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169 条记录 (耗时 0.119 秒)

    Methods and compositions for modulating and detecting wisp activity
    26.
    发明申请
    Methods and compositions for modulating and detecting wisp activity 有权
    用于调节和检测小鼠活动的方法和组合物

    公开(公告)号：US20060073135A1

    公开(公告)日：2006-04-06

    申请号：US10519621

    申请日：2003-06-28

    申请人： Luc Desnoyers ,  Ellen Filvaroff

    发明人： Luc Desnoyers ,  Ellen Filvaroff

    IPC分类号： A61K39/395 ,  C07K16/46

    CPC分类号： C07K16/22 ,  A61K39/00 ,  A61K2039/505 ,  C07K14/47 ,  C07K16/30 ,  C07K2317/76 ,  C07K2319/00 ,  C07K2319/30

    摘要： Methods and compositions for use in modulating the activity(s) of WISP-1 polypeptide are pronided. WISP-1 antagonists inlcude anti-WISP-1 antiboties, WISP-1 immunoadhesins and WISP-1 variants (and fusion proteins thereof) which inhibit or neutralize induction or secretion of IIAS2, IIA, CD4 or RIIAMM by native human WISP-1 polypeptide in at least one type of cells or pathological conditions associated with native WISP-1 polypeptides.

    摘要翻译： 用于调节WISP-1多肽活性的方法和组合物被发现。 WISP-1拮抗剂包含抗WISP-1抗体，WISP-1免疫粘附素和WISP-1变体（及其融合蛋白），其通过天然人WISP-1多肽抑制或中和IIAS2，IIA，CD4或RIIAMM的诱导或分泌 与天然WISP-1多肽相关的至少一种类型的细胞或病理状况。

    Use of anti-IL-17 antibody for the treatment of cartilage damaged by osteoarthritis
    30.
    发明申请
    Use of anti-IL-17 antibody for the treatment of cartilage damaged by osteoarthritis 审中-公开
    使用抗IL-17抗体治疗由骨关节炎损伤的软骨

    公开(公告)号：US20050147609A1

    公开(公告)日：2005-07-07

    申请号：US10948780

    申请日：2004-09-23

    申请人： Ellen Filvaroff

    发明人： Ellen Filvaroff

    IPC分类号： A61K38/28 ,  A61K38/30 ,  A61K38/55 ,  C07K14/47 ,  C07K14/52 ,  C07K14/54 ,  A61K39/395

    CPC分类号： C07K14/54 ,  A61K38/1793 ,  A61K38/18 ,  A61K38/20 ,  A61K2039/505 ,  C07K14/47 ,  C07K14/52 ,  C07K16/244 ,  C07K2317/24 ,  C07K2319/00 ,  C07K2319/30 ,  C12N2799/026 ,  A61K2300/00

    摘要： The present invention relates to methods for the treatment and repair of cartilage, including cartilage damaged by injury or cartilagenous disorders, including degenerative cartilagenous disorders such as arthritis, comprising the administration of IL-17 and/or LIF antagonists (e.g., anti-IL-17 and anti-LIF antibodies). Optionally, the administration may be in combination with a cartilage agent (e.g., peptide growth factor, catabolism antagonist, osteo-, synovial, anti-inflammatory factor). Alternatively, the method provides for the treatment and repair of cartilage damaged by injury or cartilagenous disorders comprising the administration of IL-17 or LIF antagonists in combination with standard surgical techniques. Alternatively, the method provides for the treatment and repair of cartilage damaged by injury or cartilagenous disorders comprising the administration of chondrocytes previously treated with an effective amount of IL-17 and/or LIF antagonist. Alternatively, the method provides for the treatment of a mammal suffering from a cartilagenous disorder, comprising the adminstration of a therapeutically effective amount of an IL-17 and/or LIF antagonist.

    摘要翻译： 本发明涉及用于治疗和修复软骨的方法，包括由损伤或软骨障碍（包括退行性软骨疾病如关节炎）损伤的软骨，包括施用IL-17和/或LIF拮抗剂（例如抗IL- 17和抗LIF抗体）。 任选地，给药可以与软骨剂（例如肽生长因子，分解代谢拮抗剂，骨，滑膜，抗炎因子）组合。 或者，该方法提供了由损伤或软骨疾病损伤的软骨的治疗和修复，其包括与标准手术技术组合施用IL-17或LIF拮抗剂。 或者，该方法提供了由损伤或软骨疾病损伤的软骨的治疗和修复，包括施用有效量的IL-17和/或LIF拮抗剂治疗的软骨细胞。 或者，该方法提供治疗患有软骨障碍的哺乳动物，其包括给予治疗有效量的IL-17和/或LIF拮抗剂。