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公开(公告)号：US06516143B2
公开(公告)日：2003-02-04
申请号：US09819702
申请日：2001-03-29
申请人： Eiichi Toya , Tomio Konn , Tomohiro Nagata , Sunao Seko , Takanori Saito , Kazutoshi Miura , Harunari Hasegawa , Joji Hoshi , Katsutoshi Ishii
发明人： Eiichi Toya , Tomio Konn , Tomohiro Nagata , Sunao Seko , Takanori Saito , Kazutoshi Miura , Harunari Hasegawa , Joji Hoshi , Katsutoshi Ishii
IPC分类号： H05B302
CPC分类号： H05B3/44 , H05B3/42 , H05B3/46 , H05B2203/022
摘要： The fluid heating apparatus, in accordance with the present invention, developed to solve the technological problems described above is characterized by comprising at least a heating tube heating fluid to be supplied from fluid supply source, a heater section spirally formed on an outer periphery of the heating tube and a housing accommodating the heating tube and the heater section, wherein the heater section comprises a carbon wire heating element and a quartz glass tube in which the carbon wire heating element is enclosed.
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公开(公告)号：US5252395A
公开(公告)日：1993-10-12
申请号：US792013
申请日：1991-11-13
IPC分类号： C09J7/02 , C09J133/00 , C09J133/08 , C09J143/04 , C09J155/00
CPC分类号： C09J133/08 , C09J143/04 , C09J155/005 , C09J7/0217 , C09J2201/606 , Y10T428/2891
摘要： A pressure sensitive adhesive sheet comprising a substrate and an adhesive composition which is coated on the surface of the substrate. The main components of the adhesive composition are (a) a copolymer comprising monomeric units of an acrylic ester, (b) monomeric units of a polar acrylic compound, (c) monomeric units of a high glass transition temperature (Tg) macromonomer having a Tg of 20.degree. C. or above, (d) monomeric units of a low Tg macromonomer having a Tg of below 20.degree. C. and (e) monomeric units of an oligomer having telechelic thiol functional groups. The pressure sensitive adhesive sheet has excellent adhesive strength, resistance against formation of blisters and removability upon heating.
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公开(公告)号：US5187007A
公开(公告)日：1993-02-16
申请号：US549496
申请日：1990-06-29
IPC分类号： C09J4/06 , C09J7/02 , C09J175/16 , H01L21/00 , H01L21/302 , H01L21/68
CPC分类号： H01L21/6835 , C09J175/16 , C09J4/06 , C09J7/0207 , C09J7/0239 , C09J7/0246 , H01L21/302 , H01L21/67132 , H01L21/6836 , C09J2203/326 , H01L2221/68322 , H01L2221/68327 , Y10T428/28 , Y10T428/2809 , Y10T428/2891 , Y10T428/2896
摘要： An adhesive sheet according to the present invention comprises a substrate having coated on the surface thereof an adhesive layer consisting of an adhesive and a radiation polymerizable compound, which compound is a urethane acrylate oligomer having a molecular weight of 3,000-10,000, preferably 4,000-8,000. The adhesive sheet is preferably used in subjecting semiconductor wafers to dicing operation and no adhesive sticks to and remains on the back side surface of the wafer chips as picked up.
摘要翻译： 根据本发明的粘合片包括在其表面上涂覆有由粘合剂和可辐射聚合化合物组成的粘合剂层的基材，该化合物是分子量为3,000-10,000，优选4,000-8,000的氨基甲酸酯丙烯酸酯低聚物 。 粘合片优选用于使半导体晶片进行切割操作，并且没有粘合剂粘附并保留在拾取的晶片芯片的背侧表面上。
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公开(公告)号：US4244642A
公开(公告)日：1981-01-13
申请号：US49967
申请日：1979-06-19
申请人： Shiro Toriumi , Hiroshi Endo , Takao Saijo , Takanori Saito , Kuniaki Kamimura
发明人： Shiro Toriumi , Hiroshi Endo , Takao Saijo , Takanori Saito , Kuniaki Kamimura
CPC分类号： G03B21/116 , G06K17/0016
摘要： An aperture card reader is equipped with a unit detachably mountable on the main body for automatically feeding aperture cards. The aperture card can automatically be placed between presser plates while the unit is mounted on the main body or, alternatively, can be manually fed when the unit is detached from the main body. The aperture card is automatically fed between the presser plates with the card in a position in which the minor sides of the aperture card are oriented in the direction of feed, while the card can be manually placed between the presser plates by feeding the card in a position in which the major sides of the card are oriented in the direction of feed. The image of the microfilm mounted on the aperture card can be projected on a screen in a horizontal position when the card is fed automatically, or in a vertical position when the card is fed manually.
摘要翻译： 光圈读卡器配备有可拆卸地安装在主体上用于自动馈送光圈卡的单元。 当单元安装在主体上时，光圈卡可以自动放置在压板之间，或者当本机与主体分离时可以手动进给。 光圈卡被自动地进给到压板与卡之间的位置中，孔卡的小侧在进给方向上定向，而卡可以通过将卡馈送到卡片中来手动地放置在压板之间 卡的主要侧面朝向进给方向的位置。 安装在孔卡上的缩微胶片的图像可以在卡被自动进给时处于水平位置的屏幕上，或者当手动进给卡时处于垂直位置。
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公开(公告)号：US09175074B2
公开(公告)日：2015-11-03
申请号：US14236859
申请日：2012-08-03
CPC分类号： C07K16/18 , A61K39/39558 , A61K45/06 , A61K2039/505 , C07K16/28 , C07K16/30 , C07K2317/24 , C07K2317/732
摘要： An object of the present invention is to prepare an antibody that targets CAPRIN-1 specifically expressed on the surface of cancer cells and is superior in antitumor activity to conventional antibodies and to provide use of the antibody as a therapeutic and/or preventive agent for cancer. The present invention provides use of an antibody targeting an identified cancer antigenic protein specifically expressed on the surface of cancer cells as a therapeutic and/or preventive agent for cancer, specifically, a pharmaceutical composition for treatment and/or prevention of cancer, comprising as an active ingredient an antibody or a fragment thereof which has immunological reactivity with a CAPRIN-1 protein, the antibody or the fragment thereof comprising a heavy chain variable region comprising amino acid sequences represented by SEQ ID NOs: 5, 6, and 7 and a light chain variable region comprising amino acid sequences represented by SEQ ID NOs: 9, 10, and 11.
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公开(公告)号：US20140199311A1
公开(公告)日：2014-07-17
申请号：US14236812
申请日：2012-08-03
IPC分类号： C07K16/18 , A61K39/395
CPC分类号： C07K16/18 , A61K39/39558 , A61K2039/505 , C07K16/28 , C07K16/30 , C07K2317/24 , C07K2317/732
摘要： This invention provides an antibody targeting a cancer antigenic protein specifically expressed on the surface of cancer cells and use thereof as a therapeutic and/or preventive agent for cancer. More specifically, the present invention provides an antibody, or a fragment thereof which has immunological reactivity with a CAPRIN-1 protein, the antibody comprising a heavy chain variable region comprising complementarity determining regions of SEQ ID NOs: 5, 6, and 7 and a light chain variable region comprising complementarity determining regions of SEQ ID NOs: 9, 10, and 11, and a pharmaceutical composition for treatment and/or prevention of cancer, comprising the same as an active ingredient.
摘要翻译： 本发明提供靶向癌细胞表面特异性表达的癌抗原蛋白的抗体及其作为癌症治疗和/或预防剂的用途。 更具体地，本发明提供了与CAPRIN-1蛋白具有免疫反应性的抗体或其片段，所述抗体包含包含SEQ ID NO：5,6和7的互补决定区的重链可变区和 包含SEQ ID NO：9,10和11的互补决定区的轻链可变区和用于治疗和/或预防癌症的药物组合物，其包含其作为活性成分。
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公开(公告)号：US20140154261A1
公开(公告)日：2014-06-05
申请号：US14236859
申请日：2012-08-03
IPC分类号： C07K16/18 , A61K45/06 , A61K39/395
CPC分类号： C07K16/18 , A61K39/39558 , A61K45/06 , A61K2039/505 , C07K16/28 , C07K16/30 , C07K2317/24 , C07K2317/732
摘要： An object of the present invention is to prepare an antibody that targets CAPRIN-1 specifically expressed on the surface of cancer cells and is superior in antitumor activity to conventional antibodies and to provide use of the antibody as a therapeutic and/or preventive agent for cancer. The present invention provides use of an antibody targeting an identified cancer antigenic protein specifically expressed on the surface of cancer cells as a therapeutic and/or preventive agent for cancer, specifically, a pharmaceutical composition for treatment and/or prevention of cancer, comprising as an active ingredient an antibody or a fragment thereof which has immunological reactivity with a CAPRIN-1 protein, the antibody or the fragment thereof comprising a heavy chain variable region comprising amino acid sequences represented by SEQ ID NOs: 5, 6, and 7 and a light chain variable region comprising amino acid sequences represented by SEQ ID NOs: 9, 10, and 11.
摘要翻译： 本发明的目的是制备靶向癌细胞表面特异性表达的CAPRIN-1的抗体，对常规抗体具有优异的抗肿瘤活性，并提供抗体作为癌症治疗和/或预防剂的用途 。 本发明提供了靶向癌细胞表面特异表达的鉴定癌抗原蛋白的抗体作为癌症的治疗和/或预防剂的用途，特别是用于治疗和/或预防癌症的药物组合物，其包括作为 活性成分是与CAPRIN-1蛋白具有免疫反应性的抗体或其片段，所述抗体或其片段包含包含SEQ ID NO：5,6和7所代表的氨基酸序列的重链可变区和轻链 链可变区，其包含由SEQ ID NO：9,10和11表示的氨基酸序列。
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28.发明授权公开(公告)号：US08709418B2
公开(公告)日：2014-04-29
申请号：US13576955
申请日：2011-02-04
申请人： Fumiyoshi Okano , Takanori Saito
发明人： Fumiyoshi Okano , Takanori Saito
IPC分类号： A61K39/395 , C07K16/30 , A61K35/02
CPC分类号： C07K16/30 , A61K2039/505 , C07K16/3015 , C07K16/3053 , C07K2317/23 , C07K2317/24 , C07K2317/34 , C07K2317/732 , C07K2317/734
摘要： According to the present invention, a cancer antigen protein to be specifically expressed on the surfaces of cancer cells is identified and thus the use of an antibody targeting the cancer antigen protein as an agent for treating and/or preventing a cancer is provided. Specifically, the present invention provides a pharmaceutical composition for treating and/or preventing a cancer, which comprises an antibody comprising a heavy chain variable region that comprises SEQ ID NOS: 39, 40, and 41 and a light chain variable region that comprises SEQ ID NOS: 43, 44, and 45 or a fragment thereof as an active ingredient and having immunological reactivity with a CAPRIN-1 protein.
摘要翻译： 根据本发明，鉴定在癌细胞表面特异性表达的癌抗原蛋白，因此提供了靶向癌抗原蛋白的抗体作为治疗和/或预防癌症的药剂的用途。 具体而言，本发明提供了用于治疗和/或预防癌症的药物组合物，其包含含有包含SEQ ID NO：39,40和41的重链可变区的抗体和包含SEQ ID NO：39,40和41的轻链可变区， NOS：43,44和45或其片段作为活性成分，并与CAPRIN-1蛋白具有免疫反应性。
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公开(公告)号：US20120064469A1
公开(公告)日：2012-03-15
申请号：US13221209
申请日：2011-08-30
申请人： Koji YOSHII , Tatsuya Yamaguchi , Wenling Wang , Takanori Saito
发明人： Koji YOSHII , Tatsuya Yamaguchi , Wenling Wang , Takanori Saito
CPC分类号： F27B17/0025 , H01L21/67109 , H01L21/67248
摘要： A heat treatment apparatus and control method enabling the apparatus to settle down the internal temperature of a treating vessel to a target temperature accurately and quickly. The apparatus includes a furnace body with a heater on an inner circumferential surface thereof, a treating vessel disposed inside the furnace body, a cooling medium supply blower and cooling medium release blower connected to the furnace body, and a temperature sensor provided inside the treating vessel. A signal from the temperature sensor is sent to a heater output computing unit of a controller. The computing unit determines a heater output level to be obtained during temperature regulation with the heater only, the heater output level being based on a preset temperature that has been determined by a temperature determining unit and temperature detected by the temperature sensor. A blower output computing unit activates blower output based on the heater output level.
摘要翻译： 一种热处理装置和控制方法，使得该装置能够准确而快速地将处理容器的内部温度降至目标温度。 该装置包括在炉体内部具有加热器的炉体，设置在炉体内的处理容器，与炉体连接的冷却介质供给鼓风机和冷却介质排出鼓风机，以及设置在处理容器内的温度传感器 。 来自温度传感器的信号被发送到控制器的加热器输出计算单元。 计算单元确定仅在加热器的温度调节期间获得的加热器输出水平，加热器输出水平基于由温度确定单元确定的预设温度和由温度传感器检测的温度。 鼓风机输出计算单元基于加热器输出电平激活鼓风机输出。
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公开(公告)号：US08128567B2
公开(公告)日：2012-03-06
申请号：US12342185
申请日：2008-12-23
申请人： Sei Kato , Takanori Saito
发明人： Sei Kato , Takanori Saito
摘要： An ultrasonic imaging apparatus includes an image obtaining unit for irradiating an imaging region and obtaining tomographic image information that draws the imaging region, an input unit for inputting scan parameter value information and a target sound pressure parameter value as an index of an estimated sound pressure in the subject, an estimated maximum sound pressure parameter value calculating device for calculating an estimated maximum sound pressure parameter value in the subject on the basis of the scan parameter value information and maximum drive voltage information of a piezoelectric transducer group for generating an ultrasonic wave, and a maximum drive voltage optimization device for comparing the estimated maximum sound pressure parameter value and the target sound pressure parameter value and optimizing the maximum drive voltage value of the maximum drive voltage information.
摘要翻译： 超声波成像装置包括图像获取单元，用于照射成像区域并获得绘制成像区域的断层图像信息;输入单元，用于输入扫描参数值信息和目标声压参数值作为估计声压的指标 所述被摄体，估计的最大声压参数值计算装置，用于根据用于产生超声波的压电换能器组的扫描参数值信息和最大驱动电压信息来计算被摄体中的估计最大声压参数值;以及 最大驱动电压优化装置，用于比较估计的最大声压参数值和目标声压参数值，并优化最大驱动电压信息的最大驱动电压值。
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