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公开(公告)号：US09555147B2
公开(公告)日：2017-01-31
申请号：US14224261
申请日：2014-03-25
Applicant: Kimberly-Clark Worldwide, Inc.
Inventor： Xuedong Song
CPC classification number: A61L15/225 , A61F13/42 , A61L15/56 , C09B67/0077 , C09B67/0078
Abstract: The invention describes a color-developing composition that contains at least four major components: (1) a leuco dye or a combination of leuco dyes, (2) an electron-withdrawing color-developer agent or a combination of color-developers that can form colored complexes with the leuco dyes, (3) a separator or combination of separators that when present in sufficient amounts, can prevent the formation of the colored complexes between the color-developer and leuco dyes, all contained within (4) an encapsulation matrix that includes at least one film-forming and one aqueous-insoluble polymer. All of the foregoing components are dissolved together in a volatile organic solvent medium to form a homogeneous solution that can be applied as an ink on substrates, which can be incorporated as part of absorbent articles or personal care products.
Abstract translation: 本发明描述了一种显色组合物，其含有至少四个主要成分：（1）无色染料或无色染料的组合，（2）吸电子显色剂或可形成的彩色显影剂的组合 与无色染料的着色复合物，（3）分离器或分离器的组合，当以足够的量存在时，可以防止显色剂和无色染料之间的着色复合物的形成，全部包含在（4）包封基质内 包括至少一种成膜和一种水不溶性聚合物。 所有上述组分在挥发性有机溶剂介质中一起溶解以形成均匀的溶液，该溶液可作为油墨施加在基材上，其可以作为吸收制品或个人护理产品的一部分而被掺入。
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公开(公告)号：US20140207095A1
公开(公告)日：2014-07-24
申请号：US14224261
申请日：2014-03-25
Applicant: Kimberly-Clark Worldwide, Inc.
Inventor： Xuedong Song
CPC classification number: A61L15/225 , A61F13/42 , A61L15/56 , C09B67/0077 , C09B67/0078
Abstract: The invention describes a color-developing composition that contains at least four major components: (1) a leuco dye or a combination of leuco dyes, (2) an electron-withdrawing color-developer agent or a combination of color-developers that can form colored complexes with the leuco dyes, (3) a separator or combination of separators that when present in sufficient amounts, can prevent the formation of the colored complexes between the color-developer and leuco dyes, all contained within (4) an encapsulation matrix that includes at least one film-forming and one aqueous-insoluble polymer. All of the foregoing components are dissolved together in a volatile organic solvent medium to form a homogeneous solution that can be applied as an ink on substrates, which can be incorporated as part of absorbent articles or personal care products.
Abstract translation: 本发明描述了一种显色组合物，其含有至少四个主要成分：（1）无色染料或无色染料的组合，（2）吸电子显色剂或可形成的彩色显影剂的组合 与无色染料的着色复合物，（3）分离器或分离器的组合，当以足够的量存在时，可以防止显色剂和无色染料之间的着色复合物的形成，全部包含在（4）包封基质内 包括至少一种成膜和一种水不溶性聚合物。 所有上述组分在挥发性有机溶剂介质中一起溶解以形成均匀的溶液，该溶液可作为油墨施加在基材上，其可以作为吸收制品或个人护理产品的一部分而被掺入。
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23.发明申请TRIGGERABLE COMPOSITIONS FOR TWO-STAGE, CONTROLLED RELEASE OF ACTIVE CHEMISTRY 有权两级可触发组合物，控制释放活性化学物质公开(公告)号：US20140128827A1
公开(公告)日：2014-05-08
申请号：US13671291
申请日：2012-11-07
Applicant: KIMBERLY-CLARK WORLDWIDE, INC.
Inventor： Xuedong Song
CPC classification number: A61K8/44 , A61K8/11 , A61K8/8152 , A61K8/8182 , A61K2800/56 , A61L15/24 , A61L15/44 , A61L15/46 , A61L2300/602 , A61L2300/62 , A61Q19/005 , C08L39/06 , C08L33/12
Abstract: A triggerable composition for two-stage, controlled release of a functional active chemical includes an encapsulation material for encapsulating a betaine ester or betaine ester derivative including a functional active. The encapsulation material is triggerable to release the betaine ester or betaine ester derivative at a first stage upon the occurrence with an environmental stimulus, such as a pH change, an enzymatic change, and a temperature change. The betaine ester or betaine ester derivative of a functional active with at least one hydroxyl group releases the functional active through a hydrolysis reaction upon contact with an aqueous medium.
Abstract translation: 用于功能活性化学品的两阶段，可控释放的可触发组合物包括用于包封含有功能活性物质的甜菜碱酯或甜菜碱酯衍生物的包封材料。 包封材料可触发以在发生与环境刺激如pH变化，酶促变化和温度变化相关的第一阶段释放甜菜碱酯或甜菜碱酯衍生物。 具有至少一个羟基的官能活性物质的甜菜碱酯或甜菜碱酯衍生物在与水性介质接触时通过水解反应释放功能活性物质。
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24.发明授权Membrane-based lateral flow assay devices that utilize phosphorescent detection 有权利用磷光检测的基于膜的侧流测定装置公开(公告)号：US08703504B2
公开(公告)日：2014-04-22
申请号：US14017342
申请日：2013-09-04
Applicant: Kimberly-Clark Worldwide, Inc.
Inventor： Xuedong Song
IPC: G01N33/558 , G01N33/53 , G01N33/543
CPC classification number: G01N33/558 , G01N21/6428 , G01N33/5302 , G01N33/54313 , G01N33/54393 , G01N33/582 , G01N33/587 , Y10S435/805 , Y10S435/81 , Y10S435/97 , Y10S436/805 , Y10S436/81
Abstract: A lateral flow, membrane-based assay device for detecting the presence or quantity of an analyte residing in a test sample is provided. The device utilizes phosphorescence to detect the signals generated by excited phosphorescent labels. The labels may have a long emission lifetime so that background interference from many sources, such as scattered light and autofluorescence, is practically eliminated during detection. In addition, the phosphorescent labels may be encapsulated within particles to shield the labels from quenchers, such as oxygen or water, which might disrupt the phosphorescent signal.
Abstract translation: 提供了用于检测驻留在测试样品中的分析物的存在或量的侧向流动的基于膜的测定装置。 该器件利用磷光来检测激发的磷光标记产生的信号。 标签可能具有长的发光寿命，从而在检测期间实际上消除了许多来源的背景干扰，例如散射光和自发荧光。 此外，磷光标记物可以被包封在颗粒内以将标记物遮蔽猝灭剂，例如氧气或水，这可能会破坏磷光信号。
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25.发明申请公开(公告)号：US20140004506A1
公开(公告)日：2014-01-02
申请号：US14017342
申请日：2013-09-04
Applicant: Kimberly-Clark Worldwide, Inc.
Inventor： Xuedong Song
IPC: G01N21/64
CPC classification number: G01N33/558 , G01N21/6428 , G01N33/5302 , G01N33/54313 , G01N33/54393 , G01N33/582 , G01N33/587 , Y10S435/805 , Y10S435/81 , Y10S435/97 , Y10S436/805 , Y10S436/81
Abstract: A lateral flow, membrane-based assay device for detecting the presence or quantity of an analyte residing in a test sample is provided. The device utilizes phosphorescence to detect the signals generated by excited phosphorescent labels. The labels may have a long emission lifetime so that background interference from many sources, such as scattered light and autofluorescence, is practically eliminated during detection. In addition, the phosphorescent labels may be encapsulated within particles to shield the labels from quenchers, such as oxygen or water, which might disrupt the phosphorescent signal.
Abstract translation: 提供了用于检测驻留在测试样品中的分析物的存在或量的侧向流动的基于膜的测定装置。 该器件利用磷光来检测激发的磷光标记产生的信号。 标签可能具有长的发光寿命，从而在检测期间实际上消除了许多来源的背景干扰，例如散射光和自发荧光。 此外，磷光标记物可以被包封在颗粒内以将标记物遮蔽猝灭剂，例如氧气或水，这可能会破坏磷光信号。
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Patent Agency Ranking
26.发明授权公开(公告)号：US12239746B2
公开(公告)日：2025-03-04
申请号：US17642283
申请日：2019-10-23
Applicant: Kimberly-Clark Worldwide, Inc.
Inventor： Kaiyuan Yang , Xuedong Song
IPC: A61L15/20 , A61L15/60 , B01J20/26 , C07C229/08 , C07C279/02 , C07C279/14 , C08F20/06
Abstract: A method for increasing absorbent capacity of a superabsorbent material (SAM) by treating the SAM with a selected multifunctional chemical agent (MCA) or a combination of a plurality of selected MCAs is described herein. The selected MCA(s) may interact with the polymer chain of the SAM through one or a plurality of mechanisms that enhance the absorbent capacity of the SAM. In various preferred embodiments, SAMs include polyelectrolytes that are made from polymerizing mixtures of acrylic acid monomer and acrylic acid sodium salt, and L-arginine or lysine is selected as the MCA.
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公开(公告)号：US11786884B2
公开(公告)日：2023-10-17
申请号：US17917324
申请日：2020-04-30
Applicant: Kimberly-Clark Worldwide, Inc. , MCMASTER UNIVERSITY
Inventor： Xuedong Song , Kaiyuan Yang , Todd Ryan Hoare , Zohreh Jomeh Farsangi
CPC classification number: B01J20/267 , B01J20/28004 , B01J20/28016 , B01J20/3021 , B01J20/3078 , B01J20/3221 , B01J2220/68
Abstract: Superabsorbent polymers are made of copolymers including a major portion of low molecular weight monomers each individually including a backbone and a charged moiety, a minor portion of high molecular weight monomers each individually including a backbone and a charged moiety, and optionally a crosslinker. The copolymer-based superabsorbent polymers have significantly improved absorbency under load.
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28.发明申请公开(公告)号：US20220296767A1
公开(公告)日：2022-09-22
申请号：US17642283
申请日：2019-10-23
Applicant: Kimberly-Clark Worldwide, Inc.
Inventor： Kaiyuan Yang , Xuedong Song
IPC: A61L15/20 , A61L15/60 , C07C279/14 , C07C229/08 , C07C279/02 , B01J20/26 , C08F20/06
Abstract: The present invention discloses a method for increasing absorbent capacity of a superabsorbent material (SAM) by treating the SAM with a selected multifunctional chemical agent (MCA) or a combination of a plurality of selected MCAs. The selected MCA(s) may interact with the polymer chain of the SAM through one or a plurality of mechanisms that enhance the absorbent capacity of the SAM. In various preferred embodiments, SAMs include polyelectrolytes that are made from polymerizing mixtures of acrylic acid monomer and acrylic acid sodium salt, and L-arginine or lysine is selected as the MCA.
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公开(公告)号：US20190091655A1
公开(公告)日：2019-03-28
申请号：US15564766
申请日：2016-10-25
Applicant: Kimberly-Clark Worldwide, Inc.
Inventor： Xuedong Song
CPC classification number: B01J20/267 , B01J20/24 , B01J20/28023 , B01J20/28033 , B01J20/3007 , B01J20/305 , C08L33/26 , C08L5/00
Abstract: A substrate includes a double-network polymer system including a cross-linked, covalently-bonded polymer and a reversible, partially ionicly-bonded polymer, wherein the substrate has a moisture level less than or equal to 15 percent of the total weight of the substrate, wherein the substrate is porous, and wherein the substrate includes a latent retractive force. A method for manufacturing a substrate includes producing a double-network hydrogel including a cross-linked, covalently-bonded polymer and a reversible, ionicly-bonded polymer; elongating by force the double-network hydrogel in at least one direction; treating the double-network hydrogel with an organic solvent with a volatile and water-miscible organic solvent to replace a majority of water within the double-network hydrogel; evaporating the organic solvent while the double-network hydrogel is still elongated to form a substantially-dried double-network polymer system; and releasing the force to produce the substrate.
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公开(公告)号：US09895094B2
公开(公告)日：2018-02-20
申请号：US14450901
申请日：2014-08-04
Applicant: Kimberly-Clark Worldwide, Inc.
Inventor： Xuedong Song
IPC: A61B5/20 , A61B10/00 , A61F13/42 , G01N33/558 , G01N33/543 , A61F13/84
CPC classification number: A61B5/207 , A61B10/007 , A61B2010/0006 , A61F13/42 , A61F2013/8473 , A61F2013/8488 , G01N33/54306 , G01N33/558 , G01N2800/348
Abstract: A lateral flow device for testing a bodily fluid, such as urine, blood, mucous, saliva, etc., is provided. The lateral flow device is configured to be attached to an absorbent article via an attachment mechanism located on the lateral flow device or the absorbent article. The lateral flow device includes a chromatographic medium (e.g., porous membrane) that defines a detection zone that provides a signal indicative of the presence or absence of the analyte. The device may also include a control zone that provides a signal indicative of whether a sufficient amount of bodily fluid has been provided and tested. Regardless of its specific configuration, the lateral flow device is configured to be attached onto the absorbent article to provide a user or caregiver with rapid information about a health condition. For example, the device may be attached onto a diaper to provide information about the presence of enzymes or other compounds often encountered with a patient having a urinary tract infection. This information may provide an early warning system to allow the user or caregiver to seek additional testing and/or treatment. Alternatively, semi-quantitative or quantitative results may be derived from the test.
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