公开(公告)号：US20050223001A1

公开(公告)日：2005-10-06

申请号：US11143006

申请日：2005-06-01

Applicant: Harold Kester ,  Ronald Hegli ,  John Dimm ,  Mark Anderson

Inventor： Harold Kester ,  Ronald Hegli ,  John Dimm ,  Mark Anderson

IPC: G06F21/22 ,  G06F1/00 ,  G06F7/00 ,  G06F9/44 ,  G06F9/445 ,  G06F11/34 ,  G06F12/14 ,  G06F15/16 ,  G06F17/00 ,  G06F17/30 ,  H04L29/06

CPC classification number: G06F21/56 ,  G06F21/50 ,  G06F21/55 ,  G06F21/57 ,  G06F21/6218 ,  G06Q20/203 ,  H04L63/0428 ,  H04L63/20 ,  Y10S707/99931 ,  Y10S707/99943 ,  Y10S707/99945

Abstract: A system and method for updating a system that controls files executed on a workstation. The workstation includes a workstation management module configured to detect the launch of an application. A workstation application server receives data associated with the application from the workstation. This data can include a hash value. The application server module can determine one or more categories to associate with the application by referencing an application inventory database or requesting the category from an application database factory. The application database factory can receive applications from multiple application server modules. The application database factory determines whether the application was previously categorized by the application database factory and provides the category to the application server module. Once the application server module has the category, it forwards a hash/policy table to the workstation management module. Upon receipt of the hash/policy table, the workstation management module applies the policy that is associated with the launched application to control access to the application on the workstation.

Abstract translation: 一种用于更新控制在工作站上执行的文件的系统的系统和方法。 工作站包括被配置为检测应用的启动的工作站管理模块。 工作站应用程序服务器从工作站接收与应用程序相关联的数据。 该数据可以包括哈希值。 应用服务器模块可以通过引用应用库存数据库或从应用数据库工厂请求类别来确定与应用相关联的一个或多个类别。 应用程序数据库工厂可以从多个应用程序服务器模块接收应用程序。 应用程序数据库工厂确定应用程序是否以前由应用程序数据库工厂分类，并将类别提供给应用程序服务器模块。 一旦应用程序服务器模块有类别，它将一个散列/策略表转发给工作站管理模块。 在接收到散列/策略表之后，工作站管理模块应用与所启动的应用相关联的策略来控制对工作站上的应用的访问。

公开(公告)号：US20050078731A1

公开(公告)日：2005-04-14

申请号：US10685208

申请日：2003-10-14

Applicant: Xudong Fan ,  Mark Anderson ,  Craig Schardt

Inventor： Xudong Fan ,  Mark Anderson ,  Craig Schardt

IPC: G01N21/77 ,  G02B6/12 ,  H01S3/083

CPC classification number: G01N21/7746 ,  G02B2006/12138

Abstract: There are several different applications where it is desirable to increase the amount of material that can be introduced to the surface of a microresonator that has whispering gallery modes. The use of a porous surface on the microresonator permits greater amounts of the material to be captured on or near the surface of the microresonator, resulting in an increased optical interaction between the material and the light propagating in the whispering gallery mode(s) of the microresonator.

Abstract translation: 存在几种不同的应用，其中期望增加可以引入具有耳语画廊模式的微谐振器的表面的材料的量。 在微谐振器上使用多孔表面允许在微谐振器的表面上或附近捕获更多量的材料，从而导致材料与在电子图案模式中传播的光之间增加的光学相互作用 微谐振器。

公开(公告)号：US06670167B1

公开(公告)日：2003-12-30

申请号：US09460421

申请日：1999-12-14

Applicant: Ping Chen ,  Mark Anderson ,  Ya-Li Deng ,  Smita Gaur ,  Chen Chen Kan ,  Chun Luo ,  Karen Lundgren ,  Stephen Margosiak ,  Binh Nguyen ,  Patrick O'Connor ,  James Register ,  Anna Tempczyk Russell ,  Jay Sarup

Inventor： Ping Chen ,  Mark Anderson ,  Ya-Li Deng ,  Smita Gaur ,  Chen Chen Kan ,  Chun Luo ,  Karen Lundgren ,  Stephen Margosiak ,  Binh Nguyen ,  Patrick O'Connor ,  James Register ,  Anna Tempczyk Russell ,  Jay Sarup

IPC: C07H2104

CPC classification number: C12N9/1205 ,  C12Q1/34

Abstract: The present invention relates to the identification, isolation and purification of the catalytic domain of the human effector checkpoint protein kinase (hChk1). A 1.7Å crystal structure of the hChk1 kinase domain in the active conformation is reported herein. The kinase domain of hChk1 and its associated crystal structure is described for use in the discovery, identification and characterization of inhibitors of hChk1. This structure provides a three-dimensional description of the binding site of the hChk1 for structure-based design of small molecule inhibitors thereof as therapeutic agents. Inhibitors of hChk1 find utility in the treatment of hyperproliferative disorders such as HIV and cancer.

Abstract translation: 本发明涉及人类效应子检测点蛋白激酶（hChk1）的催化结构域的鉴定，分离和纯化。 本文报道了活性构象中hChk1激酶结构域的1.7Å晶体结构。 描述了hChk1的激酶结构域及其相关晶体结构，用于hChk1抑制剂的发现，鉴定和表征。 该结构提供了hChk1的结合位点的三维描述，用于其作为治疗剂的小分子抑制剂的基于结构的设计。 hChk1的抑制剂可用于治疗过度增生性疾病如艾滋病毒和癌症。

公开(公告)号：US06644367B1

公开(公告)日：2003-11-11

申请号：US10048135

申请日：2002-07-11

Applicant: Chester Savage ,  Mark Anderson ,  Silvia Sandvoss

Inventor： Chester Savage ,  Mark Anderson ,  Silvia Sandvoss

IPC: B65B104

CPC classification number: B67D7/0294 ,  B65D77/067 ,  B67D3/04 ,  Y10T137/87957

Abstract: A two-part connector structure (22, 32) includes a male connector part (32) and a female connector part (22) which are mutually engageable to open fluid communication between the connector parts (22, 32). For example, the connector parts (22, 32) may be used to establish fluid communication between a container (12) and a conduit (14). The connector parts (22, 32) are disengageable from one another to discontinue fluid communication between them, and also to close communication between ambient and each of the container and the conduit. The male connector part (32) includes a mounting structure (32a) for supporting on the female connector part (22), and also includes a guide structure (44) effective to guide a male portion (36) of the male connector part (32) into engagement with the female connector part (22). A handnut (34) of the male connector part (32), and is effective upon manual rotation to cause axial relative movement of the male probe portion (36) into or out of engagement with the female connector part (32). This invention provides a connector structure (22, 32) with considerably lowered manual engagement and disengagement forces, along with increased convenience and ease of use.

Abstract translation: 两部分连接器结构（22,32）包括阳连接器部分（32）和阴连接器部分（22），其可相互接合以打开连接器部分（22,32）之间的流体连通。 例如，连接器部件（22,32）可用于建立容器（12）和导管（14）之间的流体连通。 连接器部件（22,32）可以彼此脱离以中止它们之间的流体连通，并且还能够密封环境与容器和导管中的每个之间的连通。 阳连接器部分（32）包括用于支撑在阴连接器部分（22）上的安装结构（32a），并且还包括有效地引导阳连接器部分（32）的阳部分（36）的引导结构（44） ）与母连接器部件（22）接合。 阳连接器部分（32）的手柄（34），并且在手动旋转时有效，以使阳探头部分（36）与阴连接器部分（32）的轴向相对移动接合或脱离与阴连接器部分（32）的接合。 本发明提供了具有显着降低的手动接合和分离力的连接器结构（22,32），以及增加的便利性和易用性。

公开(公告)号：US06194631B1

公开(公告)日：2001-02-27

申请号：US09179554

申请日：1998-10-28

Applicant: Michael A. Mitchell ,  Thomas W. Beihoffer ,  Leticia L Trzupek ,  Jerald W. Darlington, Jr. ,  Mark Anderson

Inventor： Michael A. Mitchell ,  Thomas W. Beihoffer ,  Leticia L Trzupek ,  Jerald W. Darlington, Jr. ,  Mark Anderson

IPC: A61F1315

CPC classification number: A61L15/24 ,  A61L15/60 ,  B29C47/00 ,  C08F8/04 ,  C08F2810/20 ,  C08L39/02 ,  C08F126/02 ,  C08F226/02 ,  C08F222/385

Abstract: Poly(vinylamine)-based superabsorbent gels are disclosed. The superabsorbent gels either comprise a mixture of a poly(vinylamine) polymer and an acidic water-absorbing polymer, like polyacrylic acid, or comprise a salt of a poly(vinylamine) polymer. An improved method of preparing poly(vinylamine), and improved diaper cores, also are disclosed.

Abstract translation: 公开了基于聚（乙烯基胺）的超吸收凝胶。 超吸收性凝胶还包括聚（乙烯基胺）聚合物和酸性吸水聚合物如聚丙烯酸的混合物，或包含聚（乙烯基胺）聚合物的盐。 还公开了制备聚（乙烯胺）和改进的尿布芯的改进方法。

公开(公告)号：US5795885A

公开(公告)日：1998-08-18

申请号：US483057

申请日：1995-06-07

Applicant: Michael Zasloff ,  Ann Shinnar ,  William Kinney ,  Mark Anderson ,  Jon Williams ,  Michael McLane

Inventor： Michael Zasloff ,  Ann Shinnar ,  William Kinney ,  Mark Anderson ,  Jon Williams ,  Michael McLane

IPC: C07J41/00 ,  G01N33/50 ,  A61K31/56

CPC classification number: G01N33/5011 ,  C07J41/0005 ,  G01N33/5008 ,  G01N33/5044 ,  G01N33/5047 ,  G01N33/5061 ,  G01N33/5064 ,  G01N33/5088 ,  G01N2500/00

Abstract: Aminosterol compounds are described that are useful as inhibitors of the sodium/proton exchanger (NHE). Methods of using such aminosterols compounds are also disclosed, including those employing compounds that are inhibitors of a spectrum of NHEs as well as those using compounds that are inhibitors of only one specific NHE. Advantageous screening techniques and assays for evaluating a compound's therapeutic activity are also disclosed.

Abstract translation: 描述了可用作钠/质子交换器（NHE）的抑制剂的氨基甾醇化合物。 还公开了使用这种氨基甾醇化合物的方法，包括那些使用作为NHE光谱的抑制剂的化合物以及仅使用一种特异性NHE抑制剂的化合物的方法。 还公开了有利的筛选技术和用于评价化合物治疗活性的测定法。

公开(公告)号：US5165560A

公开(公告)日：1992-11-24

申请号：US858347

申请日：1992-03-26

Applicant: James F. Ennis, III ,  Mark Anderson

Inventor： James F. Ennis, III ,  Mark Anderson

IPC: B65D45/30 ,  B65D51/00

CPC classification number: B65D45/30 ,  B65D51/002 ,  Y10S215/03

Abstract: A hermetically sealed, nonrotatable closure for a bottle having a cylindrical body containing liquid and having an integral tubular neck formed with a free open end, comprises an annular flange on the tubular neck. A flexible stopper mounts on the flange. A cup shaped cap has a flat top wall with peripherally integral pliable skirt in which is an internal beveled ridge. The ridge engages the flange to lock the cap on the neck of the bottle. The top wall of the cap has a central hole to expose the stopper which can be pierced by a hypodermic needle to extract the liquid from the bottle while the cap remains unbroken on the neck of the bottle. Inside the skirt of the cap are circumferentially spaced teeth which engage in circumferential slots in the annular flange to cooperate with the ridge in preventing axial movement on the cap and stopper on the bottle. Radial webs separate the slots in the annular flange and engage in stalls defined by flat radial walls of the spaced teeth to prevent the cap and stopper from rotating on the tubular neck of the bottle.

Abstract translation: 一种用于瓶子的气密密封的不可旋转的封闭件，其具有包含液体的圆柱体并且具有形成有自由开口端的整体管状颈部，包括在管状颈部上的环形凸缘。 柔性止动器安装在法兰上。 杯形帽具有平坦的顶壁，其具有周向整合的柔软裙部，其中是内斜面脊。 脊与凸缘接合以将盖锁在瓶颈上。 盖的顶壁具有中心孔，以露出塞子，该塞子可由皮下注射针刺穿，以从瓶中提取液体，同时盖子保持不间断地在瓶颈上。 在帽的裙部内部是周向间隔开的齿，其啮合在环形凸缘中的周向狭槽中，以与脊部配合，以防止瓶盖上的瓶塞和塞子上的轴向运动。 径向腹板将环形凸缘中的狭槽分开，并且与间隔开的齿的平坦径向壁限定的档位啮合，以防止瓶盖和止动件在瓶的管状颈部上旋转。

公开(公告)号：US10750738B2

公开(公告)日：2020-08-25

申请号：US12099687

申请日：2008-04-08

Applicant: Robert Fishman ,  Robert Havener ,  Ihab Abdel Fattah ,  Anas Abdelazim ,  Scott Newell ,  Thomas H. Bishop ,  Tamer Khayal ,  Stanley Kyi ,  Ron Taylor ,  Doug Harriott ,  Matthew De Remer ,  Paul Murray ,  John Sullivan ,  Mark Anderson ,  Richard Bringham ,  Michael Van Driel ,  Waleed Hassanein

Inventor： Robert Fishman ,  Robert Havener ,  Ihab Abdel Fattah ,  Anas Abdelazim ,  Scott Newell ,  Thomas H. Bishop ,  Tamer Khayal ,  Stanley Kyi ,  Ron Taylor ,  Doug Harriott ,  Matthew De Remer ,  Paul Murray ,  John Sullivan ,  Mark Anderson ,  Richard Bringham ,  Michael Van Driel ,  Waleed Hassanein

IPC: C12Q1/02 ,  C12M1/00 ,  A01N1/02

Abstract: Methods and systems of maintaining, evaluating, and providing therapy to a lung ex vivo. The methods and systems involve positioning the lung in an ex vivo perfusion circuit; circulating a perfusion fluid through the lung, the fluid entering the lung through a pulmonary artery interface and leaving the lung through a left atrial interface; and ventilating the lung by flowing a ventilation gas through a tracheal interface. Maintaining the lung for extended periods involves causing the lung to rebreath a captive volume of air, and reaching an equilibrium state between the perfusion fluid and the ventilation gas. Evaluating the gas exchange capability of the lung involves deoxygenating the perfusion fluid and measuring a time taken to reoxygenate the perfusion fluid by ventilating the lung with an oxygenation gas.

公开(公告)号：US09462802B2

公开(公告)日：2016-10-11

申请号：US12099725

申请日：2008-04-08

Applicant: Robert Fishman ,  Robert Havener ,  Ihab Abdel Fattah ,  Anas Abdelazim ,  Scott Newell ,  Tom Bishop ,  Tamer Khayal ,  Stanley Kyi ,  Ron Taylor ,  Doug Harriott ,  Matthew De Remer ,  Paul Murray ,  John Sullivan ,  Mark Anderson ,  Richard Bringham ,  Michael Van Driel ,  Waleed Hassanein

Inventor： Robert Fishman ,  Robert Havener ,  Ihab Abdel Fattah ,  Anas Abdelazim ,  Scott Newell ,  Tom Bishop ,  Tamer Khayal ,  Stanley Kyi ,  Ron Taylor ,  Doug Harriott ,  Matthew De Remer ,  Paul Murray ,  John Sullivan ,  Mark Anderson ,  Richard Bringham ,  Michael Van Driel ,  Waleed Hassanein

IPC: A01N1/02

CPC classification number: A01N1/021 ,  A01N1/02 ,  A01N1/0247

Abstract: Methods and systems of maintaining, evaluating, and providing therapy to a lung ex vivo. The methods and systems involve positioning the lung in an ex vivo perfusion circuit; circulating a perfusion fluid through the lung, the fluid entering the lung through a pulmonary artery interface and leaving the lung through a left atrial interface; and ventilating the lung by flowing a ventilation gas through a tracheal interface. Maintaining the lung for extended periods involves causing the lung to rebreath a captive volume of air, and reaching an equilibrium state between the perfusion fluid and the ventilation gas. Evaluating the gas exchange capability of the lung involves deoxygenating the perfusion fluid and measuring a time taken to reoxygenate the perfusion fluid by ventilating the lung with an oxygenation gas.

公开(公告)号：US09247728B2

公开(公告)日：2016-02-02

申请号：US12099715

申请日：2008-04-08

Applicant: Robert Fishman ,  Robert Havener ,  Ihab Abdel Fattah ,  Anas Abdelazim ,  Scott Newell ,  Tom Bishop ,  Tamer Khayal ,  Stanley Kyi ,  Ron Taylor ,  Doug Harriott ,  Matthew De Remer ,  Paul Murray ,  John Sullivan ,  Mark Anderson ,  Richard Bringham ,  Michael Van Driel ,  Waleed Hassanein

Inventor： Robert Fishman ,  Robert Havener ,  Ihab Abdel Fattah ,  Anas Abdelazim ,  Scott Newell ,  Tom Bishop ,  Tamer Khayal ,  Stanley Kyi ,  Ron Taylor ,  Doug Harriott ,  Matthew De Remer ,  Paul Murray ,  John Sullivan ,  Mark Anderson ,  Richard Bringham ,  Michael Van Driel ,  Waleed Hassanein

IPC: A61M16/00 ,  A01N1/02

CPC classification number: A01N1/021 ,  A01N1/02 ,  A01N1/0247

Abstract: Methods and systems of maintaining, evaluating, and providing therapy to a lung ex vivo. The methods and systems involve positioning the lung in an ex vivo perfusion circuit; circulating a perfusion fluid through the lung, the fluid entering the lung through a pulmonary artery interface and leaving the lung through a left atrial interface; and ventilating the lung by flowing a ventilation gas through a tracheal interface. Maintaining the lung for extended periods involves causing the lung to rebreath a captive volume of air, and reaching an equilibrium state between the perfusion fluid and the ventilation gas. Evaluating the gas exchange capability of the lung involves deoxygenating the perfusion fluid and measuring a time taken to reoxygenate the perfusion fluid by ventilating the lung with an oxygenation gas.