-
21.发明申请公开(公告)号：US20130101629A1
公开(公告)日：2013-04-25
申请号：US13516227
申请日：2010-12-15
IPC分类号： A61K39/39 , A61K31/496 , A61K31/683 , A61K31/675 , A61K31/4745 , A61K31/5377
CPC分类号： A61K39/39 , A61K31/4745 , A61K31/496 , A61K31/5377 , A61K31/675 , A61K31/683 , A61K31/7004 , A61K31/717 , A61K39/095 , A61K39/12 , A61K39/155 , A61K2039/55505 , A61K2039/55511 , A61K2039/55555 , A61K2039/55561 , A61K2039/55566 , C12N2760/14134 , C12N2760/18534 , Y02A50/41 , A61K2300/00
摘要： The present invention generally relates to homogeneous suspensions of small molecule immune potentiators (SMIPs) that are capable of stimulating or modulating an immune response in a subject in need thereof. The homogeneous suspensions may be used in combinations with various antigens or adjuvants for vaccine therapies.
摘要翻译： 本发明一般涉及能够刺激或调节有需要的受试者的免疫应答的小分子免疫增强剂（SMIP）的均匀悬浮液。 均匀悬浮液可以与各种抗原或佐剂组合用于疫苗疗法。
-
公开(公告)号：US20120121714A1
公开(公告)日：2012-05-17
申请号：US13345702
申请日：2012-01-07
申请人： Mario Contorni , Manmohan Singh , Derek O'Hagan
发明人： Mario Contorni , Manmohan Singh , Derek O'Hagan
IPC分类号： A61K9/18 , A61K39/12 , A61K39/02 , A61K39/39 , A61K39/145 , A61P31/16 , A61K39/095 , A61K39/09 , A61P37/04 , A61P31/12 , A61P31/04 , A61K39/00 , A61K39/102
CPC分类号： A61K39/02 , A61K39/095 , A61K2039/55505
摘要： Calcium phosphate is used as an adjuvant, with a high degree of antigen adsorption to the adjuvant. The invention is particularly useful for adjuvanting conjugated capsular saccharide antigens. Buffers, such as phosphate or histidine buffers, can advantageously be used in combination with the calcium phosphate, and compositions may have a pH in the range of 5.5 to 7.5.
摘要翻译： 使用磷酸钙作为佐剂，对佐剂具有高度的抗原吸附。 本发明特别可用于佐剂结合的荚膜糖抗原。 缓冲剂，例如磷酸盐或组氨酸缓冲液，可以有利地与磷酸钙组合使用，组合物的pH可以在5.5-7.5的范围内。
-
公开(公告)号：US20110280949A1
公开(公告)日：2011-11-17
申请号：US13057727
申请日：2009-08-05
申请人： Padma Malyala , Derek O'Hagan , Manmohan Singh
发明人： Padma Malyala , Derek O'Hagan , Manmohan Singh
CPC分类号： A61K39/39 , A61K9/14 , A61K9/19 , A61K9/5031 , A61K31/355 , A61K39/385 , A61K2039/55511 , A61K2039/55555 , A61K2039/55561 , A61K2039/6093
摘要： Immunogenic compositions are disclosed which comprise microparticles that comprise a biodegradable polymer, an immunological adjuvant and a tocol-family compound. Methods of making and using such microparticle compositions are also disclosed.
摘要翻译： 公开了包含可生物降解的聚合物，免疫佐剂和托氏家族化合物的微粒的免疫原性组合物。 还公开了制备和使用这种微粒组合物的方法。
-
公开(公告)号：US08021834B2
公开(公告)日：2011-09-20
申请号：US12215999
申请日：2008-06-30
申请人： Derek O'Hagan , Gary Van Nest , Gary S. Ott , Manmohan Singh
发明人： Derek O'Hagan , Gary Van Nest , Gary S. Ott , Manmohan Singh
CPC分类号： A61K39/39 , A61K9/1075 , A61K9/1647 , A61K39/12 , A61K39/21 , A61K39/29 , A61K2039/54 , A61K2039/545 , A61K2039/55555 , A61K2039/55566 , A61K2039/6093 , C12N2740/16134 , C12N2770/24234 , Y02A50/412
摘要： Compositions are provided which include biodegradable microparticles with entrapped or adsorbed antigens, in combination with submicron oil-in-water emulsions. Also provided are methods of immunization which comprise administering to a vertebrate subject (a) a submicron oil-in-water emulsion, and (b) a therapeutically effective amount of a selected antigen entrapped in a microparticle.
摘要翻译： 提供了包含与亚微米水包油乳剂组合的具有包埋或吸附的抗原的可生物降解的微粒的组合物。 还提供了免疫方法，其包括给予脊椎动物受试者（a）亚微米水包油乳剂，和（b）治疗有效量的包埋在微粒中的选择的抗原。
-
公开(公告)号：US20090104271A1
公开(公告)日：2009-04-23
申请号：US12215999
申请日：2008-06-30
申请人： Derek O'Hagan , Gary Van Nest , Gary S. Ott , Manmohan Singh
发明人： Derek O'Hagan , Gary Van Nest , Gary S. Ott , Manmohan Singh
CPC分类号： A61K39/39 , A61K9/1075 , A61K9/1647 , A61K39/12 , A61K39/21 , A61K39/29 , A61K2039/54 , A61K2039/545 , A61K2039/55555 , A61K2039/55566 , A61K2039/6093 , C12N2740/16134 , C12N2770/24234 , Y02A50/412
摘要： Compositions are provided which include biodegradable microparticles with entrapped or adsorbed antigens, in combination with submicron oil-in-water emulsions. Also provided are methods of immunization which comprise administering to a vertebrate subject (a) a submicron oil-in-water emulsion, and (b) a therapeutically effective amount of a selected antigen entrapped in a microparticle.
-
26.发明申请公开(公告)号：US20050281843A1
公开(公告)日：2005-12-22
申请号：US11066120
申请日：2005-02-25
申请人： Manmohan Singh , Derek O'Hagan
发明人： Manmohan Singh , Derek O'Hagan
IPC分类号： A61K9/00 , A61K9/16 , A61K39/145 , A61K39/39 , A61P31/16 , A61P37/04 , A61K39/295 , A61K39/02
CPC分类号： A61K39/39 , A61K9/1635 , A61K9/1652 , A61K39/12 , A61K39/145 , A61K2039/543 , A61K2039/55544 , A61K2039/55555 , C12N2760/16134 , Y02A50/401 , Y02A50/412 , A61K2300/00
摘要： Compositions are provided which include bioadhesives in combination with adjuvants and antigens for mucosal delivery. Also provided are methods of making the compositions, as well as methods of immunization using the same.
摘要翻译： 提供了组合物，其包括与用于粘膜递送的佐剂和抗原组合的生物粘合剂。 还提供了制备组合物的方法以及使用其的免疫方法。
-
公开(公告)号：US20050136073A1
公开(公告)日：2005-06-23
申请号：US11053290
申请日：2005-02-08
申请人： Derek O'Hagan , Gary Nest , Gary Ott , Manmohan Singh
发明人： Derek O'Hagan , Gary Nest , Gary Ott , Manmohan Singh
IPC分类号： A61K9/00 , A61K9/107 , A61K9/16 , A61K39/21 , A61K39/29 , A61K39/39 , A61P37/04 , A61K39/12 , A61K9/50
CPC分类号： A61K39/39 , A61K9/1075 , A61K9/1647 , A61K39/12 , A61K39/21 , A61K39/29 , A61K2039/54 , A61K2039/545 , A61K2039/55555 , A61K2039/55566 , A61K2039/6093 , C12N2740/16134 , C12N2770/24234 , Y02A50/412
摘要： Compositions are provided which include biodegradable microparticles with entrapped or adsorbed antigens, in combination with submicron oil-in-water emulsions. Also provided are methods of immunization which comprise administering to a vertebrate subject (a) a submicron oil-in-water emulsion, and (b) a therapeutically effective amount of a selected antigen entrapped in a microparticle.
-
公开(公告)号：US09517263B2
公开(公告)日：2016-12-13
申请号：US13377511
申请日：2010-06-10
IPC分类号： A61K39/02 , C07D471/00 , A61K39/39 , A61K39/00 , A61K39/12
CPC分类号： A61K39/39 , A61K2039/55511 , A61K2039/6093
摘要： The invention provides, inter alia, immunogenic compositions that comprise (a) a first antigen, (b) polymeric particles and (c) a benzonaphthyridine compound, which compositions elicits an immune response when administered to a vertebrate subject. The invention also provides, inter alia, methods of producing immunogenic compositions and methods for using immunogenic compositions (e.g., for treatment), among other benefits.
摘要翻译： 本发明尤其提供了免疫原性组合物，其包含（a）第一抗原，（b）聚合物颗粒和（c）苯并萘啶化合物，该组合物在施用于脊椎动物受试者时引起免疫应答。 本发明尤其提供产生免疫原性组合物的方法和使用免疫原性组合物（例如用于治疗）的方法以及其它益处。
-
公开(公告)号：US20120263753A1
公开(公告)日：2012-10-18
申请号：US13377511
申请日：2010-06-10
CPC分类号： A61K39/39 , A61K2039/55511 , A61K2039/6093
摘要： The invention provides, inter alia, immunogenic compositions that comprise (a) a first antigen, (b) polymeric particles and (c) a benzonaphthyridine compound, which compositions elicits an immune response when administered to a vertebrate subject. The invention also provides, inter alia, methods of producing immunogenic compositions and methods for using immunogenic compositions (e.g., for treatment), among other benefits.
摘要翻译： 本发明尤其提供了免疫原性组合物，其包含（a）第一抗原，（b）聚合物颗粒和（c）苯并萘啶化合物，该组合物在施用于脊椎动物受试者时引起免疫应答。 本发明尤其提供产生免疫原性组合物的方法和使用免疫原性组合物（例如用于治疗）的方法以及其它益处。
-
公开(公告)号：US08206749B1
公开(公告)日：2012-06-26
申请号：US09914279
申请日：2000-02-09
申请人： Derek O'Hagan , Gary S. Ott , John Donnelly , Jina Kazzaz , Mildred Ugozzoli , Manmohan Singh , John Barackman
发明人： Derek O'Hagan , Gary S. Ott , John Donnelly , Jina Kazzaz , Mildred Ugozzoli , Manmohan Singh , John Barackman
IPC分类号： A61K9/50
CPC分类号： A61K39/39 , A61K9/1075 , A61K9/167 , A61K39/0208 , A61K39/21 , A61K39/245 , A61K39/29 , Y02A50/411 , Y02A50/471
摘要： Microparticles with adsorbent surfaces, methods of making such microparticles, and uses thereof, are disclosed. The microparticles comprise a polymer, such as a poly(α-hydroxy acid), a polyhydroxy butyric acid, a polycaprolactone, a polyorthoester, a polyanhydride, and the like, and are formed using cationic, anionic, or nonionic detergents. The surface of the microparticles efficiently adsorb biologically active macromolecules, such as DNA, polypeptides, antigens, and adjuvants. Also provided are compositions of an oil droplet emulsion having a metabolizable oil and an emulsifying agent. Immunogenic compositions having an immunostimulating amount of an antigenic substance, and an immunostimulating amount of an adjuvant composition are also provided. Methods of stimulating an immune response, methods of immunizing a host animal against a viral, bacterial, or parasitic infection, and methods of increasing a Th1 immune response in a host animal by administering to the animal an immunogenic composition of the microparticles, and/or microemulsions of the invention, are also provided.
-
-
-
-
-
-
-
-
-
搜索结果
111 条记录 (耗时 0.04 秒)
