公开(公告)号：US06407087B1

公开(公告)日：2002-06-18

申请号：US09605014

申请日：2000-06-27

申请人： Mitsunobu Hara ,  Shiro Akinaga ,  Yutaka Kanda ,  Timothy S. Powers ,  David A. Johnson

发明人： Mitsunobu Hara ,  Shiro Akinaga ,  Yutaka Kanda ,  Timothy S. Powers ,  David A. Johnson

IPC分类号： C07D22506

CPC分类号： C07D401/12 ,  C07D225/06 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12 ,  C07D513/04

摘要： UCF116 derivatives represented by formula (I): wherein Q represents and R represents hydrogen, C(═O)R1a (wherein R1a represents methyl, ethyl, propyl, isopropyl, 2,2-dimethylpropyl, pentyl, alkyl having 6 to 10 carbon atoms, 1-propenyl, isopropenyl, 2-methyl-1-propenyl, substituted or unsubstituted alicyclic alkyl having 3 to 5 carbon atoms, substituted or unsubstituted aryl, substituted or unsubstituted aralkyl, a substituted or unsubstituted heterocyclic group, substituted or unsubstituted aralkyloxy, or substituted lower alkyl), C(═X)NHR1b (wherein X represents an oxygen or sulfur atom, and R1b represents substituted or unsubstituted lower alkyl, substituted or unsubstituted alicyclic alkyl, substituted or unsubstituted lower alkoxycarbonyl, substituted or unsubstituted aryl, substituted or unsubstituted aralkyl, or a substituted or unsubstituted heterocyclic group), or SO2R1c (wherein R1c represents substituted or unsubstituted lower alkyl, substituted or unsubstituted aryl, substituted or unsubstituted aralkyl, a substituted or unsubstituted heterocyclic group, or substituted or unsubstituted lower alkenyl), with the proviso that, when Q is R is not benzoyl; salts thereof; isomers thereof; hydrates thereof; or solvates thereof.

摘要翻译： 由式（I）表示的UCF116衍生物：其中Q表示并且R表示氢，C（= O）R 1a（其中R 1a表示甲基，乙基，丙基，异丙基，2,2-二甲基丙基，戊基，具有6至10个碳原子的烷基， 取代或未取代的芳基，取代或未取代的芳烷基，取代或未取代的杂环基，取代或未取代的芳烷氧基或取代或未取代的低级烷基 烷基），C（= X）NHR1b（其中X表示氧或硫原子，并且R1b表示取代或未取代的低级烷基，取代或未取代的脂环族烷基，取代或未取代的低级烷氧基羰基，取代或未取代的芳基，取代或未取代的芳烷基， 或取代或未取代的杂环基）或SO 2 R 1c（其中R 1c表示取代或未取代的低级烷基，取代或未取代的芳基，取代基 芳基或未取代的芳烷基，取代或未取代的杂环基或取代或未取代的低级烯基），条件是当Q不是苯甲酰基时; 的盐; 异构体; 其水合物; 或溶剂化物。

公开(公告)号：US06303347B1

公开(公告)日：2001-10-16

申请号：US09439839

申请日：1999-11-12

申请人： David A. Johnson ,  C. Gregory Sowell

发明人： David A. Johnson ,  C. Gregory Sowell

IPC分类号： C12P1904

CPC分类号： C07H13/06 ,  C07H15/04

摘要： Aminoalkyl glucosaminide phosphate (AGP) compounds that are adjuvants and immunoeffectors are described and claimed. The compounds have a 2-deoxy-2-amino glucose in glycosidic linkage with an aminoalkyl (aglycon) group. Compounds are phosphorylated at the 4 or 6 carbon on the glucosaminide ring and comprise three 3-alkanoyloxyalkanoyl residues. The compounds augment antibody production in immunized animals as well as stimulate cytokine production and activate macrophages. Methods for using the compounds as adjuvants and immunoeffectors are also disclosed.

摘要翻译： 描述和要求保护作为佐剂和免疫作用剂的氨基葡糖苷磷酸（AGP）化合物。 该化合物具有与氨基烷基（糖苷配基）基团糖苷键连接的2-脱氧-2-氨基葡萄糖。 化合物在葡糖苷环上的4或6个碳上被磷酸化并且包含三个3-烷酰氧基烷酰基残基。 该化合物增加免疫动物的抗体产生，并刺激细胞因子产生并激活巨噬细胞。 还公开了使用化合物作为佐剂和免疫机制的方法。

公开(公告)号：US6078344A

公开(公告)日：2000-06-20

申请号：US927782

申请日：1997-09-11

申请人： Xin Wen ,  Teh-Ming Kung ,  David A. Johnson

发明人： Xin Wen ,  Teh-Ming Kung ,  David A. Johnson

IPC分类号： B41J2/315

CPC分类号： B41J2/315

摘要： Printer apparatus and method for printing an image on a receiver, the printer having a non-contact heater for improving image protection and image stability on the receiver. The printer comprises a printhead for transferring a colorant to the receiver and a heater disposed in heat transfer communication with the receiver for heating the receiver, so that the colorant diffuses into the receiver. The heater is located adjacent to the receiver. The heater comprises a heating element capable of emitting radiant heat therefrom and includes a reflector oriented with respect to the heating element and the receiver so as to reflect heat from the heating element to the receiver. The heater also comprises a heater control arrangement connected to the heating element for controlling the heating element. Moreover, the heater may further include a temperature sensor disposed relative to the receiver to more accurately control the receiver temperature, by controlling the heater in response to the temperature sensed by the temperature sensor. A receiver transport mechanism capable of engaging the receiver and transporting the receiver adjacent the heater is also provided.

摘要翻译： 用于在接收器上打印图像的打印机装置和方法，该打印机具有用于改善图像保护和接收器上的图像稳定性的非接触式加热器。 打印机包括用于将着色剂转移到接收器的打印头和与接收器进行热传递通信的加热器，用于加热接收器，使得着色剂扩散到接收器中。 加热器位于接收器附近。 加热器包括能够从其发射辐射热的加热元件，并且包括相对于加热元件和接收器定向的反射器，以将来自加热元件的热​​量反射到接收器。 加热器还包括连接到加热元件的加热器控制装置，用于控制加热元件。 此外，加热器还可以包括相对于接收器设置的温度传感器，以通过响应于温度传感器感测到的温度控制加热器来更精确地控制接收器温度。 还提供了能够接合接收器并将接收器靠近加热器传送的接收器传送机构。

公开(公告)号：USD403632S

公开(公告)日：1999-01-05

申请号：US81050

申请日：1997-12-12

申请人： James G. Guspodin ,  David A. Johnson

设计人： James G. Guspodin ,  David A. Johnson

公开(公告)号：US5739838A

公开(公告)日：1998-04-14

申请号：US425278

申请日：1995-04-20

申请人： James T. Stoops ,  David A. Johnson

发明人： James T. Stoops ,  David A. Johnson

IPC分类号： B41J2/355 ,  B41J2/52 ,  G06K15/10 ,  B41J2/35

CPC分类号： B41J2/52 ,  G06K15/10 ,  G06K2215/0077

摘要： An apparatus and method for generating all of the print levels represented by an image data signal using a parallel input print head which has an input data bus which is narrower than the image data signal involves processing and printing image data multiple times. Each time the image data is processed, it is reduced from its original width down to the width which the print head can accept. The process includes the steps of determining the minimum number of times L.sub.min that the print head must be loaded to accomplish printing using the full width of the image data signal; processing the image data L times, where L.gtoreq.L.sub.min, to produce L output signals that (1) are no wider than the width of the input data bus and (2) have values such that the sum of the values of the L output signals equals the value of the input data signal; and using the L output signals to drive the print head.

摘要翻译： 使用具有比图像数据信号更窄的输入数据总线的并行输入打印头来产生由图像数据信号表示的所有打印级别的装置和方法涉及多次处理和打印图像数据。 每次处理图像数据时，它将从原始宽度减小到打印头可以接受的宽度。 该处理包括以下步骤：确定打印头必须加载的最小次数Lmin以使用图像数据信号的全宽来完成打印; 处理图像数据L次，其中L> / = Lmin，以产生（1）不比输入数据总线的宽度宽的L个输出信号，以及（2）具有使得L 输出信号等于输入数据信号的值; 并使用L个输出信号来驱动打印头。

公开(公告)号：US5427899A

公开(公告)日：1995-06-27

申请号：US189105

申请日：1994-01-31

申请人： David W. Avison ,  Agota F. Fehervari ,  David A. Johnson ,  Diana R. Koretsky

发明人： David W. Avison ,  Agota F. Fehervari ,  David A. Johnson ,  Diana R. Koretsky

IPC分类号： C08F265/00 ,  C08L33/02 ,  C08L33/04 ,  C08L33/06 ,  G03C1/81 ,  G03C8/52 ,  G03C8/24

CPC分类号： G03C8/52 ,  C08L33/02 ,  G03C1/81 ,  C08L2201/50 ,  C08L2205/18 ,  C08L33/064 ,  Y10T428/31935

摘要： A two-phase acidic aqueous composition for use as a neutralization layer is generally comprised of a water soluble aqueous phase and a water insoluble particle phase. The particle phase generally comprises a copolymer having recurring units of an organic acid monomer and an organic ester monomer. The aqueous phase comprises a water soluble polymer having recurring units of at least an organic acid monomer. The organic acid monomers selected for the aqueous phase polymer are capable of interacting with the particle phase polymers such that the particle phase polymers are brought into stabilizing, intimate association with the aqueous phase.

摘要翻译： 用作中和层的两相酸性水性组合物通常由水溶性水相和水不溶性颗粒相组成。 颗粒相通常包含具有有机酸单体和有机酯单体的重复单元的共聚物。 水相包含具有至少有机酸单体的重复单元的水溶性聚合物。 选择用于水相聚合物的有机酸单体能够与颗粒相聚合物相互作用，使得颗粒相聚合物进入稳定状态，与水相密切相关。

公开(公告)号：US5394732A

公开(公告)日：1995-03-07

申请号：US119790

申请日：1993-09-10

申请人： David A. Johnson ,  Douglas P. Miller ,  Keith J. Manica ,  William M. Dormont ,  Christopher J. Welsh ,  William R. Mandel

发明人： David A. Johnson ,  Douglas P. Miller ,  Keith J. Manica ,  William M. Dormont ,  Christopher J. Welsh ,  William R. Mandel

IPC分类号： A61M1/36 ,  G01N29/02 ,  G01N29/032 ,  G01N29/22 ,  G01N29/32 ,  G01N29/34 ,  G01N29/36 ,  G01N29/38 ,  G01N29/44

CPC分类号： G01N29/4427 ,  A61M1/3626 ,  G01N29/032 ,  G01N29/223 ,  G01N29/32 ,  G01N29/34 ,  G01N29/36 ,  G01N29/38 ,  G01N2291/015 ,  G01N2291/02433 ,  G01N2291/02466 ,  G01N2291/102

摘要： Inclusions in a liquid flow, such as air bubbles in a blood flow, are detected by transmitting a signal through the fluid and receiving and interpreting the received signal based on the expected degree of attenuation for the liquid and the inclusions. The amplitude of the transmitted signal is automatically adjusted to maintain a constant average amplitude of the detected signal, thus compensating for changes in the detection environment. The average amplitude of the transmitted signal is controlled by integrating the received signal using an integrator with a time constant longer than the time constant of the expected inclusion signals, and comparing the integrated signal to a constant reference level.The presence of microbubbles is detected and a signal comprising a string of high frequency pulses is generated while the microbubbles are present. By counting the pulses, in conjunction with knowledge about the flow of liquid and the anticipated size of the microbubbles, an estimate of the total amount of air infused into the patient within a given time period is calculated.A tubing holder for retaining a flexible tube in an inclusion detector has tubing retention grooves formed into tubing engagement faces, the tubing engagement faces being spaced closer together than the tube diameter. The tube is inserted into the tubing holder by compressing and deforming it against the tubing engagement faces, until it reaches the tubing retaining grooves.

摘要翻译： 通过传输信号通过流体并基于液体和夹杂物的预期衰减程度来接收和解释接收到的信号来检测液体流中诸如气流中的气泡的夹杂物。 自动调整发送信号的振幅，以保持检测信号的平均幅度恒定，从而补偿检测环境的变化。 通过使用积分器对接收到的信号进行积分来控制发送信号的平均幅度，时间常数大于预期包含信号的时间常数，并将积分信号与恒定参考电平进行比较。 检测到微气泡的存在，并且在存在微泡的同时产生包括一串高频脉冲的信号。 通过计算脉冲，结合关于液体流动和微泡预期尺寸的知识，计算在给定时间段内输入患者的总空气量的估计。 用于将柔性管保持在夹杂物检测器中的管保持器具有形成为管接合面的管保持槽，管接合面与管直径相距更靠近在一起。 管通过压缩并使其变形到管接合面而插入管夹中，直到其到达管保持槽。

公开(公告)号：US5388996A

公开(公告)日：1995-02-14

申请号：US56677

申请日：1993-05-03

申请人： David A. Johnson

发明人： David A. Johnson

IPC分类号： H01R4/24 ,  G01R1/04 ,  H01R9/00 ,  H01R9/03 ,  H01R12/00 ,  H01R12/55 ,  H01R33/76 ,  H05K7/10 ,  H01R9/09

CPC分类号： H05K7/1069 ,  G01R1/0433 ,  G01R1/0466 ,  H01R12/714 ,  H05K7/1046

摘要： A connector for electrically interconnecting a lead of a device to a terminal spaced at a distance from the lead. The apparatus includes a housing which has a slot to receive one of each of the one or more contacts. The contact-receiving slot extends substantially parallel to an axis which extends between a corresponding lead and spaced terminal. The housing has a first trough formed therein proximate the lead and a second trough formed therein proximate the spaced terminal. A first elastomeric element is received in the first trough formed in the housing, and a second elastomeric element is received in the second trough formed in the housing. The first and second elastomeric elements have a measure of compressibility and tensile extendibility. A contact is received within each slot. Each contact provided has a protrusion which extends outward from the surface of the housing to be engaged by the lead to which it corresponds. Each contact also has a nub which extends outward from the surface to engage the corresponding spaced terminal. Each contact also has first and second hook portions, the first hook portion being disposed proximate the contact protrusion and encircling the first elastomeric element to hold the contact to the first elastomeric element, and the second hook portion being disposed proximate the contact nub and encircling the second elastomeric element to hold the contact to the second elastomeric element.

摘要翻译： 一种用于将设备的引线电连接到与引线间隔一定距离的端子的连接器。 该装置包括壳体，该壳体具有用于容纳一个或多个触点中的每一个中的一个的槽。 触点接收槽基本上平行于在对应的引线和间隔端子之间延伸的轴线延伸。 壳体具有在其中靠近引线形成的第一槽，并且在其间形成有靠近隔开的端子的第二槽。 第一弹性体元件被容纳在形成在壳体中的第一槽中，并且第二弹性体元件容纳在形成在壳体中的第二槽中。 第一和第二弹性体元件具有可压缩性和拉伸扩展性的量度。 在每个插槽中接收到一个联系人。 提供的每个触点具有从壳体的表面向外延伸以由其对应的引线接合的突起。 每个触点还具有从表面向外延伸以接合相应的间隔端子的纽扣。 每个接触件还具有第一和第二钩部分，第一钩部分设置在接触突起附近并且环绕第一弹性体元件以将接触保持在第一弹性体元件上，并且第二钩部分设置在靠近接触部分并且环绕 第二弹性体元件以将接触保持在第二弹性体元件上。

公开(公告)号：US5254483A

公开(公告)日：1993-10-19

申请号：US846225

申请日：1992-03-04

申请人： C. David Forgerson, II ,  David A. Johnson

发明人： C. David Forgerson, II ,  David A. Johnson

IPC分类号： H01L29/417 ,  H01L29/45 ,  H01L21/265

CPC分类号： H01L29/41775 ,  H01L29/452 ,  Y10S438/927

摘要： A direct shorting contact structure comprising a metal layer (18') makes ohmic contact with a source (10) and/or drain (12) region and with a gate electrode (22). The direct contact between source or drain and gate over the active region (16) reduces the area otherwise required for such contact and eliminates a second layer (24) of interconnection metallization otherwise required for such contact. The metal layer preferably comprises a first layer (18'a) of a material selected from the group consisting of gold-germanium, nickel-germanium, gold-germanium-nickel, molybdenum-germanium, and aluminum-germanium in ohmic contact with the source or drain region and with the gate electrode and a second layer (18'b) of a good electrically conductive, thermally stable, electromigration-resistant metal capable of providing good step coverage overlying the first layer. An example of the second layer is tungsten and its nitrides and silicides. Such a composite layer avoids step coverage and reliability problems which exist with other metallization schemes.

摘要翻译： 包括金属层（18'）的直接短路接触结构与源极（10）和/或漏极（12）区域和栅电极（22）欧姆接触。 源极或漏极与有源区域（16）之间的栅极之间的直接接触减小了这种接触所需的面积，并且消除了另外为此类接触所需的互连金属化的第二层（24）。 金属层优选地包括选自金 - 锗，镍 - 锗，金 - 锗 - 镍，钼 - 锗和与源极欧姆接触的铝 - 锗的材料的第一层（18'a） 或漏极区域以及能够提供覆盖在第一层上的良好的台阶覆盖的良好的导电，热稳定的电迁移金属的栅电极和第二层（18'b）。 第二层的一个例子是钨及其氮化物和硅化物。 这种复合层避免了其他金属化方案存在的台阶覆盖和可靠性问题。

公开(公告)号：US5217549A

公开(公告)日：1993-06-08

申请号：US680714

申请日：1991-04-04

申请人： David A. Johnson

发明人： David A. Johnson

IPC分类号： B60C9/09 ,  B60C13/00 ,  B60C17/00

CPC分类号： B60C13/00 ,  B60C17/0009 ,  B60C9/09 ,  Y10T152/10864

摘要： A pneumatic safety tire, of the type preferably having a section height of five inches or greater, having a pair of crescent shaped elastomeric reinforcing members located between the innerliner and side wall and extending from adjacent the tread shoulders to at least the apex of the bead fillers of the tire. A pair of bias reinforcing plies are located between the elastomeric reinforcing members and the side walls of the tire and extend along the side walls from adjacent the tread shoulders to below the top most turn-up ends of the body ply. The elastomeric reinforcing members preferably are similar in composition to that of the bead fillers and have a low hysteresis value preferably within the range of 0.03 and 0.11, a high modulus preferably within the range of 2600 psi and 2800 psi and a Shore A hardness preferably within the range of between 85 and 91. The elastomeric reinforcing members in combination with the reinforcing bias plies, enable a high section height tire to run at high speeds for a relatively long distance in an uninflated condition, and improve the performance of heretofore low section height run flat tires.