公开(公告)号：US08431160B2

公开(公告)日：2013-04-30

申请号：US11710250

申请日：2007-02-24

申请人： Derek O'Hagan ,  Manmohan Singh ,  Janet Wendorf ,  Jina Kazzaz ,  Padma Malyala

发明人： Derek O'Hagan ,  Manmohan Singh ,  Janet Wendorf ,  Jina Kazzaz ,  Padma Malyala

IPC分类号： A61K9/14 ,  A61K39/00 ,  A61K39/39 ,  A61K39/12 ,  A61K39/02 ,  A61K39/002 ,  A61K39/21 ,  A61K39/29 ,  A61K39/145 ,  A61K39/10 ,  A61K39/05 ,  A61K39/08 ,  A61P37/04

CPC分类号： A61K9/1652 ,  A61K39/095 ,  A61K39/385 ,  A61K39/39 ,  A61K2039/55555 ,  A61K2039/55561 ,  A61K2039/6093

摘要： Immunogenic compositions are described herein which comprise microparticles that further comprise a biodegradable polymer. The microparticle compositions also comprise a cationic polysaccharide and an immunological species selected from an antigen, an immunological adjuvant and a combination thereof. Also described are methods of making such compositions and methods of administering such compositions. Methods of modulating the release rate of immunological species from microparticles are also described. These methods comprise varying the ratio of the cationic polysaccharide relative to the biodegradable polymer within the microparticles.

公开(公告)号：US08815253B2

公开(公告)日：2014-08-26

申请号：US12746723

申请日：2008-12-04

申请人： Padma Malyala ,  Derek O'Hagan ,  Manmohan Singh

发明人： Padma Malyala ,  Derek O'Hagan ,  Manmohan Singh

IPC分类号： A61K39/02 ,  A61K49/00 ,  A61K39/00 ,  A61K31/437 ,  A61K9/16 ,  A61K39/07 ,  A61K31/4745 ,  A61K39/39

CPC分类号： A61K31/437 ,  A61K9/1647 ,  A61K31/4745 ,  A61K39/07 ,  A61K39/39 ,  A61K2039/55511 ,  A61K2039/57 ,  Y02A50/466

摘要： The invention provides, inter alia, immunogenic compositions that comprise (a) a first antigen, (b) at least first and second adjuvants, wherein the first adjuvant comprises microparticles and wherein the second adjuvant comprises an imidazoquinoline compound, and (c) a pharmaceutically acceptable excipient, which compositions elicits an immune response when administered to a vertebrate subject. The invention also provides methods of producing immunogenic compositions and methods for using immunogenic compositions (e.g., for treatment), among other benefits.

摘要翻译： 本发明尤其提供包含（a）第一抗原，（b）至少第一和第二佐剂的免疫原性组合物，其中所述第一佐剂包含微粒，并且其中所述第二佐剂包含咪唑并喹啉化合物，和（c）药学上 可接受的赋形剂，当给予脊椎动物受试者时，该组合物引起免疫应答。 本发明还提供了产生免疫原性组合物的方法和用于使用免疫原性组合物（例如，用于治疗）的方法以及其它益处。

公开(公告)号：US20110280949A1

公开(公告)日：2011-11-17

申请号：US13057727

申请日：2009-08-05

申请人： Padma Malyala ,  Derek O'Hagan ,  Manmohan Singh

发明人： Padma Malyala ,  Derek O'Hagan ,  Manmohan Singh

IPC分类号： A61K47/34 ,  A61K9/18 ,  A61P37/00 ,  A61K39/00

CPC分类号： A61K39/39 ,  A61K9/14 ,  A61K9/19 ,  A61K9/5031 ,  A61K31/355 ,  A61K39/385 ,  A61K2039/55511 ,  A61K2039/55555 ,  A61K2039/55561 ,  A61K2039/6093

摘要： Immunogenic compositions are disclosed which comprise microparticles that comprise a biodegradable polymer, an immunological adjuvant and a tocol-family compound. Methods of making and using such microparticle compositions are also disclosed.

摘要翻译： 公开了包含可生物降解的聚合物，免疫佐剂和托氏家族化合物的微粒的免疫原性组合物。 还公开了制备和使用这种微粒组合物的方法。

公开(公告)号：US20130101609A1

公开(公告)日：2013-04-25

申请号：US13574958

申请日：2011-01-24

申请人： Derek O'Hagan ,  Manmohan Singh ,  Siddhartha Jain ,  Padma Malyala

发明人： Derek O'Hagan ,  Manmohan Singh ,  Siddhartha Jain ,  Padma Malyala

IPC分类号： A61K9/14 ,  A61J1/00

CPC分类号： A61K9/14 ,  A61J1/00 ,  A61K39/00 ,  A61K39/095 ,  A61K2039/55555

摘要： In one aspect, the present invention provides sterile microparticle compositions comprising biodegradable microparticles, which comprise at least one biodegradable polymer. In other aspects, the present invention provides methods of making and using such compositions as well as articles of manufacture and kits containing the same.

摘要翻译： 一方面，本发明提供了包含可生物降解的微粒的无菌微粒组合物，其包含至少一种可生物降解的聚合物。 在其它方面，本发明提供了制备和使用这些组合物以及制备制品的方法以及含有该组合物的试剂盒。

公开(公告)号：US20110135679A1

公开(公告)日：2011-06-09

申请号：US12746723

申请日：2008-12-07

申请人： Padma Malyala ,  Derek O'Hagan ,  Manmohan Singh

发明人： Padma Malyala ,  Derek O'Hagan ,  Manmohan Singh

IPC分类号： A61K39/385 ,  A61K39/00 ,  A61K39/12 ,  A61K39/02 ,  A61K39/095 ,  A61K39/29 ,  A61K39/25 ,  A61K39/13 ,  A61K39/165 ,  A61K39/20 ,  A61K39/145 ,  A61K39/10 ,  A61K39/21 ,  A61K39/245 ,  A61K39/05 ,  A61K39/08 ,  A61K39/09 ,  A61P37/04

CPC分类号： A61K31/437 ,  A61K9/1647 ,  A61K31/4745 ,  A61K39/07 ,  A61K39/39 ,  A61K2039/55511 ,  A61K2039/57 ,  Y02A50/466

摘要： The invention provides, inter alia, immunogenic compositions that comprise (a) a first antigen, (b) at least first and second adjuvants, wherein the first adjuvant comprises microparticles and wherein the second adjuvant comprises an imidazoquinoline compound, and (c) a pharmaceutically acceptable excipient, which compositions elicits an immune response when administered to a vertebrate subject. The invention also provides methods of producing immunogenic compositions and methods for using immunogenic compositions (e.g., for treatment), among other benefits.

摘要翻译： 本发明尤其提供包含（a）第一抗原，（b）至少第一和第二佐剂的免疫原性组合物，其中所述第一佐剂包含微粒，并且其中所述第二佐剂包含咪唑并喹啉化合物，和（c）药学上 可接受的赋形剂，当给予脊椎动物受试者时，该组合物引起免疫应答。 本发明还提供了产生免疫原性组合物的方法和用于使用免疫原性组合物（例如，用于治疗）的方法以及其它益处。

公开(公告)号：US20090169636A1

公开(公告)日：2009-07-02

申请号：US11710250

申请日：2007-02-24

申请人： Derek O' Hagan ,  Manmohan Singh ,  Janet Wendorf ,  Jina Kazzaz ,  Padma Malyala

发明人： Derek O' Hagan ,  Manmohan Singh ,  Janet Wendorf ,  Jina Kazzaz ,  Padma Malyala

IPC分类号： A61K9/14 ,  A61K39/00 ,  A61K39/39 ,  A61K39/12 ,  A61K39/02 ,  A61K39/002 ,  A61K39/21 ,  A61K39/29 ,  A61K39/145 ,  A61K39/10 ,  A61K39/05 ,  A61K39/08 ,  A61P37/04

CPC分类号： A61K9/1652 ,  A61K39/095 ,  A61K39/385 ,  A61K39/39 ,  A61K2039/55555 ,  A61K2039/55561 ,  A61K2039/6093

摘要： Immunogenic compositions are described herein which comprise microparticles that further comprise a biodegradable polymer. The microparticle compositions also comprise a cationic polysaccharide and an immunological species selected from an antigen, an immunological adjuvant and a combination thereof. Also described are methods of making such compositions and methods of administering such compositions. Methods of modulating the release rate of immunological species from microparticles are also described. These methods comprise varying the ratio of the cationic polysaccharide relative to the biodegradable polymer within the microparticles.

摘要翻译： 本文描述了包含进一步包含生物可降解聚合物的微粒的免疫原性组合物。 微粒组合物还包含阳离子多糖和选自抗原，免疫佐剂及其组合的免疫物质。 还描述了制备这样的组合物的方法和施用这样的组合物的方法。 还描述了将免疫物质从微粒释放速率调节的方法。 这些方法包括改变阳离子多糖相对于微粒内生物可降解聚合物的比例。

公开(公告)号：US10286056B2

公开(公告)日：2019-05-14

申请号：US13982042

申请日：2012-01-27

申请人： Luis Brito ,  Manmohan Singh ,  Derek O'Hagan

发明人： Luis Brito ,  Manmohan Singh ,  Derek O'Hagan

IPC分类号： A61K39/39 ,  A61K39/095 ,  A61K9/107 ,  A61K31/00 ,  A61K31/4745 ,  A61K9/00 ,  A61K31/4375 ,  A61K47/26 ,  A61K47/32 ,  A61K47/44

摘要： High loading of lipophilic pharmacological agents (in particular, lipophilic immunopotentiators) in oil-in-water emulsions can result in crystallisation of the lipophilic agent. To overcome this problem the invention uses an oil-in-water emulsion in combination with a crystallisation inhibitor, and this combination provides emulsions which can be loaded with high levels of lipophilic pharmacological agents.

公开(公告)号：US09636410B2

公开(公告)日：2017-05-02

申请号：US14130886

申请日：2012-07-06

申请人： Luis Brito ,  Michelle Chan ,  Andrew Geall ,  Derek O'Hagan ,  Manmohan Singh

发明人： Luis Brito ,  Michelle Chan ,  Andrew Geall ,  Derek O'Hagan ,  Manmohan Singh

IPC分类号： A61K47/48 ,  A61K9/107 ,  A61K47/06 ,  A61K47/24 ,  A61K39/12 ,  A61K39/39 ,  A61K39/00

CPC分类号： A61K39/39 ,  A61K9/1075 ,  A61K39/12 ,  A61K39/155 ,  A61K39/245 ,  A61K47/02 ,  A61K47/06 ,  A61K47/12 ,  A61K47/22 ,  A61K47/24 ,  A61K47/26 ,  A61K47/34 ,  A61K2039/5256 ,  A61K2039/53 ,  A61K2039/55555 ,  A61K2039/55566 ,  A61K2039/575 ,  C12N7/00 ,  C12N2710/16134 ,  C12N2710/16171 ,  C12N2710/16734 ,  C12N2710/16771 ,  C12N2760/18534 ,  C12N2760/18571 ,  C12N2770/36134 ,  C12N2770/36143 ,  C12N2840/203 ,  Y02A50/386 ,  Y02A50/388 ,  Y02A50/412

摘要： This invention generally relates to cationic oil-in-water emulsions that contain high concentrations of cationic lipids and have a defined oil:lipid ratio. The cationic lipid can interact with the negatively charged molecule thereby anchoring the molecule to the emulsion particles. The cationic emulsions described herein are useful for delivering negatively charged molecules, such as nucleic acid molecules to cells, and for formulating nucleic acid-based vaccines.

公开(公告)号：US09192661B2

公开(公告)日：2015-11-24

申请号：US13808245

申请日：2011-06-07

申请人： Siddhartha Jain ,  Derek O'Hagan ,  Manmohan Singh

发明人： Siddhartha Jain ,  Derek O'Hagan ,  Manmohan Singh

IPC分类号： A61K39/385 ,  A61K9/16 ,  A61K9/51 ,  A61K39/155 ,  C12N15/86 ,  C12N15/88 ,  A61K39/12 ,  A61K39/00

CPC分类号： A61K39/385 ,  A61K9/1617 ,  A61K9/1647 ,  A61K9/5123 ,  A61K9/5153 ,  A61K39/12 ,  A61K39/155 ,  A61K2039/5256 ,  A61K2039/53 ,  A61K2039/55555 ,  A61K2039/622 ,  A61P31/14 ,  C12N15/86 ,  C12N15/88 ,  C12N2760/18534 ,  C12N2770/36143

摘要： Particle compositions comprising adsorbed RNA replicons as well as methods of making and using the same are described.

摘要翻译： 描述包含吸附的RNA复制子的颗粒组合物以及其制备和使用方法。

公开(公告)号：US20130195898A1

公开(公告)日：2013-08-01

申请号：US13621174

申请日：2012-09-15

申请人： Derek O'Hagan ,  Gary S. Ott ,  John Donnelly ,  Jina Kazzaz ,  Mildred Ugozzoli ,  Manmohan Singh ,  John Barackman

发明人： Derek O'Hagan ,  Gary S. Ott ,  John Donnelly ,  Jina Kazzaz ,  Mildred Ugozzoli ,  Manmohan Singh ,  John Barackman

IPC分类号： A61K39/39

CPC分类号： A61K39/39 ,  A61K9/1075 ,  A61K9/167 ,  A61K39/0208 ,  A61K39/21 ,  A61K39/245 ,  A61K39/29 ,  Y02A50/411 ,  Y02A50/471

摘要： Microparticles with adsorbent surfaces, methods of making such microparticles, and uses thereof, are disclosed. The microparticles comprise a polymer, such as a poly(α-hydroxy acid), a polyhydroxy butyric acid, a polycaprolactone, a polyorthoester, a polyanhydride, and the like, and are formed using cationic, anionic, or nonionic detergents. The surface of the microparticles efficiently adsorb biologically active macromolecules, such as DNA, polypeptides, antigens, and adjuvants. Also provided are compositions of an oil droplet emulsion having a metabolizable oil and an emulsifying agent. Immunogenic compositions having an immunostimulating amount of an antigenic substance, and an immunostimulating amount of an adjuvant composition are also provided. Methods of stimulating an immune response, methods of immunizing a host animal against a viral, bacterial, or parasitic infection, and methods of increasing a Th1 immune response in a host animal by administering to the animal an immunogenic composition of the microparticles, and/or microemulsions of the invention, are also provided.