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公开(公告)号：US09408907B2
公开(公告)日：2016-08-09
申请号：US13516227
申请日：2010-12-15
IPC分类号： A61K39/39 , A61K31/4745 , A61K31/7004 , A61K31/717 , A61K39/095 , A61K39/155 , A61K31/496 , A61K31/5377 , A61K31/675 , A61K31/683 , A61K39/12 , A61K39/00
CPC分类号： A61K39/39 , A61K31/4745 , A61K31/496 , A61K31/5377 , A61K31/675 , A61K31/683 , A61K31/7004 , A61K31/717 , A61K39/095 , A61K39/12 , A61K39/155 , A61K2039/55505 , A61K2039/55511 , A61K2039/55555 , A61K2039/55561 , A61K2039/55566 , C12N2760/14134 , C12N2760/18534 , Y02A50/41 , A61K2300/00
摘要： The present invention generally relates to homogeneous suspensions of small molecule immune potentiators (SMIPs) that are capable of stimulating or modulating an immune response in a subject in need thereof. The homogeneous suspensions may be used in combinations with various antigens or adjuvants for vaccine therapies.
摘要翻译： 本发明一般涉及能够刺激或调节有需要的受试者的免疫应答的小分子免疫增强剂（SMIP）的均匀悬浮液。 均匀悬浮液可以与各种抗原或佐剂组合用于疫苗疗法。
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公开(公告)号：US20130101629A1
公开(公告)日：2013-04-25
申请号：US13516227
申请日：2010-12-15
IPC分类号： A61K39/39 , A61K31/496 , A61K31/683 , A61K31/675 , A61K31/4745 , A61K31/5377
CPC分类号： A61K39/39 , A61K31/4745 , A61K31/496 , A61K31/5377 , A61K31/675 , A61K31/683 , A61K31/7004 , A61K31/717 , A61K39/095 , A61K39/12 , A61K39/155 , A61K2039/55505 , A61K2039/55511 , A61K2039/55555 , A61K2039/55561 , A61K2039/55566 , C12N2760/14134 , C12N2760/18534 , Y02A50/41 , A61K2300/00
摘要： The present invention generally relates to homogeneous suspensions of small molecule immune potentiators (SMIPs) that are capable of stimulating or modulating an immune response in a subject in need thereof. The homogeneous suspensions may be used in combinations with various antigens or adjuvants for vaccine therapies.
摘要翻译： 本发明一般涉及能够刺激或调节有需要的受试者的免疫应答的小分子免疫增强剂（SMIP）的均匀悬浮液。 均匀悬浮液可以与各种抗原或佐剂组合用于疫苗疗法。
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公开(公告)号：US09950062B2
公开(公告)日：2018-04-24
申请号：US13394036
申请日：2010-09-01
IPC分类号： A61K39/39 , A61K31/66 , A61K33/08 , A61K45/06 , A61K31/4375 , A61K33/42 , A61K39/095 , A61K39/00
CPC分类号： A61K39/39 , A61K31/4375 , A61K31/66 , A61K33/08 , A61K33/42 , A61K39/095 , A61K45/06 , A61K2039/55505 , A61K2039/55511 , Y02A50/386 , Y02A50/41 , A61K2300/00
摘要： The invention provides a novel class of compounds, immunogenic compositions and pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with Toll-Like Receptors 7. In one aspect, the compounds are useful as adjuvants for enhancing the effectiveness of a vaccine.
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公开(公告)号：US20120237546A1
公开(公告)日：2012-09-20
申请号：US13394036
申请日：2010-09-01
IPC分类号： A61K39/00 , A61K39/095 , A61K39/12 , A61P37/04 , A61P31/04 , A61P31/12 , A61P31/14 , A61K39/02 , A61K39/155
CPC分类号： A61K39/39 , A61K31/4375 , A61K31/66 , A61K33/08 , A61K33/42 , A61K39/095 , A61K45/06 , A61K2039/55505 , A61K2039/55511 , Y02A50/386 , Y02A50/41 , A61K2300/00
摘要： The invention provides a novel class of compounds, immunogenic compositions and pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with Toll-Like Receptors 7. In one aspect, the compounds are useful as adjuvants for enhancing the effectiveness of a vaccine.
摘要翻译： 本发明提供了一类新颖的化合物，免疫原性组合物和包含这些化合物的药物组合物以及使用这些化合物治疗或预防与Toll样受体7相关的疾病或病症的方法。一方面，该化合物可用作增强的佐剂 疫苗的有效性。
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公开(公告)号：US20110053893A1
公开(公告)日：2011-03-03
申请号：US12874153
申请日：2010-09-01
申请人： Tom Yao Hsiang Wu , Yongkai Li , Alex Cortez , Kathy Yue , Xiaoyue Zhang , Manmohan Singh , David Skibinski
发明人： Tom Yao Hsiang Wu , Yongkai Li , Alex Cortez , Kathy Yue , Xiaoyue Zhang , Manmohan Singh , David Skibinski
IPC分类号： A61K31/675 , C07F9/38 , C07F9/42 , A61P31/00 , A61P11/00 , A61P17/00 , A61P19/02 , A61P29/00 , A61P31/18 , A61P35/00
CPC分类号： C07F9/6561 , C07D471/04
摘要： The invention provides a novel class of compounds, immunogenic compositions and pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with Toll-Like Receptors 7. In one aspect, the compounds are useful as adjuvants for enhancing the effectiveness of a vaccine.
摘要翻译： 本发明提供了一类新颖的化合物，免疫原性组合物和包含这些化合物的药物组合物以及使用这些化合物治疗或预防与Toll样受体7相关的疾病或病症的方法。一方面，该化合物可用作增强的佐剂 疫苗的有效性。
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公开(公告)号：US08466167B2
公开(公告)日：2013-06-18
申请号：US12921129
申请日：2009-02-27
申请人： Tom Yao Hsiang Wu , Yongkai Li , Alex Cortez , Yefen Zou , Pranab Mishra , Xiaoyue Zhang , David Skibinski , Manmohan Singh , Nicholas Valiante
发明人： Tom Yao Hsiang Wu , Yongkai Li , Alex Cortez , Yefen Zou , Pranab Mishra , Xiaoyue Zhang , David Skibinski , Manmohan Singh , Nicholas Valiante
IPC分类号： A61K31/44 , C07D471/00
CPC分类号： C07D471/04 , C07D221/12 , C07D471/14 , C07D491/056 , C07D495/04
摘要： The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with Toll-Like Receptors, including TLR7 and TLR8. In one aspect, the compounds are useful as adjuvants for enhancing the effectiveness of a vaccine (formula I) wherein: X3 is N; X4 is N Or CR3; X5 is —CR4═CR5.
摘要翻译： 本发明提供了一类新颖的化合物，包含这些化合物的药物组合物和使用这些化合物治疗或预防与Toll样受体（包括TLR7和TLR8）相关的疾病或病症的方法。 一方面，所述化合物可用作增强疫苗（式I）有效性的佐剂，其中：X3为N; X4是N或CR3; X5是-CR4 = CR5。
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公开(公告)号：US20110081365A1
公开(公告)日：2011-04-07
申请号：US12921129
申请日：2009-02-27
申请人： Alex Cortez , Yongkai Li , Pranab Mishra , Manmohan Singh , David Skibinski , Nicholas Valiante , Tom Yao-Hsiang Wu , Xiaoyue Zhang , Yefen Zou
发明人： Alex Cortez , Yongkai Li , Pranab Mishra , Manmohan Singh , David Skibinski , Nicholas Valiante , Tom Yao-Hsiang Wu , Xiaoyue Zhang , Yefen Zou
IPC分类号： A61K39/00 , C07D471/04 , C07D495/04 , C07D413/14 , C07D239/70 , A61K31/438 , A61K31/4985 , A61K31/5377 , A61K31/519 , A61P37/02 , A61P11/06 , A61P37/04
CPC分类号： C07D471/04 , C07D221/12 , C07D471/14 , C07D491/056 , C07D495/04
摘要： The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with Toll-Like Receptors, including TLR7 and TLR8. In one aspect, the compounds are useful as adjuvants for enhancing the effectiveness of a vaccine (formula I) wherein: X3 is N; X4 is N Or CR3; X5 is —CR4═CR5.
摘要翻译： 本发明提供了一类新颖的化合物，包含这些化合物的药物组合物和使用这些化合物治疗或预防与Toll样受体（包括TLR7和TLR8）相关的疾病或病症的方法。 一方面，所述化合物可用作增强疫苗（式I）有效性的佐剂，其中：X3为N; X4是N或CR3; X5是-CR4 = CR5。
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公开(公告)号：US09045470B2
公开(公告)日：2015-06-02
申请号：US12874153
申请日：2010-09-01
申请人： Tom Yao Hsiang Wu , Yongkai Li , Alex Cortez , Kathy Yue , Xiaoyue Zhang , Manmohan Singh , David Skibinski
发明人： Tom Yao Hsiang Wu , Yongkai Li , Alex Cortez , Kathy Yue , Xiaoyue Zhang , Manmohan Singh , David Skibinski
IPC分类号： A01N61/00 , A61K31/00 , A01N57/00 , A61K31/675 , C07D471/04
CPC分类号： C07F9/6561 , C07D471/04
摘要： The invention provides a novel class of compounds, immunogenic compositions and pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with Toll-Like Receptors 7. In one aspect, the compounds are useful as adjuvants for enhancing the effectiveness of a vaccine.
摘要翻译： 本发明提供了一类新颖的化合物，免疫原性组合物和包含这些化合物的药物组合物以及使用这些化合物治疗或预防与Toll样受体7相关的疾病或病症的方法。一方面，该化合物可用作增强的佐剂 疫苗的有效性。
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公开(公告)号：US20140112950A1
公开(公告)日：2014-04-24
申请号：US14002700
申请日：2012-03-02
申请人： Manmohan Singh , Barbara Baudner , David Skibinski
发明人： Manmohan Singh , Barbara Baudner , David Skibinski
IPC分类号： A61K39/00
CPC分类号： A61K39/0018 , A61K31/4375 , A61K31/66 , A61K33/06 , A61K39/102 , A61K39/116 , A61K39/12 , A61K39/295 , A61K39/39 , A61K2039/545 , A61K2039/55505 , A61K2039/55555 , A61K2039/55566 , A61K2039/70 , C12N2730/10134 , C12N2770/32634 , Y02A50/466 , A61K2300/00
摘要： Combination vaccine compositions as well as methods for their manufacture have a relatively low amount of antigen and/or a relatively low amount of aluminium, but they can nevertheless have immunogenicity which is comparable to combination vaccines with a relatively high amount of antigen and/or a relatively high amount of aluminium. Aluminium-free combination vaccine compositions are also provided e.g. compositions which are adjuvanted with an oil-in-water emulsion adjuvant.
摘要翻译： 组合疫苗组合物及其制备方法具有相对低量的抗原和/或相对低量的铝，但是它们仍可具有免疫原性，其可与具有相对高量抗原和/或 相对较高的铝量。 也提供了无铝组合疫苗组合物，例如， 用水包油乳剂佐剂佐剂化的组合物。
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公开(公告)号：US20150225432A1
公开(公告)日：2015-08-13
申请号：US14696165
申请日：2015-04-24
申请人： Alex Cortez , Yongkai Li , Manmohan Singh , David Skibinski , Kathy Yue , Tom Yao-Hsiang Wu , Xiaoyue Zhang
发明人： Alex Cortez , Yongkai Li , Manmohan Singh , David Skibinski , Kathy Yue , Tom Yao-Hsiang Wu , Xiaoyue Zhang
IPC分类号： C07F9/6561
CPC分类号： C07F9/6561 , C07D471/04
摘要： The invention provides a novel class of compounds, immunogenic compositions and pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with Toll-Like Receptors 7. In one aspect, the compounds are useful as adjuvants for enhancing the effectiveness of a vaccine.
摘要翻译： 本发明提供了一类新颖的化合物，免疫原性组合物和包含这些化合物的药物组合物以及使用这些化合物治疗或预防与Toll样受体7相关的疾病或病症的方法。一方面，该化合物可用作增强的佐剂 疫苗的有效性。
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