公开(公告)号：US20060084877A1

公开(公告)日：2006-04-20

申请号：US11165705

申请日：2005-06-24

Applicant: Anthony Ujhazy ,  Jonathan Wright ,  Glenn Richards ,  David Bassin ,  Michael Berthon-Jones

Inventor： Anthony Ujhazy ,  Jonathan Wright ,  Glenn Richards ,  David Bassin ,  Michael Berthon-Jones

IPC: A61B5/02 ,  A61B5/08 ,  A61M16/00

CPC classification number: A61B5/4836 ,  A61B5/0826 ,  A61B5/087 ,  A61B5/7282 ,  A61B5/746 ,  A61M16/0051 ,  A61M16/0057 ,  A61M16/0066 ,  A61M16/0069 ,  A61M16/024 ,  A61M16/06 ,  A61M2016/0021 ,  A61M2016/0036 ,  A61M2205/3344 ,  A61M2230/005 ,  A61M2230/04 ,  A61M2230/10 ,  A61M2230/18 ,  A61M2230/40 ,  A61M2230/435 ,  A61M2230/63

Abstract: Methods and apparatus for assessing the condition of and treating patients for heart failure by the delivery of continuous positive airway pressure are disclosed. Airflow of the patient is measured to determine occurrences of central apneas. A heart failure index is calculated from a count of the number of central apneas that have occurred. The present heart failure index can be compared with a previously calculated heart failure index to determine how the patient's heart failure disease has changed and how it should be treated.

Abstract translation: 公开了通过递送持续气道正压通气来评估患者心力衰竭状况和治疗方法和装置。 测量患者的气流以确定中枢性呼吸暂停的发生。 从发生的中枢性呼吸暂停的次数计算心力衰竭指数。 可以将目前的心力衰竭指数与以前计算的心力衰竭指数进行比较，以确定患者的心力衰竭疾病如何改变以及如何治疗。

公开(公告)号：US6142866A

公开(公告)日：2000-11-07

申请号：US271940

申请日：1999-03-18

Applicant: Jonathan Wright

Inventor： Jonathan Wright

IPC: H05K7/20

CPC classification number: H05K7/20572 ,  H05K7/20209 ,  H05K7/207

Abstract: An air circulation control apparatus and method for a system such as a Base Transmission (or Transceiver) System (BTS) provides a control of an ambient air flow between inside and outside of the system. The apparatus includes at least one controller, such as a fan, and a member along an air flow path of the system. The member may be moveably mounted on the inside wall of the system. The controller operates in a forcing mode or a drawing mode to open or close the member so as to allow or not allow the air flow between inside and outside of the system.

Abstract translation: 用于诸如基地传输（或收发器）系统（BTS）的系统的空气循环控制装置和方法提供对系统内部和外部之间的环境空气流的控制。 该装置包括至少一个控制器，例如风扇，以及沿着系统的空气流动路径的构件。 构件可以可移动地安装在系统的内壁上。 控制器以强制模式或绘图模式操作以打开或关闭构件，以允许或不允许系统内部和外部之间的空气流动。

公开(公告)号：US5395835A

公开(公告)日：1995-03-07

申请号：US217395

申请日：1994-03-24

Applicant: Shelly A. Glase ,  Suzanne R. Kesten ,  Lawrence D. Wise ,  Jonathan Wright

Inventor： Shelly A. Glase ,  Suzanne R. Kesten ,  Lawrence D. Wise ,  Jonathan Wright

IPC: C07D295/12 ,  A61K31/44 ,  A61K31/4402 ,  A61K31/47 ,  A61K31/495 ,  A61K31/496 ,  A61P25/18 ,  A61P25/24 ,  A61P25/30 ,  A61P43/00 ,  C07D213/38 ,  C07D215/38 ,  C07D263/58 ,  C07D275/04 ,  C07D275/06 ,  C07D277/82 ,  C07D295/13 ,  C07D307/79 ,  C07D333/66 ,  C07D401/04 ,  C07D405/04 ,  C07D409/04 ,  A61K31/50 ,  C07D401/00 ,  C07D413/00

CPC classification number: C07D275/06 ,  C07D213/38 ,  C07D295/13 ,  C07D307/79 ,  C07D333/66

Abstract: Naphthalamides are described, as well as methods for the preparation and pharmaceutical composition of same, which are useful as central nervous system agents and are particularly useful as antipsychotic agents and as agents for the treatment of disorders which respond to dopaminergic blockade including psychotic depression, substance abuse, and compulsive disorders.

Abstract translation: 描述萘二甲酰胺以及其制备方法及其药物组合物，其可用作中枢神经系统试剂，并且特别可用作抗精神病药物和作为治疗对多巴胺能阻断作用的病症的药物，包括精神抑郁症，物质 虐待和强迫症。

公开(公告)号：US07723340B2

公开(公告)日：2010-05-25

申请号：US11332617

申请日：2006-01-12

Applicant: Ronald J. Albers ,  Leticia Ayala ,  Steven S. Clareen ,  Maria Mercedes Delgado Mederos ,  Robert Hilgraf ,  Sayee G. Hegde ,  Kevin Hughes ,  Adam Kois ,  Veronique Plantevin-Krenitsky ,  Meg McCarrick ,  Lisa Nadolny ,  Moorthy S. S. Palanki ,  Kiran Sahasrabudhe ,  John Sapienza ,  Yoshitaka Satoh ,  Marianne K. Sloss ,  Elise Sudbeck ,  Jonathan Wright ,  Ian Henderson ,  Andrew G. Cole

Inventor： Ronald J. Albers ,  Leticia Ayala ,  Steven S. Clareen ,  Maria Mercedes Delgado Mederos ,  Robert Hilgraf ,  Sayee G. Hegde ,  Kevin Hughes ,  Adam Kois ,  Veronique Plantevin-Krenitsky ,  Meg McCarrick ,  Lisa Nadolny ,  Moorthy S. S. Palanki ,  Kiran Sahasrabudhe ,  John Sapienza ,  Yoshitaka Satoh ,  Marianne K. Sloss ,  Elise Sudbeck ,  Jonathan Wright ,  Ian Henderson ,  Andrew G. Cole

IPC: C07D473/32 ,  A61K31/52 ,  A61F2/82 ,  A61P3/10 ,  A61P11/00 ,  C07D239/50 ,  C07D239/48

CPC classification number: C07D473/00 ,  A61K31/52 ,  C07D473/32

Abstract: Provided herein are Aminopurine Compounds having the following structure: wherein R1, R2 and and R3 are as defined herein, compositions comprising an effective amount of an Aminopurine Compound and methods for treating or preventing cancer, a cardiovascular disease, a renal disease, an autoimmune condition, an inflammatory condition, macular degeneration, ischemia-reperfusion injury, pain and related syndromes, disease-related wasting, an asbestos-related condition, pulmonary hypertension or a condition treatable or preventable by inhibition of the JNK pathway comprising administering an effective amount of an Aminopurine Compound to a patient in need thereof.

Abstract translation: 本文提供具有以下结构的氨基嘌呤化合物：其中R1，R2和R3如本文所定义，包含有效量的氨基嘌呤化合物的组合物和治疗或预防癌症，心血管疾病，肾脏疾病，自身免疫病症 ，炎性病症，黄斑变性，缺血再灌注损伤，疼痛及相关综合征，疾病相关性消耗，石棉相关病症，肺动脉高压或通过抑制JNK途径可治疗或可预防的病症，包括施用有效量的 氨基嘌呤化合物对需要的患者。

公开(公告)号：US20100111242A1

公开(公告)日：2010-05-06

申请号：US12595572

申请日：2008-04-07

Applicant: Sture Helmersson ,  Magnus Limbäck ,  Jonathan Wright

Inventor： Sture Helmersson ,  Magnus Limbäck ,  Jonathan Wright

IPC: G21C7/32 ,  G21C7/08

CPC classification number: G21D3/06 ,  G21Y2002/50 ,  G21Y2004/40 ,  Y02E30/40

Abstract: A method of operating a nuclear reactor is disclosed. The reactor (1) encloses a core having a plurality of fuel rods (9). Each fuel rod (9) includes a cladding and fuel pellets of a nuclear fuel. The fuel pellets are arranged in an inner space of the cladding leaving a free volume comprising an upper plenum, a lower plenum and a pellet-cladding gap. The reactor is operated at a normal power and a normal inlet sub-cooling during a normal state. The reactor is monitored for detecting a defect on the cladding of any of the fuel rods. The operation of the reactor is changed to a particular state after detecting such a defect. The particular state permits an increase of the free volume in the defect fuel rod. The reactor is operated at the particular state during a limited time period, after which the reactor is operated at the normal state.

Abstract translation: 公开了一种操作核反应堆的方法。 反应器（1）包围具有多个燃料棒（9）的芯体。 每个燃料棒（9）包括核燃料的包层和燃料颗粒。 燃料颗粒被布置在包层的内部空间中，留下自由体积，其包括上部增压室，下部增压室和颗粒包层间隙。 在正常状态下，反应器以正常功率运行，正常进气冷却。 监测反应器以检测任何燃料棒的包层上的缺陷。 在检测到这样的缺陷之后，反应器的操作变为特定状态。 该特定状态允许增加缺陷燃料棒中的自由体积。 反应器在特定状态下在有限的时间段内运行，此后反应器在正常状态下运行。

公开(公告)号：US07611544B2

公开(公告)日：2009-11-03

申请号：US11855450

申请日：2007-09-14

Applicant: Delphine Allard ,  David W. Cannell ,  Michael S. DeGeorge ,  Jeremy Puco ,  Jonathan Wright

Inventor： Delphine Allard ,  David W. Cannell ,  Michael S. DeGeorge ,  Jeremy Puco ,  Jonathan Wright

IPC: A61Q5/10

CPC classification number: A61Q5/065 ,  A61K8/891 ,  A61K8/898 ,  A61K2800/594

Abstract: The invention relates to methods of artificially coloring hair including applying to hair a composition containing at least one silicone film forming resin, at least one polysilicone polymer, and at least one hair colorant.

Abstract translation: 本发明涉及人发毛发的方法，包括向毛发施用含有至少一种硅氧烷成膜树脂，至少一种聚硅氧烷聚合物和至少一种毛发着色剂的组合物。

公开(公告)号：US07589119B2

公开(公告)日：2009-09-15

申请号：US12072011

申请日：2008-02-22

Applicant: Glenn Friedman ,  Jeffrey McKie ,  Jonathan Wright ,  Sophie Perrin-Ninkovic ,  Bernd M. Stein

Inventor： Glenn Friedman ,  Jeffrey McKie ,  Jonathan Wright ,  Sophie Perrin-Ninkovic ,  Bernd M. Stein

IPC: A61K31/4025 ,  C07D405/12

CPC classification number: C07D311/16 ,  A61K31/40

Abstract: This invention relates to Benzopyranone Compounds, compositions comprising a Benzopyranone Compound and methods for treating or preventing cancer or inhibiting the growth of a cancer cell or neoplastic cell comprising administering an effective amount of a Benzopyranone Compound. The Benzopyranone Compounds have the formula: or a pharmaceutically acceptable salt thereof, wherein R1 is halogen, trifluoromethyl or C1-6 alkyl.

Abstract translation: 本发明涉及苯并吡喃酮化合物，包含苯并吡喃酮化合物的组合物和用于治疗或预防癌症或抑制癌细胞或肿瘤细胞生长的方法，包括给予有效量的苯并吡喃酮化合物。 苯并吡喃酮化合物具有下式：或其药学上可接受的盐，其中R 1是卤素，三氟甲基或C 1-6烷基。

公开(公告)号：US20080146648A1

公开(公告)日：2008-06-19

申请号：US12072011

申请日：2008-02-22

Applicant: Glenn Friedman ,  Jeffrey McKie ,  Jonathan Wright ,  Sophie Perrin-Ninkovic ,  Bernd M. Stein

Inventor： Glenn Friedman ,  Jeffrey McKie ,  Jonathan Wright ,  Sophie Perrin-Ninkovic ,  Bernd M. Stein

IPC: A61K31/40 ,  A61P35/00

CPC classification number: C07D311/16 ,  A61K31/40

Abstract: This invention relates to Benzopyranone Compounds, compositions comprising a Benzopyranone Compound and methods for treating or preventing cancer or inhibiting the growth of a cancer cell or neoplastic cell comprising administering an effective amount of a Benzopyranone Compound. The Benzopyranone Compounds have the formula: or a pharmaceutically acceptable salt thereof, wherein R1 is halogen, trifluoromethyl or C1-6 alkyl.

Abstract translation: 本发明涉及苯并吡喃酮化合物，包含苯并吡喃酮化合物的组合物和用于治疗或预防癌症或抑制癌细胞或肿瘤细胞生长的方法，包括给予有效量的苯并吡喃酮化合物。 苯并吡喃酮化合物具有下式：或其药学上可接受的盐，其中R 1是卤素，三氟甲基或C 1-6烷基。

公开(公告)号：US20070212427A1

公开(公告)日：2007-09-13

申请号：US11371580

申请日：2006-03-09

Applicant: Jonathan Wright

Inventor： Jonathan Wright

IPC: A61K31/57 ,  A61K31/56 ,  A61K31/405 ,  A61K31/202 ,  A61K33/26 ,  A61K33/04

CPC classification number: A61K31/56 ,  A61K31/202 ,  A61K31/405 ,  A61K31/4415 ,  A61K31/57 ,  A61K33/04 ,  A61K2300/00

Abstract: The basic formulation comprises a combination of three estrogens, 2-hydroxyestrone, 17-beta-estradiol and estriol, and a metabolite of an estrogen, 2-methoxyestradiol, in specified amounts. Amounts of folic acid, DHEA, testosterone, Vitamin B6, Di-Indolyl Methane, melatonin and progesterone, as well as selenium and cobalt can be added in specific amounts to the basic formulation. 2-Hydroxyestradiol, another metabolic, can also be added.

Abstract translation: 基本配方包括三种雌激素，2-羟基雌酮，17-β-雌二醇和雌三醇的组合，以及具有规定量的雌激素2-甲氧基雌二醇的代谢物。 叶酸，DHEA，睾酮，维生素B6，二吲哚甲烷，褪黑激素和孕酮以及硒和钴的量可以与基本配方相加。 也可以添加另外一种代谢的2-羟基雌二醇。

公开(公告)号：US20070135724A1

公开(公告)日：2007-06-14

申请号：US10575197

申请日：2004-10-15

Applicant: Anthony Ujhazy ,  Jonathan Wright ,  Glenn Richards ,  David Bassin ,  Michael Berthon-Jones

Inventor： Anthony Ujhazy ,  Jonathan Wright ,  Glenn Richards ,  David Bassin ,  Michael Berthon-Jones

IPC: A61B5/08

CPC classification number: A61B5/4836 ,  A61B5/0826 ,  A61B5/087 ,  A61B5/7282 ,  A61B5/746 ,  A61M16/0051 ,  A61M16/0057 ,  A61M16/0066 ,  A61M16/0069 ,  A61M16/024 ,  A61M16/06 ,  A61M2016/0021 ,  A61M2016/0036 ,  A61M2205/3344 ,  A61M2230/005 ,  A61M2230/04 ,  A61M2230/10 ,  A61M2230/18 ,  A61M2230/40 ,  A61M2230/435 ,  A61M2230/63

Abstract: Methods and apparatus for assessing the condition of and treating patients for heart failure by the delivery of continuous positive airway pressure are disclosed. Treatment of obstruction due to reflex vocal cord closure often experienced by heart failure patients is distinguished from treatment of upper airway obstruction typically associated with Obstructive Sleep Disorder. Treatment may also be implemented by delivering synchronized cardiac pressure oscillations superimposed on a respiratory pressure level to provide assistance for the heart. Heart treatment pressure dose indicator may be calculated for prescribing and monitoring the delivery of treatment. The apparatus may also generate data to track heart failure condition that may be indicative of the degree of severity of heart failure based upon breathing patterns to assist in the diagnosis and management of heart failure patients.

Abstract translation: 公开了通过递送持续气道正压通气来评估患者心力衰竭状况和治疗方法和装置。 治疗由于心力衰竭患者经常发生的反射性声带闭塞引起的阻塞与治疗通常与阻塞性睡眠障碍相关的上呼吸道阻塞是不同的。 治疗也可以通过递送叠加在呼吸压力水平上的同步心脏压力振荡来提供对心脏的辅助来实现。 可以计算心脏治疗压力剂量指标，用于处方和监测治疗的递送。 该装置还可以生成跟踪心力衰竭状况的数据，该状况可以基于呼吸模式来指示心力衰竭的严重程度，以帮助心力衰竭患者的诊断和管理。