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21.发明申请NOVEL SUBSTITUTED INDANES, METHOD FOR THE PRODUCTION THEREOF, AND USE THEREOF AS DRUGS 有权新代替印度尼西亚生产方法及其作为药物使用公开(公告)号：US20120022039A1
公开(公告)日：2012-01-26
申请号：US13201410
申请日：2010-02-12
IPC分类号： A61K31/397 , C07D207/06 , C07D211/22 , C07D223/04 , C07D221/22 , C07C235/54 , C07D307/14 , A61K31/351 , A61K31/40 , A61K31/445 , A61K31/55 , A61K31/439 , A61K31/166 , A61K31/341 , A61P3/10 , A61P3/04 , A61P3/06 , A61P1/16 , A61P3/00 , C07D309/04
CPC分类号： C07D309/04 , C07C235/54 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2602/08 , C07D205/04 , C07D207/09 , C07D207/12 , C07D211/14 , C07D211/22 , C07D211/46 , C07D213/81 , C07D295/135 , C07D307/14 , C07D401/12 , C07D405/12 , C07D471/04
摘要： The invention relates to substituted indanes and derivatives thereof, to physiologically acceptable salts and physiologically functional derivatives thereof, to the production thereof, to drugs containing at least one substituted indane according to the invention or derivative thereof, and to the use of the substituted indanes according to the invention and to derivatives thereof as MCH antagonists.
摘要翻译： 本发明涉及取代的茚满及其衍生物，其生理上可接受的盐和生理功能衍生物，其生产方法，涉及含有至少一种本发明取代的二氢化茚或其衍生物的药物，以及根据 本发明及其衍生物作为MCH拮抗剂。
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22.发明授权公开(公告)号：US07319108B2
公开(公告)日：2008-01-15
申请号：US11042563
申请日：2005-01-25
申请人： Lothar Schwink , Siegfried Stengelin , Thomas Boehme , Matthias Gossel , Gerhard Hessler , Petra Stahl
发明人： Lothar Schwink , Siegfried Stengelin , Thomas Boehme , Matthias Gossel , Gerhard Hessler , Petra Stahl
IPC分类号： A61K31/4245 , C07D271/10
CPC分类号： A61K31/4439 , A61K31/497 , A61K31/501 , A61K45/06 , A61K2300/00
摘要： The invention relates to substituted aryl-substituted heterocycles and to the physiologically tolerated salts and physiologically functional derivatives thereof, to process for their preparation and to their use as medicaments.Compounds of the Formula I in which the radicals have the stated meanings, the N-oxides thereof, and the physiologically tolerated salts thereof, and process for the preparation thereof are described. The compounds bring about for example a weight reduction in mammals and are suitable for example for the prevention and treatment of obesity and diabetes.
摘要翻译： 本发明涉及取代的芳基取代的杂环及其生理上耐受的盐和生理功能衍生物，用于其制备及其作为药物的用途。 描述了其中基团具有所述含义的式I化合物，其N-氧化物及其生理上耐受的盐及其制备方法。 所述化合物例如引起哺乳动物的体重减轻，并且适合于例如预防和治疗肥胖症和糖尿病。
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23.发明申请公开(公告)号：US20050176710A1
公开(公告)日：2005-08-11
申请号：US11042563
申请日：2005-01-25
申请人： Lothar Schwink , Siegfried Stengelin , Thomas Boehme , Matthias Gossel , Gerhard Hessler , Petra Stahl
发明人： Lothar Schwink , Siegfried Stengelin , Thomas Boehme , Matthias Gossel , Gerhard Hessler , Petra Stahl
IPC分类号： A61K31/4439 , A61K31/497 , A61K31/501 , C07D43/14
CPC分类号： A61K31/4439 , A61K31/497 , A61K31/501 , A61K45/06 , A61K2300/00
摘要： The invention relates to substituted aryl-substituted heterocycles and to the physiologically tolerated salts and physiologically functional derivatives thereof, to process for their preparation and to their use as medicaments. Compounds of the Formula I in which the radicals have the stated meanings, the N-oxides thereof, and the physiologically tolerated salts thereof, and process for the preparation thereof are described. The compounds bring about for example a weight reduction in mammals and are suitable for example for the prevention and treatment of obesity and diabetes.
摘要翻译： 本发明涉及取代的芳基取代的杂环及其生理上耐受的盐和生理功能衍生物，用于其制备及其作为药物的用途。 描述了其中基团具有所述含义的式I化合物，其N-氧化物及其生理上耐受的盐及其制备方法。 所述化合物例如引起哺乳动物的体重减轻，并且适合于例如预防和治疗肥胖症和糖尿病。
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24.发明申请SUBSTITUTED TETRAHYDRONAPHTHALENES, METHOD FOR THE PRODUCTION THEREOF, AND USE THEREOF AS DRUGS 有权取代的四氢萘甲酸酯，其生产方法及其作为药物的用途公开(公告)号：US20120015936A1
公开(公告)日：2012-01-19
申请号：US13201400
申请日：2010-02-12
IPC分类号： A61K31/351 , C07D319/12 , A61K31/357 , C07D405/12 , A61K31/453 , C07D223/04 , A61K31/55 , C07D401/12 , A61P3/00 , A61P3/10 , A61P3/06 , A61P3/04 , A61P3/08 , A61P5/48 , A61P1/16 , A61P25/00 , C07D309/06
CPC分类号： C07D207/09 , C07C235/54 , C07C2601/02 , C07C2601/04 , C07C2601/14 , C07C2602/10 , C07D205/04 , C07D209/52 , C07D211/22 , C07D211/26 , C07D211/46 , C07D213/81 , C07D295/135 , C07D305/06 , C07D307/14 , C07D307/16 , C07D309/04 , C07D309/06 , C07D319/12 , C07D401/12 , C07D405/06 , C07D405/12 , C07D453/06 , C07D471/08
摘要： The invention relates to substituted tetrahydronaphthalenes, to derivatives thereof, to physiologically acceptable salts thereof, to physiologically functional derivatives, to the production thereof, to drugs containing at least one substituted tetrahydronaphthalene according to the invention or derivative thereof, and to the use of the substituted tetrahydronaphthalenes according to the invention and to derivatives thereof as MCH antagonists.
摘要翻译： 本发明涉及取代的四氢萘，其衍生物，其生理上可接受的盐，生理功能衍生物，其生产方法，涉及含有至少一种根据本发明的取代的四氢萘或其衍生物的药物，以及取代的四氢萘 四氢萘和其衍生物作为MCH拮抗剂。
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25.发明授权Aryl-substituted polycyclic amines, method for the production thereof, and use thereof as a medicament 有权芳基取代的多环胺，其制备方法及其作为药物的用途公开(公告)号：US07838547B2
公开(公告)日：2010-11-23
申请号：US11674353
申请日：2007-02-13
IPC分类号： C07D487/02 , A61K31/40
CPC分类号： C07D471/04 , C07D471/08 , C07D487/04
摘要： The invention relates to aryl-substituted polycyclic amines of formula I, especially bicyclic amines, and to the physiologically tolerated salts and physiologically functional derivatives thereof; where the symbols and radicals are explained in the description, as well as to pharmaceutical compositions containing them and to methods of treatment using them.
摘要翻译： 本发明涉及式I的芳基取代的多环胺，特别是双环胺，以及其生理上耐受的盐和生理功能衍生物; 在说明书中解释符号和自由基以及含有它们的药物组合物以及使用它们的治疗方法。
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26.发明授权Substituted N-cycloexylimidazolinones, process for their preparation and their use as medicaments 有权取代的N-环糊精咪唑啉酮，其制备方法及其用作药物公开(公告)号：US07241787B2
公开(公告)日：2007-07-10
申请号：US11042713
申请日：2005-01-25
IPC分类号： A61K31/551 , A61K31/495 , A61K31/439 , A61K31/4439 , A61K31/454 , A61K31/4545 , A61K31/4166 , C07D243/08 , C07D403/08 , C07D453/00 , C07D211/56 , C07D211/06 , C07D401/14 , C07D401/04 , C07D233/70
CPC分类号： A61K31/4164 , A61K31/496
摘要： The invention relates to substituted N-cyclohexylheterocycles and to the physiologically tolerated salts and physiologically functional derivatives thereof, to processes for their preparation and to their use as medicaments.Compounds of the formula I, in which the radicals have the stated meanings, and the physiologically tolerated salts thereof, and process for their preparation are described. The compounds bring about for example a weight reduction in mammals and are suitable for example for the prevention and treatment of obesity and diabetes.
摘要翻译： 本发明涉及取代的N-环己基杂环和其生理上耐受的盐和生理功能衍生物，其制备方法及其用作药物。 描述了其中基团具有所述含义的式I化合物及其生理上耐受的盐及其制备方法。 所述化合物例如引起哺乳动物的体重减轻，并且适合于例如预防和治疗肥胖症和糖尿病。
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27.发明申请Substituted N-cycloexylimidazolinones, process for their preparation and their use as medicaments 有权取代的N-环糊精咪唑啉酮，其制备方法及其用作药物公开(公告)号：US20050176795A1
公开(公告)日：2005-08-11
申请号：US11042713
申请日：2005-01-25
IPC分类号： A61K31/4164 , A61K31/4196
CPC分类号： A61K31/4164 , A61K31/496
摘要： The invention relates to substituted N-cyclohexylheterocycles and to the physiologically tolerated salts and physiologically functional derivatives thereof, to processes for their preparation and to their use as medicaments. Compounds of the formula I, in which the radicals have the stated meanings, and the physiologically tolerated salts thereof, and process for their preparation are described. The compounds bring about for example a weight reduction in mammals and are suitable for example for the prevention and treatment of obesity and diabetes.
摘要翻译： 本发明涉及取代的N-环己基杂环和其生理上耐受的盐和生理功能衍生物，其制备方法及其用作药物。 描述了其中基团具有所述含义的式I化合物及其生理上耐受的盐及其制备方法。 所述化合物例如引起哺乳动物的体重减轻，并且适合于例如预防和治疗肥胖症和糖尿病。
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28.发明申请Substituted imidazoline-2,4-diones, process for preparation thereof, medicaments comprising these compounds and use thereof 审中-公开取代的咪唑啉-2,4-二酮，其制备方法，包含这些化合物的药物及其用途公开(公告)号：US20110112097A1
公开(公告)日：2011-05-12
申请号：US12852084
申请日：2010-08-06
申请人： Gerhard Jaehne , Peter Below , Siegfried Stengelin , Matthias Gossel , Thomas Klabunde , Irvin Winkler
发明人： Gerhard Jaehne , Peter Below , Siegfried Stengelin , Matthias Gossel , Thomas Klabunde , Irvin Winkler
IPC分类号： A61K31/5377 , C07D233/72 , A61K31/415 , C07D413/10 , C07D471/10 , A61K31/438 , C07D487/10 , C07D401/04 , A61K31/4439 , A61P3/00 , A61P3/10 , A61P3/04 , A61P25/34 , A61P25/32 , A61P25/00 , A61P25/18 , A61P25/28
CPC分类号： C07D401/04 , C07D233/74 , C07D235/02 , C07D405/04 , C07D409/04 , C07D471/04
摘要： The invention relates to compounds of formula (I) wherein the groups R and R′, A, D, E, G, L, p and R1 to R10 have the stated meanings and to their physiologically compatible salts. Said compounds are suitable, for example, as anti-obesity drugs.
摘要翻译： 本发明涉及式（I）化合物，其中基团R和R'，A，D，E，G，L，p和R 1至R 10具有所述含义及其生理上相容的盐。 所述化合物例如适合作为抗肥胖药物。
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![Substituted hexahydropyrazino [1,2-A] pyrimidine-4,7-dione derivatives, process for their preparation and their use as medicaments](/abs-image/US/2010/07/06/US07750005B2/abs.jpg.150x150.jpg)
29.发明授权Substituted hexahydropyrazino [1,2-A] pyrimidine-4,7-dione derivatives, process for their preparation and their use as medicaments 有权取代的六氢吡嗪并[1,2-A]嘧啶-4,7-二酮衍生物，其制备方法及其用作药物公开(公告)号：US07750005B2
公开(公告)日：2010-07-06
申请号：US12124503
申请日：2008-05-21
申请人： Stefanie Flohr , Siegfried Stengelin , Matthias Gossel , Thomas Klabunde , Pavel Safar , James Spoonamore , Martin Smrcina
发明人： Stefanie Flohr , Siegfried Stengelin , Matthias Gossel , Thomas Klabunde , Pavel Safar , James Spoonamore , Martin Smrcina
IPC分类号： C07D487/00 , A61K31/495 , A01N43/60
CPC分类号： C07D487/04
摘要： The invention relates to substituted hexahydropyrazino[1,2-a]pyrimidine-4,7-dione derivatives and to the physiologically tolerated salts and physiologically functional derivatives thereof.Compounds of the formula I in which the radicals have the stated meanings, and the physiologically tolerated salts thereof and processes for preparing them are described. The compounds are suitable for example as anorectic agents.
摘要翻译： 本发明涉及取代的六氢吡嗪并[1,2-a]嘧啶-4,7-二酮衍生物及其生理上耐受的盐和生理功能衍生物。 描述了其中基团具有所述含义的式I化合物及其生理上耐受的盐及其制备方法。 该化合物适合于例如厌食剂。
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30.发明申请Heterocycle-substituted imidazolidine-2,4-diones, process for preparation thereof, medicaments comprising them and use thereof 审中-公开杂环取代的咪唑烷-2,4-二酮，其制备方法，包含它们的药物及其用途公开(公告)号：US20110046105A1
公开(公告)日：2011-02-24
申请号：US12852233
申请日：2010-08-06
IPC分类号： A61K31/4178 , C07D401/12 , A61K31/497 , A61P3/04 , A61P3/10 , A61P25/28 , A61P25/18 , A61P25/32 , A61P25/34 , A61K31/4184 , A61K31/501 , C07D413/14 , A61K31/5355 , A61K31/454
CPC分类号： C07D233/72 , C07D401/12 , C07D403/12 , C07D405/12
摘要： The invention relates to compounds of formula (I) wherein the groups R and R′, A, D, E, G, L, p and R1 to R10 have the stated meanings and to their physiologically compatible salts. Said compounds are suitable, for example, as anti-obesity drugs.
摘要翻译： 本发明涉及式（I）化合物，其中基团R和R'，A，D，E，G，L，p和R 1至R 10具有所述含义及其生理上相容的盐。 所述化合物例如适合作为抗肥胖药物。
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