515
摘要: The invention is directed to a variety of multiplexing methods used to amplify and/or genotype a variety of samples simultaneously.
摘要翻译: 本发明涉及用于同时扩增和/或基因型多种样品的多种多样化方法。
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30.
公开(公告)号:US07060431B2
公开(公告)日:2006-06-13
申请号:US09344526
申请日:1999-06-24
CPC分类号: C12Q1/6837 , B01J19/0046 , B01J2219/00317 , B01J2219/00459 , B01J2219/00466 , B01J2219/005 , B01J2219/00572 , B01J2219/00576 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00617 , B01J2219/00619 , B01J2219/00621 , B01J2219/00626 , B01J2219/0063 , B01J2219/00637 , B01J2219/00641 , B01J2219/00644 , B01J2219/00648 , B01J2219/00659 , B01J2219/00677 , B01J2219/00702 , B01J2219/00722 , B01L3/5085 , B82Y30/00 , C12Q1/6816 , C12Q1/6825 , C12Q1/6834 , C40B40/06 , C40B60/14 , C40B70/00 , G01N33/54313 , G06K9/6202 , Y10S977/924 , C12Q2563/155 , C12Q2563/179 , C12Q2563/107 , C12Q2527/137 , C12Q2521/313 , C12Q2537/143
摘要: The invention relates to compositions and methods for decoding microsphere array sensors.
摘要翻译: 本发明涉及用于解码微球阵列传感器的组合物和方法。
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