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    Mechanism for the deployment of endovascular implants
    21.
    发明授权
    Mechanism for the deployment of endovascular implants 有权
    部署血管内植入物的机制

    公开(公告)号：US06689141B2

    公开(公告)日：2004-02-10

    申请号：US10143724

    申请日：2002-05-10

    申请人： David A. Ferrera ,  George R. Greene, Jr. ,  Brian J. Cox ,  Robert F. Rosenbluth

    发明人： David A. Ferrera ,  George R. Greene, Jr. ,  Brian J. Cox ,  Robert F. Rosenbluth

    IPC分类号： A61F1100

    CPC分类号： A61B17/1215 ,  A61B17/12022 ,  A61B17/1214 ,  A61B17/12163 ,  A61B17/1219 ,  A61B2017/00477 ,  A61B2017/00535 ,  A61B2017/00539 ,  A61B2017/00867 ,  A61B2017/1205 ,  A61B2017/12054

    摘要： A mechanism for the deployment of a filamentous endovascular device includes a flexible deployment tube having an open proximal end, and a coupling element attached to the proximal end of the endovascular device. The deployment tube includes a distal section terminating in an open distal end, with a lumen defined between the proximal and distal ends. A retention sleeve is fixed around the distal section and includes a distal extension extending a short distance past the distal end of the deployment tube. The endovascular device is attached to the distal end of the deployment tube by fixing the retention sleeve around the coupling element, so that the coupling element is releasably held within the distal extension of the deployment tube. In use, the deployment tube, with the implant attached to its distal end, is passed intravascularly through a microcatheter to a target vascular site until the endovascular device is located within the site. To detach the endovascular device from the deployment tube, a liquid is injected through the lumen of the deployment tube so as to apply pressure to the upstream side of the coupling element, which is thus pushed out of the retention sleeve by the fluid pressure. The coupling element may include an internal or peripheral purge passage that allows air to be purged from the microcatheter prior to the intravascular passage of the endovascular device.

    摘要翻译： 用于部署丝状血管内装置的机构包括具有开口近端的柔性展开管和附接到血管内装置的近端的联接元件。 展开管包括终止于开放远端的远侧部分，其中限定在近端和远端之间的内腔。 保持套固定在远端部分周围，并且包括远离展开管远端延伸的远端延伸部。 血管内装置通过将保持套固定在联接元件周围而附接到展开管的远端，使得联接元件可释放地保持在展开管的远侧延伸部内。 在使用中，将植入物连接到其远端的展开管通过血管内通过微导管至目标血管部位，直到血管内装置位于部位内。 为了将血管内装置从展开管中分离出来，液体通过展开管的内腔被注入，以便向耦合元件的上游侧施加压力，由此通过流体压力将其推出保持套筒。 联接元件可以包括内部或周边清洗通道，其允许空气在血管内装置的血管内通过之前从微导管清除。

    Apparatus and method for vascular embolization
    22.
    发明授权
    Apparatus and method for vascular embolization 有权
    血管栓塞的装置和方法

    公开(公告)号：US06375669B1

    公开(公告)日：2002-04-23

    申请号：US09471507

    申请日：1999-12-23

    申请人： Robert F. Rosenbluth ,  Brian J. Cox ,  George R. Green, Jr.

    发明人： Robert F. Rosenbluth ,  Brian J. Cox ,  George R. Green, Jr.

    IPC分类号： A61M2900

    CPC分类号： A61B17/12022 ,  A61B17/12113 ,  A61B17/1214 ,  A61B17/12163 ,  A61B17/12186 ,  A61B17/12195 ,  A61B2017/1205 ,  A61B2017/12063

    摘要： Apparatus for vascular embolization, deployable through a microcatheter, includes a flexible, elongate deployment tube dimensioned for insertion through the microcatheter, and a filamentous embolic device releasably attached to the distal end of the tube. The embolic device is controllably transformable from a soft, compliant state to a rigid or semi-rigid state. The embolic device may include a polymeric material that is transformable by contact with vascular blood or with a liquid that is cooler than vascular blood, or it may include a metallic material that is transformable by electrolytic corrosion. The embolic device may be a continuous filamentous polymeric extrusion; an elongate microcoil filled with polymeric material; an elongate, multi-segmented chain including polymeric interconnecting portions; or an elongate chain of metal segments that are fused together by electrolytic corrosion. An aneurysm is embolized with this apparatus by deploying a microcatheter so that its distal end is adjacent the aneurysm; deploying the embolic device through the microcatheter and into the aneurysm so that the embolic device forms a web-like mass in the aneurysm; and transforming the embolic device from its soft, compliant state to its rigid or semi-rigid state. The embolic device is advantageously deployed by releasably attaching it to a flexible, elongate deployment tube that is passed through the microcatheter, and then detaching the embolic device from the tube when the embolic device is suitably situated.

    摘要翻译： 用于通过微导管展开的血管栓塞的装置包括尺寸适于插入通过微导管的柔性细长展开管和可释放地附接到管的远端的丝状栓塞装置。 栓塞装置可以从柔软的柔顺状态可控地变形成刚性或半刚性状态。 栓塞装置可以包括通过与血管或与血液血液更冷的液体接触可变形的聚合材料，或者它可以包括可通过电解腐蚀转化的金属材料。 栓塞装置可以是连续的丝状聚合物挤出物; 填充有聚合物材料的细长的微线圈; 包括聚合物互连部分的细长多段链; 或通过电解腐蚀熔合在一起的金属段的细长链。 通过部署微导管使其远端邻近动脉瘤，将动脉瘤栓塞在该装置上; 将栓塞装置通过微导管部署到动脉瘤中，使得栓塞装置在动脉瘤中形成网状质量; 并将栓塞装置从其柔软的柔顺状态转变为刚性或半刚性状态。 栓塞装置有利地通过将其可释放地附接到穿过微导管的柔性细长的展开管来展开，然后当栓塞装置适当地定位时将栓塞装置从管中分离出来。

    Apparatus and method for vascular embolization
    23.
    发明授权
    Apparatus and method for vascular embolization 失效

    公开(公告)号：US6015424A

    公开(公告)日：2000-01-18

    申请号：US69008

    申请日：1998-04-28

    申请人： Robert F. Rosenbluth ,  Brian J. Cox ,  George R. Greene, Jr.

    发明人： Robert F. Rosenbluth ,  Brian J. Cox ,  George R. Greene, Jr.

    IPC分类号： A61B17/12 ,  A61M29/00

    CPC分类号： A61B17/12022 ,  A61B17/12113 ,  A61B17/1214 ,  A61B17/12163 ,  A61B17/12186 ,  A61B17/12195 ,  A61B2017/1205 ,  A61B2017/12063

    摘要： Apparatus for vascular embolization, deployable through a microcatheter, includes a flexible, elongate deployment tube dimensioned for insertion through the microcatheter, and a filamentous embolic device releasably attached to the distal end of the tube. The embolic device is controllably transformable from a soft, compliant state to a rigid or semi-rigid state. The embolic device may include a polymeric material that is transformable by contact with vascular blood or with a liquid that is cooler than vascular blood, or it may include a metallic material that is transformable by electrolytic corrosion. The embolic device may be a continuous filamentous polymeric extrusion; an elongate microcoil filled with polymeric material; an elongate, multi-segmented chain including polymeric interconnecting portions; or an elongate chain of metal segments that are fused together by electrolytic corrosion. An aneurysm is embolized with this apparatus by deploying a microcatheter so that its distal end is adjacent the aneurysm; deploying the embolic device through the microcatheter and into the aneurysm so that the embolic device forms a web-like mass in the aneurysm; and transforming the embolic device from its soft, compliant state to its rigid or semi-rigid state. The embolic device is advantageously deployed by releasably attaching it to a flexible, elongate deployment tube that is passed through the microcatheter, and then detaching the embolic device from the tube when the embolic device is suitably situated.

    Method and apparatus for treating impotence
    24.
    发明授权
    Method and apparatus for treating impotence 失效
    治疗阳的方法和装置

    公开(公告)号：US5048511A

    公开(公告)日：1991-09-17

    申请号：US588090

    申请日：1990-09-25

    申请人： Robert F. Rosenbluth ,  Brian J. Cox

    发明人： Robert F. Rosenbluth ,  Brian J. Cox

    IPC分类号： A61B17/12 ,  A61F2/00 ,  A61F2/26

    CPC分类号： A61F2/26 ,  A61B17/12 ,  A61F2/004

    摘要： A method for the treatment of impotence in a human male patient includes the steps of (1) selecting a penile vein or a crus of a corpus cavernosum; and (2) implanting in the patient a vascular occlusion device that allows the selective restriction of the flow of blood from the selected vein or crus when erectile function is desired, normal flow being otherwise maintained. A preferred embodiment of the vascular occlusion device comprises an inflatable cuff adapted to receive the vein or crus, a squeeze-bulb reservoir containing a working fluid, and a valving mechanism that allows fluid to flow from the squeeze bulb to the cuff, through a tube, when the bulb is squeezed, thereby inflating the cuff to restrict blood flow through the vein or crus. To deflate the cuff, the valving mechanism is manually operable to allow fluid to flow out of the cuff back into the reservoir due to the pressure gradient created by the partial evacuation of the previously-squeezed bulb. A drainage channel is provided in the valving mechanism to provide automatic and gradual cuff deflation over a selected time interval. Alternative embodiments of the invention include the surgical creation of an arteriovenous anastamosis that is received in a second cuff operated in a complementary manner with the first cuff, and the provision of a drug delivery adaptor that delivers a measured dose of a drug to the penile tissue in response to the squeezing of the bulb.

    摘要翻译： 用于治疗男性患者阳A的方法包括以下步骤：（1）选择阴茎海绵体的阴茎静脉或小腿; 和（2）在患者中植入血管闭塞装置，其允许在需要勃起功能时选择性地限制来自所选静脉或血液的血液的流动，否则保持正常流动。 血管闭塞装置的优选实施例包括适于接收静脉或血液的充气套囊，包含工作流体的挤压球囊储存器和允许流体从挤压球泡通过套管的阀机构，通过管 当灯泡被挤压时，从而使袖带膨胀以限制通过静脉或小腿的血流。 为了使袖带松开，阀门机构可手动操作，以允许流体由于先前挤压的灯泡的部分排空产生的压力梯度而流出袖带回到储存器中。 在阀机构中提供排水通道，以在选定的时间间隔内提供自动和逐渐的袖带收缩。 本发明的替代实施例包括手术创建动静脉吻合术，其以与第一袖口互补的方式操作的第二套囊接收，以及提供将测量剂量的药物递送至阴茎组织的药物递送适配器 响应于灯泡的挤压。

    Embolectomy catheters and methods for treating stroke and other small vessel thromboembolic disorders
    28.
    发明授权
    Embolectomy catheters and methods for treating stroke and other small vessel thromboembolic disorders 有权
    止血导管和治疗中风和其他小血管血栓栓塞障碍的方法

    公开(公告)号：US08100935B2

    公开(公告)日：2012-01-24

    申请号：US11773601

    申请日：2007-07-05

    申请人： Robert F. Rosenbluth ,  George R. Green, Jr. ,  Brian J. Cox ,  Thomas R. Sternweiler ,  Sean L. Chow ,  Richard R. Monetti

    发明人： Robert F. Rosenbluth ,  George R. Green, Jr. ,  Brian J. Cox ,  Thomas R. Sternweiler ,  Sean L. Chow ,  Richard R. Monetti

    IPC分类号： A61M29/00

    CPC分类号： A61B17/22032 ,  A61B17/135 ,  A61B17/221 ,  A61B2017/22034 ,  A61B2017/22044 ,  A61B2017/22077 ,  A61B2017/22084 ,  A61B2017/22094 ,  A61B2017/2212 ,  A61B2017/320716 ,  A61F2/013 ,  A61F2002/016 ,  A61F2002/018 ,  A61F2230/008 ,  A61F2230/0091 ,  A61M2025/0042 ,  A61M2025/0183

    摘要： Embolectomy catheters, rapid exchange microcatheters, systems and methods for removing clots or other obstructive matter (e.g., thrombus, thromboemboli, embolic fragments of atherosclerotic plaque, foreign objects, etc.) from blood vessels. This invention is particularly useable for percutaneous removal of thromboemboli or other obstructive matter from small blood vessels of the brain, during an evolving stroke or period of cerebral ischemia. In some embodiments, the embolectomy catheters of this invention are advanceable with or over a guidewire which has been pre-inserted through or around the clot. Also, in some embodiments, the embolectomy catheters include clot removal devices which are deployable from the catheter after the catheter has been advanced at least partially through the clot. The clot removal device may include a deployable wire nest that is designed to prevent a blood clot from passing therethrough. The delivery catheter may include telescoping inner and outer tubes, with the clot removal device being radially constrained by the outer tube. Retraction of the outer tube removes the constraint on the clot removal device and permits it to expand to its deployed configuration. An infusion guidewire is particularly useful in conjunction with the embolectomy catheter, and permits infusion of medicaments or visualization fluids distal to the clot.

    摘要翻译： 用于从血管中去除凝块或其他阻塞物（例如，血栓，血栓栓塞，动脉粥样硬化斑块的栓塞碎片，异物等）的系统和方法，快速交换微导管。 本发明特别可用于在脑卒中或脑缺血期间经皮去除血栓栓塞或其他来自脑小血管的阻塞物质。 在一些实施例中，本发明的止血栓塞导管可以在已经插入穿过凝块或围绕凝块的导丝上或之上前进。 此外，在一些实施例中，止血管切除导管包括在导管至少部分地穿过血块前进之后可从导管展开的凝块移除装置。 凝块移除装置可以包括被设计成防止血块从其中通过的可展开的线巢。 输送导管可以包括伸缩的内管和外管，其中血块去除装置由外管径向约束。 外管的收缩消除了对凝块去除装置的约束，并允许其扩展到其部署构型。 输注导丝特别适用于结肠切除术导管，并且可以输送远离凝块的药物或可视化液体。

    Vascular embolization with an expansible implant
    29.
    发明授权
    Vascular embolization with an expansible implant 有权
    血管栓塞与可扩展植入物

    公开(公告)号：US07799047B2

    公开(公告)日：2010-09-21

    申请号：US12337520

    申请日：2008-12-17

    申请人： George R. Greene, Jr. ,  Robert F. Rosenbluth ,  Brian J. Cox

    发明人： George R. Greene, Jr. ,  Robert F. Rosenbluth ,  Brian J. Cox

    IPC分类号： A61B19/00 ,  A61F2/06

    CPC分类号： A61L31/146 ,  A61B17/12022 ,  A61B17/12113 ,  A61B17/12186 ,  A61B17/1219 ,  A61B34/10 ,  A61B2017/00526 ,  A61B2017/1205 ,  A61F2/06 ,  A61L31/145 ,  A61L31/18 ,  A61L2430/36 ,  B33Y50/00 ,  B33Y80/00 ,  Y10S623/901 ,  Y10S623/903 ,  Y10T29/49

    摘要： A vascular implant formed of a compressible foam material has a compressed configuration from which it is expansible into a configuration substantially conforming to the shape and size of a vascular site to be embolized. Preferably, the implant is formed of a hydrophilic, macroporous foam material, having an initial configuration of a scaled-down model of the vascular site, from which it is compressible into the compressed configuration. The implant is made by scanning the vascular site to create a digitized scan data set; using the scan data set to create a three-dimensional digitized virtual model of the vascular site; using the virtual model to create a scaled-down physical mold of the vascular site; and using the mold to create a vascular implant in the form of a scaled-down model of the vascular site. To embolize a vascular site, the implant is compressed and passed through a microcatheter, the distal end of which has been passed into a vascular site. Upon entering the vascular site, the implant expands in situ substantially to fill the vascular site. A retention element is contained within the microcatheter and has a distal end detachably connected to the implant. A flexible, tubular deployment element is used to pass the implant and the retention element through the microcatheter, and then to separate the implant from the retention element when the implant has been passed out of the microcatheter and into the vascular site.

    摘要翻译： 由可压缩泡沫材料形成的血管植入物具有压缩构型，其可膨胀到基本上符合要栓塞的血管部位的形状和尺寸的构造。 优选地，植入物由亲水的大孔泡沫材料形成，具有血管部位的缩小模型的初始构型，从而可压缩成压缩构型。 通过扫描血管部位来创建植入物以产生数字化的扫描数据集; 使用扫描数据集创建血管部位的三维数字化虚拟模型; 使用虚拟模型创建血管部位的缩小物理模具; 并使用模具以血管部位的缩小模型的形式产生血管植入物。 为了栓塞血管部位，植入物被压缩并通过微导管，其远端已经进入血管部位。 在进入血管部位时，植入物基本上扩张以填充血管部位。 保持元件容纳在微导管内并且具有可拆卸地连接到植入物的远端。 使用柔性的管状展开元件将植入物和保持元件通过微导管，然后当植入物从微导管通过并进入血管部位时，将植入物与保留元件分离。