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    RAPID MEMBRANE ISOLATION METHOD FOR ANIMAL AND PLANT SAMPLES
    22.
    发明申请
    RAPID MEMBRANE ISOLATION METHOD FOR ANIMAL AND PLANT SAMPLES 有权
    用于动物和植物样品的快速膜分离方法

    公开(公告)号：US20130217114A1

    公开(公告)日：2013-08-22

    申请号：US13767655

    申请日：2013-02-14

    申请人： Lin Yan ,  Quanzhi Li

    发明人： Lin Yan ,  Quanzhi Li

    IPC分类号： C12N5/00

    CPC分类号： C12N5/0006 ,  C12M47/06

    摘要： Disclosed herein are methods for quickly obtaining crude membranes from cells, including animal and plant cells. The methods include incubating cells in a buffer and forcing the cells through a filter that causes rupture of the cells, and then separating the resulting crude membranes from most cytosolic proteins.

    摘要翻译： 本文公开了从细胞（包括动物和植物细胞）快速获得粗制膜的方法。 所述方法包括将细胞孵育在缓冲液中并迫使细胞通过导致细胞破裂的过滤器，然后将所得粗制膜与大多数胞质蛋白质分离。

    DIAZENIUMDIOLATE CYCLOPENTYL DERIVATIVES
    23.
    发明申请
    DIAZENIUMDIOLATE CYCLOPENTYL DERIVATIVES 有权
    二氮杂环戊烷衍生物

    公开(公告)号：US20130053352A1

    公开(公告)日：2013-02-28

    申请号：US13577797

    申请日：2011-02-10

    申请人： Amjad Ali ,  Michael Man-Chu Lo ,  Edward Metzger ,  Lin Yan

    发明人： Amjad Ali ,  Michael Man-Chu Lo ,  Edward Metzger ,  Lin Yan

    IPC分类号： A61K31/655 ,  A61P9/12 ,  C07D249/04 ,  C07C245/24

    CPC分类号： C07C291/00 ,  C07C291/08 ,  C07C2601/08 ,  C07D249/04

    摘要： A compound having the structure or a pharmaceutically acceptable salt thereof, wherein R1 is hydrogen, —OH, —O—C1-6 alkyl, ═O, or halogen; R2 is hydrogen, C(O)OR8, C6H5C(O)OR8, (CH2)1-2OH, CR9R10OH, C(O)O(CH2)0-2 aryl, C(O)NR9R10, C(O)SO2NR9R10, C6H5OR9, W—C(O)OR8, W—OR9, Y, or P(O)(OR9)(ORlO); R3 is hydrogen or —C1-6 alkyl; R4 is hydrogen, —OH or —C(O)OR9; R5 is hydrogen or deuterium; R6 and R7 are independently —C1-6 alkyl, fluoro-substituted —C1-6 alkyl, deutero-substituted —C1-6 alkyl or —(CH2)1-2R11, wherein any carbon atom of the fluoro-substituted —C1-6 alkyl is mono- or di-substituted with fluoro, and any carbon atom of the deutero-substituted —C1-6 alkyl is mono- or di-substituted with fluoro; R8, in each instance in which it occurs, is independently hydrogen, —C1-6 alkyl, or —(CH2)2N+(CH3)3; R9 and R10, in each instance in which they occur, are independently —C1-6 alkyl; R11 is —OH, —O—C1-6 alkyl, -0CD3, —OC(O)OC1-6 alkyl, —NH2, —C6H5, —N3, or W; W is an unsubslituted 5- or 6-raembered heteroaryl ring having 1, 2, or 3 nitrogen atoms, or a substituted 5- or 6-membered heteroaryl ring having 1, 2, or 3 nitrogen atoms that is mono- or di-substituted at any carbon atom with R6 or R7; Y is a 5- or 6-membered heterocyclic ring having 1, 2, 3 or 4 heteroatoms which are N, O, or S or stereoisomers thereof, or pharmaceutically acceptable salts thereof, or pharmaceutically acceptable salts of stereoisomers thereof, and methods of using the compounds for treating hypertension.

    摘要翻译： 具有结构或其药学上可接受的盐的化合物，其中R 1是氢，-OH，-O-C 1-6烷基，= O或卤素; R2是氢，C（O）OR8，C6H5C（O）OR8，（CH2）1-2OH，CR9R10OH，C（O）O（CH2）O2芳基，C（O）NR9R10，C（O）SO2NR9R10， C6H5OR9，W-C（O）OR8，W-OR9，Y或P（O）（OR9）（OR10）。 R3是氢或-C 1-6烷基; R4是氢，-OH或-C（O）OR9; R5是氢或氘; R 6和R 7独立地是C 1-6烷基，氟取代的C 1-6烷基，取代的C 1-6烷基或 - （CH 2）1-2 R 11，其中氟取代的-C 1-6的任何碳原子 烷基被氟单取代或二取代，氘取代的C 1-6烷基的任何碳原子被氟单取代或二取代; 在其每次发生的情况下，R 8独立地为氢，-C 1-6烷基或 - （CH 2）2 N +（CH 3）3; 在其各自出现的情况下，R 9和R 10独立地为-C 1-6烷基; R 11是-OH，-O-C 1-6烷基，-CD 3，-OC（O）OC 1-6烷基，-NH 2，-C 6 H 5，-N 3或W; W是具有1,2或3个氮原子的未取代的5-或6-元杂芳基环，或具有1,2或3个氮原子的取代的5-或6-元杂芳基环，其被单取代或二取代 在任何具有R6或R7的碳原子上; Y是具有1,2,3或4个杂原子的5或6元杂环，其为N，O或S或其立体异构体，或其药学上可接受的盐，或其立体异构体的药学上可接受的盐，以及使用 用于治疗高血压的化合物。

    2-(aryl)azacyclylmethyl carboxylates, sulfonates, phosphonates, phosphinates and heterocycles as S1P receptor agonists
    25.
    发明授权
    2-(aryl)azacyclylmethyl carboxylates, sulfonates, phosphonates, phosphinates and heterocycles as S1P receptor agonists 失效
    作为S1P受体激动剂的2-（芳基）氮杂环甲基甲基羧酸盐，磺酸盐，膦酸盐，次膦酸盐和杂环

    公开(公告)号：US07659294B2

    公开(公告)日：2010-02-09

    申请号：US11665046

    申请日：2005-10-18

    申请人： Jeffrey John Hale ,  Lin Yan

    发明人： Jeffrey John Hale ,  Lin Yan

    IPC分类号： A61K31/4245 ,  C07D271/10 ,  C07D413/10

    CPC分类号： C07D413/10 ,  C07D413/14

    摘要： The present invention encompasses compounds of Formula I: as well as the pharmaceutically acceptable salts thereof. The compounds are S1P1/Edg1 receptor agonists and thus have immunosuppressive, anti-inflammatory and hemostatic activities by modulating leukocyte trafficking, sequestering lymphocytes in secondary lymphoid tissues, and enhancing vascular integrity. The invention is also directed to pharmaceutical compositions containing such compounds and methods of treatment or prevention.

    摘要翻译： 本发明包括式I的化合物及其药学上可接受的盐。 化合物是S1P1 / Edg1受体激动剂，因此通过调节白细胞运输，隔离淋巴细胞在次级淋巴组织中并增强血管完整性具有免疫抑制，抗炎和止血活性。 本发明还涉及含有这些化合物和治疗或预防方法的药物组合物。

    AUTOMATIC PACKAGING SYSTEM AND METHOD
    27.
    发明申请
    AUTOMATIC PACKAGING SYSTEM AND METHOD 审中-公开
    自动包装系统及方法

    公开(公告)号：US20070174211A1

    公开(公告)日：2007-07-26

    申请号：US11308950

    申请日：2006-05-29

    申请人： CHUN-NAN OU ,  Lin Yan ,  Zhi-Wei Wang ,  Min Guo ,  Yu-Wu Yang ,  Lin-Sheng Hu

    发明人： CHUN-NAN OU ,  Lin Yan ,  Zhi-Wei Wang ,  Min Guo ,  Yu-Wu Yang ,  Lin-Sheng Hu

    IPC分类号： G06F17/00 ,  G06G7/00

    CPC分类号： G06Q50/04 ,  G06Q30/0283 ,  Y02P90/30

    摘要： An automatic packaging system is provided. The automatic packaging system includes a user interface, a selection-controlling module, an alarm-controlling module, and a package module. The user interface is for receiving user input. The selection-controlling module is for enabling and controlling a vibrating plate to select parts according to the user input, and generating a detection signal. The alarm-controlling module is for generating a package signal according to the detection signal and the user input. The package module is for packaging the parts according to the package signal.

    摘要翻译： 提供自动包装系统。 自动包装系统包括用户界面，选择控制模块，报警控制模块和包装模块。 用户界面用于接收用户输入。 所述选择控制模块用于启用和控制振动板以根据用户输入选择部件，并产生检测信号。 报警控制模块用于根据检测信号和用户输入产生封装信号。 封装模块用于根据封装信号封装零件。

    Test fixture for printed circuit board assembly
    28.
    发明授权
    Test fixture for printed circuit board assembly 失效
    印刷电路板组件测试夹具

    公开(公告)号：US06917212B2

    公开(公告)日：2005-07-12

    申请号：US10310340

    申请日：2002-12-04

    申请人： Yue Qing Zhao ,  Lin Yan ,  Ga Lei Hu

    发明人： Yue Qing Zhao ,  Lin Yan ,  Ga Lei Hu

    IPC分类号： G01R31/28 ,  G01R31/02

    CPC分类号： G01R31/2808

    摘要： A test fixture for a printed circuit board (PCB) assembly (6) includes lower and upper units (2, 4). The PCB assembly includes a PCB (60) defining two spaced positioning holes (62), and a reinforcing plate (64) defining a plurality of openings (65). The lower unit includes a fixed base (20) and an adjustable support plate (21) defining a plurality of through holes (27). The upper unit includes a movable base (40), and a test plate (41) having two rows of identical columns (44) for engaging with the support plate. The support plate includes first and second positioning members (24, 25) supporting the PCB assembly. Support posts (272) are arranged on the fixed base for supporting a bottom of the PCB. The test plate includes two positioning pins (45) engaging in the positioning holes of the PCB, and a plurality of pressing posts (46) for pressing a top of the PCB.

    摘要翻译： 用于印刷电路板（PCB）组件（6）的测试夹具包括下部和上部单元（2,4）。 PCB组件包括限定两个间隔开的定位孔（62）的PCB（60）和限定多个开口（65）的加强板（64）。 下部单元包括限定多个通孔（27）的固定基座（20）和可调节支撑板（21）。 上部单元包括可移动基座（40）和具有两排相同列（44）的测试板（41），用于与支撑板接合。 支撑板包括支撑PCB组件的第一和第二定位构件（24,25）。 支撑柱（272）布置在固定底座上，用于支撑PCB的底部。 测试板包括接合PCB的定位孔的两个定位销（45）和用于按压PCB顶部的多个按压柱（46）。