公开(公告)号：US07098312B2

公开(公告)日：2006-08-29

申请号：US10006130

申请日：2001-12-06

申请人： Kevin P. Baker ,  David Botstein ,  Luc Desnoyers ,  Dan L. Eaton ,  Napoleone Ferrara ,  Sherman Fong ,  Wei-Qiang Gao ,  Audrey Goddard ,  Paul J. Godowski ,  J. Christopher Grimaldi ,  Austin L. Gurney ,  Kenneth J. Hillan ,  James Pan ,  Nicholas F. Paoni ,  Margaret Ann Roy ,  Victoria Smith ,  Timothy A. Stewart ,  Daniel Tumas ,  Colin K. Watanabe ,  P. Mickey Williams ,  William I. Wood

发明人： Kevin P. Baker ,  David Botstein ,  Luc Desnoyers ,  Dan L. Eaton ,  Napoleone Ferrara ,  Sherman Fong ,  Wei-Qiang Gao ,  Audrey Goddard ,  Paul J. Godowski ,  J. Christopher Grimaldi ,  Austin L. Gurney ,  Kenneth J. Hillan ,  James Pan ,  Nicholas F. Paoni ,  Margaret Ann Roy ,  Victoria Smith ,  Timothy A. Stewart ,  Daniel Tumas ,  Colin K. Watanabe ,  P. Mickey Williams ,  William I. Wood

IPC分类号： C07K14/00 ,  C07K19/00 ,  C07K16/46 ,  C12N15/62 ,  C12N15/63

CPC分类号： C07K14/47 ,  C07K14/705

摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

公开(公告)号：US07034123B2

公开(公告)日：2006-04-25

申请号：US10007236

申请日：2001-12-06

申请人： Kevin P. Baker ,  David Botstein ,  Luc Desnoyers ,  Dan L. Eaton ,  Napoleone Ferrara ,  Sherman Fong ,  Wei-Qiang Gao ,  Audrey Goddard ,  Paul J. Godowski ,  J. Christopher Grimaldi ,  Austin L. Gurney ,  Kenneth J. Hillan ,  James Pan ,  Nicholas F. Paoni ,  Margaret Ann Roy ,  Victoria Smith ,  Timothy A. Stewart ,  Daniel Tumas ,  Colin K. Watanabe ,  P. Mickey Williams ,  William I. Wood

发明人： Kevin P. Baker ,  David Botstein ,  Luc Desnoyers ,  Dan L. Eaton ,  Napoleone Ferrara ,  Sherman Fong ,  Wei-Qiang Gao ,  Audrey Goddard ,  Paul J. Godowski ,  J. Christopher Grimaldi ,  Austin L. Gurney ,  Kenneth J. Hillan ,  James Pan ,  Nicholas F. Paoni ,  Margaret Ann Roy ,  Victoria Smith ,  Timothy A. Stewart ,  Daniel Tumas ,  Colin K. Watanabe ,  P. Mickey Williams ,  William I. Wood

IPC分类号： C07K16/00 ,  C12P21/08

CPC分类号： C07K14/47

摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

摘要翻译： 本发明涉及新型多肽和编码那些多肽的核酸分子。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。

公开(公告)号：US07033786B2

公开(公告)日：2006-04-25

申请号：US10015715

申请日：2001-12-12

申请人： Kevin P. Baker ,  David Botstein ,  Luc Desnoyers ,  Dan L. Eaton ,  Napoleone Ferrara ,  Sherman Fong ,  Wei-Qiang Gao ,  Audrey Goddard ,  Paul J. Godowski ,  J. Christopher Grimaldi ,  Austin L. Gurney ,  Kenneth J. Hillan ,  James Pan ,  Nicholas F. Paoni ,  Margaret Ann Roy ,  Victoria Smith ,  Timothy A. Stewart ,  Daniel Tumas ,  Colin K. Watanabe ,  P. Mickey Williams ,  William I. Wood

发明人： Kevin P. Baker ,  David Botstein ,  Luc Desnoyers ,  Dan L. Eaton ,  Napoleone Ferrara ,  Sherman Fong ,  Wei-Qiang Gao ,  Audrey Goddard ,  Paul J. Godowski ,  J. Christopher Grimaldi ,  Austin L. Gurney ,  Kenneth J. Hillan ,  James Pan ,  Nicholas F. Paoni ,  Margaret Ann Roy ,  Victoria Smith ,  Timothy A. Stewart ,  Daniel Tumas ,  Colin K. Watanabe ,  P. Mickey Williams ,  William I. Wood

IPC分类号： C12P21/06 ,  C12N1/20 ,  C12N15/00 ,  C12N15/74 ,  C07H21/04

CPC分类号： C07K14/47

摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

摘要翻译： 本发明涉及新型多肽和编码那些多肽的核酸分子。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。

公开(公告)号：US20090197301A1

公开(公告)日：2009-08-06

申请号：US11796725

申请日：2007-04-27

申请人： Kevin P. Baker ,  David Botstein ,  Luc Desnoyers ,  Dan L. Eaton ,  Napoleone Ferrara ,  Sherman Fong ,  Wei-Qiang Gao ,  Audrey Goddard ,  Paul J. Godowski ,  J. Chistopher Grimaldi ,  Austin L. Gurney ,  Kenneth J. Hillan ,  James Pan ,  Nicholas F. Paoni ,  Margaret Ann Roy ,  Victoria Smith ,  Timothy A. Stewart ,  Daniel Tumas ,  Colin K. Watanabe ,  P. Mickey Williams ,  William I. Wood

发明人： Kevin P. Baker ,  David Botstein ,  Luc Desnoyers ,  Dan L. Eaton ,  Napoleone Ferrara ,  Sherman Fong ,  Wei-Qiang Gao ,  Audrey Goddard ,  Paul J. Godowski ,  J. Chistopher Grimaldi ,  Austin L. Gurney ,  Kenneth J. Hillan ,  James Pan ,  Nicholas F. Paoni ,  Margaret Ann Roy ,  Victoria Smith ,  Timothy A. Stewart ,  Daniel Tumas ,  Colin K. Watanabe ,  P. Mickey Williams ,  William I. Wood

IPC分类号： C12P21/04 ,  C12N15/11 ,  C12N15/00 ,  C12N5/06 ,  C07K16/18 ,  C07K14/00 ,  C12N1/21 ,  C12N1/19

CPC分类号： C07K14/47

摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

公开(公告)号：US07026448B2

公开(公告)日：2006-04-11

申请号：US10006485

申请日：2001-12-06

申请人： Kevin P. Baker ,  David Botstein ,  Luc Desnoyers ,  Dan L. Eaton ,  Napoleone Ferrara ,  Sherman Fong ,  Wei-Qiang Gao ,  Audrey Goddard ,  Paul J. Godowski ,  J. Christopher Grimaldi ,  Austin L. Gurney ,  Kenneth J. Hillan ,  James Pan ,  Nicholas F. Paoni ,  Margaret Ann Roy ,  Victoria Smith ,  Timothy A. Stewart ,  Daniel Tumas ,  Colin K. Watanabe ,  P. Mickey Williams ,  William I. Wood

发明人： Kevin P. Baker ,  David Botstein ,  Luc Desnoyers ,  Dan L. Eaton ,  Napoleone Ferrara ,  Sherman Fong ,  Wei-Qiang Gao ,  Audrey Goddard ,  Paul J. Godowski ,  J. Christopher Grimaldi ,  Austin L. Gurney ,  Kenneth J. Hillan ,  James Pan ,  Nicholas F. Paoni ,  Margaret Ann Roy ,  Victoria Smith ,  Timothy A. Stewart ,  Daniel Tumas ,  Colin K. Watanabe ,  P. Mickey Williams ,  William I. Wood

IPC分类号： C07K14/00 ,  C12N15/62 ,  C12N15/63

CPC分类号： C07K14/47

摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

公开(公告)号：US07041805B2

公开(公告)日：2006-05-09

申请号：US10007194

申请日：2001-12-06

申请人： Kevin P. Baker ,  David Botstein ,  Luc Desnoyers ,  Dan L. Eaton ,  Napoleone Ferrara ,  Sherman Fong ,  Wei-Qiang Gao ,  Audrey Goddard ,  Paul J. Godowski ,  J. Christopher Grimaldi ,  Austin L. Gurney ,  Kenneth J. Hillan ,  James Pan ,  Nicholas F. Paoni ,  Margaret Ann Roy ,  Victoria Smith ,  Timothy A. Stewart ,  Daniel Tumas ,  Colin K. Watanabe ,  P. Mickey Williams ,  William I. Wood

发明人： Kevin P. Baker ,  David Botstein ,  Luc Desnoyers ,  Dan L. Eaton ,  Napoleone Ferrara ,  Sherman Fong ,  Wei-Qiang Gao ,  Audrey Goddard ,  Paul J. Godowski ,  J. Christopher Grimaldi ,  Austin L. Gurney ,  Kenneth J. Hillan ,  James Pan ,  Nicholas F. Paoni ,  Margaret Ann Roy ,  Victoria Smith ,  Timothy A. Stewart ,  Daniel Tumas ,  Colin K. Watanabe ,  P. Mickey Williams ,  William I. Wood

IPC分类号： C07K16/18 ,  C07K17/08 ,  A61K39/395

CPC分类号： C07K14/47 ,  C07K14/705

摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

公开(公告)号：US07026449B2

公开(公告)日：2006-04-11

申请号：US10006746

申请日：2001-12-06

申请人： Kevin P. Baker ,  David Botstein ,  Luc Desnoyers ,  Dan L. Eaton ,  Napoleone Ferrara ,  Sherman Fong ,  Wei-Qiang Gao ,  Audrey Goddard ,  Paul J. Godowski ,  J. Christopher Grimaldi ,  Austin L. Gurney ,  Kenneth J. Hillan ,  James Pan ,  Nicholas F. Paoni ,  Margaret Ann Roy ,  Victoria Smith ,  Timothy A. Stewart ,  Daniel Tumas ,  Colin K. Watanabe ,  P. Mickey Williams ,  William I. Wood

发明人： Kevin P. Baker ,  David Botstein ,  Luc Desnoyers ,  Dan L. Eaton ,  Napoleone Ferrara ,  Sherman Fong ,  Wei-Qiang Gao ,  Audrey Goddard ,  Paul J. Godowski ,  J. Christopher Grimaldi ,  Austin L. Gurney ,  Kenneth J. Hillan ,  James Pan ,  Nicholas F. Paoni ,  Margaret Ann Roy ,  Victoria Smith ,  Timothy A. Stewart ,  Daniel Tumas ,  Colin K. Watanabe ,  P. Mickey Williams ,  William I. Wood

IPC分类号： A61K38/17 ,  C07K14/47 ,  C12N15/12 ,  C12P21/02

CPC分类号： A61K38/17 ,  C07H21/04 ,  C07K14/435 ,  C07K16/40 ,  C12N5/06 ,  C12N9/00 ,  C12P21/02 ,  G01N33/53

摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

公开(公告)号：US06936436B2

公开(公告)日：2005-08-30

申请号：US10015389

申请日：2001-12-11

申请人： Kevin P. Baker ,  David Botstein ,  Luc Desnoyers ,  Dan L. Eaton ,  Napoleone Ferrara ,  Sherman Fong ,  Wei-Qiang Gao ,  Audrey Goddard ,  Paul J. Godowski ,  J. Christopher Grimaldi ,  Austin L. Gurney ,  Kenneth J. Hillan ,  James Pan ,  Nicholas F. Paoni ,  Margaret Ann Roy ,  Victoria Smith ,  Timothy A. Stewart ,  Daniel Tumas ,  Colin K. Watanabe ,  P. Mickey Williams ,  William I. Wood

发明人： Kevin P. Baker ,  David Botstein ,  Luc Desnoyers ,  Dan L. Eaton ,  Napoleone Ferrara ,  Sherman Fong ,  Wei-Qiang Gao ,  Audrey Goddard ,  Paul J. Godowski ,  J. Christopher Grimaldi ,  Austin L. Gurney ,  Kenneth J. Hillan ,  James Pan ,  Nicholas F. Paoni ,  Margaret Ann Roy ,  Victoria Smith ,  Timothy A. Stewart ,  Daniel Tumas ,  Colin K. Watanabe ,  P. Mickey Williams ,  William I. Wood

IPC分类号： C07K14/705 ,  C12N15/12 ,  C07K14/00 ,  C12N15/63

CPC分类号： C07K14/705 ,  C07K2319/00

摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

公开(公告)号：US20070020735A1

公开(公告)日：2007-01-25

申请号：US11529324

申请日：2006-09-29

申请人： Jian Chen ,  Ellen Filvaroff ,  Sherman Fong ,  Dorothy French ,  Audrey Goddard ,  Paul Godowski ,  J. Grimaldi ,  Austin Gumey ,  Kenneth Hillan ,  Sarah Hymowitz ,  Hanzhong Li ,  James Pan ,  Melissa Starovasnik ,  Daniel Tumas ,  Menno Lookeren ,  Richard Vandlen ,  Colin Watanabe ,  P. Williams ,  William Wood ,  Daniel Yansura

发明人： Jian Chen ,  Ellen Filvaroff ,  Sherman Fong ,  Dorothy French ,  Audrey Goddard ,  Paul Godowski ,  J. Grimaldi ,  Austin Gumey ,  Kenneth Hillan ,  Sarah Hymowitz ,  Hanzhong Li ,  James Pan ,  Melissa Starovasnik ,  Daniel Tumas ,  Menno Lookeren ,  Richard Vandlen ,  Colin Watanabe ,  P. Williams ,  William Wood ,  Daniel Yansura

IPC分类号： C07H21/04 ,  C12P21/04 ,  C07K14/54

CPC分类号： C07K16/244 ,  A61K38/00 ,  C07H21/04 ,  C07K14/54 ,  C07K14/7155 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/35 ,  C07K2317/54 ,  C07K2317/55 ,  C07K2317/62 ,  G01N33/505 ,  G01N33/564 ,  G01N33/574 ,  G01N33/57407 ,  G01N33/57423 ,  G01N33/57438 ,  G01N33/57492 ,  G01N2333/54 ,  G01N2333/7155

摘要： The present invention is directed to novel polypeptides having sequence identity with IL-17, IL-17 receptors and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided herein are methods for treating degenerative cartilaginous disorders and other inflammatory diseases.

摘要翻译： 本发明涉及与IL-17，IL-17受体和编码那些多肽的核酸分子具有序列同一性的新型多肽。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。 本文还提供了治疗退行性软骨疾病和其它炎性疾病的方法。

公开(公告)号：US06635468B2

公开(公告)日：2003-10-21

申请号：US09907794

申请日：2001-07-17

申请人： Avi Ashkenazi ,  David Botstein ,  Luc Desnoyers ,  Dan L. Eaton ,  Napoleone Ferrara ,  Ellen Filvaroff ,  Sherman Fong ,  Wei-Qiang Gao ,  Hanspeter Gerber ,  Mary E. Gerritsen ,  Audrey Goddard ,  Paul J. Godowski ,  J. Christopher Grimaldi ,  Austin L. Gurney ,  Kenneth J. Hillan ,  Ivar J. Kljavin ,  Jennie P. Mather ,  James Pan ,  Nicholas F. Paoni ,  Margaret Ann Roy ,  Timothy A. Stewart ,  Daniel Tumas ,  P. Mickey Williams ,  William I. Wood

发明人： Avi Ashkenazi ,  David Botstein ,  Luc Desnoyers ,  Dan L. Eaton ,  Napoleone Ferrara ,  Ellen Filvaroff ,  Sherman Fong ,  Wei-Qiang Gao ,  Hanspeter Gerber ,  Mary E. Gerritsen ,  Audrey Goddard ,  Paul J. Godowski ,  J. Christopher Grimaldi ,  Austin L. Gurney ,  Kenneth J. Hillan ,  Ivar J. Kljavin ,  Jennie P. Mather ,  James Pan ,  Nicholas F. Paoni ,  Margaret Ann Roy ,  Timothy A. Stewart ,  Daniel Tumas ,  P. Mickey Williams ,  William I. Wood

IPC分类号： C12N121

CPC分类号： C07K14/47 ,  C07K14/705 ,  C07K2319/00

摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.