公开(公告)号：US09159544B2

公开(公告)日：2015-10-13

申请号：US14001747

申请日：2011-09-28

Applicant: Li Ding ,  Mikhail Sudakov ,  Sumio Kumashiro

Inventor： Li Ding ,  Mikhail Sudakov ,  Sumio Kumashiro

IPC: H01J49/42 ,  H01J49/02 ,  H01J49/00 ,  H01J49/06 ,  H01J49/40

CPC classification number: H01J49/027 ,  H01J49/0031 ,  H01J49/061 ,  H01J49/406 ,  H01J49/408 ,  H01J49/4245

Abstract: An electrostatic ion trap for mass analysis includes a first array of electrodes and a second array of electrodes, spaced from the first array of electrode. The first and second arrays of electrodes may be planar arrays formed by parallel strip electrodes or by concentric, circular or part-circular electrically conductive rings. The electrodes of the arrays are supplied with substantially the same pattern of voltage whereby the distribution of electrical potential in the space between the arrays is such as to reflect ions isochronously in a flight direction causing them to undergo periodic, oscillatory motion in the space, focused substantially mid-way between the arrays. Amplifier circuitry is used to detect image current having frequency components related to the mass-to-charge ratio of ions undergoing the periodic, oscillatory motion.

Abstract translation: 用于质量分析的静电离子阱包括第一电极阵列和与第一电极阵列间隔开的第二电极阵列。 第一和第二电极阵列可以是由平行条形电极或同心圆形或部分圆形导电环形成的平面阵列。 阵列的电极被提供有基本上相同的电压模式，由此阵列之间的空间中的电位分布使得在飞行方向上等离子地反射离子，使得它们在空间中经历周期性的振荡运动 基本上位于阵列之间。 放大器电路用于检测具有与经历周期性振荡运动的离子的质荷比相关的频率分量的图像电流。

公开(公告)号：US08890058B2

公开(公告)日：2014-11-18

申请号：US12093862

申请日：2005-11-16

Applicant: Sadao Takeuchi ,  Hiroaki Waki ,  Li Ding ,  Roger Giles

Inventor： Sadao Takeuchi ,  Hiroaki Waki ,  Li Ding ,  Roger Giles

IPC: H01J49/00 ,  H01J49/06

CPC classification number: H01J49/067 ,  H01J49/066

Abstract: The present invention provides a mass spectrometer having an ion lens capable of transporting an ion having a large mass to charge ratio with a high level of ion-passing efficiency even under a low-vacuum atmosphere. In conventional atmospheric pressure ionization mass spectrometers or similar mass spectrometers, applying an excessively high voltage to the ion lens undesirably causes an electric discharge. Therefore, the passing efficiency for an ion having a large mass to charge ratio cannot be adequately improved, which leads to a poor detection sensitivity. To solve this problem, the mass spectrometer according to the present invention includes a voltage controller 21 that controls a variable radiofrequency (RF) voltage generator 24 so that both the amplitude and the frequency of the RF voltage applied to the lens electrodes of an ion lens 5 are changed according to the mass to charge ratio of an ion to be analyzed. This control enables the ion lens 5 to focus an ion and transport it to the subsequent stage with a high level of passing efficiency even in the case of analyzing an ion having a large mass to charge ratio. Thus, the detection sensitivity is improved. The aforementioned control is conducted on the basis of the control data stored in a voltage control data storage 22. These data are obtained in advance by a measurement of a sample containing a substance having a known mass to charge ratio, in which the intensity of the signal of an ion detector is maintained while the analysis conditions are changed.

Abstract translation: 本发明提供一种质谱仪，其具有能够即使在低真空气氛下也能以高水平的离子通过效率将具有大质荷比的离子输送的离子透镜。 在传统的大气压电离质谱仪或类似的质谱仪中，对离子透镜施加过高的电压会导致放电。 因此，不能充分提高质荷比大的离子的通过效率，导致检测灵敏度差。 为了解决这个问题，根据本发明的质谱仪包括控制可变射频（RF）电压发生器24的电压控制器21，使得施加到离子透镜的透镜电极的RF电压的幅度和频率 5根据待分析的离子的质荷比而改变。 这种控制使得离子透镜5能够聚焦离子并且即使在分析具有大的质荷比的离子的情况下，也可以将其输送到具有高水平的通过效率的后续阶段。 因此，提高了检测灵敏度。 上述控制是根据存储在电压控制数据存储器22中的控制数据进行的。这些数据是通过测量包含具有已知质荷比的物质的样品预先获得的，其中， 在分析条件改变的同时保持离子检测器的信号。

公开(公告)号：US20140217275A1

公开(公告)日：2014-08-07

申请号：US14001747

申请日：2011-09-28

Applicant: Li Ding ,  Mikhail Sudakov ,  Sumio Kumashiro

Inventor： Li Ding ,  Mikhail Sudakov ,  Sumio Kumashiro

IPC: H01J49/42 ,  H01J49/00 ,  H01J49/06

CPC classification number: H01J49/027 ,  H01J49/0031 ,  H01J49/061 ,  H01J49/406 ,  H01J49/408 ,  H01J49/4245

Abstract: An electrostatic ion trap for mass analysis includes a first array of electrodes and a second array of electrodes, spaced from the first array of electrode. The first and second arrays of electrodes may be planar arrays formed by parallel strip electrodes or by concentric, circular or part-circular electrically conductive rings. The electrodes of the arrays are supplied with substantially the same pattern of voltage whereby the distribution of electrical potential in the space between the arrays is such as to reflect ions isochronously in a flight direction causing them to undergo periodic, oscillatory motion in the space, focused substantially mid-way between the arrays. Amplifier circuitry is used to detect image current having frequency components related to the mass-to-charge ratio of ions undergoing the periodic, oscillatory motion.

Abstract translation: 用于质量分析的静电离子阱包括第一电极阵列和与第一电极阵列间隔开的第二电极阵列。 第一和第二电极阵列可以是由平行条形电极或同心圆形或部分圆形导电环形成的平面阵列。 阵列的电极被提供有基本上相同的电压模式，由此阵列之间的空间中的电位分布使得在飞行方向上等离子地反射离子，使得它们在空间中经历周期性的振荡运动 基本上位于阵列之间。 放大器电路用于检测具有与经历周期性振荡运动的离子的质荷比相关的频率分量的图像电流。

公开(公告)号：US08486055B2

公开(公告)日：2013-07-16

申请号：US12146976

申请日：2008-06-26

Applicant: Wayne H. Knox ,  Li Ding ,  Krystel R. Huxlin ,  Jay F. Kunzler

Inventor： Wayne H. Knox ,  Li Ding ,  Krystel R. Huxlin ,  Jay F. Kunzler

IPC: A61B18/18

CPC classification number: A61F9/00804 ,  A61F9/008 ,  A61F9/00829 ,  A61F2009/00842 ,  A61F2009/00848 ,  A61F2009/0087 ,  A61F2009/00872 ,  A61F2009/0088

Abstract: A method for modifying the refractive index of ocular tissues. The method comprises irradiating select regions of ocular tissue with a visible or near-IR laser. The irradiation results in the formation of structures in the ocular tissue, characterized by a change in refractive index, and which exhibit little or no scattering loss.

Abstract translation: 一种改变眼组织折射率的方法。 该方法包括用可见光或近红外激光照射眼组织的选择区域。 照射导致眼组织中的结构的形成，其特征在于折射率的变化，并且表现出很少或没有散射损失。

公开(公告)号：US20120248307A1

公开(公告)日：2012-10-04

申请号：US13079740

申请日：2011-04-04

Applicant: Li Ding ,  Tao Lin ,  Gongyu Jiang ,  Hui Mu

Inventor： Li Ding ,  Tao Lin ,  Gongyu Jiang ,  Hui Mu

IPC: H01J49/34

CPC classification number: H01J49/423

Abstract: The present invention relates generally to the field of ion storage and analysis, in particular to a linear ion trap mass analyzer comprised by multiple columnar electrodes. High frequency voltages are applied on at least one of the columnar electrodes to form ion confining space, which mainly consists of two-dimensional quadrupole electric radial trapping field, and there is at least one through slot for ion ejection in at least one direction perpendicular to the axis of the ion trap, wherein an AC electric field superposition is applied to invoke dipole excitation. Opposite to the through slot, there is an elongated electrode for field adjusting between two columnar electrodes or inside the slit of one of the columnar electrodes mentioned above. The potential on the elongated electrode for field adjusting is set as the sum of a portion of the high frequency voltage which applied on one adjacent columnar electrode and a DC offset, which can be adjusted freely. Through adjusting the portion of the high frequency potential and DC potential on this electrode, one or more objectives, including field optimization inside the ion trap as well as ion motion characteristics of resonant ejection, can be realized.

Abstract translation: 本发明一般涉及离子存储和分析领域，特别涉及由多个柱状电极组成的线性离子阱质量分析仪。 在至少一个柱状电极上施加高频电压以形成主要由二维四极电子径向捕获场组成的离子限制空间，并且至少有一个通孔用于在至少一个垂直于 离子阱的轴线，其中施加AC电场叠加以调用偶极子激发。 与通孔相对，有一个用于在两个柱状电极之间进行现场调节的细长电极或者在上述一个柱状电极的狭缝内部。 用于场调整的细长电极上的电位被设置为施加在一个相邻柱状电极上的高频电压的一部分和可以自由调节的DC偏移之和。 通过调节该电极上的高频电位和直流电位的一部分，可以实现一个或多个目标，包括离子阱内的场优化以及共振喷射的离子运动特性。

公开(公告)号：US20110270038A1

公开(公告)日：2011-11-03

申请号：US13138112

申请日：2009-12-31

Applicant: Wenqiang Jiang ,  Li Ding

Inventor： Wenqiang Jiang ,  Li Ding

IPC: A61B1/267

CPC classification number: A61B1/267 ,  A61B1/00052 ,  A61B1/00073 ,  A61B1/06

Abstract: A video laryngoscope has a handle and a groove on one side of the handle. The groove is used for guiding a guide wire when the larynogoscope is placed in a patient's mouth. A video camera located near the end of the handle is used to view the area around the glottis. When the guide wire is properly positioned near the glottis, the upper part of the guide wire is disengaged from the groove so as to allow an endotracheal tube to be slipped over the guide wire and to be inserted into part of the trachea through the glottis. When the tube is properly inserted for intubation, the guide wire is removed from the tube. An illuminating light source such as an LED lamp can be installed at the end of the handle to provide illumination for the video camera.

Abstract translation: 视频喉镜在手柄的一侧具有手柄和凹槽。 当喉镜放置在患者口中时，该凹槽用于引导导丝。 位于手柄末端附近的摄像机用于查看声门周围的区域。 当引导线适当地定位在声门附近时，导丝的上部与凹槽脱离，以允许气管内导管滑过导丝并通过声门插入到气管的一部分中。 当管正确插入插管时，导丝从管中取出。 诸如LED灯的照明光源可以安装在手柄的端部以为摄像机提供照明。

公开(公告)号：US20110253903A1

公开(公告)日：2011-10-20

申请号：US13141864

申请日：2009-12-29

Applicant: Wenjian Sun ,  Xiaohui Yang ,  Li Ding

Inventor： Wenjian Sun ,  Xiaohui Yang ,  Li Ding

IPC: H01J27/08

CPC classification number: H01J49/168

Abstract: The current invention involves a desorption corona beam ionization source/device for analyzing samples under atmospheric pressure without sample pretreatment. It includes a gas source, a gas flow tube, a gas flow heater, a metal tube, a DC power supply and a sample support/holder for placing the samples. A visible corona beam is formed at a sharply pointed tip at the exit of the metal tube when a stream of inert gas flows through the metal tube that is applied with a high DC voltage. The gas is heated for desorbing the analyte from solid samples and the desorbed species are ionized by the energized particles embedded in the corona beam. The ions formed are then transferred through an adjacent inlet into a mass spectrometer or other devices capable of analyzing ions. Visibility of the corona beam in the current invention greatly facilitates pinpointing a sampling area on the analyte and also makes profiling of sample surfaces possible.

Abstract translation: 本发明涉及一种解吸电晕束电离源/装置，用于在大气压力下分析样品而无需样品预处理。 其包括气体源，气体流管，气流加热器，金属管，直流电源和用于放置样品的样品支撑/保持器。 当惰性气体流过施加有高直流电压的金属管时，在金属管的出口处的尖锐尖端处形成可见的电晕束。 加热气体以从固体样品中解吸分析物，并且解吸物质被嵌入电晕束中的通电颗粒电离。 所形成的离子然后通过相邻入口转移到质谱仪或其他能够分析离子的装置中。 本发明中电晕束的可见性大大有助于精确分析分析物上的采样区域，并且还使得样品表面的轮廓成为可能。

公开(公告)号：US20110240845A1

公开(公告)日：2011-10-06

申请号：US13140346

申请日：2009-12-22

Applicant: Li Ding

Inventor： Li Ding

IPC: H01J49/40

CPC classification number: H01J49/027 ,  H01J49/0036 ,  H01J49/4245

Abstract: A mass spectrometric analyzer and an analysis method based on the detection of ion image current are provided. The method in one embodiment includes using electrostatic reflectors or electrostatic deflectors to enable pulsed ions to move periodically for multiple times in the analyzer, forming time focusing in a portion of the ion flight region thereof, and forming an confined ion beam in space; enabling the ion beam to pass through multiple tubular image current detectors arranged in series along an axial direction of the ion beam periodically, using a low-noise electronic amplification device to detect image currents picked up by the multiple tubular detectors differentially, and using a data conversion method, such as a least square regression, to acquire a mass spectrum.

Abstract translation: 提供了基于离子图像电流检测的质谱分析仪和分析方法。 在一个实施例中的方法包括使用静电反射器或静电偏转器使得脉冲离子能够在分析器中周期性移动多次，形成时间聚焦在其离子飞行区域的一部分中，并在空间中形成约束离子束; 使得离子束能够通过使用低噪声电子放大装置周期性地沿着离子束的轴向方向串联布置的多个管状图像电流检测器，以差分地检测由多个管状检测器拾取的图像电流，并使用数据 转换方法，如最小二乘回归，以获得质谱。

公开(公告)号：US07993677B2

公开(公告)日：2011-08-09

申请号：US10722968

申请日：2003-11-26

Applicant: Li Ding ,  Stephanie Morar ,  David Schlossman

Inventor： Li Ding ,  Stephanie Morar ,  David Schlossman

IPC: A61K9/14 ,  A61K9/50 ,  A61K9/56

CPC classification number: A61Q5/02 ,  A61K8/0283 ,  A61K8/8152 ,  A61K9/0014 ,  A61K2800/56 ,  A61Q19/00

Abstract: Stable and uniform distribution of gel beads or other particulate material, dispersed in a liquid medium can be obtained by including a density-reducing agent within the gel beads to provide the particle with a desired bulk density, for example a density close to that of the disperse liquid medium. Suitable density control can prevent migration due to gravity leading to settling in storage. Gel beads formulated with agar are suitable for use in cosmetics and for inclusion in cosmetics formulating processes which may employ modestly elevated temperatures. Attractive and novel cosmetics bead suspensions are described. Additional to cosmetics, pharmaceutical, foodstuff and other applications are disclosed. Examples of suitable density-reducing agents include very low density hollow polymeric microspheres and temperature-sensitive expandable thermoplastic microspheres.

Abstract translation: 分散在液体介质中的凝胶珠或其它颗粒材料的稳定和均匀分布可以通过在凝胶珠内包含密度降低剂来提供颗粒以获得所需的堆积密度，例如接近于 分散液体介质。 合适的密度控制可以防止由重力引起的迁移导致储存沉降。 用琼脂配制的凝胶珠适用于化妆品和包含在可能采用温和升高的温度的化妆品配方中。 描述了有吸引力和新颖的化妆品珠悬浮液。 披露了化妆品，制药，食品和其他应用的附加物。 合适的减密剂的实例包括非常低密度的中空聚合物微球和温度敏感的可发性热塑性微球。

公开(公告)号：US07943902B2

公开(公告)日：2011-05-17

申请号：US11916355

申请日：2006-05-26

Applicant: Li Ding ,  Alan Joseph Smith ,  Evgenij Nikolaevich Nikolaev

Inventor： Li Ding ,  Alan Joseph Smith ,  Evgenij Nikolaevich Nikolaev

IPC: H01J49/04 ,  H01J49/26

CPC classification number: H01J49/4295 ,  H01J49/0072 ,  H01J49/0095 ,  H01J49/062

Abstract: A method of introducing ions into an ion trap and an ion storage apparatus are described. Introduction means are used to introduce first ions into an ion trap through an entrance aperture to the ion trap. An operating condition of the introduction means is adjusted to cause second ions, of different polarity to the first ions to be introduced into the ion trap through the same entrance aperture.

Abstract translation: 描述了将离子引入离子阱和离子存储装置的方法。 引入装置用于通过离子阱的入口将第一离子引入离子阱。 引入装置的操作条件被调整以使得与第一离子不同的第二离子通过相同的入口孔引入离子阱。