摘要:
The present invention relates to the identification, isolation and purification of the catalytic domain of the human effector checkpoint protein kinase (hChk1). A 1.7Å crystal structure of the hChk1 kinase domain in the active conformation is reported herein. The kinase domain of hChk1 and its associated crystal structure is described for use in the discovery, identification and characterization of inhibitors of hChk1. This structure provides a three-dimensional description of the binding site of the hChk1 for structure-based design of small molecule inhibitors thereof as therapeutic agents. Inhibitors of hChk1 find utility in the treatment of hyperproliferative disorders such as HIV and cancer.
摘要:
Described herein are compounds, pharmaceutical compositions and methods for the inhibition of RAF kinae mediated signaling. Said compounds, pharmaceutical compositions and methods have utility in the treatment of human disease and disorders.
摘要:
Described herein are compounds, pharmaceutical compositions and methods for the inhibition of Hedgehog signaling. Said compounds, pharmaceutical compositions and methods have utility in the treatment of human and veterinary disease and disorders.
摘要:
The invention is directed to methods of bone healing by administering a p38 MAP kinase inhibitor. The invention is directed to methods of treating bone fractures, bone diseases, bone grafting, especially enhancing bone healing following facial reconstruction, maxillary reconstruction, mandibular reconstruction or tooth extraction, enhancing long bone extension, enhancing prosthetic ingrowth, and increasing bone synostosis by administering a p38 MAP kinase inhibitor.
摘要:
A method for laying a snow road or an airplane runway on a snow or ice covered surface includes the removal of a predetermined and relatively small portion of the snow or ice surface, which is melted to water and mixed with the snow or ice remaining on the snow surface. The mixture of water and snow or ice is leveled so as to form a road surface when the mixture freezes. Preferably, the snow remaining on the surface is mechanically worked with a rototiller, while the melted snow is injected into the snow being worked. The method is particularly advantageous in that it can be carried out without requiring melting of all the snow necessary to form the snow road, or requiring the addition of any water from an external source, other than the portion of snow removed from the snow surface. An apparatus for performing the method is also described.
摘要:
An intramedullary nail has a proximal part for engagement with a proximal bone fragment and a distal part for engagement with a distal bone fragment. A motion assembly interconnects the parts and allows limited axial relative motion of the proximal and distal parts. This limited axial motion provides micromotion and in some embodiments also dynamization. The nail may comprise a stem for fastening to one bone fragment and an insert within the stem for fastening to the other bone fragment, the insert being adapted to guide insertion of a bone screw through the stem and to prevent relative rotation of the distal and proximal bone fragments. The motion assembly may include spring bias and/or damping means between the parts, possibly including one or more Belleville washers.
摘要:
Described herein are compounds, pharmaceutical compositions and methods for the inhibition of Hedgehog signaling. Said compounds, pharmaceutical compositions and methods have utility in the treatment of human and veterinary diseases and disorders.
摘要:
An improved implantable valve accumulator pump for the delivery of medication is disclosed. The implantable pump comprises a pressurized drug reservoir. The medication metering assembly comprises a fixed volume accumulator positioned between a pair of valves. The valves alternately open and close to admit medication from the reservoir into the accumulator and to dispense a precise volume pulse to an outlet catheter. In order to improve the pump's accuracy and to increase pumping volume while optimizing the pump's overall size and energy usage a two way diaphragm accumulator is used. The unit can be externally programmed or can be used in a fixed rate configuration that is never programmed but set at the factory or in the current programmable configuration.
摘要:
A method and apparatus for accurately measuring superheat, bath ratio and alumina concentration in an aluminum smelting bath. In one embodiment, a reusable probe determines the bath temperature and bath sample superheat. In other embodiments, the probe also determines bath composition including bath cryolite ratio and alumina concentration.
摘要:
A method of synchronizing digitized audio information and digitized picture information establishes a reference time base based on timecodes included with the audio and picture information. The reference time base may be used to synchronize output between a digitized source and one which may be digitized or undigitized.