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    Sequencing device
    3.
    发明授权
    Sequencing device 有权

    公开(公告)号：US10240193B2

    公开(公告)日：2019-03-26

    申请号：US15891485

    申请日：2018-02-08

    Applicant: Life Technologies Corporation

    Inventor： Jonathan Schultz ,  Todd Roswech ,  Jon A. Hoshizaki ,  Albert L. Carrillo ,  James A. Ball

    IPC: C12Q1/68 ,  B01L3/00 ,  G01N27/414 ,  G01N35/10 ,  B01F11/00 ,  B01F1/00 ,  B01F5/06 ,  C12Q1/6869 ,  C12Q1/6806

    Abstract: A method of preparing reagents includes inserting a cartridge into an instrument. The cartridge includes a plurality of reagent enclosures disposed in a cavity of the cartridge and exposing a port to an exterior of the cartridge. Each reagent enclosure includes a reagent container including a reagent and an internal cavity defining a compressible volume, an opening defined through the reagent container to the internal cavity. The method further includes connecting a plurality of fluid ports to the openings of the plurality of reagent enclosures; applying a solution through the fluid ports to at least partially fill the plurality of reagent enclosures; and cycling a pressure of the cavity, whereby for each of the reagent enclosures, during increasing pressure, the solution enters the internal cavity of the reagent container, combines with the reagent, and compresses the compressible volume, and during decreasing pressure, the compressible volume decreases and the reagent is ejected through the opening.

    Sequencing device
    4.
    发明授权
    Sequencing device 有权

    公开(公告)号：US10894982B2

    公开(公告)日：2021-01-19

    申请号：US16289508

    申请日：2019-02-28

    Applicant: LIFE TECHNOLOGIES CORPORATION

    Inventor： Jonathan Schultz ,  Todd Roswech ,  Jon A. Hoshizaki ,  Albert L. Carrillo ,  James A. Ball

    IPC: C12Q1/6869 ,  C12Q1/6806 ,  B01L3/00 ,  G01N27/414 ,  G01N35/10 ,  B01F5/06 ,  B01F11/00 ,  B01F1/00

    Abstract: A method of preparing reagents includes inserting a cartridge into an instrument. The cartridge includes a plurality of reagent enclosures disposed in a cavity of the cartridge and exposing a port to an exterior of the cartridge. Each reagent enclosure includes a reagent container including a reagent and an internal cavity defining a compressible volume, an opening defined through the reagent container to the internal cavity. The method further includes connecting a plurality of fluid ports to the openings of the plurality of reagent enclosures; applying a solution through the fluid ports to at least partially fill the plurality of reagent enclosures; and cycling a pressure of the cavity, whereby for each of the reagent enclosures, during increasing pressure, the solution enters the internal cavity of the reagent container, combines with the reagent, and compresses the compressible volume, and during decreasing pressure, the compressible volume decreases and the reagent is ejected through the opening.

    SEQUENCING DEVICE
    5.
    发明申请
    SEQUENCING DEVICE 审中-公开

    公开(公告)号：US20190264274A1

    公开(公告)日：2019-08-29

    申请号：US16289508

    申请日：2019-02-28

    Applicant: LIFE TECHNOLOGIES CORPORATION

    Inventor： Jonathan Schultz ,  Todd Roswech ,  Jon A. Hoshizaki ,  Albert L. Carrillo ,  James A, Ball

    IPC: C12Q1/6869 ,  B01F5/06 ,  B01F11/00 ,  B01L3/00 ,  G01N35/10 ,  C12Q1/6806 ,  B01F1/00 ,  G01N27/414

    Abstract: A method of preparing reagents includes inserting a cartridge into an instrument. The cartridge includes a plurality of reagent enclosures disposed in a cavity of the cartridge and exposing a port to an exterior of the cartridge. Each reagent enclosure includes a reagent container including a reagent and an internal cavity defining a compressible volume, an opening defined through the reagent container to the internal cavity. The method further includes connecting a plurality of fluid ports to the openings of the plurality of reagent enclosures; applying a solution through the fluid ports to at least partially fill the plurality of reagent enclosures; and cycling a pressure of the cavity, whereby for each of the reagent enclosures, during increasing pressure, the solution enters the internal cavity of the reagent container, combines with the reagent, and compresses the compressible volume, and during decreasing pressure, the compressible volume decreases and the reagent is ejected through the opening.

    AMPLIFICATION AND ARRAY LOADING APPARATUS AND METHODS
    6.
    发明申请
    AMPLIFICATION AND ARRAY LOADING APPARATUS AND METHODS 有权
    放大和阵列装载装置和方法

    公开(公告)号：US20130288873A1

    公开(公告)日：2013-10-31

    申请号：US13828633

    申请日：2013-03-14

    Applicant: LIFE TECHNOLOGIES CORPORATION

    Inventor： Kristopher BARBEE ,  Ryan Jones ,  Sean McCusker ,  Maximilan Carpino ,  John Leamon ,  Jonathan Schultz ,  Jon A. Hoshizaki

    IPC: B04B13/00

    CPC classification number: C12Q1/6806 ,  B04B5/0421 ,  B04B13/00 ,  C12Q1/6869 ,  G01N35/00693 ,  G01N35/1011 ,  G01N2035/00495 ,  G01N2035/1013 ,  G01N2035/103

    Abstract: An apparatus includes a robotic system providing movement in three orthogonal directions to an arm operable to receive a pipette tip and to facilitate movement of fluid into and out of the pipette tip. In addition, the apparatus can include a tray for receiving pipette tips, receptacles for receiving tubes, an apparatus for forming an emulsion, a device for forming particles that include copies of the polynucleotide, a device for enriching the particles and an apparatus for loading such particles onto a sensor array. The apparatus can further include receptacles for holding containers of reagent solutions. Optionally, the robot can include a gripper arm in addition to the pipette receiving arm.

    Abstract translation: 一种装置包括机器人系统，该机器人系统在三个正交方向上提供可操作以接收移液管尖端的臂并促进流体进入和移出移液管尖端的运动。 此外，该装置可以包括用于接收移液管吸头的托盘，用于接收管的容器，用于形成乳液的装置，用于形成包括多核苷酸的拷贝的颗粒的装置，用于富集颗粒的装置和用于加载颗粒的装置 颗粒到传感器阵列上。 该装置还可以包括容纳试剂溶液容器的容器。 可选地，除了移液管接收臂之外，机器人还可以包括夹持臂。

    Methods to control dissolved gas
    8.
    发明授权
    Methods to control dissolved gas 有权
    控制溶解气体的方法

    公开(公告)号：US09045795B2

    公开(公告)日：2015-06-02

    申请号：US13802610

    申请日：2013-03-13

    Applicant: LIFE TECHNOLOGIES CORPORATION

    Inventor： James Ball ,  David Kupec ,  David Marran ,  Jon A. Hoshizaki

    IPC: C12Q1/68

    CPC classification number: C12Q1/68 ,  C12Q1/6869 ,  C12Q1/6883 ,  G01N27/4141 ,  Y10T436/143333 ,  C12Q2527/119 ,  C12Q2565/607

    Abstract: A method of sensing nucleotide reactions includes flowing at least one nucleotide solution from a container of at least two containers of a sensor system. The sensor system includes a sensor sensitive to a byproduct of nucleotide incorporation. Each container of the at least two containers includes a different nucleotide solution. The sensor system enters an idle mode after flowing. The method further includes cycling the at least two containers through at least two cycles. Each cycle includes depressurizing the at least two containers for a first period and pressurizing the at least two containers for a second period. The method also includes pressurizing the at least two containers when the sensor system enters an active mode.

    Abstract translation: 感测核苷酸反应的方法包括从传感器系统的至少两个容器的容器流出至少一个核苷酸溶液。 传感器系统包括对核苷酸掺入的副产物敏感的传感器。 至少两个容器的每个容器都包含不同的核苷酸解决方案。 传感器系统在流动后进入空闲模式。 该方法还包括使至少两个容器循环至少两个循环。 每个循环包括使至少两个容器减压第一时间段，并且将至少两个容器加压第二周期。 该方法还包括当传感器系统进入活动模式时对至少两个容器进行加压。

    SYSTEMS AND METHODS TO CONTROL DISSOLVED GAS
    9.
    发明申请
    SYSTEMS AND METHODS TO CONTROL DISSOLVED GAS 有权
    控制溶解气体的系统和方法

    公开(公告)号：US20140272980A1

    公开(公告)日：2014-09-18

    申请号：US13802610

    申请日：2013-03-13

    Applicant: LIFE TECHNOLOGIES CORPORATION

    Inventor： James Ball ,  David Kupec ,  David Marran ,  Jon A. Hoshizaki

    IPC: C12Q1/68

    CPC classification number: C12Q1/68 ,  C12Q1/6869 ,  C12Q1/6883 ,  G01N27/4141 ,  Y10T436/143333 ,  C12Q2527/119 ,  C12Q2565/607

    Abstract: A method of sensing nucleotide reactions includes flowing at least one nucleotide solution from a container of at least two containers of a sensor system. The sensor system includes a sensor sensitive to a byproduct of nucleotide incorporation. Each container of the at least two containers includes a different nucleotide solution. The sensor system enters an idle mode after flowing. The method further includes cycling the at least two containers through at least two cycles. Each cycle includes depressurizing the at least two containers for a first period and pressurizing the at least two containers for a second period. The method also includes pressurizing the at least two containers when the sensor system enters an active mode.

    Abstract translation: 感测核苷酸反应的方法包括从传感器系统的至少两个容器的容器流出至少一个核苷酸溶液。 传感器系统包括对核苷酸掺入的副产物敏感的传感器。 至少两个容器的每个容器都包含不同的核苷酸解决方案。 传感器系统在流动后进入空闲模式。 该方法还包括使至少两个容器循环至少两个循环。 每个循环包括使至少两个容器减压第一时间段，并且将至少两个容器加压第二周期。 该方法还包括当传感器系统进入活动模式时对至少两个容器进行加压。

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