公开(公告)号：US6016448A

公开(公告)日：2000-01-18

申请号：US179619

申请日：1998-10-27

申请人： James W. Busacker ,  Can Cinbis

发明人： James W. Busacker ,  Can Cinbis

IPC分类号： A61N1/37 ,  A61N1/378

CPC分类号： A61N1/3708 ,  A61N1/3688

摘要： An automatic, body-implantable medical device having at least two modes of operation is disclosed. The device is provided with circuitry for automatically detecting when the device has been implanted in a patient, so that the device can automatically switch from a first mode to a second mode of operation upon implantation. In one embodiment, the first mode is a power conserving mode in which one or more non-essential sub-systems of the device are disabled. Prior to detection of implant, at least two conditions of the device known to reflect whether the device has been implanted are monitored. After implant has been detected, situations in which power to the device is disrupted and then restored will cause the device to enter a predefined "power-on-reset" mode of operation. Prior to detection of implant, however, such conditions do not result in the device entering the power-on-reset mode, or this mode is reset. An Elective Replacement Indicator mode is also used which is based on measured impedance against a target battery impedance. When the measured battery impedance reaches the target level, the voltage of the battery that precipitates an ERI condition is modified.

摘要翻译： 公开了具有至少两种操作模式的自动植入式医疗装置。 该装置设置有用于自动检测装置何时植入患者的电路，使得装置可以在植入时自动地从第一模式切换到第二模式。 在一个实施例中，第一模式是功率节省模式，其中该设备的一个或多个非必要子系统被禁用。 在检测植入物之前，监测已知反映装置是否植入的装置的至少两个条件。 在检测到植入物之后，设备电源中断然后恢复的情况将导致设备进入预定义的“上电复位”操作模式。 然而，在检测到植入物之前，这种条件不会导致器件进入上电复位模式，或者该模式被复位。 还使用选择性替换指示器模式，其基于针对目标电池阻抗的测量阻抗。 当测得的电池阻抗达到目标水平时，会改变引起ERI条件的电池电压。

公开(公告)号：US09867990B2

公开(公告)日：2018-01-16

申请号：US12915788

申请日：2010-10-29

申请人： Can Cinbis ,  David A. Anderson ,  Michael A. Reinert ,  Xiaonan Shen ,  James K. Carney ,  Michael B. Terry

发明人： Can Cinbis ,  David A. Anderson ,  Michael A. Reinert ,  Xiaonan Shen ,  James K. Carney ,  Michael B. Terry

IPC分类号： A61N1/40 ,  A61N1/372 ,  A61B5/00 ,  A61N1/08 ,  H04B13/00

CPC分类号： A61N1/37217 ,  A61B5/0028 ,  A61N1/08 ,  H04B13/005

摘要： Aspects of the present disclosure include a medical device system including an implantable medical device and an external device with three or more electrodes configured to contact a patient's skin. The external device either transmits or receives a test signal to or from the implantable medical device using a plurality of possible receive dipoles, where each possible receive dipole is formed by a pair of electrodes. A signal quality monitor, either at the implantable medical device or at the external device, measures a signal quality for the possible receive dipoles.

公开(公告)号：US09126049B2

公开(公告)日：2015-09-08

申请号：US12797781

申请日：2010-06-10

申请人： Jonathan L. Kuhn ,  Can Cinbis ,  David A. Anderson ,  James K. Carney

发明人： Jonathan L. Kuhn ,  Can Cinbis ,  David A. Anderson ,  James K. Carney

IPC分类号： A61B5/00 ,  A61N1/362 ,  A61B5/02 ,  A61B5/145 ,  A61B5/1459 ,  A61N1/365 ,  A61N1/39 ,  A61B5/0215 ,  A61B5/042 ,  A61B5/11

CPC分类号： A61N1/3622 ,  A61B5/02028 ,  A61B5/0215 ,  A61B5/042 ,  A61B5/1116 ,  A61B5/14542 ,  A61B5/1459 ,  A61N1/36557 ,  A61N1/3956

摘要： An implantable medical device for detecting and treating an arrhythmia includes an optical sensor adapted for positioning adjacent to a blood-perfused tissue volume. In one embodiment for controlling arrhythmia therapies delivered by the device, the optical sensor is controlled to emit light in response to detecting an arrhythmia, detect light scattered by the volume of blood perfused tissue including measuring an optical sensor output signal corresponding to the intensity of scattered light for at least four spaced-apart wavelengths, and compute a volume-independent measure of tissue oxygen saturation from the detected light. The hemodynamic status of the arrhythmia is detected in response to the measure of tissue oxygen saturation.

摘要翻译： 用于检测和治疗心律失常的可植入医疗装置包括适于邻近于血液灌注的组织体积定位的光学传感器。 在用于控制由装置传送的心律失常治疗的一个实施例中，响应于检测到心律失常，控制光学传感器发光，检测由血液灌注组织的体积散射的光，包括测量对应于散射强度的光学传感器输出信号 用于至少四个间隔波长的光，并且从检测到的光计算组织氧饱和度的体积独立测量。 响应于组织氧饱和度的测量，检测心律失常的血液动力学状态。

公开(公告)号：US09042983B2

公开(公告)日：2015-05-26

申请号：US11930583

申请日：2007-10-31

申请人： Can Cinbis ,  Bozidar Ferek-Petric ,  Branko Breyer

发明人： Can Cinbis ,  Bozidar Ferek-Petric ,  Branko Breyer

IPC分类号： A61N1/00 ,  A61N1/05 ,  A61B5/027 ,  A61N1/365 ,  A61N1/08 ,  A61N1/375

CPC分类号： A61N1/056 ,  A61B5/027 ,  A61N1/08 ,  A61N1/36514 ,  A61N1/36571 ,  A61N1/375

摘要： An implantable medical device lead having a flow measurement sensor mounted thereon is provided with a capsule mounted proximate to the sensor. The capsule is used to house electrical circuitry corresponding to the sensor in order to prevent impedance on conductors of the lead, which gradually decreases over chronic periods, from directly affecting signal transmission between the sensor and the electrical circuitry. The electrical circuitry includes a charge amplifier used for processing signals from the sensor. In some cases, the amplifier can be initially calibrated and periodically tuned so as to have consistent functioning with the sensor over chronic periods.

摘要翻译： 具有安装在其上的流量测量传感器的可植入医疗装置引线设置有靠近传感器安装的胶囊。 胶囊用于容纳对应于传感器的电路，以便防止在慢性期逐渐减少的导线的阻抗直接影响传感器和电路之间的信号传输。 电路包括用于处理来自传感器的信号的电荷放大器。 在某些情况下，可以对放大器进行初始校准并定期调谐，以便在慢性期间与传感器具有一致的功能。

公开(公告)号：US08170650B2

公开(公告)日：2012-05-01

申请号：US12039242

申请日：2008-02-28

申请人： Can Cinbis ,  James K. Carney ,  William T. Donofrio ,  Robert M. Ecker

发明人： Can Cinbis ,  James K. Carney ,  William T. Donofrio ,  Robert M. Ecker

IPC分类号： A61B6/00

CPC分类号： A61B5/1459 ,  A61B5/0059 ,  A61B5/024 ,  A61B5/046 ,  A61B5/0464 ,  A61B5/14542 ,  A61B5/7214 ,  A61N1/3925

摘要： A medical device for sensing cardiac events that includes a plurality of light sources capable of emitting light at a plurality of wavelengths, and a detector to detect the emitted light. A processor generates an ambient light measurement in response to ambient light detected by the detector, generates a plurality of light measurements in response to the emitted light detected by the detector, and adjusts the plurality of light measurements in response to the ambient light measurement.

摘要翻译： 一种用于感测心脏事件的医疗装置，其包括能够发射多个波长的光的多个光源，以及检测器，用于检测发射的光。 处理器响应于由检测器检测到的环境光产生环境光测量，响应于由检测器检测到的发射光产生多个光测量，并且响应于环境光测量来调整多个光测量。

公开(公告)号：US20120035490A1

公开(公告)日：2012-02-09

申请号：US12852740

申请日：2010-08-09

申请人： Xiaonan Shen ,  Can Cinbis

发明人： Xiaonan Shen ,  Can Cinbis

IPC分类号： A61B5/0464 ,  A61B5/053

CPC分类号： A61B5/6846 ,  A61B5/0245 ,  A61B5/0538 ,  A61N1/3937 ,  A61N1/3956 ,  A61N1/3987

摘要： An implantable medical device system and associated method monitor changes in transimpedance in a body tissue due to changes in cardiac pulsatility. A first dipole is used to deliver a non-stimulating electrical current. The first dipole includes a first electrode and a second electrode adapted to be deployed along a first body location. A second dipole is used to measure a voltage resulting from the non-stimulating electrical current being conducted through a portion of a patient's body. The second dipole includes a third electrode and a fourth electrode different than the first electrode and the second electrode and adapted to be deployed along a second body location spaced apart from the first body location.

摘要翻译： 可植入医疗装置系统和相关方法监测由于心脏搏动的变化而导致的身体组织中的跨阻抗变化。 第一偶极子用于传递非刺激电流。 第一偶极子包括适于沿着第一身体位置展开的第一电极和第二电极。 使用第二偶极子来测量通过患者身体的一部分传导的非刺激性电流产生的电压。 第二偶极子包括不同于第一电极和第二电极的第三电极和第四电极，并且适于沿着与第一主体位置间隔开的第二主体位置展开。

公开(公告)号：US08090432B2

公开(公告)日：2012-01-03

申请号：US12039294

申请日：2008-02-28

申请人： Can Cinbis ,  James K. Carney

发明人： Can Cinbis ,  James K. Carney

IPC分类号： A61B6/00

CPC分类号： A61B5/1459 ,  A61B5/0059 ,  A61B5/024 ,  A61B5/046 ,  A61B5/0464 ,  A61B5/14542 ,  A61B5/7214 ,  A61N1/3925

摘要： A medical device for sensing cardiac events that includes a plurality of electrodes sensing cardiac signals utilized to identify a cardiac event, a plurality of light sources capable of emitting light at a plurality of wavelengths, and a detector to detect the emitted light. A processor determines a plurality of light measurements in response to the emitted light detected by the detector, an isobestic blood volume index in response to determined light measurements of the plurality of light measurements from a first light source of the plurality of light sources emitting light at an isobestic wavelength, determines an oxygen index associated with light measurements of the plurality of light measurements from a light source of the plurality of light sources other than the first light source, and verifies the identifying of the cardiac event in response to the determined isobestic blood volume index and the determined oxygen index.

摘要翻译： 一种用于感测心脏事件的医疗装置，其包括感测用于识别心脏事件的心脏信号的多个电极，能够发射多个波长的光的多个光源以及检测发射光的检测器。 处理器响应于由检测器检测到的发射光来确定多个光测量值，响应于来自多个光源中的多个光源的确定的光测量而测量的异常血液体积指数 异常波长，确定与来自除了第一光源之外的多个光源的光源的多个光测量的光测量相关联的氧指数，并且响应于所确定的异源血液来验证心脏事件的识别 体积指数和确定的氧指数。

公开(公告)号：US20110160801A1

公开(公告)日：2011-06-30

申请号：US12732433

申请日：2010-03-26

申请人： H. Toby Markowitz ,  Can Cinbis

发明人： H. Toby Markowitz ,  Can Cinbis

IPC分类号： A61N1/08

CPC分类号： A61B5/0028 ,  A61B5/0031 ,  A61B2034/2053 ,  A61B2560/0271 ,  A61N1/37205 ,  A61N1/37217 ,  A61N1/37241 ,  A61N1/3756

摘要： A system and method are described for delivering an implantable medical device in a patient and through a catheter. The delivery catheter comprises telemetry means for communicatively coupling the implantable medical device with an external instrumentation during implantation.

摘要翻译： 描述了用于将可植入医疗装置递送到患者体内并通过导管的系统和方法。 递送导管包括用于在植入期间将可植入医疗装置与外部装置通信地连接的遥测装置。

公开(公告)号：US20110066206A1

公开(公告)日：2011-03-17

申请号：US12845843

申请日：2010-07-29

申请人： Jonathan L. Kuhn ,  Can Cinbis ,  David A. Anderson ,  William J. Havel

发明人： Jonathan L. Kuhn ,  Can Cinbis ,  David A. Anderson ,  William J. Havel

IPC分类号： A61N1/365

CPC分类号： A61B5/14551 ,  A61B5/1459 ,  A61B5/6846 ,  A61B5/7285 ,  A61N1/36557 ,  A61N1/3925 ,  A61N1/3956

摘要： A method and device for delivering therapy that includes an electrode to sense cardiac signals and to deliver a therapy, a monitoring module detecting a cardiac event in response to the sensed cardiac signals using first detection criteria, a sensor emitting light and detecting emitted light scattered by a tissue volume adjacent the sensor to generate a corresponding detected light intensity output signal, a control module coupled to the sensor to control light emission of the sensor in response to delivering the therapy, and a controller coupled to the monitoring module, the therapy delivery module and the sensor, the controller configured to determine tissue oxygenation measurements in response to the output signal, determine a tissue oxygenation trend in response to the tissue oxygenation measurements, determine a recovery index in response to the determined tissue oxygenation trend, and control one or both of detecting a cardiac event by the monitoring module and delivery of therapy by the therapy delivery module in response to the determined recovery index.

摘要翻译： 一种用于递送疗法的方法和装置，其包括用于感测心脏信号并递送治疗的电极，监测模块，响应于使用第一检测标准的所感测到的心脏信号检测心脏事件，发射光并检测由 与所述传感器相邻的组织体积以产生相应的检测到的光强度输出信号;控制模块，耦合到所述传感器以响应于递送所述治疗来控制所述传感器的光发射;以及控制器，耦合到所述监测模块，所述治疗递送模块 以及所述传感器，所述控制器被配置为响应于所述输出信号确定组织氧合测量，响应于组织氧合测量确定组织氧合趋势，响应于所确定的组织氧合趋势确定恢复指数，并且控制一个或两个 通过监测模块检测心脏事件并进行治疗 y由治疗递送模块响应于确定的恢复指数。

公开(公告)号：US20110066204A1

公开(公告)日：2011-03-17

申请号：US12845818

申请日：2010-07-29

申请人： Jonathan L. Kuhn ,  Can Cinbis ,  David A. Anderson ,  William J. Havel

发明人： Jonathan L. Kuhn ,  Can Cinbis ,  David A. Anderson ,  William J. Havel

IPC分类号： A61B5/1455 ,  A61N1/365

CPC分类号： A61B5/14551 ,  A61B5/1459 ,  A61B5/6846 ,  A61B5/7285 ,  A61N1/36557 ,  A61N1/3925 ,  A61N1/3956

摘要： A method and device for delivering therapy that includes an electrode to sense cardiac signals and to deliver a therapy, a therapy delivery module coupled to the electrode to deliver a therapy via the electrode in response to the sensed cardiac signals, a sensor emitting light and detecting emitted light scattered by a tissue volume adjacent the sensor to generate a corresponding detected light intensity output signal, a control module coupled to the sensor to control light emission of the sensor in response to delivering the therapy; and a controller coupled to the therapy delivery module and the sensor, the controller configured to determine a tissue oxygenation measurement in response to the output signal, and determine whether the delivered therapy was successful in restoring cardiac hemodynamic function in response to the tissue oxygenation measurement.

摘要翻译： 一种用于递送治疗的方法和装置，其包括用于感测心脏信号并递送治疗的电极，治疗递送模块，其耦合到所述电极，以响应于感测到的心脏信号经由所述电极递送治疗;发射光和检测的传感器 发射由邻近传感器的组织体积散射的光，以产生相应的检测到的光强度输出信号;控制模块，其耦合到所述传感器，以响应于递送所述治疗来控制所述传感器的光发射; 以及耦合到所述治疗递送模块和所述传感器的控制器，所述控制器被配置为响应于所述输出信号确定组织氧合测量，并且确定所递送的治疗是否成功响应于所述组织氧合测量来恢复心脏血液动力学功能。