摘要:
A composition having BACE 1 inhibitory activity containing a compound represented by the general formula (I): wherein ring A is an optionally substituted carbocyclic group or an optionally substituted heterocyclic group; E is lower alkylene; X is S, O, or NR1; R1 is a hydrogen atom or lower alkyl; R2a, R2b, R3a, R3b, R4a and R4b is each independently a hydrogen atom, halogen, or hydroxy etc.; n and m are each independently an integer of 0 to 3; n+m is an integer of 0 to 3; R5 is a hydrogen atom or substituted lower alkyl; its pharmaceutically acceptable salt, or a solvate thereof.
摘要:
A composition having BACE 1 inhibitory activity containing a compound represented by the general formula (I): wherein ring A is an optionally substituted carbocyclic group or an optionally substituted heterocyclic group; E is lower alkylene; X is S, O, or NR1; R1 is a hydrogen atom or lower alkyl; R2a, R2b, R3a, R3b, R4a and R4b is each independently a hydrogen atom, halogen, or hydroxy etc.; n and m are each independently an integer of 0 to 3; n+m is an integer of 0 to 3; R5 is a hydrogen atom or substituted lower alkyl; its pharmaceutically acceptable salt, or a solvate thereof.
摘要:
A composition having BACE 1 inhibitory activity containing a compound represented by the general formula (I): wherein ring A is an optionally substituted carbocyclic group or an optionally substituted heterocyclic group; E is lower alkylene; X is S, O, or NR1; R1 is a hydrogen atom or lower alkyl; R2a, R2b, R3a, R3b, R4a and R4b is each independently a hydrogen atom, halogen, or hydroxy etc.; n and m are each independently an integer of 0 to 3; n+m is an integer of 0 to 3; R5 is a hydrogen atom or substituted lower alkyl; its pharmaceutically acceptable salt, or a solvate thereof.
摘要:
A compound represented by the formula (I): wherein, for example, R1, R2, R3, and R4 are each independently hydrogen atom, alky, and the like, R5 and R6 are each independently hydrogen atom, alkyl, and the like, X is —O—, —S—, and the like, Y is 5-membered heteroaryl-diyl and the like, Z is optionally substituted aryl and the like, the prodrugs thereof, or their pharmaceutically acceptable salts, or their solvates.
摘要:
Disclosed is a vinyl chloride polymer composition comprising:(i) 100 parts by weight of a vinyl chloride polymer containing at least 80 wt. % of vinyl chloride units, and(ii) 0.05 to 25 wt. parts of a three-stage polymer (II), which is obtained by polymerizing 10 to 30 wt. parts of at least one monomer (B), which is selected from acrylic acid esters, methacrylic acid esters, aromatic vinyl compounds, cyano-vinyl compounds and vinyl ester compounds so that the glass transition temperature of a polymer obtained by separately polymerizing the monomer (B) is 0.degree. to 60.degree. C., in the presence of 45 to 85 wt. parts of a methyl methacrylate polymer (A) containing at least 80 wt. % of methyl methacrylate units; and then polymerizing 5 to 25 wt. parts of a methyl methacrylate monomer or monomer mixture (C) containing at least 80 wt. % of methyl methacrylate in the presence of the obtained copolymer comprising the components (A) and (B) so that the total amount of the components (A), (B), and (C) is 100 wt. parts. The vinyl chloride polymer composition is advantageous in that the gelation speed is high, the parting property at the calendering step is good, adhesion to the vessel wall is not caused at the blending step before the processing, the processability is excellent, and the composition gives a molded articles having a good transparency and a good surface condition.
摘要:
A packaging machine comprising an endless conveyor, a mandrel wheel disposed above the starting end of the path of transport of the conveyor and having mandrels, a closed main chamber enclosing the conveyor and the mandrel wheel entirely, a series of devices arranged on the top wall of the main chamber from the rear to the front in succession for making tubular blanks into containers by closing one end of each blank to form the bottom of the container, filling contents into the bottomed blank and thereafter closing the other end of the blank to form the top of the container, the series of devices having portions operative on the blank and extending into the main chamber, and a closed subchamber disposed to the rear of the main chamber and communicating therewith, the subchamber having installed therein a blank sterilizer and a blank transfer assembly for transferring tubular blanks from a blank shaping-feeding unit to the blank sterilizer and for transferring sterilized tubular blanks from the sterilizer to the mandrel wheel. The device for filling contents into the bottomed blank includes a filling nozzle and a liquid conduit disposed therebelow which is rotatably mounted so as to be able to be positioned to receive contents passed through the filling nozzle.
摘要:
A method of coloring a glass sheet which must contain reducing ions such as tin ions diffused into a surface layer thereof. The reducing ions may originate in a molten metal bath used in producing the glass sheet by the float process. A coloring agent comprising a powder mixture of 1 part by weight of a substance expressed by Ag.sub.x W.sub.y O.sub.z, wherein x:y:z is 1-2:1:2-4, and 5 to 20 parts by weight of a transition metal oxide, e.g. Cr.sub.2 O.sub.3, is applied to the glass sheet surface, and the glass sheet is heated so as to cause silver ions to diffuse into the surface layer of the glass sheet and undergo reduction by the action of the precedingly diffused ions to produce color. Conveniently, use is made of a paste prepared by dispersing the powder mixture in an organic liquid vehicle. Owing to the stability of the silver-containing oxide Ag.sub.x W.sub.y O.sub.z, uniform coloring is achieved without encountering difficulty and without degrading the quality of the glass sheet.
摘要翻译:将含有还原离子如锡离子扩散到其表面层中的玻璃板着色的方法。 还原离子可以源自用于通过浮法生产玻璃板的熔融金属浴。 一种着色剂,其包含1重量份由Ag x W y O z表示的物质,其中x:y:z为1-2:1-2:2-4的粉末混合物和5至20重量份的过渡金属氧化物,例如, 将Cr 2 O 3施加到玻璃板表面,并且加热玻璃板以使银离子扩散到玻璃板的表面层中,并通过前述扩散离子的作用进行还原以产生颜色。 方便地,使用通过将粉末混合物分散在有机液体载体中制备的糊剂。 由于含银氧化物Ag x W y O z的稳定性,可以实现均匀的着色而不会困难,而且不降低玻璃板的质量。
摘要:
Device for use in measurement of blood pressure, according to the intermediate blood pressure measuring method of RIVA ROCCI, which detects negative signals of Korotkoff sound pulses comprised in asymmetrical alternating current signal waves coming from a ceramic microphone through a band pass filter and a half-wave rectifier, and indicates the presence of the Korotkoff sound after shaping the negative signals in a monostable multivibrator.
摘要:
An improvement is disclosed in the dry method for manufacturing friction materials of the resin mold type, especially brake lining pads, which comprises uniformly mixing graphite particles and a phenolic resin in a liquid form, solidifying the mixture, grinding the solidified mixture, and using the ground material as a binder in forming a friction member of the resin mold type. The binder has a graphite powder content of 2-31 wt.% and a phenolic resin content of 69-98 wt.%. Brake linings of improved wear resistance and fade resistance can be produced using this improved method.
摘要:
A sphygmomanometer cuff adapted to be easily applicable to any limb of a patient by himself. The cuff comprises an elongated flexible double layered fabric strap holding an inflatable pouch with tubes to be connected at the outside of the strap to a sphygmomanometer and to an air pump, and having a length sufficient to wrap by about one and a half to two turns round the patient's limb. A loop shaped rigid member is fitted at one longitudinal end of the strap, and received in the other longitudinal end thereof is a resiliently compressible rod like member. The rod like member can be forced through the loop shaped rigid member and prevents the strap from withdrawing from the loop shaped rigid member. A pair of female and male adhesive tapes are provided on the strap and are spaced apart by a distance permitting superimposing for fastening when the strap is wrapped round a patient's limb so as to stop the flow of blood through the arteries.