公开(公告)号：US11059046B2

公开(公告)日：2021-07-13

申请号：US16227081

申请日：2018-12-20

Applicant: Meso Scale Technologies, LLC.

Inventor： Eli N. Glezer ,  Sudeep Kumar ,  Pankaj Oberoi ,  George Sigal ,  Michael Tsionsky

IPC: C12Q1/6804 ,  G01N33/68 ,  G01N33/543 ,  C12Q1/6816 ,  C12Q1/6876 ,  B01L3/00

Abstract: The invention relates to methods for conducting solid-phase binding assays. One example is an assay method having improved analyte specificity where specificity is limited by the presence of non-specific binding interactions.

公开(公告)号：US20200209234A1

公开(公告)日：2020-07-02

申请号：US16815598

申请日：2020-03-11

Applicant: Meso Scale Technologies, LLC.

Inventor： Sudeep Kumar ,  George Sigal ,  Michael Tsionsky

IPC: G01N33/543 ,  C12Q1/6834 ,  C12Q1/6832 ,  C12Q1/6823 ,  G01N33/53

Abstract: The invention relates to methods for conducting binding assays in an assay device that includes one or more storage and use zone. The storage zones of the assay device are configured to house one or more reagents used in an assay conducted in the use zone of the device.

公开(公告)号：US20190201906A1

公开(公告)日：2019-07-04

申请号：US16292521

申请日：2019-03-05

Applicant: Meso Scale Technologies, LLC.

Inventor： Eli N. Glezer ,  Bandele Jeffrey-Coker ,  Kenneth Page ,  Sandor Kovacs ,  Sudeep Kumar ,  Kristian Roth

IPC: B01L3/00 ,  F16K11/074

CPC classification number: B01L3/567 ,  B01L3/502 ,  B01L3/502738 ,  B01L3/5085 ,  B01L2300/0681 ,  B01L2300/0816 ,  B01L2300/0867 ,  B01L2300/0874 ,  B01L2400/0487 ,  B01L2400/0622 ,  B01L2400/0644 ,  F16K11/0743 ,  Y10T436/2575

Abstract: Assay cartridges are described that have a plurality of chambers and a fluidic network that includes fluidic conduits and a multi-port valve designed to selectively connect the valve inlet and one valve outlet through a fluidic connector in the valve as the remaining valve outlets are sealed.

公开(公告)号：US20180029034A1

公开(公告)日：2018-02-01

申请号：US15784399

申请日：2017-10-16

Applicant: Meso Scale Technologies, LLC.

Inventor： Eli N. Glezer ,  Sudeep Kumar ,  Pankaj Oberoi ,  George Sigal ,  Michael Tsionsky

IPC: B01L3/00 ,  G01N33/543 ,  C12Q1/68 ,  G01N33/68

CPC classification number: B01L3/50853 ,  B01L2300/021 ,  B01L2300/043 ,  B01L2300/0609 ,  B01L2300/0829 ,  C12Q1/6804 ,  C12Q1/6816 ,  C12Q1/6876 ,  G01N33/54306 ,  G01N33/54353 ,  G01N33/6845 ,  G01N2458/10 ,  C12Q2563/131

Abstract: The invention relates to methods for conducting solid-phase binding assays. One example is an assay method having improved analyte specificity where specificity is limited by the presence of non-specific binding interactions.

公开(公告)号：US20170312751A1

公开(公告)日：2017-11-02

申请号：US15646578

申请日：2017-07-11

Applicant: Meso Scale Technologies, LLC.

Inventor： Eli N. Glezer ,  Stephen Higgins ,  Sandor Kovacs ,  Sudeep Kumar ,  Kenneth Page ,  Kristian Roth ,  George Sigal

IPC: B01L7/00 ,  B01L3/00 ,  C12Q1/68

CPC classification number: B01L7/525 ,  B01L3/5027 ,  B01L2200/027 ,  B01L2200/0605 ,  B01L2200/0621 ,  B01L2200/0631 ,  B01L2200/10 ,  B01L2200/146 ,  B01L2200/16 ,  B01L2300/0645 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2300/0867 ,  B01L2300/087 ,  B01L2300/0883 ,  B01L2400/0487 ,  B01L2400/0688 ,  B01L2400/0694 ,  C12Q1/686

Abstract: Assay cartridges are described that have purification, reaction, and detection zones and other fluidic components which can include sample chambers, waste chambers, conduits, vents, reagent chambers, reconstitution chambers and the like. The assay cartridges are used to conduct multiplexed nucleic acid measurements. Also described are kits including such cartridges, methods of using the same, and a reader configured to analyze an assay conducted using an assay cartridge.

公开(公告)号：US20170160281A1

公开(公告)日：2017-06-08

申请号：US15440136

申请日：2017-02-23

Applicant: Meso Scale Technologies, LLC.

Inventor： Anahit Aghvanyan ,  Eli N. Glezer ,  John Kenten ,  Sudeep Kumar ,  Galina Nikolenko ,  Martin Stengelin

IPC: G01N33/574

CPC classification number: G01N33/57423 ,  A61K39/39533

Abstract: The present invention relates to methods of diagnosing lung cancer in a patient, as well as methods of monitoring the progression of lung cancer and/or methods of monitoring a treatment protocol of a therapeutic agent or a therapeutic regimen. The invention also relates to assay methods used in connection with the diagnostic methods described herein.

公开(公告)号：US20160349253A1

公开(公告)日：2016-12-01

申请号：US15206656

申请日：2016-07-11

Applicant: Meso Scale Technologies, LLC.

Inventor： Sudeep Kumar ,  George Sigal ,  Michael Tsionsky

IPC: G01N33/543 ,  C12Q1/68

CPC classification number: G01N33/54386 ,  C12Q1/6823 ,  C12Q1/6832 ,  C12Q1/6834 ,  G01N33/5306 ,  G01N2446/00 ,  G01N2458/30

Abstract: The invention relates to methods for conducting binding assays in an assay device that includes one or more storage and use zone. The storage zones of the assay device are configured to house one or more reagents used in an assay conducted in the use zone of the device.

公开(公告)号：US20140315742A1

公开(公告)日：2014-10-23

申请号：US14348275

申请日：2012-09-28

Applicant: MESO SCALE TECHNOLOGIES, LLC ,  THE HENRY M. JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE, INC.

Inventor： William F Blakely ,  Eli N. Glezer ,  John Kenten ,  Sudeep Kumar ,  Anu Mathew ,  Natalia I. Ossetrova ,  George Sigal

IPC: G01N33/566

CPC classification number: G01N33/56972 ,  G01N33/566 ,  G01N33/6893 ,  G01N2333/70535 ,  G01N2333/70578 ,  G01N2800/40 ,  G01N2800/60 ,  G01T1/00 ,  G01T1/02

Abstract: The present invention relates to methods and kits to assess an absorbed dose of ionizing radiation and/or the severity of tissue injury from radiation in a patient. The invention also relates to algorithms used to calculate an absorbed dose of radiation based on biomarker measurements of a plurality of biomarkers that are altered relative to a normal control in the event of radiation exposure.

Abstract translation: 本发明涉及用于评估电离辐射吸收剂量和/或患者辐射组织损伤严重程度的方法和试剂盒。 本发明还涉及用于基于在辐射暴露的情况下相对于正常对照改变的多个生物标志物的生物标志物测量来计算辐射的吸收剂量的算法。

公开(公告)号：US12216117B2

公开(公告)日：2025-02-04

申请号：US17553441

申请日：2021-12-16

Applicant: Meso Scale Technologies, LLC.

Inventor： Sudeep Kumar ,  George Sigal ,  Michael Tsionsky

IPC: G01N33/543 ,  C12Q1/6823 ,  C12Q1/6832 ,  C12Q1/6834 ,  G01N33/53

Abstract: The invention relates to methods for conducting binding assays in an assay device that includes one or more storage and use zone. The storage zones of the assay device are configured to house one or more reagents used in an assay conducted in the use zone of the device.

公开(公告)号：US11951483B2

公开(公告)日：2024-04-09

申请号：US17215962

申请日：2021-03-29

Applicant: Meso Scale Technologies, LLC.

Inventor： Eli N. Glezer ,  Sudeep Kumar ,  Pankaj Oberoi ,  George Sigal ,  Michael Tsionsky

IPC: G01N33/543 ,  B01L3/00 ,  C12Q1/6804 ,  C12Q1/6816 ,  C12Q1/6876 ,  G01N33/68

CPC classification number: B01L3/50853 ,  C12Q1/6804 ,  C12Q1/6816 ,  C12Q1/6876 ,  G01N33/54306 ,  G01N33/54353 ,  G01N33/6845 ,  B01L2300/021 ,  B01L2300/043 ,  B01L2300/0609 ,  B01L2300/0829 ,  G01N2458/10 ,  C12Q1/6816 ,  C12Q2563/131

Abstract: The invention relates to methods for conducting solid-phase binding assays. One example is an assay method having improved analyte specificity where specificity is limited by the presence of non-specific binding interactions.