公开(公告)号：USD912269S1

公开(公告)日：2021-03-02

申请号：US29660066

申请日：2018-08-16

Applicant: LIFE TECHNOLOGIES CORPORATION

Designer： David Marran ,  Earl Zergiebel ,  Jamsheed Ghadiri ,  Mark T. Reed

公开(公告)号：USD895144S1

公开(公告)日：2020-09-01

申请号：US29660064

申请日：2018-08-16

Applicant: LIFE TECHNOLOGIES CORPORATION

Designer： Earl Zergiebel ,  Nathan Kane ,  Mark T. Reed ,  David Marran

公开(公告)号：USD865220S1

公开(公告)日：2019-10-29

申请号：US29660062

申请日：2018-08-16

Applicant: LIFE TECHNOLOGIES CORPORATION

Designer： Oliver Davidson ,  Sandro Klein ,  Patrick Leung ,  Mark T. Reed ,  David Marran

公开(公告)号：US20190240659A9

公开(公告)日：2019-08-08

申请号：US15348907

申请日：2016-11-10

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： Jonathan Schultz ,  David Marran

IPC: B01L3/00 ,  G01N27/447

CPC classification number: B01L3/502715 ,  B01J2219/00389 ,  B01J2219/00394 ,  B01L3/502 ,  B01L3/50273 ,  B01L3/502738 ,  B01L3/502746 ,  B01L3/502769 ,  B01L3/502776 ,  B01L3/52 ,  B01L2200/16 ,  B01L2300/0636 ,  B01L2300/0645 ,  B01L2300/0861 ,  B01L2300/0864 ,  B01L2300/0867 ,  B01L2300/0874 ,  B01L2300/0877 ,  B01L2400/0487 ,  C12Q1/6869 ,  G01N27/447 ,  G01N35/1002 ,  G01N35/1097 ,  Y10T137/0318 ,  Y10T137/0424 ,  Y10T137/85938 ,  C12Q2565/629 ,  C12Q2527/119

Abstract: The invention provides a passive fluidics circuit for directing different fluids to a common volume, such as a reaction chamber or flow cell, without intermixing or cross contamination. The direction and rate of flow through junctions, nodes and passages of the fluidics circuit are controlled by the states of upstream valves (e.g. opened or closed), differential fluid pressures at circuit inlets or upstream reservoirs, flow path resistances, and the like. Free diffusion or leakage of fluids from unselected inlets into the common outlet or other inlets at junctions or nodes is prevented by the flow of the selected inlet fluid, a portion of which sweeps by the inlets of unselected fluids and exits the fluidics circuit by waste ports, thereby creating a barrier against undesired intermixing with the outlet flow through leakage or diffusion. The invention is particularly advantageous in apparatus for performing sensitive multistep reactions, such as pH-based DNA sequencing reactions.

公开(公告)号：US09045795B2

公开(公告)日：2015-06-02

申请号：US13802610

申请日：2013-03-13

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： James Ball ,  David Kupec ,  David Marran ,  Jon A. Hoshizaki

IPC: C12Q1/68

CPC classification number: C12Q1/68 ,  C12Q1/6869 ,  C12Q1/6883 ,  G01N27/4141 ,  Y10T436/143333 ,  C12Q2527/119 ,  C12Q2565/607

Abstract: A method of sensing nucleotide reactions includes flowing at least one nucleotide solution from a container of at least two containers of a sensor system. The sensor system includes a sensor sensitive to a byproduct of nucleotide incorporation. Each container of the at least two containers includes a different nucleotide solution. The sensor system enters an idle mode after flowing. The method further includes cycling the at least two containers through at least two cycles. Each cycle includes depressurizing the at least two containers for a first period and pressurizing the at least two containers for a second period. The method also includes pressurizing the at least two containers when the sensor system enters an active mode.

Abstract translation: 感测核苷酸反应的方法包括从传感器系统的至少两个容器的容器流出至少一个核苷酸溶液。 传感器系统包括对核苷酸掺入的副产物敏感的传感器。 至少两个容器的每个容器都包含不同的核苷酸解决方案。 传感器系统在流动后进入空闲模式。 该方法还包括使至少两个容器循环至少两个循环。 每个循环包括使至少两个容器减压第一时间段，并且将至少两个容器加压第二周期。 该方法还包括当传感器系统进入活动模式时对至少两个容器进行加压。

公开(公告)号：US20140272980A1

公开(公告)日：2014-09-18

申请号：US13802610

申请日：2013-03-13

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： James Ball ,  David Kupec ,  David Marran ,  Jon A. Hoshizaki

IPC: C12Q1/68

CPC classification number: C12Q1/68 ,  C12Q1/6869 ,  C12Q1/6883 ,  G01N27/4141 ,  Y10T436/143333 ,  C12Q2527/119 ,  C12Q2565/607

Abstract: A method of sensing nucleotide reactions includes flowing at least one nucleotide solution from a container of at least two containers of a sensor system. The sensor system includes a sensor sensitive to a byproduct of nucleotide incorporation. Each container of the at least two containers includes a different nucleotide solution. The sensor system enters an idle mode after flowing. The method further includes cycling the at least two containers through at least two cycles. Each cycle includes depressurizing the at least two containers for a first period and pressurizing the at least two containers for a second period. The method also includes pressurizing the at least two containers when the sensor system enters an active mode.

Abstract translation: 感测核苷酸反应的方法包括从传感器系统的至少两个容器的容器流出至少一个核苷酸溶液。 传感器系统包括对核苷酸掺入的副产物敏感的传感器。 至少两个容器的每个容器都包含不同的核苷酸解决方案。 传感器系统在流动后进入空闲模式。 该方法还包括使至少两个容器循环至少两个循环。 每个循环包括使至少两个容器减压第一时间段，并且将至少两个容器加压第二周期。 该方法还包括当传感器系统进入活动模式时对至少两个容器进行加压。