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公开(公告)号：US11041068B2
公开(公告)日：2021-06-22
申请号：US16305372
申请日：2017-06-07
Inventor： Kristian Andersson , Geir Fonnum , Korbinian Heil
IPC: C08L25/14 , C08L25/08 , B01J19/00 , C08F212/08 , C08F220/58 , C08F293/00
Abstract: This invention relates to polymer particles for solid phase oligonucleotide synthesis. The oligonucleotide may be linked to the particle via a linker having an amide-oligoethyleneglycol-amine structure. The particles may be considered to act as a solid support during the oligonucleotide synthesis. Also disclosed are processes for preparing such polymer particles, compositions and systems comprising such particles, and uses thereof.
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公开(公告)号：US10947333B2
公开(公告)日：2021-03-16
申请号：US16259963
申请日：2019-01-28
Applicant: LIFE TECHNOLOGIES CORPORATION , LIFE TECHNOLOGIES AS
Inventor： Geir Fonnum , Grete Irene Modahl , Nini Hofsloekken Kjus , Astrid Evenroed Molteberg , Diem Thuy Thi Tran , Jo Aaserud , Muhammed Gokmen , Steven M. Menchen , Carl Fuller , Luisa Andruzzi , Wolfgang Hinz
IPC: C08F230/08 , C08F220/58 , C08F8/34 , C08F8/32 , C08F8/12 , C08F2/20 , C08F130/08 , C08F6/24 , C07F7/18 , C12Q1/686 , C08F2/26 , C08F222/38 , C12P19/34 , C12Q1/6874 , G01N27/414 , C08J9/20
Abstract: A method of forming a particle includes, in a disperse phase within an aqueous suspension, polymerizing a plurality of mer units of a hydrophilic monomer having a hydrophobic protection group, thereby forming a polymeric particle including a plurality of the hydrophobic protection groups. The method further includes converting the polymeric particle to a hydrophilic particle.
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公开(公告)号：US20200308630A1
公开(公告)日：2020-10-01
申请号：US16849833
申请日：2020-04-15
Applicant: LIFE TECHNOLOGIES AS
Inventor： Darren Ellis , Geir Fonnum , Nini Kjus
IPC: C12Q1/6806 , C12N15/10
Abstract: A method for processing a nucleic acid, in which the nucleic acid is exposed to an aqueous medium which includes a polyol in sufficient proportion for at least a portion of the nucleic acid to enter or remain in an extra-solution phase. Thus, a polyol may be used to bind a nucleic acid which is in solution to a solid support or to wash a nucleic acid on a solid support whilst maintaining it on the support. The polyol may for example be a C2-C10 alkanediol.
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公开(公告)号：US09828453B2
公开(公告)日：2017-11-28
申请号：US15212532
申请日：2016-07-18
Applicant: LIFE TECHNOLOGIES CORPORATION , LIFE TECHNOLOGIES AS
Inventor： Nini Hofslokken Kjus , Geir Fonnum , Bruce Branchaud , Lai-Qiang Ying , Steven M. Menchen , Dmitriy Gremyachinskiy , Hee Chol Kang
IPC: C07F7/10 , C08F230/08 , C07F7/18 , C08F222/38 , C08F220/58 , C08F236/20 , C08K3/20
CPC classification number: C08F230/08 , C07F7/10 , C07F7/1804 , C08F220/58 , C08F222/385 , C08F236/20 , C08K3/20
Abstract: A silyl protected diacrylamide compound is described. A method of forming such a compound includes mixing a silylation reagent with a hydroxylated diamine compound under first reactive conditions to form a product in a first solution, separating the product from the first solution, and mixing the product with acryloyl chloride under second reactive conditions in a second solution to form a silyl protected diacrylamide compound.
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公开(公告)号：US09309368B2
公开(公告)日：2016-04-12
申请号：US14152793
申请日：2014-01-10
Applicant: LIFE TECHNOLOGIES AS
Inventor： Arne Jørgedal , Elin Marie Aksnes , Geir Fonnum , Astrid Molteberg , Rolf Nordal , Henning Pettersen , Tollef Tårneby , Solveig Staale , Ellen Weng , Finn Hansen , Silje Nordbø , Oddvar Aune , Arvid Berge , John Bjørgum , Turid Ellingsen , John Ugelstad
IPC: C08J9/16 , C08F257/02 , C08F265/04 , C08F265/10 , C08F291/00 , C08J9/224
CPC classification number: C08J9/16 , C08F2/22 , C08F257/02 , C08F265/04 , C08F265/10 , C08F291/00 , C08J9/22 , C08J9/224 , C08J2203/14 , C08J2325/06 , C08J2347/00
Abstract: A process for the preparation of monodisperse polymer particles which are formed by contacting monomers with aqueous dispersions comprising monodisperse swellable seed polymers/oligomers, and initiating polymerization in the presence of a steric stabilizer. The resulting swollen seed particles are characterized by the particle mode diameter.
Abstract translation: 通过使单体与包含单分散可溶胀种子聚合物/低聚物的水性分散体接触而形成的单分散聚合物颗粒的制备方法，以及在空间稳定剂存在下引发聚合。 所得的溶胀种子颗粒的特征在于颗粒模式直径。
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Patent Agency Ranking
公开(公告)号：US09139666B2
公开(公告)日：2015-09-22
申请号：US14082368
申请日：2013-11-18
Applicant: LIFE TECHNOLOGIES CORPORATION , LIFE TECHNOLOGIES AS
Inventor： Geir Fonnum , Grete I. Modahl , Nini H. Kjus , Astrid E. Molteberg , Diem Tran , Jo Aaserud , Talha M. Gokmen , Steven M. Menchen , Carl Fuller , Luisa Andruzzi , Wolfgang Hinz
IPC: C12Q1/68 , C08F8/34 , C07F7/18 , C08F6/24 , C08F130/08 , C08F2/20 , C08F2/26 , C08F220/58 , C08F230/08 , C08F222/38 , C08F8/32
CPC classification number: C08F130/08 , C07F7/1804 , C07F7/188 , C08F2/20 , C08F2/26 , C08F6/24 , C08F8/12 , C08F8/32 , C08F8/34 , C08F220/58 , C08F222/385 , C08F230/08 , C08F2800/20 , C08J9/20 , C08J2343/04 , C12P19/34 , C12Q1/686 , C12Q1/6874 , G01N27/4145 , Y10T428/2982 , C08F257/02 , C08F2222/1013 , C08F212/36 , C08F220/60 , C12Q2563/149 , C12Q2563/159 , C12Q2565/543
Abstract: A method of forming a particle includes, in a disperse phase within an aqueous suspension, polymerizing a plurality of mer units of a hydrophilic monomer having a hydrophobic protection group, thereby forming a polymeric particle including a plurality of the hydrophobic protection groups. The method further includes converting the polymeric particle to a hydrophilic particle.
Abstract translation: 形成颗粒的方法包括在水性悬浮液中的分散相中聚合具有疏水保护基团的亲水性单体的多个聚合单元，从而形成包含多个疏水保护基团的聚合物颗粒。 该方法还包括将聚合物颗粒转化为亲水性颗粒。
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公开(公告)号：US08658733B2
公开(公告)日：2014-02-25
申请号：US13649045
申请日：2012-10-10
Applicant: Life Technologies AS , Arvid Tygve Berge , Viola Ugelstad
Inventor： Arne Jorgedal , Elin Aksnes , Geir Fonnum , Astrid Molteberg , Rolf Nordal , Henning Pettersen , Tollef Taarneby , Solveig Staale , Ellen Weng , Finn Hansen , Silje Nordbo , Oddvar Aune , Arvid Berge , John Bjorgum , Turid Ellingsen , John Ugelstad
IPC: C08F8/30
CPC classification number: C08J9/16 , C08F2/22 , C08F257/02 , C08F265/04 , C08F265/10 , C08F291/00 , C08J9/22 , C08J9/224 , C08J2203/14 , C08J2325/06 , C08J2347/00
Abstract: A process for the preparation of monodisperse polymer particles which are formed by contacting monomers with aqueous dispersions comprising monodisperse swellable seed polymers/oligomers, and initiating polymerization in the presence of a steric stabilizer. The resulting swollen seed particles are characterized by the particle mode diameter.
Abstract translation: 通过使单体与包含单分散可溶胀种子聚合物/低聚物的水性分散体接触而形成的单分散聚合物颗粒的制备方法，以及在空间稳定剂存在下引发聚合。 所得的溶胀种子颗粒的特征在于颗粒模式直径。
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公开(公告)号：US12122859B2
公开(公告)日：2024-10-22
申请号：US18101785
申请日：2023-01-26
Applicant: LIFE TECHNOLOGIES CORPORATION , LIFE TECHNOLOGIES AS
Inventor： Geir Fonnum , Grete Irene Modahl , Nini Hofsloekken Kjus , Astrid Evenroed Molteberg , Diem Thuy Thi Tran , Jo Aaserud , M. Talha Gokmen , Steven M. Menchen , Carl Fuller , Luisa Andruzzi , Wolfgang Hinz
IPC: C08F230/08 , C07F7/18 , C08F2/20 , C08F2/26 , C08F6/24 , C08F8/12 , C08F8/32 , C08F8/34 , C08F130/08 , C08F220/58 , C08F222/38 , C08J9/20 , C12P19/34 , C12Q1/686 , C12Q1/6874 , G01N27/414 , C08F220/60
CPC classification number: C08F130/08 , C07F7/1804 , C07F7/188 , C08F2/20 , C08F2/26 , C08F6/24 , C08F8/12 , C08F8/32 , C08F8/34 , C08F222/385 , C08F230/085 , C08J9/20 , C12P19/34 , C12Q1/686 , C12Q1/6874 , G01N27/4145 , C08F220/603 , C08F2800/20 , C08J2343/04 , Y10T428/2982 , C08F8/12 , C08F257/02 , C08F8/34 , C08F8/12 , C08F257/02 , C12Q1/686 , C12Q2563/149 , C12Q2563/159 , C12Q2565/543 , C08F257/02 , C08F230/085 , C08F8/12 , C08F230/085 , C08F8/34 , C08F8/12 , C08F230/085 , C08F230/085 , C08F230/085 , C08F230/085 , C08F230/085 , C08F220/603 , C08F230/085 , C08F212/36 , C08F230/085 , C08F222/102
Abstract: A method of forming a particle includes, in a disperse phase within an aqueous suspension, polymerizing a plurality of mer units of a hydrophilic monomer having a hydrophobic protection group, thereby forming a polymeric particle including a plurality of the hydrophobic protection groups. The method further includes converting the polymeric particle to a hydrophilic particle.
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公开(公告)号：US11572427B2
公开(公告)日：2023-02-07
申请号：US17165039
申请日：2021-02-02
Applicant: LIFE TECHNOLOGIES CORPORATION , LIFE TECHNOLOGIES AS
Inventor： Geir Fonnum , Grete Irene Modahl , Nini Hofsloekken Kjus , Astrid Evenroed Molteberg , Diem Thuy Thi Tran , Jo Aaserud , M. Talha Gokmen , Steven M. Menchen , Carl Fuller , Luisa Andruzzi , Wolfgang Hinz
IPC: C08F230/08 , C08F220/58 , C08F8/34 , C08F8/32 , C08F8/12 , C08F2/20 , C08F130/08 , C08F6/24 , C07F7/18 , C12Q1/686 , C08F2/26 , C08F222/38 , C12P19/34 , C12Q1/6874 , G01N27/414 , C08J9/20 , C08F220/60
Abstract: A method of forming a particle includes, in a disperse phase within an aqueous suspension, polymerizing a plurality of mer units of a hydrophilic monomer having a hydrophobic protection group, thereby forming a polymeric particle including a plurality of the hydrophobic protection groups. The method further includes converting the polymeric particle to a hydrophilic particle.
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公开(公告)号：US11261480B2
公开(公告)日：2022-03-01
申请号：US16849833
申请日：2020-04-15
Applicant: LIFE TECHNOLOGIES AS
Inventor： Darren Ellis , Geir Fonnum , Nini Kjus
IPC: C12Q1/68 , C12N15/10 , C12Q1/6806
Abstract: A method for processing a nucleic acid, in which the nucleic acid is exposed to an aqueous medium which includes a polyol in sufficient proportion for at least a portion of the nucleic acid to enter or remain in an extra-solution phase. Thus, a polyol may be used to bind a nucleic acid which is in solution to a solid support or to wash a nucleic acid on a solid support whilst maintaining it on the support. The polyol may for example be a C2-C10 alkanediol.
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